| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alison Ruth Jennings, William M Carrol. Oligodendrocyte Lineage Cells in Chronic Demyelination of Multiple Sclerosis Optic Nerve. Brain pathology (Zurich, Switzerland). vol 25. issue 5. 2016-05-04. PMID:25175564. |
the findings advance our understanding of oligodendrocyte activity in chronically demyelinated human optic nerve and may have implications for studies aimed at enhancement of endogenous repair in multiple sclerosis. |
2016-05-04 |
2023-08-13 |
human |
| D Kremer, H-P Hartung, M Stangel, P Kür. [New therapeutic strategies for remyelination in multiple sclerosis]. Der Nervenarzt. vol 86. issue 8. 2016-05-04. PMID:26122637. |
multiple sclerosis (ms) is characterized by oligodendrocyte death and myelin sheath destruction of the central nervous system (cns) in response to autoinflammatory processes. |
2016-05-04 |
2023-08-13 |
Not clear |
| Hyun Kyoung Lee, Dylan Laug, Wenyi Zhu, Jay M Patel, Kevin Ung, Benjamin R Arenkiel, Stephen P J Fancy, Carrie Mohila, Benjamin Denee. Apcdd1 stimulates oligodendrocyte differentiation after white matter injury. Glia. vol 63. issue 10. 2016-05-03. PMID:25946682. |
examination of apcdd1 expression in white matter lesions from neonatal wmi and adult multiple sclerosis revealed its expression in subsets of oligodendrocyte (ol) precursors. |
2016-05-03 |
2023-08-13 |
Not clear |
| Tobias Derfuss, François Curtin, Claudia Guebelin, Claire Bridel, Maria Rasenack, Alain Matthey, Renaud Du Pasquier, Myriam Schluep, Jules Desmeules, Alois B Lang, Hervé Perron, Raphael Faucard, Hervé Porchet, Hans-Peter Hartung, Ludwig Kappos, Patrice H Laliv. A phase IIa randomised clinical study of GNbAC1, a humanised monoclonal antibody against the envelope protein of multiple sclerosis-associated endogenous retrovirus in multiple sclerosis patients. Multiple sclerosis (Houndmills, Basingstoke, England). vol 21. issue 7. 2016-03-29. PMID:25392325. |
gnbac1 is an immunoglobulin (igg4) humanised monoclonal antibody against multiple sclerosis-associated retrovirus (msrv)-env, a protein of endogenous retroviral origin, expressed in multiple sclerosis (ms) lesions, which is pro-inflammatory and inhibits oligodendrocyte precursor cell differentiation. |
2016-03-29 |
2023-08-13 |
Not clear |
| Philippe Horellou, Min Wang, Vixra Keo, Pascale Chrétien, Ché Serguera, Patrick Waters, Kumaran Deiv. Increased interleukin-6 correlates with myelin oligodendrocyte glycoprotein antibodies in pediatric monophasic demyelinating diseases and multiple sclerosis. Journal of neuroimmunology. vol 289. 2016-03-14. PMID:26616865. |
increased interleukin-6 correlates with myelin oligodendrocyte glycoprotein antibodies in pediatric monophasic demyelinating diseases and multiple sclerosis. |
2016-03-14 |
2023-08-13 |
human |
| Ewa Kozela, Ana Juknat, Nathali Kaushansky, Avraham Ben-Nun, Giovanni Coppola, Zvi Voge. Cannabidiol, a non-psychoactive cannabinoid, leads to EGR2-dependent anergy in activated encephalitogenic T cells. Journal of neuroinflammation. vol 12. 2016-03-07. PMID:25880134. |
cannabidiol (cbd), the main non-psychoactive cannabinoid, has been previously shown by us to ameliorate clinical symptoms and to decrease inflammation in myelin oligodendrocyte glycoprotein (mog)35-55-induced mouse experimental autoimmune encephalomyelitis model of multiple sclerosis as well as to decrease mog35-55-induced t cell proliferation and il-17 secretion. |
2016-03-07 |
2023-08-13 |
mouse |
| Annie Elong Ngono, Maud Lepetit, Markus Reindl, Alexandra Garcia, Flora Guillot, Athénaïs Genty, Mélanie Chesneau, Marion Salou, Laure Michel, Fabienne Lefrere, Kathrin Schanda, Berthe-Marie Imbert-Marcille, Nicolas Degauque, Arnaud Nicot, Sophie Brouard, David-Axel Laplaud, Jean-Paul Soulillo. Decreased Frequency of Circulating Myelin Oligodendrocyte Glycoprotein B Lymphocytes in Patients with Relapsing-Remitting Multiple Sclerosis. Journal of immunology research. vol 2015. 2016-03-03. PMID:26090495. |
decreased frequency of circulating myelin oligodendrocyte glycoprotein b lymphocytes in patients with relapsing-remitting multiple sclerosis. |
2016-03-03 |
2023-08-13 |
Not clear |
| Sheila Tsau, Mitchell R Emerson, Sharon G Lynch, Steven M LeVin. Aspirin and multiple sclerosis. BMC medicine. vol 13. 2016-01-28. PMID:26123634. |
in an experimental setting of a cerebral ischemic lesion, aspirin promoted the proliferation and/or differentiation of oligodendrocyte precursors, raising the possibility that aspirin could facilitate remyelination efforts in multiple sclerosis. |
2016-01-28 |
2023-08-13 |
Not clear |
| David Kremer, Patrick Küry, Ranjan Dutt. Promoting remyelination in multiple sclerosis: current drugs and future prospects. Multiple sclerosis (Houndmills, Basingstoke, England). vol 21. issue 5. 2015-12-15. PMID:25623245. |
myelin destruction due to inflammatory oligodendrocyte cell damage or death in conjunction with axonal degeneration are among the major histopathological hallmarks of multiple sclerosis (ms). |
2015-12-15 |
2023-08-13 |
Not clear |
| Jane M Rodgers, Andrew P Robinson, Elen S Rosler, Karen Lariosa-Willingham, Rachael E Persons, Jason C Dugas, Stephen D Mille. IL-17A activates ERK1/2 and enhances differentiation of oligodendrocyte progenitor cells. Glia. vol 63. issue 5. 2015-12-07. PMID:25557204. |
inflammatory signals present in demyelinated multiple sclerosis lesions affect the reparative remyelination process conducted by oligodendrocyte progenitor cells (opcs). |
2015-12-07 |
2023-08-13 |
Not clear |
| Chao Zhao, Dan Ma, Malgorzata Zawadzka, Stephen P J Fancy, Lowri Elis-Williams, Guy Bouvier, John H Stockley, Glaucia Monteiro de Castro, Bowei Wang, Sabrina Jacobs, Patrizia Casaccia, Robin J M Frankli. Sox2 Sustains Recruitment of Oligodendrocyte Progenitor Cells following CNS Demyelination and Primes Them for Differentiation during Remyelination. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 33. 2015-11-05. PMID:26290228. |
here we show that the expression of sox2 occurs in oligodendrocyte progenitor cells (opcs) in rodent models during myelination and in activated adult opcs responding to demyelination, and is also detected in multiple sclerosis lesions. |
2015-11-05 |
2023-08-13 |
mouse |
| Marcin Czepiel, Erik Boddeke, Sjef Copra. Human oligodendrocytes in remyelination research. Glia. vol 63. issue 4. 2015-10-29. PMID:25421998. |
studies on myelination and oligodendrocyte development are inevitably linked with demyelinating conditions such as multiple sclerosis (ms), leukodystrophies or spinal cord injury (sci). |
2015-10-29 |
2023-08-13 |
human |
| Izumi Kawachi, Etsuji Saji, Masatoyo Nishizaw. [Gray matter lesions and cognitive impairment in multiple sclerosis]. Rinsho shinkeigaku = Clinical neurology. vol 54. issue 12. 2015-10-19. PMID:25672709. |
multiple sclerosis (ms) has long been considered to be the autoimmune disease that primarily affects oligodendrocyte and myelin in the white matter (wm) of the cns. |
2015-10-19 |
2023-08-13 |
Not clear |
| Tobias Derfuss, François Curtin, Claudia Guebelin, Claire Bridel, Maria Rasenack, Alain Matthey, Renaud Du Pasquier, Myriam Schluep, Jules Desmeules, Alois B Lang, Hervé Perron, Raphael Faucard, Hervé Porchet, Hans-Peter Hartung, Ludwig Kappos, Patrice H Laliv. A phase IIa randomized clinical study testing GNbAC1, a humanized monoclonal antibody against the envelope protein of multiple sclerosis associated endogenous retrovirus in multiple sclerosis patients - a twelve month follow-up. Journal of neuroimmunology. vol 285. 2015-10-16. PMID:26198921. |
gnbac1 is a humanized monoclonal antibody targeting msrv-env, an endogenous retroviral protein, which is expressed in multiple sclerosis (ms) lesions, is pro-inflammatory and inhibits oligodendrocyte precursor cell differentiation. |
2015-10-16 |
2023-08-13 |
Not clear |
| François Curtin, Hervé Perron, Arno Kromminga, Hervé Porchet, Alois B Lan. Preclinical and early clinical development of GNbAC1, a humanized IgG4 monoclonal antibody targeting endogenous retroviral MSRV-Env protein. mAbs. vol 7. issue 1. 2015-09-28. PMID:25427053. |
in contrast with mabs targeting immune function, gnbac1, a humanized igg4 mab, targets the multiple sclerosis associated retrovirus envelope (msrv-env) protein, an upstream factor in the pathophysiology of ms. msrv-env protein is of endogenous retroviral origin, expressed in ms brain lesions, and it is pro-inflammatory and toxic to the remyelination process, by preventing the differentiation of oligodendrocyte precursor cells. |
2015-09-28 |
2023-08-13 |
mouse |
| Maren Lindner, Katja Thümmler, Ariel Arthur, Sarah Brunner, Christina Elliott, Daniel McElroy, Hema Mohan, Anna Williams, Julia M Edgar, Cornelia Schuh, Christine Stadelmann, Susan C Barnett, Hans Lassmann, Steve Mücklisch, Manikhandan Mudaliar, Nicole Schaeren-Wiemers, Edgar Meinl, Christopher Liningto. Fibroblast growth factor signalling in multiple sclerosis: inhibition of myelination and induction of pro-inflammatory environment by FGF9. Brain : a journal of neurology. vol 138. issue Pt 7. 2015-09-07. PMID:25907862. |
this inhibitory activity is associated with the appearance of multi-branched 'pre-myelinating' mbp+ / plp+ oligodendrocytes that interact with axons but fail to assemble myelin sheaths; an oligodendrocyte phenotype described previously in chronically demyelinated multiple sclerosis lesions. |
2015-09-07 |
2023-08-13 |
Not clear |
| Jilpa Patel, Roumen Balabano. Molecular mechanisms of oligodendrocyte injury in multiple sclerosis and experimental autoimmune encephalomyelitis. International journal of molecular sciences. vol 13. issue 8. 2015-08-31. PMID:22949885. |
molecular mechanisms of oligodendrocyte injury in multiple sclerosis and experimental autoimmune encephalomyelitis. |
2015-08-31 |
2023-08-12 |
Not clear |
| Jilpa Patel, Roumen Balabano. Molecular mechanisms of oligodendrocyte injury in multiple sclerosis and experimental autoimmune encephalomyelitis. International journal of molecular sciences. vol 13. issue 8. 2015-08-31. PMID:22949885. |
new evidence has emerged over the last decade indicating that oligodendrocyte injury in multiple sclerosis (ms) is not a single unified phenomenon but rather a spectrum of processes ranging from massive immune destruction to a subtle cell death in the absence of significant inflammation. |
2015-08-31 |
2023-08-12 |
Not clear |
| Weixing Tan, Yingyan Pu, Qi Shao, Xue Fang, Dunxin Han, Ming Zhao, Li Ca. Insulin-like growth factor-binding protein 7 is up-regulated during EAE and inhibits the differentiation of oligodendrocyte precursor cells. Biochemical and biophysical research communications. vol 460. issue 3. 2015-08-21. PMID:25819415. |
oligodendrocyte precursor cells (opcs) differentiation failure is one of the leading causes for remyelination defects in the demyelinating lesions of multiple sclerosis (ms). |
2015-08-21 |
2023-08-13 |
mouse |
| Josephine M J Stoffels, Dick Hoekstra, Robin J M Franklin, Wia Baron, Chao Zha. The EIIIA domain from astrocyte-derived fibronectin mediates proliferation of oligodendrocyte progenitor cells following CNS demyelination. Glia. vol 63. issue 2. 2015-08-19. PMID:25156142. |
central nervous system remyelination by oligodendrocyte progenitor cells (opcs) ultimately fails in the majority of multiple sclerosis (ms) lesions. |
2015-08-19 |
2023-08-13 |
mouse |