| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sonia Podvin, Alexander Jones, Qing Liu, Brent Aulston, Linnea Ransom, Janneca Ames, Gloria Shen, Christopher B Lietz, Zhenze Jiang, Anthony J O'Donoghue, Charisse Winston, Tsuneya Ikezu, Robert A Rissman, Shauna Yuan, Vivian Hoo. Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses. Molecular & cellular proteomics : MCP. vol 19. issue 6. 2021-06-03. PMID:32295833. |
accumulation and propagation of hyperphosphorylated tau (p-tau) is a common neuropathological hallmark associated with neurodegeneration of alzheimer's disease (ad), frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17), and related tauopathies. |
2021-06-03 |
2023-08-13 |
mouse |
| Elena Britti, Joaquim Ros, Noemi Esteras, Andrey Y Abramo. Tau inhibits mitochondrial calcium efflux and makes neurons vulnerable to calcium-induced cell death. Cell calcium. vol 86. 2021-06-01. PMID:31918031. |
aggregation or phosphorylation of the microtubule-associated protein tau is the pathological hallmark in a number of diseases termed tauopathies, which include the most common neurodegenerative disorder, alzheimer's disease; or frontotemporal dementia, linked to mutations in the gene mapt encoding tau. |
2021-06-01 |
2023-08-13 |
Not clear |
| Elena Britti, Joaquim Ros, Noemi Esteras, Andrey Y Abramo. Tau inhibits mitochondrial calcium efflux and makes neurons vulnerable to calcium-induced cell death. Cell calcium. vol 86. 2021-06-01. PMID:31918031. |
here we studied the effect of tau on the cytosolic and mitochondrial calcium homeostasis using primary cortical cultures treated with the protein and ipsc-derived neurons bearing the 10 + 16 mapt mutation linked to frontotemporal dementia. |
2021-06-01 |
2023-08-13 |
Not clear |
| Soo Jung Shin, Yong Ho Park, Seong Gak Jeon, Sujin Kim, Yunkwon Nam, Sang-Muk Oh, Yong Yook Lee, Minho Moo. Red Ginseng Inhibits Tau Aggregation and Promotes Tau Dissociation Oxidative medicine and cellular longevity. vol 2020. 2021-05-14. PMID:32685100. |
therefore, suppressing tau aggregation or stimulating the dissociation of tau aggregates has been proposed as an effective strategy for treating neurodegenerative diseases associated with tau pathology such as alzheimer's disease (ad) and frontotemporal dementia. |
2021-05-14 |
2023-08-13 |
Not clear |
| Lucy Vivash, Charles B Malpas, Leonid Churilov, Mark Walterfang, Amy Brodtmann, Olivier Piguet, Rebekah M Ahmed, Ashley I Bush, Christopher M Hovens, T Kalincik, David Darby, Dennis Velakoulis, Terence J O'Brie. A study protocol for a phase II randomised, double-blind, placebo-controlled trial of sodium selenate as a disease-modifying treatment for behavioural variant frontotemporal dementia. BMJ open. vol 10. issue 11. 2021-05-14. PMID:33199422. |
behavioural variant frontotemporal dementia (bvftd) is a neurodegenerative disorder often neuropathologically associated with the accumulation of abnormally hyperphosphorylated tau, for which there is currently no disease-modifying treatment. |
2021-05-14 |
2023-08-13 |
Not clear |
| Shweta Kishor Sonawane, Subashchandrabose Chinnathamb. P301 L, an FTDP-17 Mutant, Exhibits Enhanced Glycation in vitro. Journal of Alzheimer's disease : JAD. vol 75. issue 1. 2021-05-10. PMID:32250308. |
frontotemporal dementia and parkinsonism-linked to chromosome-17 are a group of diseases with tau mutations leading to primary tauopathies which include progressive supranuclear palsy, corticobasal syndrome, and frontotemporal lobar degeneration. |
2021-05-10 |
2023-08-13 |
Not clear |
| Ya Su, Jiayu Fu, Jintai Yu, Qianhua Zhao, Yihui Guan, Chuantao Zuo, Ming Li, Haibo Tan, Xin Chen. Tau PET Imaging with [18F]PM-PBB3 in Frontotemporal Dementia with MAPT Mutation. Journal of Alzheimer's disease : JAD. vol 76. issue 1. 2021-05-07. PMID:32444551. |
tau pet imaging with [18f]pm-pbb3 in frontotemporal dementia with mapt mutation. |
2021-05-07 |
2023-08-13 |
Not clear |
| Ya Su, Jiayu Fu, Jintai Yu, Qianhua Zhao, Yihui Guan, Chuantao Zuo, Ming Li, Haibo Tan, Xin Chen. Tau PET Imaging with [18F]PM-PBB3 in Frontotemporal Dementia with MAPT Mutation. Journal of Alzheimer's disease : JAD. vol 76. issue 1. 2021-05-07. PMID:32444551. |
flortaucipir (av-1451) and pyridinyl-butadienyl-benzothiazole 3 (pbb3) are newly developed and commonly used positron emission tomography (pet) tracers to detect tau deposition in tauopathies, including frontotemporal dementia (ftd). |
2021-05-07 |
2023-08-13 |
Not clear |
| Jonathan L Chen, Peiyuan Zhang, Masahito Abe, Haruo Aikawa, Liying Zhang, Alexander J Frank, Timothy Zembryski, Christopher Hubbs, HaJeung Park, Jane Withka, Claire Steppan, Lucy Rogers, Shawn Cabral, Martin Pettersson, Travis T Wager, Matthew A Fountain, Gavin Rumbaugh, Jessica L Childs-Disney, Matthew D Disne. Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing. Journal of the American Chemical Society. vol 142. issue 19. 2021-04-13. PMID:32364710. |
one pre-mrna that is alternatively spliced and linked to neurodegenerative diseases is tau (microtubule-associated protein tau), which can cause frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17) and can contribute to alzheimer's disease. |
2021-04-13 |
2023-08-13 |
human |
| Marcello Giunta, Eino Solje, Fabrizio Gardoni, Barbara Borroni, Alberto Benuss. Experimental Disease-Modifying Agents for Frontotemporal Lobar Degeneration. Journal of experimental pharmacology. vol 13. 2021-04-02. PMID:33790662. |
frontotemporal dementia is a clinically, genetically and pathologically heterogeneous neurodegenerative disorder, enclosing a wide range of different pathological entities, associated with the accumulation of proteins such as tau and tpd-43. |
2021-04-02 |
2023-08-13 |
Not clear |
| Julie Pilliod, Alexandre Desjardins, Camille Pernègre, Hélène Jamann, Catherine Larochelle, Edward A Fon, Nicole Lecler. Clearance of intracellular tau protein from neuronal cells via VAMP8-induced secretion. The Journal of biological chemistry. vol 295. issue 51. 2021-04-01. PMID:33454017. |
finally, overexpression of vamp8 reduced the intracellular accumulation of tau mutants linked to frontotemporal dementia with parkinsonism and α-synuclein by increasing their secretion. |
2021-04-01 |
2023-08-13 |
Not clear |
| Noemi Esteras, Andrey Y Abramo. Mitochondrial Calcium Deregulation in the Mechanism of Beta-Amyloid and Tau Pathology. Cells. vol 9. issue 9. 2021-03-24. PMID:32967303. |
aggregation and deposition of β-amyloid and/or tau protein are the key neuropathological features in neurodegenerative disorders such as alzheimer's disease (ad) and other tauopathies including frontotemporal dementia (ftd). |
2021-03-24 |
2023-08-13 |
Not clear |
| Nora Lemke, Valeria Melis, Dilyara Lauer, Mandy Magbagbeolu, Boris Neumann, Charles R Harrington, Gernot Riedel, Claude M Wischik, Franz Theuring, Karima Schwa. Differential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the line 66 model of frontotemporal dementia. The Journal of biological chemistry. vol 295. issue 52. 2021-03-23. PMID:33127647. |
differential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the line 66 model of frontotemporal dementia. |
2021-03-23 |
2023-08-13 |
mouse |
| Nora Lemke, Valeria Melis, Dilyara Lauer, Mandy Magbagbeolu, Boris Neumann, Charles R Harrington, Gernot Riedel, Claude M Wischik, Franz Theuring, Karima Schwa. Differential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the line 66 model of frontotemporal dementia. The Journal of biological chemistry. vol 295. issue 52. 2021-03-23. PMID:33127647. |
synapse loss is associated with motor and cognitive decline in multiple neurodegenerative disorders, and the cellular redistribution of tau is related to synaptic impairment in tauopathies, such as alzheimer's disease and frontotemporal dementia. |
2021-03-23 |
2023-08-13 |
mouse |
| Nora Lemke, Valeria Melis, Dilyara Lauer, Mandy Magbagbeolu, Boris Neumann, Charles R Harrington, Gernot Riedel, Claude M Wischik, Franz Theuring, Karima Schwa. Differential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the line 66 model of frontotemporal dementia. The Journal of biological chemistry. vol 295. issue 52. 2021-03-23. PMID:33127647. |
here, we examined the cellular distribution of tau protein species in human tau overexpressing line 66 mice, a transgenic mouse model akin to genetic variants of frontotemporal dementia. |
2021-03-23 |
2023-08-13 |
mouse |
| Morgan D Strong, Matthew D Hart, Tony Z Tang, Babajide A Ojo, Lei Wu, Mariah R Nacke, Workneh T Agidew, Hong J Hwang, Peter R Hoyt, Ahmed Bettaieb, Stephen L Clarke, Brenda J Smith, Barbara J Stoecker, Edralin A Lucas, Dingbo Lin, Winyoo Chowanadisa. Role of zinc transporter ZIP12 in susceptibility-weighted brain magnetic resonance imaging (MRI) phenotypes and mitochondrial function. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 9. 2021-03-22. PMID:32716562. |
mutant forms of α-synuclein and tau linked to familial parkinson's disease and frontotemporal dementia, respectively, reduced neurite outgrowth in cells deficient in zip12. zinc and zip12 may confer resilience against neurological diseases or premature aging of the brain. |
2021-03-22 |
2023-08-13 |
Not clear |
| Vincent Paquin, Joseph Therriault, Tharick Ali Pascoal, Pedro Rosa-Neto, Serge Gauthie. Frontal Variant of Alzheimer Disease Differentiated From Frontotemporal Dementia Using in Vivo Amyloid and Tau Imaging. Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology. vol 33. issue 4. 2021-02-19. PMID:33264158. |
frontal variant of alzheimer disease differentiated from frontotemporal dementia using in vivo amyloid and tau imaging. |
2021-02-19 |
2023-08-13 |
Not clear |
| Tharick A Pascoal, Joseph Therriault, Andrea L Benedet, Melissa Savard, Firoza Z Lussier, Mira Chamoun, Cécile Tissot, Muhammad Naveed Iqbal Qureshi, Min Su Kang, Sulantha Mathotaarachchi, Jenna Stevenson, Robert Hopewell, Gassan Massarweh, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Net. 18F-MK-6240 PET for early and late detection of neurofibrillary tangles. Brain : a journal of neurology. vol 143. issue 9. 2021-02-16. PMID:32671408. |
to this end, we studied 301 individuals (30 cognitively unimpaired young, 138 cognitively unimpaired elderly, 67 with mild cognitive impairment, 54 with alzheimer's disease dementia, and 12 with frontotemporal dementia) with amyloid-β 18f-nav4694, tau 18f-mk-6240, mri, and clinical assessments. |
2021-02-16 |
2023-08-13 |
human |
| Mercedes Prudencio, Jack Humphrey, Sarah Pickles, Anna-Leigh Brown, Sarah E Hill, Jennifer M Kachergus, J Shi, Michael G Heckman, Matthew R Spiegel, Casey Cook, Yuping Song, Mei Yue, Lillian M Daughrity, Yari Carlomagno, Karen Jansen-West, Cristhoper Fernandez de Castro, Michael DeTure, Shunsuke Koga, Ying-Chih Wang, Prasanth Sivakumar, Cristian Bodo, Ana Candalija, Kevin Talbot, Bhuvaneish T Selvaraj, Karen Burr, Siddharthan Chandran, Jia Newcombe, Tammaryn Lashley, Isabel Hubbard, Demetra Catalano, Duyang Kim, Nadia Propp, Samantha Fennessey, Delphine Fagegaltier, Hemali Phatnani, Maria Secrier, Elizabeth Mc Fisher, Björn Oskarsson, Marka van Blitterswijk, Rosa Rademakers, Neil R Graff-Radford, Bradley F Boeve, David S Knopman, Ronald C Petersen, Keith A Josephs, E Aubrey Thompson, Towfique Raj, Michael Ward, Dennis W Dickson, Tania F Gendron, Pietro Fratta, Leonard Petrucell. Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia. The Journal of clinical investigation. vol 130. issue 11. 2021-02-16. PMID:32790644. |
no treatment for frontotemporal dementia (ftd), the second most common type of early-onset dementia, is available, but therapeutics are being investigated to target the 2 main proteins associated with ftd pathological subtypes: tdp-43 (ftld-tdp) and tau (ftld-tau). |
2021-02-16 |
2023-08-13 |
human |
| Michel Goedert, Maria Grazia Spillantini, Benjamin Falcon, Wenjuan Zhang, Kathy L Newell, Masato Hasegawa, Sjors H W Scheres, Bernardino Ghett. Tau Protein and Frontotemporal Dementias. Advances in experimental medicine and biology. vol 1281. 2021-02-15. PMID:33433876. |
tau protein and frontotemporal dementias. |
2021-02-15 |
2023-08-13 |
Not clear |