| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Silvana Konermann, Peter Lotfy, Nicholas J Brideau, Jennifer Oki, Maxim N Shokhirev, Patrick D Hs. Transcriptome Engineering with RNA-Targeting Type VI-D CRISPR Effectors. Cell. vol 173. issue 3. 2019-02-11. PMID:29551272. |
we target virally encoded, catalytically inactive casrx to cis elements of pre-mrna to manipulate alternative splicing, alleviating dysregulated tau isoform ratios in a neuronal model of frontotemporal dementia. |
2019-02-11 |
2023-08-13 |
human |
| Heike J Wobst, Franziska Denk, Peter L Oliver, Achilleas Livieratos, Tonya N Taylor, Maria H Knudsen, Nora Bengoa-Vergniory, David Bannerman, Richard Wade-Martin. Increased 4R tau expression and behavioural changes in a novel MAPT-N296H genomic mouse model of tauopathy. Scientific reports. vol 7. 2018-11-05. PMID:28233851. |
mutations in the tau gene mapt cause frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17). |
2018-11-05 |
2023-08-13 |
mouse |
| Anna-Lena Hallmann, Marcos J Araúzo-Bravo, Lampros Mavrommatis, Marc Ehrlich, Albrecht Röpke, Johannes Brockhaus, Markus Missler, Jared Sterneckert, Hans R Schöler, Tanja Kuhlmann, Holm Zaehres, Gunnar Hargu. Astrocyte pathology in a human neural stem cell model of frontotemporal dementia caused by mutant TAU protein. Scientific reports. vol 7. 2018-10-29. PMID:28256506. |
astrocyte pathology in a human neural stem cell model of frontotemporal dementia caused by mutant tau protein. |
2018-10-29 |
2023-08-13 |
human |
| Anna-Lena Hallmann, Marcos J Araúzo-Bravo, Lampros Mavrommatis, Marc Ehrlich, Albrecht Röpke, Johannes Brockhaus, Markus Missler, Jared Sterneckert, Hans R Schöler, Tanja Kuhlmann, Holm Zaehres, Gunnar Hargu. Astrocyte pathology in a human neural stem cell model of frontotemporal dementia caused by mutant TAU protein. Scientific reports. vol 7. 2018-10-29. PMID:28256506. |
astroglial pathology is seen in various neurodegenerative diseases including frontotemporal dementia (ftd), which can be caused by mutations in the gene encoding the microtubule-associated protein tau (mapt). |
2018-10-29 |
2023-08-13 |
human |
| Mara Bourbouli, Michael Rentzos, Anastasia Bougea, Vasiliki Zouvelou, Vasilios C Constantinides, Ioannis Zaganas, Ioannis Evdokimidis, Elisabeth Kapaki, George P Paraskeva. Cerebrospinal Fluid TAR DNA-Binding Protein 43 Combined with Tau Proteins as a Candidate Biomarker for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Spectrum Disorders. Dementia and geriatric cognitive disorders. vol 44. issue 3-4. 2018-10-09. PMID:28848086. |
cerebrospinal fluid tar dna-binding protein 43 combined with tau proteins as a candidate biomarker for amyotrophic lateral sclerosis and frontotemporal dementia spectrum disorders. |
2018-10-09 |
2023-08-13 |
Not clear |
| Hanna Cho, Sang Won Seo, Jae Yong Choi, Hye Sun Lee, Young Hoon Ryu, Myung Sik Lee, Duk L Na, Hee Jin Kim, Chul Hyoung Lyo. Predominant subcortical accumulation of Neurobiology of aging. vol 66. 2018-10-05. PMID:29554554. |
predominant subcortical accumulation of behavioral variant frontotemporal dementia (bvftd) is the most common form of frontotemporal dementia, and tau pathology can be found in 40%-50% of bvftd patients. |
2018-10-05 |
2023-08-13 |
Not clear |
| Alban Chauderlier, Melissa Gilles, Andrea Spolcova, Raphaelle Caillierez, Maggy Chwastyniak, Michel Kress, Herve Drobecq, Eliette Bonnefoy, Florence Pinet, Dominique Weil, Luc Buée, Marie-Christine Galas, Bruno Lefebvr. Tau/DDX6 interaction increases microRNA activity. Biochimica et biophysica acta. Gene regulatory mechanisms. vol 1861. issue 8. 2018-10-04. PMID:29966762. |
importantly, tau mutations (p301s, p301l) found in the inherited tauopathies, frontotemporal dementia and parkinsonism linked to chromosome 17, disrupt tau/ddx6 interaction and impair gene silencing by let-7a. |
2018-10-04 |
2023-08-13 |
Not clear |
| Denisa Floriana Vasilica Pîrşcoveanu, Ionica Pirici, Valerica Tudorică, Tudor Adrian Bălşeanu, Valeria Carmen Albu, Simona Bondari, Ana Maria Bumbea, Mircea Pîrşcovean. Tau protein in neurodegenerative diseases - a review. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 58. issue 4. 2018-09-05. PMID:29556602. |
almost 80 diseases caused by missense mutations and intronic mutations in the tau gene have been found in familial cases of frontotemporal dementia (ftd). |
2018-09-05 |
2023-08-13 |
human |
| Pawel Tacik, Michael A DeTure, Yari Carlomagno, Wen-Lang Lin, Melissa E Murray, Matthew C Baker, Keith A Josephs, Bradley F Boeve, Zbigniew K Wszolek, Neill R Graff-Radford, Joseph E Parisi, Leonard Petrucelli, Rosa Rademakers, Richard S Isaacson, Kenneth M Heilman, Ronald C Petersen, Dennis W Dickson, Naomi Kour. FTDP-17 with Pick body-like inclusions associated with a novel tau mutation, p.E372G. Brain pathology (Zurich, Switzerland). vol 27. issue 5. 2018-08-20. PMID:27529406. |
mutations in microtubule-associated protein tau gene (mapt) cause frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17). |
2018-08-20 |
2023-08-13 |
Not clear |
| Mikaeel Valli, Antonio P Strafell. New advances in tau imaging in parkinsonism. International review of psychiatry (Abingdon, England). vol 29. issue 6. 2018-07-25. PMID:29206491. |
neurodegenerative conditions, including progressive supranuclear palsy (psp), corticobasal degeneration (cbd), and frontotemporal dementia (ftd), are primarily characterized by accumulation of tau protein in the brain. |
2018-07-25 |
2023-08-13 |
Not clear |
| E G B Vijverberg, A C M Pijnenburg, P Scheltens, Y A L Pijnenbur. [Chronic traumatic encephalopathy: an old acquaintance in athletes]. Nederlands tijdschrift voor geneeskunde. vol 161. 2018-06-18. PMID:28181891. |
- chronic traumatic encephalopathy (cte) is a neurodegenerative disease caused by repetitive head injuries like those seen in sports such as boxing, american football and soccer.- the clinical features of cte are a range of cognitive, psychiatric and motor symptoms, and histopathology involves deposits of hyperphosphorylated tau protein and the presence of tar dna-binding protein (tdp-43) with relatively little beta-amyloid.- cte is difficult to differentiate clinically from alzheimer's disease, frontotemporal dementia and psychiatric disorders because of the major symptom overlap between these conditions.- the most important risk factors for developing cte are the cumulative effect of repetitive head injuries, with or without clinical symptoms, and the duration of exposure to the repetitive injuries (the sporting career).- there is no treatment for cte at present and the strategy must be primarily geared to prevention.- in view of the large number of people, including those in the netherlands, who take part in sports in which head injuries may occur, research into cte is of major societal importance. |
2018-06-18 |
2023-08-13 |
Not clear |
| Taeko Kimura, Tomohisa Hosokawa, Masato Taoka, Koji Tsutsumi, Kanae Ando, Koichi Ishiguro, Masato Hosokawa, Masato Hasegawa, Shin-Ichi Hisanag. Quantitative and combinatory determination of in situ phosphorylation of tau and its FTDP-17 mutants. Scientific reports. vol 6. 2018-06-04. PMID:27641626. |
tau is hyperphosphorylated in the brains of patients with tauopathies, such as alzheimer's disease and frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17). |
2018-06-04 |
2023-08-13 |
mouse |
| Sangyun Jeon. Molecular and Cellular Basis of Neurodegeneration in Alzheimer's Disease. Molecules and cells. vol 40. issue 9. 2018-05-30. PMID:28927263. |
interestingly, tau-mediated formation of nfts in ad brains shows better correlation with cognitive impairment than aβ plaque accumulation; pathological tau alone is sufficient to elicit frontotemporal dementia, but it does not cause ad. |
2018-05-30 |
2023-08-13 |
Not clear |
| Jitendra Subhash Rane, Prasenjit Bhaumik, Dulal Pand. Curcumin Inhibits Tau Aggregation and Disintegrates Preformed Tau Filaments in vitro. Journal of Alzheimer's disease : JAD. vol 60. issue 3. 2018-05-30. PMID:28984591. |
the pathological aggregation of tau is a common feature of most of the neuronal disorders including frontotemporal dementia, parkinson's disease, and alzheimer's disease. |
2018-05-30 |
2023-08-13 |
Not clear |
| Xiang-Qian Che, Qian-Hua Zhao, Yue Huang, Xia Li, Ru-Jing Ren, Sheng-Di Chen, Gang Wang, Qi-Hao Gu. Genetic Features of MAPT, GRN, C9orf72 and CHCHD10 Gene Mutations in Chinese Patients with Frontotemporal Dementia. Current Alzheimer research. vol 14. issue 10. 2018-05-29. PMID:28462717. |
mutations in microtubule associated protein tau (mapt), progranulin (grn), chromosome 9 open-reading frame 72 (c9orf72) and chchd10 genes have been reported causing frontotemporal dementia (ftd) in different populations. |
2018-05-29 |
2023-08-13 |
Not clear |
| Di Xia, Julia M Gutmann, Jürgen Göt. Mobility and subcellular localization of endogenous, gene-edited Tau differs from that of over-expressed human wild-type and P301L mutant Tau. Scientific reports. vol 6. 2018-05-25. PMID:27378256. |
alzheimer's disease (ad) and a subset of frontotemporal dementia termed ftld-tau are characterized by a massive, yet incompletely characterized and understood redistribution of tau. |
2018-05-25 |
2023-08-13 |
mouse |
| Patrick Reilly, Charisse N Winston, Kelsey R Baron, Margarita Trejo, Edward M Rockenstein, Johnny C Akers, Najla Kfoury, Marc Diamond, Eliezer Masliah, Robert A Rissman, Shauna H Yua. Novel human neuronal tau model exhibiting neurofibrillary tangles and transcellular propagation. Neurobiology of disease. vol 106. 2018-05-15. PMID:28610892. |
tauopathies are a class of neurodegenerative diseases, including alzheimer's disease, frontotemporal dementia and progressive supranuclear palsy, which are associated with the pathological aggregation of tau protein into neurofibrillary tangles (nft). |
2018-05-15 |
2023-08-13 |
mouse |
| P Tacik, M Sanchez-Contreras, M DeTure, M E Murray, R Rademakers, O A Ross, Z K Wszolek, J E Parisi, D S Knopman, R C Petersen, D W Dickso. Clinicopathologic heterogeneity in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) due to microtubule-associated protein tau (MAPT) p.P301L mutation, including a patient with globular glial tauopathy. Neuropathology and applied neurobiology. vol 43. issue 3. 2018-04-11. PMID:27859539. |
clinicopathologic heterogeneity in frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17) due to microtubule-associated protein tau (mapt) p.p301l mutation, including a patient with globular glial tauopathy. |
2018-04-11 |
2023-08-13 |
Not clear |
| P Tacik, M Sanchez-Contreras, M DeTure, M E Murray, R Rademakers, O A Ross, Z K Wszolek, J E Parisi, D S Knopman, R C Petersen, D W Dickso. Clinicopathologic heterogeneity in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) due to microtubule-associated protein tau (MAPT) p.P301L mutation, including a patient with globular glial tauopathy. Neuropathology and applied neurobiology. vol 43. issue 3. 2018-04-11. PMID:27859539. |
the p.p301l mutation in microtubule-associated protein tau (mapt) is a common cause of frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17). |
2018-04-11 |
2023-08-13 |
Not clear |
| Cheng-Cheng Zhang, Jun-Xia Zhu, Yu Wan, Lin Tan, Hui-Fu Wang, Jin-Tai Yu, Lan Ta. Meta-analysis of the association between variants in MAPT and neurodegenerative diseases. Oncotarget. vol 8. issue 27. 2018-03-29. PMID:28402959. |
microtubule-associated protein tau (mapt) gene is compelling among the susceptibility genes of neurodegenerative diseases which include alzheimer's disease (ad), parkinson's disease (pd), progressive supranuclear palsy (psp), corticobasal degeneration (cbd), frontotemporal dementia (ftd) and amyotrophic lateral sclerosis (als). |
2018-03-29 |
2023-08-13 |
Not clear |