| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michel Goedert, Maria Grazia Spillantini, Benjamin Falcon, Wenjuan Zhang, Kathy L Newell, Masato Hasegawa, Sjors H W Scheres, Bernardino Ghett. Tau Protein and Frontotemporal Dementias. Advances in experimental medicine and biology. vol 1281. 2021-02-15. PMID:33433876. |
filamentous inclusions of tau protein are found in cases of inherited and sporadic frontotemporal dementias (ftds). |
2021-02-15 |
2023-08-13 |
Not clear |
| Marangelie Criado-Marrero, Jonathan J Sabbagh, Margaret R Jones, Dale Chaput, Chad A Dickey, Laura J Blai. Hippocampal Neurogenesis Is Enhanced in Adult Tau Deficient Mice. Cells. vol 9. issue 1. 2021-02-08. PMID:31947657. |
tau dysfunction is common in several neurodegenerative diseases including alzheimer's disease (ad) and frontotemporal dementia (ftd). |
2021-02-08 |
2023-08-13 |
mouse |
| Nicole M Maphis, Julianne Peabody, Erin Crossey, Shanya Jiang, Fadi A Jamaleddin Ahmad, Maria Alvarez, Soiba Khalid Mansoor, Amanda Yaney, Yirong Yang, Laurel O Sillerud, Colin M Wilson, Reed Selwyn, Jonathan L Brigman, Judy L Cannon, David S Peabody, Bryce Chackerian, Kiran Bhaska. Qß Virus-like particle-based vaccine induces robust immunity and protects against tauopathy. NPJ vaccines. vol 4. 2021-02-03. PMID:31231552. |
tauopathies, including frontotemporal dementia (ftd) and alzheimer's disease (ad) are progressive neurodegenerative diseases clinically characterized by cognitive decline and could be caused by the aggregation of hyperphosphorylated pathological tau (ptau) as neurofibrillary tangles (nfts) inside neurons. |
2021-02-03 |
2023-08-13 |
mouse |
| Eun-Joo Kim, Ji-Hye L Hwang, Stephanie E Gaus, Alissa L Nana, Jersey Deng, Jesse A Brown, Salvatore Spina, Myung Jun Lee, Eliana Marisa Ramos, Lea T Grinberg, Joel H Kramer, Adam L Boxer, Maria Luisa Gorno-Tempini, Howard J Rosen, Bruce L Miller, William W Seele. Evidence of corticofugal tau spreading in patients with frontotemporal dementia. Acta neuropathologica. vol 139. issue 1. 2021-01-19. PMID:31542807. |
evidence of corticofugal tau spreading in patients with frontotemporal dementia. |
2021-01-19 |
2023-08-13 |
human |
| Magdalena Przybyla, Janet van Eersel, Annika van Hummel, Julia van der Hoven, Miheer Sabale, Anne Harasta, Julius Müller, Mehul Gajwani, Emmanuel Prikas, Thomas Mueller, Claire H Stevens, John Power, Gary D Housley, Tim Karl, Michael Kassiou, Yazi D Ke, Arne Ittner, Lars M Ittne. Onset of hippocampal network aberration and memory deficits in P301S tau mice are associated with an early gene signature. Brain : a journal of neurology. vol 143. issue 6. 2021-01-19. PMID:32375177. |
hyperphosphorylation and deposition of tau in the brain characterizes frontotemporal dementia and alzheimer's disease. |
2021-01-19 |
2023-08-13 |
mouse |
| Lennart Müller-Thomsen, Diba Borgmann, Kerstin Morcinek, Sophia Schröder, Brigitte Dengler, Natasha Moser, Felix Neumaier, Toni Schneider, Hannsjörg Schröder, Stefan Huggenberge. Consequences of hyperphosphorylated tau on the morphology and excitability of hippocampal neurons in aged tau transgenic mice. Neurobiology of aging. vol 93. 2021-01-15. PMID:32278495. |
the intracellular accumulation of hyperphosphorylated tau characterizes many neurodegenerative diseases such as alzheimer's disease and frontotemporal dementia. |
2021-01-15 |
2023-08-13 |
mouse |
| Pragati, Soram Idiyasan Chanu, Surajit Sarka. Reduced expression of dMyc mitigates Tau Neuroscience letters. vol 715. 2021-01-04. PMID:31715291. |
reduced expression of dmyc mitigates tau tauopathies such as alzheimer's disease (ad), pick's disease (pid), frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17) etc. |
2021-01-04 |
2023-08-13 |
human |
| Fuyuki Kametani, Mari Yoshida, Tomoyasu Matsubara, Shigeo Murayama, Yuko Saito, Ito Kawakami, Mitsumoto Onaya, Hidetomo Tanaka, Akiyoshi Kakita, Andrew C Robinson, David M A Mann, Masato Hasegaw. Comparison of Common and Disease-Specific Post-translational Modifications of Pathological Tau Associated With a Wide Range of Tauopathies. Frontiers in neuroscience. vol 14. 2020-12-01. PMID:33250706. |
we analyzed sarkosyl-insoluble pathological tau proteins prepared from brains of patients with alzheimer's disease, pick's disease, progressive supranuclear palsy, corticobasal degeneration, globular glial tauopathy, and frontotemporal dementia and parkinsonisms linked to chromosome 17 with tau inclusions using liquid chromatography mass spectrometry. |
2020-12-01 |
2023-08-13 |
Not clear |
| Laibaik Park, Karin Hochrainer, Yorito Hattori, Sung Ji Ahn, Antoine Anfray, Gang Wang, Ken Uekawa, James Seo, Victoria Palfini, Ismary Blanco, Diana Acosta, David Eliezer, Ping Zhou, Josef Anrather, Costantino Iadecol. Tau induces PSD95-neuronal NOS uncoupling and neurovascular dysfunction independent of neurodegeneration. Nature neuroscience. vol 23. issue 9. 2020-11-30. PMID:32778793. |
cerebrovascular abnormalities have emerged as a preclinical manifestation of alzheimer's disease and frontotemporal dementia, diseases characterized by the accumulation of hyperphosphorylated forms of the microtubule-associated protein tau. |
2020-11-30 |
2023-08-13 |
mouse |
| Shanya Jiang, Kiran Bhaska. Degradation and Transmission of Tau by Autophagic-Endolysosomal Networks and Potential Therapeutic Targets for Tauopathy. Frontiers in molecular neuroscience. vol 13. 2020-11-14. PMID:33177989. |
tauopathies are a class of neurodegenerative diseases, including alzheimer's disease (ad), frontotemporal dementia (ftd), progressive supranuclear palsy (psp), corticobasal degeneration (cbd), and many others where microtubule-associated protein tau (mapt or tau) is hyperphosphorylated and aggregated to form insoluble paired helical filaments (phfs) and ultimately neurofibrillary tangles (nfts). |
2020-11-14 |
2023-08-13 |
Not clear |
| Xinzhu Wang, Declan Williams, Iris Müller, Mackenzie Lemieux, Ramona Dukart, Isabella B L Maia, Hansen Wang, Amanda L Woerman, Gerold Schmitt-Ulm. Tau interactome analyses in CRISPR-Cas9 engineered neuronal cells reveal ATPase-dependent binding of wild-type but not P301L Tau to non-muscle myosins. Scientific reports. vol 9. issue 1. 2020-11-04. PMID:31700063. |
protein interactions of tau are of interest in efforts to decipher pathogenesis in alzheimer's disease, a subset of frontotemporal dementias, and other tauopathies. |
2020-11-04 |
2023-08-13 |
mouse |
| Marta Scarioni, Priya Gami-Patel, Yannick Timar, Harro Seelaar, John C van Swieten, Annemieke J M Rozemuller, Annemiek Dols, Elio Scarpini, Daniela Galimberti, Jeroen J M Hoozemans, Yolande A L Pijnenburg, Anke A Dijkstr. Frontotemporal Dementia: Correlations Between Psychiatric Symptoms and Pathology. Annals of neurology. vol 87. issue 6. 2020-10-13. PMID:32281118. |
the pathology of frontotemporal dementia, termed frontotemporal lobar degeneration (ftld), is characterized by distinct molecular classes of aggregated proteins, the most common being tar dna-binding protein-43 (tdp-43), tau, and fused in sarcoma (fus). |
2020-10-13 |
2023-08-13 |
Not clear |
| Mariana Vargas-Caballero, Franziska Denk, Heike J Wobst, Emily Arch, Chrysia-Maria Pegasiou, Peter L Oliver, Olivia A Shipton, Ole Paulsen, Richard Wade-Martin. Wild-Type, but Not Mutant N296H, Human Tau Restores Aβ-Mediated Inhibition of LTP in Frontiers in neuroscience. vol 11. 2020-10-01. PMID:28484365. |
wild-type, but not mutant n296h, human tau restores aβ-mediated inhibition of ltp in microtubule associated protein tau (mapt) is involved in the pathogenesis of alzheimer's disease and many forms of frontotemporal dementia (ftd). |
2020-10-01 |
2023-08-13 |
mouse |
| Brandon Lucke-Wold, Kay Seidel, Rub Udo, Bennet Omalu, Mark Ornstein, Richard Nolan, Charles Rosen, Joel Ros. Role of Tau Acetylation in Alzheimer's Disease and Chronic Traumatic Encephalopathy: The Way Forward for Successful Treatment. Journal of neurology and neurosurgery. vol 4. issue 2. 2020-10-01. PMID:29276758. |
the current pathology of progressive neurodegenerative tauopathies, such as alzheimer's disease (ad), pick's disease, frontotemporal dementia (ftd), and progressive supranuclear palsy, primarily revolves around phosphorylation and hyperphosphorylation of the tau protein. |
2020-10-01 |
2023-08-13 |
Not clear |
| Petr Novak, Eva Kontsekova, Norbert Zilka, Michal Nova. Ten Years of Tau-Targeted Immunotherapy: The Path Walked and the Roads Ahead. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:30450030. |
while they are individually rarer, a range of other disorders, the tauopathies (including pick's disease, progressive supranuclear palsy, corticobasal degeneration, primary progressive aphasia, and ∼50% of behavioral variant frontotemporal dementia cases) display pronounced underlying tau pathology. |
2020-10-01 |
2023-08-13 |
Not clear |
| Aidan Kenny, Félix Hernández, Jesús Avila, José J Lucas, David C Henshall, Jochen Hm Prehn, Eva M Jiménez-Mateos, Tobias Enge. Profiling of Argonaute-2-loaded microRNAs in a mouse model of frontotemporal dementia with parkinsonism-17. International journal of physiology, pathophysiology and pharmacology. vol 10. issue 6. 2020-10-01. PMID:30697364. |
to determine whether a pathological expression of tau leads to altered microrna expression, we investigated a mouse model (vlw), which overexpresses tau carrying three mutations identified in patients suffering from frontotemporal dementia with parkinsonism-17. |
2020-10-01 |
2023-08-13 |
mouse |
| Jerrah Holth, Tirth Patel, David M Holtzma. Sleep in Alzheimer's Disease - Beyond Amyloid. Neurobiology of sleep and circadian rhythms. vol 2. 2020-09-30. PMID:28217760. |
furthermore, human tau mouse models exhibit ad-like sleep disturbances and sleep changes are very common in other tauopathies including frontotemporal dementia and progressive supranuclear palsy. |
2020-09-30 |
2023-08-13 |
mouse |
| Luis Fernando Arredondo, Saray Aranda-Romo, Ildefonso Rodríguez-Leyva, Erika Chi-Ahumada, Sami K Saikaly, Diana P Portales-Pérez, Roberto González-Amaro, Mariana Salgado-Bustamante, Lourdes Enriquez-Macias, William Eng, Robert A Norman, Maria E Jimenez-Capdevill. Tau Protein in Oral Mucosa and Cognitive State: A Cross-sectional Study. Frontiers in neurology. vol 8. 2020-09-30. PMID:29081764. |
among them, the presence of aggregates of phosphorylated tau protein (p-tau) is the hallmark of alzheimer's disease (ad) and other major neurodegenerative disorders such as corticobasal degeneration and frontotemporal dementia among others. |
2020-09-30 |
2023-08-13 |
human |
| Kwun Chung Yu, Ping Kwan, Stanley K K Cheung, Amy Ho, Larry Bau. Effects of Resveratrol and Morin on Insoluble Tau in Tau Transgenic Mice. Translational neuroscience. vol 9. 2020-09-30. PMID:30479844. |
tauopathies are neurodegenerative diseases, including alzheimer's disease (ad) and frontotemporal dementia (ftd), in which tau protein aggregates within neurons. |
2020-09-30 |
2023-08-13 |
mouse |
| Thomas K Karikari, David A Nagel, Alastair Grainger, Charlotte Clarke-Bland, James Crowe, Eric J Hill, Kevin G Moffa. Distinct Conformations, Aggregation and Cellular Internalization of Different Tau Strains. Frontiers in cellular neuroscience. vol 13. 2020-09-30. PMID:31338022. |
we have used a combined structural and cell biological approach to study if two frontotemporal dementia (ftd)-associated pathologic mutations, v337m and n279k, affect the aggregation, conformation and cellular internalization of the tau four-repeat domain (k18) fragment. |
2020-09-30 |
2023-08-13 |
human |