| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Linjuan Feng, Hsuan Lo, Zhaoxiang Hong, Jiahao Zheng, Yuhong Yan, Zucheng Ye, Xiaochun Chen, Xiaodong Pa. Microglial LRRK2-mediated NFATc1 attenuates α-synuclein immunotoxicity in association with CX3CR1-induced migration and the lysosome-initiated degradation. Glia. 2023-06-10. PMID:37300531. |
synucleinopathies refer to a range of neurodegenerative diseases caused by abnormal α-synuclein (α-syn) deposition, including parkinson's disease (pd), dementia with lewy bodies (dlb), and multiple system atrophy (msa). |
2023-06-10 |
2023-08-14 |
mouse |
| Camilla Christina Pedersen, Anastasia Ushakova, Ragnhild Eide Skogseth, Guido Alves, Ole-Bjørn Tysnes, Dag Aarsland, Johannes Lange, Jodi Maple-Grøde. Inflammatory Biomarkers in Newly Diagnosed Patients With Parkinson Disease and Related Neurodegenerative Disorders. Neurology(R) neuroimmunology & neuroinflammation. vol 10. issue 4. 2023-05-31. PMID:37258413. |
neuroinflammation also plays a role in related neurodegenerative diseases, such as dementia with lewy bodies (dlb) and alzheimer disease (ad). |
2023-05-31 |
2023-08-14 |
Not clear |
| Youngsoon Yang, Eva Bagyinszky, Seong Soo A A. Presenilin-1 (PSEN1) Mutations: Clinical Phenotypes beyond Alzheimer's Disease. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37176125. |
taken together, neurodegenerative diseases such as ad, pd, dlb and ftd may share several common hallmarks (cognitive and motor impairment, associated with abnormal protein aggregates). |
2023-05-14 |
2023-08-14 |
Not clear |
| Cheryl E G Leyns, Alice Prigent, Brenna Beezhold, Lihang Yao, Nathan G Hatcher, Peining Tao, John Kang, EunRan Suh, Vivianna M Van Deerlin, John Q Trojanowski, Virginia M Y Lee, Matthew E Kennedy, Matthew J Fell, Michael X Henderso. Glucocerebrosidase activity and lipid levels are related to protein pathologies in Parkinson's disease. NPJ Parkinson's disease. vol 9. issue 1. 2023-05-11. PMID:37169750. |
parkinson's disease (pd) and dementia with lewy bodies (dlb) are progressive neurodegenerative diseases characterized by the accumulation of misfolded α-synuclein in the form of lewy pathology. |
2023-05-11 |
2023-08-14 |
Not clear |
| Alejandra Collía, Alex Iranzo, Mónica Serradell, Amaia Muñoz-Lopetegi, Gerard Mayà, Joan Santamaría, Raquel Sánchez-Valle, Carles Gai. Former participation in professional football as an occupation in patients with isolated REM sleep behavior disorder leading to a synucleinopathy: a case-control study. Journal of neurology. 2023-03-20. PMID:36939930. |
isolated rem sleep behavior disorder (irbd) represents an early manifestation of neurodegenerative diseases including parkinson disease (rbd) and dementia with lewy bodies (dlb). |
2023-03-20 |
2023-08-14 |
Not clear |
| Suman Dutta, Simon Hornung, Hash Brown Taha, Karl Biggs, Ibrar Siddique, Lea M Chamoun, Hedieh Shahpasand-Kroner, Carter Lantz, Marcos Herrera-Vaquero, Nadia Stefanova, Joseph A Loo, Gal Bita. Development of a Novel Electrochemiluminescence ELISA for Quantification of α-Synuclein Phosphorylated at Ser ACS chemical neuroscience. 2023-03-15. PMID:36920792. |
development of a novel electrochemiluminescence elisa for quantification of α-synuclein phosphorylated at ser synucleinopathies are a group of neurodegenerative diseases including parkinson's disease (pd), dementia with lewy bodies (dlb), and multiple system atrophy (msa). |
2023-03-15 |
2023-08-14 |
Not clear |
| Matthias Schmitz, Niccolò Candelise, Sezgi Canaslan, Hermann C Altmeppen, Jakob Matschke, Markus Glatzel, Neelam Younas, Saima Zafar, Peter Hermann, Inga Zer. α-Synuclein conformers reveal link to clinical heterogeneity of α-synucleinopathies. Translational neurodegeneration. vol 12. issue 1. 2023-03-14. PMID:36915212. |
α-synucleinopathies, such as parkinson's disease (pd), dementia with lewy bodies (dlb) and multiple system atrophy, are a class of neurodegenerative diseases exhibiting intracellular inclusions of misfolded α-synuclein (αsyn), referred to as lewy bodies or oligodendroglial cytoplasmic inclusions (papp-lantos bodies). |
2023-03-14 |
2023-08-14 |
Not clear |
| Joseph R Phillips, Elie Matar, Kaylena A Ehgoetz Martens, Ahmed A Moustafa, Glenda M Halliday, Simon J G Lewi. Exploring the Sensitivity of Prodromal Dementia with Lewy Bodies Research Criteria. Brain sciences. vol 12. issue 12. 2022-12-23. PMID:36552054. |
dementia with lewy bodies (dlb) is an insidious neurodegenerative disease characterised by a precipitous decline in cognition, sleep disturbances, motor impairment and psychiatric features. |
2022-12-23 |
2023-08-14 |
Not clear |
| Sinead Gaubert, Claire Hourregue, François Mouton-Liger, Périne Millot, Mélanie Franco, Elodie Amar-Bouaziz, Dag Aarsland, Jacques Hugon, Claire Paque. Exploring the link between GBA1 mutations and Dementia with Lewy bodies, A Mini-Review. Neuroscience and biobehavioral reviews. 2022-09-09. PMID:36084847. |
dementia with lewy bodies (dlb) is a neurodegenerative disease linked to abnormal accumulation of phosphorylated α-synuclein. |
2022-09-09 |
2023-08-14 |
Not clear |
| Michiyo Iba, Ross A McDevitt, Changyoun Kim, Roshni Roy, Dimitra Sarantopoulou, Ella Tommer, Byron Siegars, Michelle Sallin, Somin Kwon, Jyoti Misra Sen, Ranjan Sen, Eliezer Maslia. Aging exacerbates the brain inflammatory micro-environment contributing to α-synuclein pathology and functional deficits in a mouse model of DLB/PD. Molecular neurodegeneration. vol 17. issue 1. 2022-09-05. PMID:36064424. |
although ɑ-synuclein (ɑ-syn) spreading in age-related neurodegenerative diseases such as parkinson's disease (pd) and dementia with lewy bodies (dlb) has been extensively investigated, the role of aging in the manifestation of disease remains unclear. |
2022-09-05 |
2023-08-14 |
mouse |
| Mauro Montalbano, Lajja Majmundar, Urmi Sengupta, Leiana Fung, Rakez Kaye. Pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in Alzheimer's disease, progressive supranuclear palsy, and dementia with Lewy bodies. Brain pathology (Zurich, Switzerland). 2022-09-02. PMID:36054524. |
here, we have investigated the immunological and biochemical properties of aggregated tau species in different brain cell types in tau-induced neurodegenerative diseases such as alzheimer's disease (ad), progressive supranuclear palsy (psp), and dementia with lewy bodies (dlb). |
2022-09-02 |
2023-08-14 |
mouse |
| Olivier Bousiges, Frédéric Blan. Biomarkers of Dementia with Lewy Bodies: Differential Diagnostic with Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 12. 2022-06-24. PMID:35742814. |
dementia with lewy bodies (dlb) is a common form of cognitive neurodegenerative disease. |
2022-06-24 |
2023-08-14 |
Not clear |
| b' Joan Prats-Climent, Maria Teresa Gandia-Ferrero, Irene Torres-Espallardo, Lourdes \\xc3\\x81lvarez-Sanchez, Bego\\xc3\\xb1a Mart\\xc3\\xadnez-Sanchis, Consuelo Ch\\xc3\\xa1fer-Peric\\xc3\\xa1s, Ignacio G\\xc3\\xb3mez-Rico, Leonor Cerd\\xc3\\xa1-Alberich, Fernando Aparici-Robles, Miquel Baquero-Toledo, Mar\\xc3\\xada Jos\\xc3\\xa9 Rodr\\xc3\\xadguez-\\xc3\\x81lvarez, Luis Mart\\xc3\\xad-Bonmat\\xc3\\xa. Artificial Intelligence on FDG PET Images Identifies Mild Cognitive Impairment Patients with Neurodegenerative Disease. Journal of medical systems. vol 46. issue 8. 2022-06-17. PMID:35713815.' |
the purpose of this project is to develop and validate a deep learning (dl) fdg pet imaging algorithm able to identify patients with any neurodegenerative diseases (alzheimer's disease (ad), frontotemporal degeneration (ftd) or dementia with lewy bodies (dlb)) among patients with mild cognitive impairment (mci). |
2022-06-17 |
2023-08-14 |
human |
| b' Joan Prats-Climent, Maria Teresa Gandia-Ferrero, Irene Torres-Espallardo, Lourdes \\xc3\\x81lvarez-Sanchez, Bego\\xc3\\xb1a Mart\\xc3\\xadnez-Sanchis, Consuelo Ch\\xc3\\xa1fer-Peric\\xc3\\xa1s, Ignacio G\\xc3\\xb3mez-Rico, Leonor Cerd\\xc3\\xa1-Alberich, Fernando Aparici-Robles, Miquel Baquero-Toledo, Mar\\xc3\\xada Jos\\xc3\\xa9 Rodr\\xc3\\xadguez-\\xc3\\x81lvarez, Luis Mart\\xc3\\xad-Bonmat\\xc3\\xa. Artificial Intelligence on FDG PET Images Identifies Mild Cognitive Impairment Patients with Neurodegenerative Disease. Journal of medical systems. vol 46. issue 8. 2022-06-17. PMID:35713815.' |
this dataset contained 90 subjects with mci, 71 of them developed a neurodegenerative disease (64 ad, 4 ftd and 3 dlb) while 19 did not associate any neurodegenerative disease. |
2022-06-17 |
2023-08-14 |
human |
| Sindhu Menon, Sabrina Armstrong, Amir Hamzeh, Naomi P Visanji, Sergio Pablo Sardi, Anurag Tando. Alpha-Synuclein Targeting Therapeutics for Parkinson's Disease and Related Synucleinopathies. Frontiers in neurology. vol 13. 2022-05-26. PMID:35614915. |
α-synuclein (asyn) is a key pathogenetic factor in a group of neurodegenerative diseases generically known as synucleinopathies, including parkinson's disease (pd), dementia with lewy bodies (dlb) and multiple system atrophy (msa). |
2022-05-26 |
2023-08-13 |
Not clear |
| F Blanc, O Bousige. Biomarkers and diagnosis of dementia with Lewy bodies including prodromal: Practical aspects. Revue neurologique. 2022-05-01. PMID:35491246. |
dementia with lewy bodies (dlb) is a common form of cognitive neurodegenerative disease. |
2022-05-01 |
2023-08-13 |
Not clear |
| Urmi Sengupta, Rakez Kaye. Amyloid β, Tau, and α-Synuclein aggregates in the pathogenesis, prognosis, and therapeutics for neurodegenerative diseases. Progress in neurobiology. 2022-04-21. PMID:35447272. |
aggregation of specific proteins are histopathological hallmarks of several neurodegenerative diseases, such as, amyloid β (aβ) plaques and tau neurofibrillary tangles in alzheimer's disease (ad); morphologically different inclusions of ratiometric 3 repeat (3r) and 4 repeat (4r) tau isoforms in progressive supranuclear palsy (psp), corticobasal degeneration (cbd), and pick's disease (pid); α-synuclein (α-syn) containing lewy bodies (lbs) and dystrophic lewy neurites (lns) in parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2022-04-21 |
2023-08-13 |
Not clear |
| Urmi Sengupta, Rakez Kaye. Amyloid β, Tau, and α-Synuclein aggregates in the pathogenesis, prognosis, and therapeutics for neurodegenerative diseases. Progress in neurobiology. 2022-04-21. PMID:35447272. |
in this review, we summarize the emerging evidence of aβ, tau, and α-syn aggregation in pathophysiology, and their overlap in a spectrum of neurodegenerative diseases including ad, psp, pid, cbd, pd and dlb. |
2022-04-21 |
2023-08-13 |
Not clear |
| Carlo Alberto Artusi, Domiziana Rinaldi, Roberta Balestrino, Leonardo Lopian. Deep brain stimulation for atypical parkinsonism: A systematic review on efficacy and safety. Parkinsonism & related disorders. 2022-03-15. PMID:35288028. |
atypical parkinsonisms (aps) -including progressive supranuclear palsy (psp), multiple system atrophy (msa), and dementia with lewy bodies (dlb)- are neurodegenerative diseases lacking satisfying symptomatic therapies. |
2022-03-15 |
2023-08-13 |
Not clear |
| Jennifer L Imm, Joshua Harvey, Ehsan Pishva, Byron Creese, Leonidas Chouliaras, Emma Dempster, Clive Ballard, John T O'Brien, Dag Aarsland, Jonathan Mill, Katie Lunno. A role for epigenetic mechanisms in Lewy body dementias. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108855. |
the lewy body diseases, dementia with lewy bodies (dlb), parkinson's disease (pd) and parkinson's disease dementia (pdd) are all neurodegenerative diseases classified by the accumulation of alpha-synuclein in neurons, forming lewy bodies (lb). |
2022-02-03 |
2023-08-13 |
Not clear |