| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael J Van Kanegan, Denise E Dunn, Linda S Kaltenbach, Bijal Shah, Dong Ning He, Daniel D McCoy, Peiying Yang, Jiangnan Peng, Li Shen, Lin Du, Robert H Cichewicz, Robert A Newman, Donald C L. Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke. Scientific reports. vol 6. 2018-03-27. PMID:27172999. |
finally, we show that fraction 0-4 provides broad neuroprotection in organotypic brain slice models for neurodegeneration driven by amyloid precursor protein (app) and tau implicated in alzheimer's disease and frontotemporal dementias, respectively, in addition to ischemic injury modeled by ogd. |
2018-03-27 |
2023-08-13 |
Not clear |
| Lone Helboe, Jan Egebjerg, Pernille Barkholt, Christiane Volbrach. Early depletion of CA1 neurons and late neurodegeneration in a mouse tauopathy model. Brain research. vol 1665. 2018-03-22. PMID:28411086. |
alzheimer's disease (ad) and tauopathies, such as frontotemporal dementia (ftd), are characterized by formation of neurofibrillary tangles consisting of hyperphosphorylated tau. |
2018-03-22 |
2023-08-13 |
mouse |
| Noemí Esteras, Jonathan D Rohrer, John Hardy, Selina Wray, Andrey Y Abramo. Mitochondrial hyperpolarization in iPSC-derived neurons from patients of FTDP-17 with 10+16 MAPT mutation leads to oxidative stress and neurodegeneration. Redox biology. vol 12. 2018-03-20. PMID:28319892. |
the 10+16 intronic mutation in mapt gene, encoding tau, causes frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17), by altering the splicing of the gene and inducing an increase in the production of 4r tau isoforms, which are more prone to aggregation. |
2018-03-20 |
2023-08-13 |
Not clear |
| Ian R Macdonald, Selena P Maxwell, George A Reid, Meghan K Cash, Drew R DeBay, Sultan Darves. Quantification of Butyrylcholinesterase Activity as a Sensitive and Specific Biomarker of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 58. issue 2. 2018-03-16. PMID:28453492. |
we present aβ, thioflavin-s, and bche quantification of 26 postmortem brain tissues; ad (n = 8), nwaβ (n = 6), cognitively normal without plaques (n = 8), and other common dementias including corticobasal degeneration, frontotemporal dementia with tau, dementia with lewy bodies, and vascular dementia. |
2018-03-16 |
2023-08-13 |
Not clear |
| Selina Wra. Modeling tau pathology in human stem cell derived neurons. Brain pathology (Zurich, Switzerland). vol 27. issue 4. 2018-03-16. PMID:28585382. |
tau pathology is a defining characteristic of multiple neurodegenerative disorders including alzheimer's disease (ad) and frontotemporal dementia (ftd) with tau pathology. |
2018-03-16 |
2023-08-13 |
human |
| David J Koss, Lianne Robinson, Benjamin D Drever, Kaja Plucińska, Sandra Stoppelkamp, Peter Veselcic, Gernot Riedel, Bettina Plat. Mutant Tau knock-in mice display frontotemporal dementia relevant behaviour and histopathology. Neurobiology of disease. vol 91. 2018-02-20. PMID:26949217. |
mutant tau knock-in mice display frontotemporal dementia relevant behaviour and histopathology. |
2018-02-20 |
2023-08-13 |
mouse |
| David J Koss, Lianne Robinson, Benjamin D Drever, Kaja Plucińska, Sandra Stoppelkamp, Peter Veselcic, Gernot Riedel, Bettina Plat. Mutant Tau knock-in mice display frontotemporal dementia relevant behaviour and histopathology. Neurobiology of disease. vol 91. 2018-02-20. PMID:26949217. |
models of tau pathology related to frontotemporal dementia (ftd) are essential to determine underlying neurodegenerative pathologies and resulting tauopathy relevant behavioural changes. |
2018-02-20 |
2023-08-13 |
mouse |
| David M A Mann, Julie S Snowde. Frontotemporal lobar degeneration: Pathogenesis, pathology and pathways to phenotype. Brain pathology (Zurich, Switzerland). vol 27. issue 6. 2018-01-26. PMID:28100023. |
there are three major associated clinical syndromes, behavioral variant frontotemporal dementia (bvftd), semantic dementia (sd) and progressive non-fluent aphasia (pnfa); three principal histologies, involving tau, tdp-43 and fus proteins; and mutations in three major genes, mapt, grn and c9orf72, along with several other less common gene mutations. |
2018-01-26 |
2023-08-13 |
Not clear |
| Natakarn Nimsanor, Narisorn Kitiyanant, Ulla Poulsen, Mikkel A Rasmussen, Christian Clausen, Ulrike A Mau-Holzmann, Jørgen E Nielsen, Troels T Nielsen, Poul Hyttel, Bjørn Holst, Benjamin Schmi. Generation of an isogenic, gene-corrected iPSC line from a symptomatic 57-year-old female patient with frontotemporal dementia caused by a P301L mutation in the microtubule associated protein tau (MAPT) gene. Stem cell research. vol 17. issue 3. 2018-01-22. PMID:27789409. |
generation of an isogenic, gene-corrected ipsc line from a symptomatic 57-year-old female patient with frontotemporal dementia caused by a p301l mutation in the microtubule associated protein tau (mapt) gene. |
2018-01-22 |
2023-08-13 |
Not clear |
| Natakarn Nimsanor, Ida Jørring, Mikkel A Rasmussen, Christian Clausen, Ulrike A Mau-Holzmann, Narisorn Kitiyanant, Jørgen E Nielsen, Troels T Nielsen, Poul Hyttel, Bjørn Holst, Benjamin Schmi. Induced pluripotent stem cells (iPSCs) derived from a symptomatic carrier of a S305I mutation in the microtubule-associated protein tau (MAPT)-gene causing frontotemporal dementia. Stem cell research. vol 17. issue 3. 2018-01-22. PMID:27789411. |
induced pluripotent stem cells (ipscs) derived from a symptomatic carrier of a s305i mutation in the microtubule-associated protein tau (mapt)-gene causing frontotemporal dementia. |
2018-01-22 |
2023-08-13 |
Not clear |
| Natakarn Nimsanor, Ulla Poulsen, Mikkel A Rasmussen, Christian Clausen, Ulrike A Mau-Holzmann, Jørgen E Nielsen, Troels T Nielsen, Poul Hyttel, Bjørn Holst, Benjamin Schmi. Generation of an isogenic, gene-corrected iPSC line from a symptomatic 59-year-old female patient with frontotemporal dementia caused by an R406W mutation in the microtubule associated protein tau (MAPT) gene. Stem cell research. vol 17. issue 3. 2018-01-22. PMID:27934586. |
generation of an isogenic, gene-corrected ipsc line from a symptomatic 59-year-old female patient with frontotemporal dementia caused by an r406w mutation in the microtubule associated protein tau (mapt) gene. |
2018-01-22 |
2023-08-13 |
Not clear |
| Christian Schön, Jochen Herm. In Vivo Imaging of Tau Aggregates in the Mouse Retina. Methods in molecular biology (Clifton, N.J.). vol 1523. 2018-01-22. PMID:27975264. |
in the following protocol, we describe a method to image fibrillar tau in the retina of a transgenic mouse model of frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17). |
2018-01-22 |
2023-08-13 |
mouse |
| Benjamin Hall, Elijah Mak, Simon Cervenka, Franklin I Aigbirhio, James B Rowe, John T O'Brie. In vivo tau PET imaging in dementia: Pathophysiology, radiotracer quantification, and a systematic review of clinical findings. Ageing research reviews. vol 36. 2018-01-16. PMID:28315409. |
in this article, we provide a comprehensive discussion of tau pathophysiology, its quantification with novel pet radiotracers, as well as a systematic review of tau pet imaging in normal aging and various dementia conditions: mild cognitive impairment, alzheimer's disease, frontotemporal dementia, progressive supranuclear palsy, and lewy body dementia. |
2018-01-16 |
2023-08-13 |
human |
| Rachelle Crescenzi, Catherine DeBrosse, Ravi P R Nanga, Matthew D Byrne, Guruprasad Krishnamoorthy, Kevin D'Aquilla, Hari Nath, Knashawn H Morales, Michiyo Iba, Hari Hariharan, Virginia M Y Lee, John A Detre, Ravinder Redd. Longitudinal imaging reveals subhippocampal dynamics in glutamate levels associated with histopathologic events in a mouse model of tauopathy and healthy mice. Hippocampus. vol 27. issue 3. 2018-01-09. PMID:27997993. |
tauopathies are neurodegenerative disorders characterized by abnormal intracellular aggregates of tau protein, and include alzheimer's disease, corticobasal degeneration, frontotemporal dementia, and traumatic brain injury. |
2018-01-09 |
2023-08-13 |
mouse |
| Gianluigi Forloni, Vladimiro Artuso, Pietro La Vitola, Claudia Balducc. Oligomeropathies and pathogenesis of Alzheimer and Parkinson's diseases. Movement disorders : official journal of the Movement Disorder Society. vol 31. issue 6. 2017-12-27. PMID:27030592. |
detrimental effects have been associated with the oligomeric forms of prion, tau, and huntingtin, the key proteins in prion diseases, frontotemporal dementia, and huntington's disease, respectively. |
2017-12-27 |
2023-08-13 |
mouse |
| Patrícia Silva Guerreiro, Ellen Gerhardt, Tomás Lopes da Fonseca, Mathias Bähr, Tiago Fleming Outeiro, Katrin Eckerman. LRRK2 Promotes Tau Accumulation, Aggregation and Release. Molecular neurobiology. vol 53. issue 5. 2017-12-25. PMID:26014385. |
hyperphosphorylated tau protein accumulates in neurofibrillary tangles, a typical pathological hallmark in alzheimer's disease and frontotemporal dementia. |
2017-12-25 |
2023-08-13 |
Not clear |
| David C Perry, Jesse A Brown, Katherine L Possin, Samir Datta, Andrew Trujillo, Anneliese Radke, Anna Karydas, John Kornak, Ana C Sias, Gil D Rabinovici, Maria Luisa Gorno-Tempini, Adam L Boxer, Mary De May, Katherine P Rankin, Virginia E Sturm, Suzee E Lee, Brandy R Matthews, Aimee W Kao, Keith A Vossel, Maria Carmela Tartaglia, Zachary A Miller, Sang Won Seo, Manu Sidhu, Stephanie E Gaus, Alissa L Nana, Jose Norberto S Vargas, Ji-Hye L Hwang, Rik Ossenkoppele, Alainna B Brown, Eric J Huang, Giovanni Coppola, Howard J Rosen, Daniel Geschwind, John Q Trojanowski, Lea T Grinberg, Joel H Kramer, Bruce L Miller, William W Seele. Clinicopathological correlations in behavioural variant frontotemporal dementia. Brain : a journal of neurology. vol 140. issue 12. 2017-12-13. PMID:29053860. |
patients with ftld were distributed between ftld-tau (34 patients: 10 corticobasal degeneration, nine progressive supranuclear palsy, eight pick's disease, three frontotemporal dementia with parkinsonism associated with chromosome 17, three unclassifiable tauopathy, and one argyrophilic grain disease); ftld-tdp (55 patients: nine type a including one with motor neuron disease, 27 type b including 21 with motor neuron disease, eight type c with right temporal lobe presentations, and 11 unclassifiable including eight with motor neuron disease), ftld-fus (eight patients), and one patient with ftld-ubiquitin proteasome system positive inclusions (ftld-ups) that stained negatively for tau, tdp-43, and fus. |
2017-12-13 |
2023-08-13 |
Not clear |
| Ghulam Jeelani Pir, Bikash Choudhary, Eckhard Mandelko. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 31. issue 12. 2017-12-11. PMID:29191965. |
one of the hallmarks of the tauopathies, which include the neurodegenerative disorders, such as alzheimer disease (ad), corticobasal degeneration, frontotemporal dementia, and progressive supranuclear palsy (psp), is the abnormal accumulation of post-translationally modified, insoluble tau. |
2017-12-11 |
2023-08-13 |
Not clear |
| M Catarina Silva, Chialin Cheng, Waltraud Mair, Sandra Almeida, Helen Fong, M Helal U Biswas, Zhijun Zhang, Yadong Huang, Sally Temple, Giovanni Coppola, Daniel H Geschwind, Anna Karydas, Bruce L Miller, Kenneth S Kosik, Fen-Biao Gao, Judith A Steen, Stephen J Haggart. Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability. Stem cell reports. vol 7. issue 3. 2017-11-21. PMID:27594585. |
frontotemporal dementia (ftd) and other tauopathies characterized by focal brain neurodegeneration and pathological accumulation of proteins are commonly associated with tau mutations. |
2017-11-21 |
2023-08-13 |
human |
| Md Helal U Biswas, Sandra Almeida, Rodrigo Lopez-Gonzalez, Wenjie Mao, Zhijun Zhang, Anna Karydas, Michael D Geschwind, Jacek Biernat, Eva-Maria Mandelkow, Kensuke Futai, Bruce L Miller, Fen-Biao Ga. MMP-9 and MMP-2 Contribute to Neuronal Cell Death in iPSC Models of Frontotemporal Dementia with MAPT Mutations. Stem cell reports. vol 7. issue 3. 2017-11-21. PMID:27594586. |
how mutations in the microtubule-associated protein tau (mapt) gene cause frontotemporal dementia (ftd) remains poorly understood. |
2017-11-21 |
2023-08-13 |
human |