| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yazi D Ke, Gabriella Chan, Kristie Stefanoska, Carol Au, Mian Bi, Julius Müller, Magdalena Przybyla, Astrid Feiten, Emmanuel Prikas, Glenda M Halliday, Olivier Piguet, Matthew C Kiernan, Michael Kassiou, John R Hodges, Clement T Loy, John S Mattick, Arne Ittner, Jillian J Kril, Greg T Sutherland, Lars M Ittne. CNS cell type-specific gene profiling of P301S tau transgenic mice identifies genes dysregulated by progressive tau accumulation. The Journal of biological chemistry. vol 294. issue 38. 2020-05-12. PMID:31366728. |
the microtubule-associated protein tau undergoes aberrant modification resulting in insoluble brain deposits in various neurodegenerative diseases, including frontotemporal dementia (ftd), progressive supranuclear palsy, and corticobasal degeneration. |
2020-05-12 |
2023-08-13 |
mouse |
| Yin Xu, Sheng Zhang, Hui Zhen. The cargo receptor SQSTM1 ameliorates neurofibrillary tangle pathology and spreading through selective targeting of pathological MAPT (microtubule associated protein tau). Autophagy. vol 15. issue 4. 2020-05-11. PMID:30290707. |
abbreviations: aav: adeno-associated virus; ad: alzheimer disease; alp: autophagy-lysosomal pathway; als: amyotrophic lateral sclerosis; calcoco2/ndp52: calcium binding and coiled-coil domain 2; ftd: frontotemporal dementias; hd: huntington disease; htt: huntingtin; lir: lc3-interacting region; nbr1: autophagy cargo receptor; nfe2l2/nrf2: nuclear factor, erythroid derived 2, like 2; nfts: neurofibrillary tangles; mapt: microtubule associated protein tau; optn: optineurin; p-mapt: hyperphosphorylated mapt; pfa: paraformaldehyde; tardbp/tdp-43: tar dna binding protein; tax1bp1 tax1: binding protein 1; thios: thioflavin-s; uba: ubiquitin-associated. |
2020-05-11 |
2023-08-13 |
mouse |
| Emily J Koller, Elsa Gonzalez De La Cruz, Timothy Machula, Kristen R Ibanez, Wen-Lang Lin, Tosha Williams, Cara J Riffe, Daniel Ryu, Kevin H Strang, Xuefei Liu, Christopher Janus, Todd E Golde, Dennis Dickson, Benoit I Giasson, Paramita Chakrabart. Combining P301L and S320F tau variants produces a novel accelerated model of tauopathy. Human molecular genetics. vol 28. issue 19. 2020-05-11. PMID:31261380. |
we selected four different tau variants-wt tau associated with ad, p301l mutant tau associated with frontotemporal dementia (ftd), s320f mutant tau associated with pick's disease and a combinatorial approach using p301l/s320f mutant tau. |
2020-05-11 |
2023-08-13 |
mouse |
| Jennifer N Rauch, Gabriel Luna, Elmer Guzman, Morgane Audouard, Collin Challis, Youssef E Sibih, Carolina Leshuk, Israel Hernandez, Susanne Wegmann, Bradley T Hyman, Viviana Gradinaru, Martin Kampmann, Kenneth S Kosi. LRP1 is a master regulator of tau uptake and spread. Nature. vol 580. issue 7803. 2020-05-08. PMID:32296178. |
the microtubule-associated protein tau has a central role in the pathogenesis of several forms of dementia known as tauopathies-including alzheimer's disease, frontotemporal dementia and chronic traumatic encephalopathy |
2020-05-08 |
2023-08-13 |
Not clear |
| Israel Hernandez, Gabriel Luna, Jennifer N Rauch, Surya A Reis, Michel Giroux, Celeste M Karch, Daniel Boctor, Youssef E Sibih, Nadia J Storm, Antonio Diaz, Susmita Kaushik, Cezary Zekanowski, Alexander A Kang, Cassidy R Hinman, Vesna Cerovac, Elmer Guzman, Honjun Zhou, Stephen J Haggarty, Alison M Goate, Steven K Fisher, Ana M Cuervo, Kenneth S Kosi. A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy. Science translational medicine. vol 11. issue 485. 2020-04-27. PMID:30918111. |
tau inclusions are a shared feature of many neurodegenerative diseases, among them frontotemporal dementia caused by tau mutations. |
2020-04-27 |
2023-08-13 |
mouse |
| Jeffrey W Hofmann, William W Seeley, Eric J Huan. RNA Binding Proteins and the Pathogenesis of Frontotemporal Lobar Degeneration. Annual review of pathology. vol 14. 2020-04-20. PMID:30355151. |
frontotemporal dementia is a group of early onset dementia syndromes linked to underlying frontotemporal lobar degeneration (ftld) pathology that can be classified based on the formation of abnormal protein aggregates involving tau and two rna binding proteins, tdp-43 and fus. |
2020-04-20 |
2023-08-13 |
Not clear |
| Cristina Vergara, Sarah Houben, Valérie Suain, Zehra Yilmaz, Robert De Decker, Virginie Vanden Dries, Alain Boom, Salwa Mansour, Karelle Leroy, Kunie Ando, Jean-Pierre Brio. Amyloid-β pathology enhances pathological fibrillary tau seeding induced by Alzheimer PHF in vivo. Acta neuropathologica. vol 137. issue 3. 2020-04-20. PMID:30599077. |
neuropathological analysis in alzheimer's disease (ad) and experimental evidence in transgenic models overexpressing frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17) mutant tau suggest that amyloid-β pathology enhances the development of tau pathology. |
2020-04-20 |
2023-08-13 |
Not clear |
| Julien Lagarde, Pauline Olivieri, Fabien Caillé, Philippe Gervais, Jean-Claude Baron, Michel Bottlaender, Marie Sarazi. [ Journal of neurology. vol 266. issue 12. 2020-04-14. PMID:31535269. |
[ the utility of tau pet imaging in non-alzheimer's disease (ad) tauopathies like behavioural frontotemporal dementia (bvftd), which is mainly underlain by tdp-43 or tau pathology, remains debated. |
2020-04-14 |
2023-08-13 |
Not clear |
| Michel Goedert, Maria Grazia Spillantin. Ordered Assembly of Tau Protein and Neurodegeneration. Advances in experimental medicine and biology. vol 1184. 2020-04-08. PMID:32096024. |
their formation is important, because dominantly inherited mutations in mapt, the tau gene, cause frontotemporal dementia with abundant filamentous tau inclusions. |
2020-04-08 |
2023-08-13 |
mouse |
| Tara Tracy, Kathryn C Claiborn, Li Ga. Regulation of Tau Homeostasis and Toxicity by Acetylation. Advances in experimental medicine and biology. vol 1184. 2020-04-08. PMID:32096027. |
multiple neurodegenerative conditions including alzheimer's disease and frontotemporal dementia are characterized by the accumulation of tau in the brain, associated with synapse loss and cognitive decline. |
2020-04-08 |
2023-08-13 |
Not clear |
| Diane P Hanger, Despoina Goniotaki, Wendy Nobl. Synaptic Localisation of Tau. Advances in experimental medicine and biology. vol 1184. 2020-04-08. PMID:32096032. |
in alzheimer's disease, frontotemporal dementia and related tauopathies, highly phosphorylated tau accumulates as intraneuronal protein aggregates that are likely responsible for the demise of neurons and the subsequent progressive cognitive decline. |
2020-04-08 |
2023-08-13 |
Not clear |
| Zhi Ruan, Tsuneya Ikez. Tau Secretion. Advances in experimental medicine and biology. vol 1184. 2020-04-08. PMID:32096034. |
the pathological propagation of tau protein is a hallmark of multiple neurodegenerative disorders, collectively referred to tauopathies with alzheimer's disease (ad) being most prevalent, but including a range of frontotemporal dementias (ftds). |
2020-04-08 |
2023-08-13 |
Not clear |
| Julika J Götz, Jürgen Göt. Experimental Models of Tauopathy - From Mechanisms to Therapies. Advances in experimental medicine and biology. vol 1184. 2020-04-08. PMID:32096051. |
in this chapter, we focus on models that overexpress wild-type or mutant forms of tau, the latter being based on mutations found in familial cases of frontotemporal dementia. |
2020-04-08 |
2023-08-13 |
mouse |
| Peter Dongmin Sohn, Cindy Tzu-Ling Huang, Rui Yan, Li Fan, Tara E Tracy, Carolina M Camargo, Kelly M Montgomery, Taylor Arhar, Sue-Ann Mok, Rebecca Freilich, Justin Baik, Manni He, Shiaoching Gong, Erik D Roberson, Celeste M Karch, Jason E Gestwicki, Ke Xu, Kenneth S Kosik, Li Ga. Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis. Neuron. vol 104. issue 3. 2020-03-30. PMID:31542321. |
dysregulation of neuronal excitability underlies the pathogenesis of tauopathies, including frontotemporal dementia (ftd) with tau inclusions. |
2020-03-30 |
2023-08-13 |
human |
| M Catarina Silva, Fleur M Ferguson, Quan Cai, Katherine A Donovan, Ghata Nandi, Debasis Patnaik, Tinghu Zhang, Hai-Tsang Huang, Diane E Lucente, Bradford C Dickerson, Timothy J Mitchison, Eric S Fischer, Nathanael S Gray, Stephen J Haggart. Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models. eLife. vol 8. 2020-03-20. PMID:30907729. |
targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models. |
2020-03-20 |
2023-08-13 |
Not clear |
| Martha S Foiani, Claudia Cicognola, Natalia Ermann, Ione O C Woollacott, Carolin Heller, Amanda J Heslegrave, Ashvini Keshavan, Ross W Paterson, Keqiang Ye, Johannes Kornhuber, Nick C Fox, Jonathan M Schott, Jason D Warren, Piotr Lewczuk, Henrik Zetterberg, Kaj Blennow, Kina Höglund, Jonathan D Rohre. Searching for novel cerebrospinal fluid biomarkers of tau pathology in frontotemporal dementia: an elusive quest. Journal of neurology, neurosurgery, and psychiatry. vol 90. issue 7. 2020-03-17. PMID:30981993. |
searching for novel cerebrospinal fluid biomarkers of tau pathology in frontotemporal dementia: an elusive quest. |
2020-03-17 |
2023-08-13 |
Not clear |
| Martha S Foiani, Claudia Cicognola, Natalia Ermann, Ione O C Woollacott, Carolin Heller, Amanda J Heslegrave, Ashvini Keshavan, Ross W Paterson, Keqiang Ye, Johannes Kornhuber, Nick C Fox, Jonathan M Schott, Jason D Warren, Piotr Lewczuk, Henrik Zetterberg, Kaj Blennow, Kina Höglund, Jonathan D Rohre. Searching for novel cerebrospinal fluid biomarkers of tau pathology in frontotemporal dementia: an elusive quest. Journal of neurology, neurosurgery, and psychiatry. vol 90. issue 7. 2020-03-17. PMID:30981993. |
frontotemporal dementia (ftd) is a pathologically heterogeneous neurodegenerative disorder associated usually with tau or tdp-43 pathology, although some phenotypes such as logopenic variant primary progressive aphasia are more commonly associated with alzheimer's disease pathology. |
2020-03-17 |
2023-08-13 |
Not clear |
| Timir Tripathi, Jupitara Kalit. Abnormal Microtubule Dynamics Impair the Nuclear-Cytoplasmic Transport in Dementia. ACS chemical neuroscience. vol 10. issue 3. 2020-03-05. PMID:30785261. |
a recent study revealed that tau is mislocalized to the neuronal cell body and, thus, deforms the nuclear membrane in the frontotemporal dementia (ftd). |
2020-03-05 |
2023-08-13 |
Not clear |
| Pranesh Padmanabhan, Ramón Martínez-Mármol, Di Xia, Jürgen Götz, Frédéric A Meunie. Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines. eLife. vol 8. 2020-02-24. PMID:31237563. |
frontotemporal dementia mutant tau promotes aberrant fyn nanoclustering in hippocampal dendritic spines. |
2020-02-24 |
2023-08-13 |
mouse |
| Pranesh Padmanabhan, Ramón Martínez-Mármol, Di Xia, Jürgen Götz, Frédéric A Meunie. Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines. eLife. vol 8. 2020-02-24. PMID:31237563. |
by contrast, expression of frontotemporal dementia p301l mutant tau immobilizes fyn in dendritic spines, affecting its motion state distribution and nanoclustering. |
2020-02-24 |
2023-08-13 |
mouse |