| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alex E Powers, Dushyant S Pate. Expression and Purification of Untagged α-Synuclein. Methods in molecular biology (Clifton, N.J.). vol 1948. 2019-07-15. PMID:30771184. |
α-synuclein (αs) is an abundant neuronal protein which has been implicated, among others, in the pathogenesis of neurodegenerative diseases like parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2019-07-15 |
2023-08-13 |
Not clear |
| Celia Kun-Rodrigues, Tatiana Orme, Susana Carmona, Dena G Hernandez, Owen A Ross, John D Eicher, Claire Shepherd, Laura Parkkinen, Lee Darwent, Michael G Heckman, Sonja W Scholz, Juan C Troncoso, Olga Pletnikova, Ted Dawson, Liana Rosenthal, Olaf Ansorge, Jordi Clarimon, Alberto Lleo, Estrella Morenas-Rodriguez, Lorraine Clark, Lawrence S Honig, Karen Marder, Afina Lemstra, Ekaterina Rogaeva, Peter St George-Hyslop, Elisabet Londos, Henrik Zetterberg, Imelda Barber, Anne Braae, Kristelle Brown, Kevin Morgan, Claire Troakes, Safa Al-Sarraj, Tammaryn Lashley, Janice Holton, Yaroslau Compta, Vivianna Van Deerlin, Geidy E Serrano, Thomas G Beach, Suzanne Lesage, Douglas Galasko, Eliezer Masliah, Isabel Santana, Pau Pastor, Monica Diez-Fairen, Miquel Aguilar, Pentti J Tienari, Liisa Myllykangas, Minna Oinas, Tamas Revesz, Andrew Lees, Brad F Boeve, Ronald C Petersen, Tanis J Ferman, Valentina Escott-Price, Neill Graff-Radford, Nigel J Cairns, John C Morris, Stuart Pickering-Brown, David Mann, Glenda M Halliday, John Hardy, John Q Trojanowski, Dennis W Dickson, Andrew Singleton, David J Stone, Rita Guerreiro, Jose Bra. A comprehensive screening of copy number variability in dementia with Lewy bodies. Neurobiology of aging. vol 75. 2019-07-11. PMID:30448004. |
we also identified dlb cases presenting rare cnvs in genes previously associated with dlb or related neurodegenerative diseases, such as snca, app, and mapt. |
2019-07-11 |
2023-08-13 |
Not clear |
| Eleanor King, John Tiernan O'Brien, Paul Donaghy, Christopher Morris, Nicola Barnett, Kirsty Olsen, Carmen Martin-Ruiz, John-Paul Taylor, Alan J Thoma. Peripheral inflammation in prodromal Alzheimer's and Lewy body dementias. Journal of neurology, neurosurgery, and psychiatry. vol 89. issue 4. 2019-07-08. PMID:29248892. |
there is growing evidence for the role of systemic inflammation in alzheimer's disease (ad) and other neurodegenerative diseases; however the systemic inflammatory profile in dementia with lewy bodies (dlb) has never before been investigated. |
2019-07-08 |
2023-08-13 |
Not clear |
| Michael G Erkkinen, Mee-Ohk Kim, Michael D Geschwin. Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases. Cold Spring Harbor perspectives in biology. vol 10. issue 4. 2019-06-26. PMID:28716886. |
this review summarizes and highlights clinical aspects of several of the most commonly encountered neurodegenerative diseases, including ad, frontotemporal dementia (ftd) and its variants, progressive supranuclear palsy (psp), corticobasal degeneration (cbd), parkinson's disease (pd), dementia with lewy bodies (dlb), multiple system atrophy (msa), and huntington's disease (hd). |
2019-06-26 |
2023-08-13 |
Not clear |
| Jiayin Zhou, Yuanyuan Deng, Fei Li, Caixia Yin, Jingshan Shi, Qihai Gon. Icariside II attenuates lipopolysaccharide-induced neuroinflammation through inhibiting TLR4/MyD88/NF-κB pathway in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 111. 2019-06-13. PMID:30590319. |
inflammation in central nervous system (cns) plays a vital role in neurodegenerative diseases such as alzheimer's disease (ad), parkinson's disease (pd), lewy body dementia (dlb), hiv-related dementia and traumatic brain injury. |
2019-06-13 |
2023-08-13 |
rat |
| Linda A Hershey, Rhonda Coleman-Jackso. Pharmacological Management of Dementia with Lewy Bodies. Drugs & aging. vol 36. issue 4. 2019-06-04. PMID:30680679. |
dlb is the third most common of all the neurodegenerative diseases behind both alzheimer's disease and parkinson's disease (pd). |
2019-06-04 |
2023-08-13 |
Not clear |
| Fang Fang, Wanlin Yang, Jazmin B Florio, Edward Rockenstein, Brian Spencer, Xavier M Orain, Stephanie X Dong, Huayan Li, Xuqiao Chen, Kijung Sung, Robert A Rissman, Eliezer Masliah, Jianqing Ding, Chengbiao W. Synuclein impairs trafficking and signaling of BDNF in a mouse model of Parkinson's disease. Scientific reports. vol 7. issue 1. 2018-12-31. PMID:28634349. |
recent studies have demonstrated that hyperphosphorylation of tau protein plays a role in neuronal toxicities of α-synuclein (asyn) in neurodegenerative disease such as familial alzheimer's disease (ad), dementia with lewy bodies (dlb) and parkinson's disease. |
2018-12-31 |
2023-08-13 |
mouse |
| Lucie Jurek, Mathieu Herrmann, Mathilde Bonze, Sophie Brunet, Catherine Padovan, Jean-Michel Dore. Behavioral and psychological symptoms in Lewy body disease: a review. Geriatrie et psychologie neuropsychiatrie du vieillissement. vol 16. issue 1. 2018-09-27. PMID:29569570. |
dementia with lewy bodies (dlb) is a common neurodegenerative disease, second in terms of prevalence after alzheimer's disease (ad). |
2018-09-27 |
2023-08-13 |
human |
| Lucie Jurek, Mathieu Herrmann, Mathilde Bonze, Sophie Brunet, Catherine Padovan, Jean-Michel Dore. Behavioral and psychological symptoms in Lewy body disease: a review. Geriatrie et psychologie neuropsychiatrie du vieillissement. vol 16. issue 1. 2018-09-27. PMID:29569570. |
behavorial and psychological symptoms associated with dlb are more frequent, more severe and appear earlier than those found in other neurodegenerative diseases. |
2018-09-27 |
2023-08-13 |
human |
| Magdalena I Tolea, James E Galvi. The genetics of dementia with Lewy bodies. Handbook of clinical neurology. vol 148. 2018-08-10. PMID:29478592. |
dementia with lewy bodies (dlb), the most common non-ad neurodegenerative disease has in the past several decades attracted the attention of the neurological scientific community due to its highly negative impact on the quality of life of both the affected individuals and those caring for them. |
2018-08-10 |
2023-08-13 |
Not clear |
| Silvia Favaretto, Uwe Walter, Claudio Baracchini, Annachiara Cagni. Transcranial Sonography in Neurodegenerative Diseases with Cognitive Decline. Journal of Alzheimer's disease : JAD. vol 61. issue 1. 2018-07-13. PMID:29103031. |
here, we aimed to review the main applications of tcs in neurodegenerative diseases presenting with dementia syndrome, focusing on alzheimer's disease (ad), dementia with lewy bodies (dlb), frontotemporal lobar degeneration, idiopathic normal pressure hydrocephalus, and atypical and secondary parkinsonisms. |
2018-07-13 |
2023-08-13 |
Not clear |
| Julia Heller, Nikolina Brcina, Imis Dogan, Florian Holtbernd, Sandro Romanzetti, Jörg B Schulz, Johannes Schiefer, Kathrin Reet. Brain imaging findings in idiopathic REM sleep behavior disorder (RBD) - A systematic review on potential biomarkers for neurodegeneration. Sleep medicine reviews. vol 34. 2018-05-14. PMID:27542516. |
rbd may be the initial manifestation of neurodegenerative diseases, particularly of α-synucleinopathies such as parkinson's disease (pd), dementia with lewy bodies (dlb), and multiple system atrophy (msa). |
2018-05-14 |
2023-08-13 |
human |
| Rathan M Subramaniam, Kirk A Frey, Christopher H Hunt, Gustavo A Mercier, Lilja B Solnes, Patrick M Colletti, Yang Lu, Bital Savir-Baruch, Hadyn T William. ACR-ACNM Practice Parameter for the Performance of Dopamine Transporter (DaT) Single Photon Emission Computed Tomography (SPECT) Imaging for Movement Disorders. Clinical nuclear medicine. vol 42. issue 11. 2018-04-02. PMID:28922189. |
parkinsonian syndrome (ps) consists of a group of neurodegenerative diseases including parkinson disease (pd), progressive supranuclear palsy (psp), multiple system atrophy (msa), corticobasal degeneration (cbd), and dementia with lewy bodies (dlb). |
2018-04-02 |
2023-08-13 |
Not clear |
| Jack C de la Torr. Are Major Dementias Triggered by Poor Blood Flow to the Brain? Theoretical Considerations. Journal of Alzheimer's disease : JAD. vol 57. issue 2. 2018-02-26. PMID:28211814. |
virtually all neurodegenerative diseases, including ftd, dlb, and cjd, are characterized by oxidative stress that promotes inclusion bodies which differ in structure, location, and origin, as well as which neurological disorder they typify. |
2018-02-26 |
2023-08-13 |
Not clear |
| Shuling Liu, Yi Jin, Zhihong Shi, Ya Ruth Huo, Yalin Guan, Mengyuan Liu, Shuai Liu, Yong J. The effects of behavioral and psychological symptoms on caregiver burden in frontotemporal dementia, Lewy body dementia, and Alzheimer's disease: clinical experience in China. Aging & mental health. vol 21. issue 6. 2018-02-09. PMID:26882509. |
caregivers of individuals with neurodegenerative diseases, including frontotemporal dementia (ftd), lewy body dementia (dlb), and alzheimer's disease (ad), experience high levels of psychological and physical stress, likely due to behavioral and psychological symptoms of dementia (bpsd). |
2018-02-09 |
2023-08-13 |
Not clear |
| Natasha L Lethbridge, Paul L Chazo. Ligand autoradiographical quantification of histamine H Pharmacological research. vol 113. issue Pt A. 2017-12-20. PMID:27592250. |
ligand autoradiographical quantification of histamine h dementia with lewy bodies (dlb) is a serious age-dependent human neurodegenerative disease, with multiple debilitating symptoms, including dementia, psychosis and significant motor deficits, but with little or no effective treatments. |
2017-12-20 |
2023-08-13 |
human |
| Raquel Marin, Noemí Fabelo, Virginia Martín, Paula Garcia-Esparcia, Isidre Ferrer, David Quinto-Alemany, Mario Día. Anomalies occurring in lipid profiles and protein distribution in frontal cortex lipid rafts in dementia with Lewy bodies disclose neurochemical traits partially shared by Alzheimer's and Parkinson's diseases. Neurobiology of aging. vol 49. 2017-11-16. PMID:27768960. |
compelling evidence has demonstrated that alterations in lipid rafts are associated with neurodegenerative diseases such alzheimer's disease, but at present, whether alterations in lipid raft microdomains occur in other types of dementia such dementia with lewy bodies (dlb) remains unknown. |
2017-11-16 |
2023-08-13 |
Not clear |
| Camille Heitz, Vincent Noblet, Clélie Phillipps, Benjamin Cretin, Natacha Vogt, Nathalie Philippi, Jennifer Kemp, Xavier de Petigny, Mathias Bilger, Catherine Demuynck, Catherine Martin-Hunyadi, Jean-Paul Armspach, Frédéric Blan. Cognitive and affective theory of mind in dementia with Lewy bodies and Alzheimer's disease. Alzheimer's research & therapy. vol 8. issue 1. 2016-12-13. PMID:26979460. |
this function has been studied in many neurodegenerative diseases; however, to our knowledge, no studies investigating tom in dementia with lewy bodies (dlb) have been published. |
2016-12-13 |
2023-08-13 |
Not clear |
| b' Hana P\\xc5\\x99ikrylov\\xc3\\xa1 Vranov\\xc3\\xa1, Eva H\\xc3\\xa9nykov\\xc3\\xa1, Jan Mare\\xc5\\xa1, Michaela Kaiserov\\xc3\\xa1, Kate\\xc5\\x99ina Men\\xc5\\xa1\\xc3\\xadkov\\xc3\\xa1, Miroslav Va\\xc5\\xa1t\\xc3\\xadk, Petr Hlu\\xc5\\xa1t\\xc3\\xadk, Jana Zapletalov\\xc3\\xa1, Miroslav Strnad, David Stejskal, Petr Ka\\xc5\\x88ovsk\\xc3\\xb. Clusterin CSF levels in differential diagnosis of neurodegenerative disorders. Journal of the neurological sciences. vol 361. 2016-10-20. PMID:26810527.' |
in the brain, post-mortem analysis has found increased clusterin associated with the pathology of many other neurodegenerative diseases (nd) such as parkinson's disease (pd), dementia with lewy bodies (dlb), alzheimer's disease (ad) and multiple system atrophy (msa). |
2016-10-20 |
2023-08-13 |
Not clear |
| M J Keogh, M Kurzawa-Akanbi, H Griffin, K Douroudis, K L Ayers, R I Hussein, G Hudson, A Pyle, H J Cordell, J Attems, I G McKeith, J T O'Brien, D J Burn, C M Morris, A J Thomas, P F Chinner. Exome sequencing in dementia with Lewy bodies. Translational psychiatry. vol 6. 2016-10-17. PMID:26836416. |
we set out to determine whether mutations in known highly penetrant neurodegenerative disease genes are found in patients with dlb. |
2016-10-17 |
2023-08-13 |
Not clear |