| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael X Henderson, Dustin J Covell, Charlotte Hiu-Yan Chung, Rose M Pitkin, Raizel M Sandler, Samantha C Decker, Dawn M Riddle, Bin Zhang, Ronald J Gathagan, Michael J James, John Q Trojanowski, Kurt R Brunden, Virginia M Y Lee, Kelvin C Lu. Characterization of novel conformation-selective α-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease. Neurobiology of disease. vol 136. 2021-01-04. PMID:31837422. |
parkinson's disease (pd) and dementia with lewy bodies (dlb) are progressive neurodegenerative diseases for which there is no disease-modifying treatment. |
2021-01-04 |
2023-08-13 |
mouse |
| Tatiana Orme, Dena Hernandez, Owen A Ross, Celia Kun-Rodrigues, Lee Darwent, Claire E Shepherd, Laura Parkkinen, Olaf Ansorge, Lorraine Clark, Lawrence S Honig, Karen Marder, Afina Lemstra, Ekaterina Rogaeva, Peter St George-Hyslop, Elisabet Londos, Henrik Zetterberg, Kevin Morgan, Claire Troakes, Safa Al-Sarraj, Tammaryn Lashley, Janice Holton, Yaroslau Compta, Vivianna Van Deerlin, John Q Trojanowski, Geidy E Serrano, Thomas G Beach, Suzanne Lesage, Douglas Galasko, Eliezer Masliah, Isabel Santana, Pau Pastor, Pentti J Tienari, Liisa Myllykangas, Minna Oinas, Tamas Revesz, Andrew Lees, Brad F Boeve, Ronald C Petersen, Tanis J Ferman, Valentina Escott-Price, Neill Graff-Radford, Nigel J Cairns, John C Morris, Stuart Pickering-Brown, David Mann, Glenda Halliday, David J Stone, Dennis W Dickson, John Hardy, Andrew Singleton, Rita Guerreiro, Jose Bra. Analysis of neurodegenerative disease-causing genes in dementia with Lewy bodies. Acta neuropathologica communications. vol 8. issue 1. 2020-12-23. PMID:31996268. |
here, we performed whole exome sequencing of a cohort of 1118 caucasian dlb patients, and focused on genes causative of monogenic neurodegenerative diseases. |
2020-12-23 |
2023-08-13 |
Not clear |
| Tatiana Orme, Dena Hernandez, Owen A Ross, Celia Kun-Rodrigues, Lee Darwent, Claire E Shepherd, Laura Parkkinen, Olaf Ansorge, Lorraine Clark, Lawrence S Honig, Karen Marder, Afina Lemstra, Ekaterina Rogaeva, Peter St George-Hyslop, Elisabet Londos, Henrik Zetterberg, Kevin Morgan, Claire Troakes, Safa Al-Sarraj, Tammaryn Lashley, Janice Holton, Yaroslau Compta, Vivianna Van Deerlin, John Q Trojanowski, Geidy E Serrano, Thomas G Beach, Suzanne Lesage, Douglas Galasko, Eliezer Masliah, Isabel Santana, Pau Pastor, Pentti J Tienari, Liisa Myllykangas, Minna Oinas, Tamas Revesz, Andrew Lees, Brad F Boeve, Ronald C Petersen, Tanis J Ferman, Valentina Escott-Price, Neill Graff-Radford, Nigel J Cairns, John C Morris, Stuart Pickering-Brown, David Mann, Glenda Halliday, David J Stone, Dennis W Dickson, John Hardy, Andrew Singleton, Rita Guerreiro, Jose Bra. Analysis of neurodegenerative disease-causing genes in dementia with Lewy bodies. Acta neuropathologica communications. vol 8. issue 1. 2020-12-23. PMID:31996268. |
the rarity of previously reported pathogenic mutations in this cohort suggests that the genetic overlap of other neurodegenerative diseases with dlb is not substantial. |
2020-12-23 |
2023-08-13 |
Not clear |
| Yu-Mi Jeon, Younghwi Kwon, Myungjin Jo, Shinrye Lee, Seyeon Kim, Hyung-Jun Ki. The Role of Glial Mitochondria in α-Synuclein Toxicity. Frontiers in cell and developmental biology. vol 8. 2020-12-07. PMID:33262983. |
the abnormal accumulation of alpha-synuclein (α-syn) aggregates in neurons and glial cells is widely known to be associated with many neurodegenerative diseases, including parkinson's disease (pd), dementia with lewy bodies (dlb), and multiple system atrophy (msa). |
2020-12-07 |
2023-08-13 |
Not clear |
| Manuel Schweighauser, Yang Shi, Airi Tarutani, Fuyuki Kametani, Alexey G Murzin, Bernardino Ghetti, Tomoyasu Matsubara, Taisuke Tomita, Takashi Ando, Kazuko Hasegawa, Shigeo Murayama, Mari Yoshida, Masato Hasegawa, Sjors H W Scheres, Michel Goeder. Structures of α-synuclein filaments from multiple system atrophy. Nature. vol 585. issue 7825. 2020-10-21. PMID:32461689. |
synucleinopathies, which include multiple system atrophy (msa), parkinson's disease, parkinson's disease with dementia and dementia with lewy bodies (dlb), are human neurodegenerative diseases |
2020-10-21 |
2023-08-13 |
human |
| José Javier Mendoza-Velásquez, Juan Francisco Flores-Vázquez, Evalinda Barrón-Velázquez, Ana Luisa Sosa-Ortiz, Ben-Min Woo Illigens, Timo Siepman. Autonomic Dysfunction in α-Synucleinopathies. Frontiers in neurology. vol 10. 2020-10-01. PMID:31031694. |
the α-synucleinopathies are a group of neurodegenerative diseases characterized by abnormal accumulation of insoluble α-synuclein in neurons and glial cells, comprising parkinson's disease (pd), dementia with lewy bodies (dlb) and multiple system atrophy (msa). |
2020-10-01 |
2023-08-13 |
Not clear |
| Matilde Bongianni, Anna Ladogana, Stefano Capaldi, Sigrid Klotz, Simone Baiardi, Annachiara Cagnin, Daniela Perra, Michele Fiorini, Anna Poleggi, Giuseppe Legname, Tatiana Cattaruzza, Francesco Janes, Massimo Tabaton, Bernardino Ghetti, Salvatore Monaco, Gabor G Kovacs, Piero Parchi, Maurizio Pocchiari, Gianluigi Zanuss. α-Synuclein RT-QuIC assay in cerebrospinal fluid of patients with dementia with Lewy bodies. Annals of clinical and translational neurology. vol 6. issue 10. 2020-09-07. PMID:31599499. |
we applied rt-quic assay to detect α-synuclein aggregates in cerebrospinal fluid (csf) of patients with suspected creutzfeldt-jakob disease who had a neuropathological diagnosis of dementia with lewy bodies (dlb) (n = 7), other neurodegenerative diseases with α-synuclein mixed pathology (n = 20), or without lewy-related pathology (n = 49). |
2020-09-07 |
2023-08-13 |
Not clear |
| Brian J Balin, Christine J Hammond, Katherine E Galluzz. Intriguing Mixed Pathologic Features in a Case of Dementia With Lewy Bodies. The Journal of the American Osteopathic Association. vol 119. issue 9. 2020-06-24. PMID:31449309. |
in this case of dlb, neuropathologic inclusions were consistent with the disease diagnosis, but also with alzheimer disease and other neurodegenerative diseases, such as polyglucosan body disease. |
2020-06-24 |
2023-08-13 |
Not clear |
| Jinbin Xu, Jianjun Sun, Richard J Perrin, Robert H Mach, Kelly R Bales, John C Morris, Tammie L S Benzinger, David M Holtzma. Translocator protein in late stage Alzheimer's disease and Dementia with Lewy bodies brains. Annals of clinical and translational neurology. vol 6. issue 8. 2020-05-29. PMID:31402620. |
increased translocator protein (tspo), previously known as the peripheral benzodiazepine receptor (pbr), in glial cells of the brain has been used as a neuroinflammation marker in the early and middle stages of neurodegenerative diseases, such as alzheimer's disease (ad) and dementia with lewy bodies (dlb). |
2020-05-29 |
2023-08-13 |
Not clear |
| Viktor Bencs, János Bencze, V László Módis, Viktória Simon, János Kálmán, Tibor Hortobágy. Pathological and clinical comparison of Parkinson’s disease dementia and dementia with Lewy bodies. Orvosi hetilap. vol 161. issue 18. 2020-05-19. PMID:32338488. |
dementia with lewy bodies (dlb) and parkinson's disease dementia (pdd) are two major neurodegenerative diseases sharing common clinical, pathophysiological and morphologic features. |
2020-05-19 |
2023-08-13 |
Not clear |
| Sarah B Berman, Cameron Miller-Patterso. PD and DLB: Brain imaging in Parkinson's disease and dementia with Lewy bodies. Progress in molecular biology and translational science. vol 165. 2020-04-17. PMID:31481162. |
parkinson's disease (pd) and dementia with lewy bodies (dlb) are both neurodegenerative diseases characterized by the abnormal intraneuronal accumulation of misfolded α-synuclein into lewy bodies and lewy neurites. |
2020-04-17 |
2023-08-13 |
Not clear |
| Alon Seifan, Christine A Ganzer, Krista Ryon, Michael Lin, Rahman Mahmudur, Henriquez Adolfo, Cindy Shih, Alan R Jacobs, Molly Greenwald, Richard S Isaacso. Detecting Non-cognitive Features of Prodromal Neurodegenerative Diseases. Current aging science. vol 11. issue 4. 2020-03-30. PMID:30845903. |
prodromal neurodegenerative disease (nd) due to tauopathies such as alzheimer's disease (ad) and synucleinopathies (sn) such as parkinson's disease (pd) and dementia with lewy bodies (dlb) present subtly. |
2020-03-30 |
2023-08-13 |
Not clear |
| Astrid Melani Suantio, Hian Liang Huang, Cecilia Sze Nga Kwok, Darren Cheng Han Teo, Minh Ha Nguye. FDG-PET in suspected dementia with Lewy bodies: a case report. BMC geriatrics. vol 19. issue 1. 2020-03-16. PMID:31138141. |
dementia with lewy bodies (dlb) is still underdiagnosed or mistaken for other types of neurodegenerative diseases. |
2020-03-16 |
2023-08-13 |
Not clear |
| Qiang Zhang, Dennis Jung, Travis Larson, Youngcho Kim, Nandakumar S Narayana. Scopolamine and Medial Frontal Stimulus-Processing during Interval Timing. Neuroscience. vol 414. 2020-03-13. PMID:31299344. |
neurodegenerative diseases such as parkinson's disease (pd), dementia with lewy bodies (dlb), and alzheimer's disease (ad) involve loss of cholinergic neurons in the basal forebrain. |
2020-03-13 |
2023-08-13 |
mouse |
| Harm Ruesink, Lasse Reimer, Emil Gregersen, Arne Moeller, Cristine Betzer, Poul Henning Jense. Stabilization of α-synuclein oligomers using formaldehyde. PloS one. vol 14. issue 10. 2020-03-10. PMID:31603909. |
the group of neurodegenerative diseases, parkinson's disease (pd), dementia with lewy bodies (dlb), and multiple system atrophy (msa) all exhibit inclusions containing amyloid-type α-synuclein (α-syn) aggregates within degenerating brain cells. |
2020-03-10 |
2023-08-13 |
Not clear |
| Arthur Viodé, Stéphane Epelbaum, Imen Benyounes, Marc Verny, Bruno Dubois, Christophe Junot, François Fenaille, Foudil Lamari, François Beche. Simultaneous quantification of tau and α-synuclein in cerebrospinal fluid by high-resolution mass spectrometry for differentiation of Lewy Body Dementia from Alzheimer's Disease and controls. The Analyst. vol 144. issue 21. 2020-02-24. PMID:31553333. |
tau and α-synuclein are central in several neurodegenerative diseases, including alzheimer disease (ad), dementia with lewy bodies (dlb) and parkinson disease (pd). |
2020-02-24 |
2023-08-13 |
Not clear |
| Arthur Viodé, Stéphane Epelbaum, Imen Benyounes, Marc Verny, Bruno Dubois, Christophe Junot, François Fenaille, Foudil Lamari, François Beche. Simultaneous quantification of tau and α-synuclein in cerebrospinal fluid by high-resolution mass spectrometry for differentiation of Lewy Body Dementia from Alzheimer's Disease and controls. The Analyst. vol 144. issue 21. 2020-02-24. PMID:31553333. |
the multiplex method was successfully applied to csf samples from ad and dlb patients, two clinically overlapping neurodegenerative diseases. |
2020-02-24 |
2023-08-13 |
Not clear |
| Ravali L Vinnakota, Deepthi Yedlapudi, Krishna Madhuri Manda, Keerti Bhamidipati, Kirthi Theja Bommakanti, G Sree RangaLakshmi, Shasi V Kalivend. Identification of an Alternatively Spliced α-Synuclein Isoform That Generates a 41-Amino Acid N-Terminal Truncated Peptide, 41-syn: Role in Dopamine Homeostasis. ACS chemical neuroscience. vol 9. issue 12. 2019-12-23. PMID:29996045. |
the presynaptic protein, α-synuclein (α-syn), has been shown to play a crucial role in multiple neurodegenerative diseases, such as parkinson's disease (pd), alzheimer's disease (ad), and dementia with lewy bodies (dlb). |
2019-12-23 |
2023-08-13 |
Not clear |
| Lucilla Parnetti, Silvia Paciotti, Lucia Farotti, Giovanni Bellomo, Federica Nicoletta Sepe, Paolo Euseb. Parkinson's and Lewy body dementia CSF biomarkers. Clinica chimica acta; international journal of clinical chemistry. vol 495. 2019-12-11. PMID:31051162. |
the clinical diagnosis of parkinson's disease (pd) and dementia with lewy bodies (dlb) is challenging due to highly variable clinical presentation and clinical and pathological overlap with other neurodegenerative diseases. |
2019-12-11 |
2023-08-13 |
Not clear |
| Tatiana Orme, Rita Guerreiro, Jose Bra. The Genetics of Dementia with Lewy Bodies: Current Understanding and Future Directions. Current neurology and neuroscience reports. vol 18. issue 10. 2019-09-16. PMID:30097731. |
dementia with lewy bodies (dlb) is a neurodegenerative disease that can be clinically and pathologically similar to parkinson's disease (pd) and alzheimer's disease (ad). |
2019-09-16 |
2023-08-13 |
Not clear |