| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aya Ikeda, Hitoshi Shimada, Kenya Nishioka, Masashi Takanashi, Arisa Hayashida, Yuanzhe Li, Hiroyo Yoshino, Manabu Funayama, Yuji Ueno, Taku Hatano, Naruhiko Sahara, Tetsuya Suhara, Makoto Higuchi, Nobutaka Hattor. Clinical heterogeneity of frontotemporal dementia and Parkinsonism linked to chromosome 17 caused by MAPT N279K mutation in relation to tau positron emission tomography features. Movement disorders : official journal of the Movement Disorder Society. vol 34. issue 4. 2020-01-09. PMID:30773680. |
clinical heterogeneity of frontotemporal dementia and parkinsonism linked to chromosome 17 caused by mapt n279k mutation in relation to tau positron emission tomography features. |
2020-01-09 |
2023-08-13 |
Not clear |
| Aya Ikeda, Hitoshi Shimada, Kenya Nishioka, Masashi Takanashi, Arisa Hayashida, Yuanzhe Li, Hiroyo Yoshino, Manabu Funayama, Yuji Ueno, Taku Hatano, Naruhiko Sahara, Tetsuya Suhara, Makoto Higuchi, Nobutaka Hattor. Clinical heterogeneity of frontotemporal dementia and Parkinsonism linked to chromosome 17 caused by MAPT N279K mutation in relation to tau positron emission tomography features. Movement disorders : official journal of the Movement Disorder Society. vol 34. issue 4. 2020-01-09. PMID:30773680. |
while mechanistic links between tau abnormalities and neurodegeneration have been proven in frontotemporal dementia and parkinsonism linked to chromosome 17 caused by mapt mutations, variability of the tau pathogenesis and its relation to clinical progressions in the same mapt mutation carriers are yet to be clarified. |
2020-01-09 |
2023-08-13 |
Not clear |
| Janice C Malcolm, Lionel Breuillaud, Sonia Do Carmo, Hélène Hall, Lindsay A Welikovitch, Jennifer A Macdonald, Michel Goedert, A Claudio Cuell. Neuropathological changes and cognitive deficits in rats transgenic for human mutant tau recapitulate human tauopathy. Neurobiology of disease. vol 127. 2020-01-09. PMID:30905766. |
the assembly of tau protein into abnormal filaments and brain cell degeneration are characteristic of a number of human neurodegenerative diseases, including alzheimer's disease and frontotemporal dementia and parkinsonism linked to chromosome 17. |
2020-01-09 |
2023-08-13 |
human |
| Nadia Cummins, Andrea Tweedie, Steven Zuryn, Jesus Bertran-Gonzalez, Jürgen Göt. Disease-associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria. The EMBO journal. vol 38. issue 3. 2020-01-06. PMID:30538104. |
accumulation of the protein tau characterises alzheimer's disease and other tauopathies, including familial forms of frontotemporal dementia (ftd) that carry pathogenic tau mutations. |
2020-01-06 |
2023-08-13 |
human |
| Harrison Tudor Evans, Joseph Benetatos, Marloes van Roijen, Liviu-Gabriel Bodea, Jürgen Göt. Decreased synthesis of ribosomal proteins in tauopathy revealed by non-canonical amino acid labelling. The EMBO journal. vol 38. issue 13. 2019-12-23. PMID:31268600. |
tau is a scaffolding protein that serves multiple cellular functions that are perturbed in neurodegenerative diseases, including alzheimer's disease (ad) and frontotemporal dementia (ftd). |
2019-12-23 |
2023-08-13 |
mouse |
| Petar Marinković, Sonja Blumenstock, Pieter M Goltstein, Viktoria Korzhova, Finn Peters, Andreas Knebl, Jochen Herm. In vivo imaging reveals reduced activity of neuronal circuits in a mouse tauopathy model. Brain : a journal of neurology. vol 142. issue 4. 2019-12-10. PMID:30847469. |
in the present study, we used mice transgenic for human tau with the frontotemporal dementia with parkinsonism-associated p301s mutation. |
2019-12-10 |
2023-08-13 |
mouse |
| Estrella Gómez-Tortosa, Yalda Baradaran-Heravi, Valentina González Alvarez, María José Sainz, Cristina Prieto-Jurczynska, Rosa Guerrero-López, Pablo Agüero Rabes, Christine Van Broeckhoven, Julie van der Zee, Alberto Rábano Gutiérre. Presence of tau astrogliopathy in frontotemporal dementia caused by a novel Grn nonsense (Trp2*) mutation. Neurobiology of aging. vol 76. 2019-12-06. PMID:30545478. |
presence of tau astrogliopathy in frontotemporal dementia caused by a novel grn nonsense (trp2*) mutation. |
2019-12-06 |
2023-08-13 |
Not clear |
| P K. Pal, Z K. Wszolek, A Kishore, R de la Fuente-Fernandez, V Sossi, R J. Uitti, T Dobko, A J. Stoess. Positron emission tomography in pallido-ponto-nigral degeneration (PPND) family (frontotemporal dementia with parkinsonism linked to chromosome 17 and point mutation in tau gene). Parkinsonism & related disorders. vol 7. issue 2. 2019-11-20. PMID:11248587. |
positron emission tomography in pallido-ponto-nigral degeneration (ppnd) family (frontotemporal dementia with parkinsonism linked to chromosome 17 and point mutation in tau gene). |
2019-11-20 |
2023-08-12 |
Not clear |
| Luke Tait, Kyle Wedgwood, Krasimira Tsaneva-Atanasova, Jon T Brown, Marc Goodfello. Control of clustered action potential firing in a mathematical model of entorhinal cortex stellate cells. Journal of theoretical biology. vol 449. 2019-10-31. PMID:29654854. |
the entorhinal cortex is a crucial component of our memory and spatial navigation systems and is one of the first areas to be affected in dementias featuring tau pathology, such as alzheimer's disease and frontotemporal dementia. |
2019-10-31 |
2023-08-13 |
Not clear |
| Ramon Velazquez, Eric Ferreira, An Tran, Emily C Turner, Ramona Belfiore, Caterina Branca, Salvatore Odd. Acute tau knockdown in the hippocampus of adult mice causes learning and memory deficits. Aging cell. vol 17. issue 4. 2019-10-14. PMID:29749079. |
misfolded and hyperphosphorylated tau accumulates in several neurodegenerative disorders including alzheimer's disease, frontotemporal dementia with parkinsonism, corticobasal degeneration, progressive supranuclear palsy, down syndrome, and pick's disease. |
2019-10-14 |
2023-08-13 |
mouse |
| Martha S Foiani, Ione Oc Woollacott, Carolin Heller, Martina Bocchetta, Amanda Heslegrave, Katrina M Dick, Lucy L Russell, Charles R Marshall, Simon Mead, Jonathan M Schott, Nick C Fox, Jason D Warren, Henrik Zetterberg, Jonathan D Rohre. Plasma tau is increased in frontotemporal dementia. Journal of neurology, neurosurgery, and psychiatry. vol 89. issue 8. 2019-10-03. PMID:29440230. |
plasma tau is increased in frontotemporal dementia. |
2019-10-03 |
2023-08-13 |
Not clear |
| Yuta Takaichi, Yasuhisa Ano, James K Chambers, Kazuyuki Uchida, Akihiko Takashima, Hiroyuki Nakayam. Deposition of Phosphorylated α-Synuclein in the rTg4510 Mouse Model of Tauopathy. Journal of neuropathology and experimental neurology. vol 77. issue 10. 2019-10-03. PMID:30107539. |
specifically, hyperphosphorylated tau (hp-tau) accumulates in alzheimer disease, frontotemporal dementia with parkinsonism linked to chromosome 17, and progressive supranuclear palsy; furthermore, phosphorylated α-synuclein (p-αsyn) accumulates in parkinson disease, dementia with lewy bodies, and multiple system atrophy. |
2019-10-03 |
2023-08-13 |
mouse |
| Yamini Mutreja, Benjamin Combs, T Chris Gambli. FTDP-17 Mutations Alter the Aggregation and Microtubule Stabilization Propensity of Tau in an Isoform-Specific Fashion. Biochemistry. vol 58. issue 6. 2019-09-30. PMID:30562452. |
more than 50 different intronic and exonic autosomal dominant mutations in the tau gene have been linked to the neurodegenerative disorder frontotemporal dementia with parkinsonism linked to chromosome-17 (ftdp-17). |
2019-09-30 |
2023-08-13 |
Not clear |
| Juan Antonio García-León, Alfredo Cabrera-Socorro, Kristel Eggermont, Ann Swijsen, Joke Terryn, Raheem Fazal, FatemehArefeh Nami, Laura Ordovás, Ana Quiles, Frederic Lluis, Lutgarde Serneels, Keimpe Wierda, Annerieke Sierksma, Mohamed Kreir, Francisco Pestana, Philip Van Damme, Bart De Strooper, Lieven Thorrez, Andreas Ebneth, Catherine M Verfailli. Generation of a human induced pluripotent stem cell-based model for tauopathies combining three microtubule-associated protein TAU mutations which displays several phenotypes linked to neurodegeneration. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 14. issue 10. 2019-09-27. PMID:30036493. |
tauopathies are neurodegenerative diseases characterized by tau protein-related pathology, including frontotemporal dementia and alzheimer's disease among others. |
2019-09-27 |
2023-08-13 |
human |
| Adam M Staffaroni, Peter A Ljubenkov, John Kornak, Yann Cobigo, Samir Datta, Gabe Marx, Samantha M Walters, Kevin Chiang, Nick Olney, Fanny M Elahi, David S Knopman, Bradford C Dickerson, Bradley F Boeve, Maria Luisa Gorno-Tempini, Salvatore Spina, Lea T Grinberg, William W Seeley, Bruce L Miller, Joel H Kramer, Adam L Boxer, Howard J Rose. Longitudinal multimodal imaging and clinical endpoints for frontotemporal dementia clinical trials. Brain : a journal of neurology. vol 142. issue 2. 2019-09-19. PMID:30698757. |
frontotemporal dementia refers to a group of progressive neurodegenerative syndromes usually caused by the accumulation of pathological tau or tdp-43 proteins. |
2019-09-19 |
2023-08-13 |
human |
| Emil Ygland, Danielle van Westen, Elisabet Englund, Rosa Rademakers, Zbigniew K Wszolek, Karin Nilsson, Christer Nilsson, Maria Landqvist Waldö, Irina Alafuzoff, Oskar Hansson, Lars Gustafson, Andreas Puschman. Slowly progressive dementia caused by MAPT R406W mutations: longitudinal report on a new kindred and systematic review. Alzheimer's research & therapy. vol 10. issue 1. 2019-09-16. PMID:29370822. |
the mapt c.1216c > t (p.arg406trp; r406w) mutation is a known cause of frontotemporal dementia with parkinsonism linked to chromosome 17 tau with alzheimer's disease-like clinical features. |
2019-09-16 |
2023-08-13 |
Not clear |
| Lize C Jiskoot, Jessica L Panman, Lieke H Meeter, Elise G P Dopper, Laura Donker Kaat, Sanne Franzen, Emma L van der Ende, Rick van Minkelen, Serge A R B Rombouts, Janne M Papma, John C van Swiete. Longitudinal multimodal MRI as prognostic and diagnostic biomarker in presymptomatic familial frontotemporal dementia. Brain : a journal of neurology. vol 142. issue 1. 2019-08-20. PMID:30508042. |
in the longitudinal frontotemporal dementia risk cohort, presymptomatic mutation carriers and non-carriers from families with familial frontotemporal dementia due to microtubule-associated protein tau (mapt) and progranulin (grn) mutations underwent a clinical assessment and multimodal mri at baseline, 2-, and 4-year follow-up. |
2019-08-20 |
2023-08-13 |
human |
| Chengyu Li, Tetsuya Takahashi, Tejashwi Shrestha, Eiji Kinoshita, Tomoyasu Matsubara, Masayasu Matsumoto, Hirofumi Maruyam. 4',6-Diamidino-2-Phenylindole Distinctly Labels Tau Deposits. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 66. issue 10. 2019-08-16. PMID:30106598. |
dapi was positive in 3r/4r (3-repeat/4-repeat) tau deposits in alzheimer's disease, myotonic dystrophy, and neurodegeneration with brain iron accumulation, and in 4r tau deposits in corticobasal degeneration, but negative in 4r tau deposits in frontotemporal dementia with parkinsonism-17 and progressive supranuclear palsy. |
2019-08-16 |
2023-08-13 |
Not clear |
| Lieke H H Meeter, Everard G Vijverberg, Marta Del Campo, Annemieke J M Rozemuller, Laura Donker Kaat, Frank Jan de Jong, Wiesje M van der Flier, Charlotte E Teunissen, John C van Swieten, Yolande A L Pijnenbur. Clinical value of neurofilament and phospho-tau/tau ratio in the frontotemporal dementia spectrum. Neurology. vol 90. issue 14. 2019-08-08. PMID:29514947. |
to examine the clinical value of neurofilament light chain (nfl) and the phospho-tau/total tau ratio (p/t-tau) across the entire frontotemporal dementia (ftd) spectrum in a large, well-defined cohort. |
2019-08-08 |
2023-08-13 |
Not clear |
| Mei Ji, Xi-Xiu Xie, Dong-Qun Liu, Xiao-Lin Yu, Yue Zhang, Ling-Xiao Zhang, Shao-Wei Wang, Ya-Ru Huang, Rui-Tian Li. Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau.P301S mouse model of Alzheimer's disease and frontotemporal dementia. Alzheimer's research & therapy. vol 10. issue 1. 2019-08-02. PMID:29914543. |
hepatitis b core vlp-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in tau.p301s mouse model of alzheimer's disease and frontotemporal dementia. |
2019-08-02 |
2023-08-13 |
mouse |