| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christine S Liu, Chris Park, Tony Ngo, Janani Saikumar, Carter R Palmer, Anis Shahnaee, William J Romanow, Jerold Chu. RNA isoform diversity in human neurodegenerative diseases. eNeuro. 2024-12-10. PMID:39658200. |
these data expand available single-cell datasets of the human prefrontal cortical transcriptome with combined short- and long-read sequencing across ad, dlb, and pd, revealing increased mrna isoform diversity that may contribute to disease features and could potentially represent therapeutic targets for neurodegenerative diseases. |
2024-12-10 |
2024-12-13 |
human |
| Brendan Huang, Sara Sawicki, Carolyn Habiger, Paul J Mattis, Marc L Gordon, Ana M Franceschi, Luca Gilibert. Memories and mimics: unveiling the potential of FDG-PET in guiding therapeutic approaches for neurodegenerative cognitive disorders. Frontiers in neurology. vol 15. 2024-12-04. PMID:39628892. |
dementia with lewy bodies (dlb) had the highest propensity for being misidentified as another neurodegenerative disease, followed by alzheimer's disease (ad) and frontotemporal dementia (ftd). |
2024-12-04 |
2024-12-06 |
Not clear |
| Sheng-Chieh Lin, Ching-Chi Chang, Sing-Hua Tsou, Pai-Yi Chiu, Ju-Fang Cheng, Hui-Chih Hung, Wei-Jen Chen, Ying-Jui Ho, Chih-Li Li. Protective Effects of Ambroxol on Aβ and α-Synuclein-Induced Neurotoxicity Through Glucocerebrosidase Activation in HT-22 Hippocampal Neuronal Cells. International journal of molecular sciences. vol 25. issue 22. 2024-11-27. PMID:39596182. |
this study underscores the potential of ambx as a therapeutic agent for dlb and supports further investigation in animal models and clinical trials to validate its efficacy in neurodegenerative disease contexts. |
2024-11-27 |
2024-11-29 |
Not clear |
| Marta Sidoryk-Węgrzynowicz, Kamil Adamiak, Lidia Strużyńsk. Targeting Protein Misfolding and Aggregation as a Therapeutic Perspective in Neurodegenerative Disorders. International journal of molecular sciences. vol 25. issue 22. 2024-11-27. PMID:39596513. |
synucleinopathies such as parkinson's disease (pd), dementia with lewy bodies (dlb) or multiple system atrophy (msa) are neurodegenerative diseases characterized by the aggregation of the α-synucleinprotein in neurons and/or in oligodendrocytes (glial cytoplasmic inclusions), neuronal loss, and astrogliosis. |
2024-11-27 |
2024-11-29 |
Not clear |
| Anna Planas-Ballvé, Jose Rios, Mireia Gea, Neus Rabaneda-Lombarte, Lourdes Ispierto, Laia Grau, Marta Jiménez, Cynthia Cáceres, Sílvia Martínez, Katrin Beyer, Ramiro Álvarez, Pau Pastor, Dolores Vila. Substantia nigra hyperechogenicity and brain ventricular size as biomarkers of early dementia with Lewy bodies. Alzheimer's research & therapy. vol 16. issue 1. 2024-10-16. PMID:39407323. |
diagnosis of dementia with lewy bodies (dlb) is challenging, especially in the earlier stages of the disease, owing to the clinical overlap with other neurodegenerative diseases such as alzheimer's (ad) and parkinson's disease (pd). |
2024-10-16 |
2024-10-18 |
Not clear |
| Junyun Wu, Jia Nan Wu, Tao Chen, Jing Cai, Reng Re. Protein Aggregation and its Affecting Mechanisms in Neurodegenerative Diseases. Neurochemistry international. 2024-10-13. PMID:39396709. |
protein aggregation serves as a critical pathological marker in a spectrum of neurodegenerative diseases (nds), including the formation of amyloid β (aβ) and tau neurofibrillary tangles in alzheimer's disease, as well as α-synuclein (α-syn) aggregates in parkinson's disease, parkinson's disease-related dementia (pdd), dementia with lewy bodies (dlb), and multiple system atrophy (msa). |
2024-10-13 |
2024-10-16 |
Not clear |
| Kurt A Jellinge. Behavioral disorders in dementia with Lewy bodies: old and new knowledge. Journal of neural transmission (Vienna, Austria : 1996). 2024-09-05. PMID:39237792. |
behavioral problems in dlb are more frequent, more severe and appear earlier than in other neurodegenerative diseases and, together with other neuropsychiatric symptoms, contribute to impairment of quality of life of the patients, but their pathophysiology is poorly understood. |
2024-09-05 |
2024-09-08 |
Not clear |
| Jana Schepers, Timo Löser, Christian Beh. Lipids and α-Synuclein: adding further variables to the equation. Frontiers in molecular biosciences. vol 11. 2024-08-28. PMID:39188788. |
aggregation of alpha-synuclein (αsyn) has been connected to several neurodegenerative diseases, such as parkinson's disease (pd), dementia with lewy bodies (dlb), and multiple system atrophy (msa), that are collected under the umbrella term |
2024-08-28 |
2024-08-30 |
Not clear |
| Catherine M Kopil, Angelica Asis, Clyde Campbell, Sohini Chowdhury, David T Dexter, Keith N Fargo, Karen K Lee, Helen Matthews, Angela Taylor, Yuge Xiao, Diane Stephenso. A Coalition to Advance Treatments for Parkinson's Disease, Dementia with Lewy Bodies, and Related Disorders. Journal of Parkinson's disease. 2024-08-09. PMID:39121136. |
amid growing momentum in the field to develop biological definitions for these neurodegenerative diseases, 7 international nonprofit organizations focused on pd and dlb came together to drive multistakeholder discussion and input on a biological staging system for research. |
2024-08-09 |
2024-08-12 |
Not clear |
| Cui Yang, Guangdong Liu, Xi Chen, Weidong L. Cerebellum in Alzheimer's disease and other neurodegenerative diseases: an emerging research frontier. MedComm. vol 5. issue 7. 2024-07-16. PMID:39006764. |
alzheimer's disease (ad), alongside other dementias such as vascular dementia (vad), lewy body dementia (dlb), and frontotemporal dementia (ftd), as well as other neurodegenerative diseases (nds) like parkinson's disease (pd), amyotrophic lateral sclerosis (als), huntington's disease (hd), and spinocerebellar ataxias (sca), are characterized by specific and non-specific neurodegenerations in central nervous system. |
2024-07-16 |
2024-07-18 |
Not clear |
| Erica Costantini, Claudia Carrarini, Dario Calisi, Matteo De Rosa, Marianna Simone, Adolfo Di Crosta, Rocco Palumbo, Alessia Cipollone, Lisa Aielli, Maria De Laurentis, Lucilla Colarusso, Andrea Pilotto, Alessandro Padovani, Fani Konstantinidou, Valentina Gatta, Liborio Stuppia, Francesco Cipollone, Marta Di Nicola, Marcella Reale, Laura Bonann. Search in the Periphery for Potential Inflammatory Biomarkers of Dementia with Lewy Bodies and Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2024-05-17. PMID:38759010. |
neuroinflammation, with altered peripheral proinflammatory cytokine production, plays a major role in the pathogenesis of neurodegenerative diseases, such as alzheimer's disease (ad), while the role of inflammation in dementia with lewy bodies (dlb) is less known and the results of different studies are often in disagreement. |
2024-05-17 |
2024-05-27 |
Not clear |
| El Jeong, Yong Woo Shin, Jung-Ick Byun, Jun-Sang Sunwoo, Monica Roascio, Pietro Mattioli, Laura Giorgetti, Francesco Famà, Gabriele Arnulfo, Dario Arnaldi, Han-Joon Kim, Ki-Young Jun. EEG-based Machine Learning Models for the Prediction of Phenoconversion Time and Subtype in iRBD. Sleep. 2024-02-08. PMID:38330231. |
idiopathic/isolated rapid eye movement sleep behavior disorder (irbd) is a prodromal stage of α-synucleinopathies and eventually phenoconverts to overt neurodegenerative diseases including parkinson's disease (pd), dementia with lewy bodies (dlb) and multiple system atrophy (msa). |
2024-02-08 |
2024-02-11 |
Not clear |
| Manoel Alves Sobreira-Neto, Fernando Gustavo Stelzer, Lívia Leite Góes Gitaí, Rosana Cardoso Alves, Alan Luiz Eckeli, Carlos H Schenc. REM sleep behavior disorder: update on diagnosis and management. Arquivos de neuro-psiquiatria. vol 81. issue 12. 2023-12-29. PMID:38157884. |
knowledge of this pathology is important to predict neurodegenerative diseases since there is a strong association of rbd with diseases caused by the deposition of alpha-synuclein in neurons (synucleinopathies), such as parkinson's disease (pd), multiple system atrophy (msa), and dementia with lewy bodies (dlb). |
2023-12-29 |
2024-01-05 |
Not clear |
| Alya Gharbi, Amina Nasri, Ikram Sghaier, Imen Kacem, Saloua Mrabet, Amira Souissi, Mouna Ben Djebara, Amina Gargouri, Riadh Gouide. Subtypes of Dementia with Lewy Bodies: Clinical Features, Survival, and Apolipoprotein E Effect. Journal of Alzheimer's disease reports. vol 7. issue 1. 2023-12-25. PMID:38143772. |
dementia with lewy bodies (dlb) is a progressive neurodegenerative disease with various clinical symptoms. |
2023-12-25 |
2023-12-27 |
Not clear |
| Tsukasa Hara, Ryosuke Amagai, Ryuji Sakakibara, Ayako Okado-Matsumot. Supercomplex formation of mitochondrial respiratory chain complexes in leukocytes from patients with neurodegenerative diseases. Journal of biochemistry. 2023-11-28. PMID:38016934. |
with population aging, cognitive impairments and movement disorders due to neurodegenerative diseases, such as alzheimer's disease (ad), parkinson's disease (pd), and dementia with lewy bodies (dlb), are increasingly considered as key social issues. |
2023-11-28 |
2023-12-07 |
Not clear |
| Fabio Moda, Arianna Ciullini, Ilaria Linda Dellarole, Annalisa Lombardo, Nicole Campanella, Giuseppe Bufano, Federico Angelo Cazzaniga, Giorgio Giaccon. Secondary Protein Aggregates in Neurodegenerative Diseases: Almost the Rule Rather than the Exception. Frontiers in bioscience (Landmark edition). vol 28. issue 10. 2023-11-02. PMID:37919089. |
finally, aggregates of tdp-43, typically associated with ftld and amyotrophic lateral sclerosis (als), have been observed in ad, progressive supranuclear palsy (psp), corticobasal degeneration (cbd), msa, dlb, and other neurodegenerative diseases. |
2023-11-02 |
2023-11-08 |
human |
| Sanjesh Kumar, Siva Prasad Pand. Targeting GM2 Ganglioside Accumulation in Dementia: Current Therapeutic Approaches and Future Directions. Current molecular medicine. 2023-10-25. PMID:37877564. |
dementia in neurodegenerative diseases, such as alzheimer's disease (ad), parkinson's disease (pd), and dementia with lewy bodies (dlb) is a progressive neurological condition affecting millions worldwide. |
2023-10-25 |
2023-11-08 |
human |
| Margaux Teil, Sandra Dovero, Mathieu Bourdenx, Marie-Laure Arotcarena, Morgane Darricau, Gregory Porras, Marie-Laure Thiolat, Inés Trigo-Damas, Celine Perier, Cristina Estrada, Nuria Garcia-Carrillo, María Trinidad Herrero, Miquel Vila, José A Obeso, Erwan Bezard, Benjamin Deha. Cortical Lewy body injections induce long-distance pathogenic alterations in the non-human primate brain. NPJ Parkinson's disease. vol 9. issue 1. 2023-09-19. PMID:37726343. |
aggregation of α-synuclein (α-syn) is the cornerstone of neurodegenerative diseases termed synucleinopathies, which include parkinson's disease (pd), dementia with lewy bodies (dlb), and multiple system atrophy (msa). |
2023-09-19 |
2023-10-07 |
monkey |
| Manuel Flores-Leon, Tiago Fleming Outeir. More than meets the eye in Parkinson's disease and other synucleinopathies: from proteinopathy to lipidopathy. Acta neuropathologica. 2023-07-08. PMID:37421475. |
the accumulation of proteinaceous inclusions in the brain is a common feature among neurodegenerative diseases such as alzheimer's disease, parkinson's disease (pd), and dementia with lewy bodies (dlb). |
2023-07-08 |
2023-08-14 |
Not clear |
| Katherine Fodder, Rohan de Silva, Thomas T Warner, Conceição Bettencour. The contribution of DNA methylation to the (dys)function of oligodendroglia in neurodegeneration. Acta neuropathologica communications. vol 11. issue 1. 2023-06-29. PMID:37386505. |
aberrant dna methylation, the most widely studied epigenetic modification, has been associated with many neurodegenerative diseases, including ad, pd, dlb and msa, and recent findings highlight aberrant dna methylation in oligodendrocyte/myelin-related genes. |
2023-06-29 |
2023-08-14 |
Not clear |