| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yoori Choi, Seunggyun Ha, Yun-Sang Lee, Yun Kyung Kim, Dong Soo Lee, Dong Jin Ki. Development of tau PET Imaging Ligands and their Utility in Preclinical and Clinical Studies. Nuclear medicine and molecular imaging. vol 52. issue 1. 2020-09-29. PMID:29391909. |
neurofibrillary tangles are aggregates of hyperphosphorylated tau proteins, and these induce various other neurodegenerative diseases, such as progressive supranuclear palsy, corticobasal degeneration, frontotemporal lobar degeneration, frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17), and chronic traumatic encephalopathy. |
2020-09-29 |
2023-08-13 |
Not clear |
| Yong-Lei Gao, Nan Wang, Fu-Rong Sun, Xi-Peng Cao, Wei Zhang, Jin-Tai Y. Tau in neurodegenerative disease. Annals of translational medicine. vol 6. issue 10. 2020-09-29. PMID:29951497. |
tau, a microtubule-associated protein, is the main component of the intracellular filamentous inclusions that are involved in neurodegenerative diseases known as tauopathies, including alzheimer disease (ad), frontotemporal dementia with parkinsonism-17 (ftdp-17), pick disease (pid), progressive supranuclear palsy (psp) and corticobasal degeneration (cbd). |
2020-09-29 |
2023-08-13 |
Not clear |
| Daniela Vieira, João Durães, Inês Baldeiras, Beatriz Santiago, Diana Duro, Marisa Lima, Maria João Leitão, Miguel Tábuas-Pereira, Isabel Santan. Lower CSF Amyloid-Beta Diagnostics (Basel, Switzerland). vol 9. issue 4. 2020-09-28. PMID:31731494. |
lower csf amyloid-beta frontotemporal lobar degeneration, the neuropathological substrate of frontotemporal dementia (ftd), is characterized by the deposition of protein aggregates, including tau. |
2020-09-28 |
2023-08-13 |
Not clear |
| Marlène Cassar, Alexander D Law, Eileen S Chow, Jadwiga M Giebultowicz, Doris Kretzschma. Disease-Associated Mutant Tau Prevents Circadian Changes in the Cytoskeleton of Central Pacemaker Neurons. Frontiers in neuroscience. vol 14. 2020-09-28. PMID:32292325. |
a hallmark feature of alzheimer's disease (ad) and other tauopathies, like frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17), is the accumulation of neurofibrillary tangles composed of the microtubule-associated protein tau. |
2020-09-28 |
2023-08-13 |
Not clear |
| Lynn van Olst, Daan Verhaege, Marc Franssen, Alwin Kamermans, Bart Roucourt, Sofie Carmans, Ellen Ytebrouck, Susanne M A van der Pol, Dennis Wever, Marko Popovic, Roosmarijn E Vandenbroucke, Tomás Sobrino, Marijn Schouten, Helga E de Vrie. Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model. Neurobiology of aging. vol 89. 2020-09-23. PMID:32008854. |
alzheimer's disease, progressive supranuclear palsy and frontotemporal dementia are characterized by neuronal expression of aberrant tau protein, tau hyperphosphorylation (ptau), tau aggregation and neurofibrillary tangle formation sequentially culminating into neuronal cell death, a process termed tauopathy. |
2020-09-23 |
2023-08-13 |
mouse |
| Mauro Montalbano, Salome McAllen, Nicha Puangmalai, Urmi Sengupta, Nemil Bhatt, Omar D Johnson, Michael G Kharas, Rakez Kaye. RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction. Nature communications. vol 11. issue 1. 2020-09-21. PMID:32855391. |
here, we investigated the expression and cellular localization of msi1 and msi2 in the brains tissues of alzheimer's disease (ad), amyotrophic lateral sclerosis (als) and frontotemporal dementia (ftd) as well as in the wild-type mice and tau knock-out and p301l tau mouse models. |
2020-09-21 |
2023-08-13 |
mouse |
| Grace I Hallinan, Aleksandra P Pitera, Prutha Patel, Jonathan West, Katrin Deinhard. Minimalistic in vitro systems for investigating tau pathology. Journal of neuroscience methods. vol 319. 2020-08-19. PMID:30278185. |
neurofibrillary tangles, formed of hyperphosphorylated, misfolded tau accumulations, are a pathological hallmark of neurodegenerative diseases such as alzheimer's disease (ad) and frontotemporal dementia. |
2020-08-19 |
2023-08-13 |
Not clear |
| Sachiko Nakayama, Shotaro Shimonaka, Montasir Elahi, Kenya Nishioka, Yutaka Oji, Shin-Ei Matsumoto, Yuanzhe Li, Hiroyo Yoshino, Kaoru Mogushi, Taku Hatano, Takeshi Sato, Teikichi Ikura, Nobutoshi Ito, Yumiko Motoi, Nobutaka Hattor. Tau aggregation and seeding analyses of two novel MAPT variants found in patients with motor neuron disease and progressive parkinsonism. Neurobiology of aging. vol 84. 2020-08-04. PMID:31027853. |
variants in the microtubule-associated protein tau (mapt) gene cause the genetic tauopathies, a subgroup of frontotemporal dementia (ftd) disorders. |
2020-08-04 |
2023-08-13 |
Not clear |
| Fred Yeboah, Tae-Eun Kim, Anke Bill, Ulf Dettme. Dynamic behaviors of α-synuclein and tau in the cellular context: New mechanistic insights and therapeutic opportunities in neurodegeneration. Neurobiology of disease. vol 132. 2020-07-27. PMID:31351173. |
dyshomeostasis and aggregation of both proteins are central in the pathogenesis of neurodegenerative diseases: parkinson's disease, dementia with lewy bodies, multi-system atrophy and other 'synucleinopathies' in the case of αs; alzheimer's disease, frontotemporal dementia, progressive supranuclear palsy and other 'tauopathies' in the case of tau. |
2020-07-27 |
2023-08-13 |
Not clear |
| Emily A Ferenczi, Michael G Erkkinen, Mel B Feany, Barry S Fogel, Kirk R Daffne. New-Onset Delusions Heralding an Underlying Neurodegenerative Condition: A Case Report and Review of the Literature. The Journal of clinical psychiatry. vol 81. issue 2. 2020-07-21. PMID:32237299. |
to examine the role of genetics, especially mutations of the microtubule-associated protein tau (mapt) gene, in familial cases of frontotemporal dementia (ftd). |
2020-07-21 |
2023-08-13 |
Not clear |
| Li-Chun Lin, Alissa L Nana, Mackenzie Hepker, Ji-Hye Lee Hwang, Stephanie E Gaus, Salvatore Spina, Celica G Cosme, Li Gan, Lea T Grinberg, Daniel H Geschwind, Giovanni Coppola, Howard J Rosen, Bruce L Miller, William W Seele. Preferential tau aggregation in von Economo neurons and fork cells in frontotemporal lobar degeneration with specific MAPT variants. Acta neuropathologica communications. vol 7. issue 1. 2020-07-13. PMID:31640778. |
tau aggregation is a hallmark feature in a subset of patients with frontotemporal dementia (ftd). |
2020-07-13 |
2023-08-13 |
Not clear |
| Kevin H Strang, Todd E Golde, Benoit I Giasso. MAPT mutations, tauopathy, and mechanisms of neurodegeneration. Laboratory investigation; a journal of technical methods and pathology. vol 99. issue 7. 2020-06-25. PMID:30742061. |
mutations in the mapt gene that encodes tau can cause frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17), providing the clearest evidence that tauopathy plays a causal role in neurodegeneration. |
2020-06-25 |
2023-08-13 |
Not clear |
| Peng Liu, Benjamin R Smith, Eric S Huang, Abhishek Mahesh, Jean Paul G Vonsattel, Ashley J Petersen, Rocio Gomez-Pastor, Karen H Ash. A soluble truncated tau species related to cognitive dysfunction and caspase-2 is elevated in the brain of Huntington's disease patients. Acta neuropathologica communications. vol 7. issue 1. 2020-06-23. PMID:31358058. |
our recent study indicates that casp2-catalyzed tau cleavage at aspartate 314 (tau 2n4r isoform numbering system) mediates synaptotoxicity, cognitive deficits and neurodegeneration in cellular and mouse models of frontotemporal dementia; further, levels of Δtau314, the soluble, n-terminal cleavage product, are elevated in individuals with mild cognitive impairment and alzheimer's disease, compared with cognitively normal individuals. |
2020-06-23 |
2023-08-13 |
mouse |
| Benjamin R Smith, Kathryn M Nelson, Lisa J Kemper, Kailee Leinonen-Wright, Ashley Petersen, C Dirk Keene, Karen H Ash. A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease. Acta neuropathologica communications. vol 7. issue 1. 2020-06-23. PMID:31362787. |
recently, a soluble form of tau, Δtau314, which is generated when caspase-2 (casp2) cleaves tau at asp314, was reported to be associated with impaired cognition in mice modeling frontotemporal dementia, and with mild cognitive impairment and alzheimer's disease (ad) in humans. |
2020-06-23 |
2023-08-13 |
mouse |
| Yuxing Xia, Zachary A Sorrentino, Justin D Kim, Kevin H Strang, Cara J Riffe, Benoit I Giasso. Impaired tau-microtubule interactions are prevalent among pathogenic tau variants arising from missense mutations. The Journal of biological chemistry. vol 294. issue 48. 2020-06-22. PMID:31653695. |
tau can aberrantly aggregate into pathological inclusions that define alzheimer's disease, frontotemporal dementias, and other tauopathies. |
2020-06-22 |
2023-08-13 |
Not clear |
| Clifford R Jack, Heather J Wiste, Hugo Botha, Stephen D Weigand, Terry M Therneau, David S Knopman, Jonathan Graff-Radford, David T Jones, Tanis J Ferman, Bradley F Boeve, Kejal Kantarci, Val J Lowe, Prashanthi Vemuri, Michelle M Mielke, Julie A Fields, Mary M Machulda, Christopher G Schwarz, Matthew L Senjem, Jeffrey L Gunter, Ronald C Peterse. The bivariate distribution of amyloid-β and tau: relationship with established neurocognitive clinical syndromes. Brain : a journal of neurology. vol 142. issue 10. 2020-06-15. PMID:31501889. |
we studied 1343 participants who had amyloid pet and tau pet from 2 april 2015 to 3 may 2019, and met criteria for membership in one of five clinical diagnostic groups: cognitively unimpaired, mild cognitive impairment, frontotemporal dementia, probable dementia with lewy bodies, and alzheimer clinical syndrome. |
2020-06-15 |
2023-08-13 |
human |
| Mari Nakamura, Seiji Shiozawa, Daisuke Tsuboi, Mutsuki Amano, Hirotaka Watanabe, Sumihiro Maeda, Taeko Kimura, Sho Yoshimatsu, Fumihiko Kisa, Celeste M Karch, Tomohiro Miyasaka, Akihiko Takashima, Naruhiko Sahara, Shin-Ichi Hisanaga, Takeshi Ikeuchi, Kozo Kaibuchi, Hideyuki Okan. Pathological Progression Induced by the Frontotemporal Dementia-Associated R406W Tau Mutation in Patient-Derived iPSCs. Stem cell reports. vol 13. issue 4. 2020-06-10. PMID:31543469. |
mutations in the microtubule-associated protein tau (mapt) gene are known to cause familial frontotemporal dementia (ftd). |
2020-06-10 |
2023-08-13 |
Not clear |
| David J Wales, Matthew D Disney, Ilyas Yildiri. Computational Investigation of RNA A-Bulges Related to the Microtubule-Associated Protein Tau Causing Frontotemporal Dementia and Parkinsonism. The journal of physical chemistry. B. vol 123. issue 1. 2020-06-01. PMID:30517788. |
computational investigation of rna a-bulges related to the microtubule-associated protein tau causing frontotemporal dementia and parkinsonism. |
2020-06-01 |
2023-08-13 |
human |
| David J Wales, Matthew D Disney, Ilyas Yildiri. Computational Investigation of RNA A-Bulges Related to the Microtubule-Associated Protein Tau Causing Frontotemporal Dementia and Parkinsonism. The journal of physical chemistry. B. vol 123. issue 1. 2020-06-01. PMID:30517788. |
mutations in the human tau gene result in alternative splicing of the tau protein, which causes frontotemporal dementia and parkinsonism. |
2020-06-01 |
2023-08-13 |
human |
| Sergi Borrego-Écija, Anna Antonell, Joan Anton Puig-Butillé, Inmaculada Pericot, Carme Prat-Bravo, Maria Teresa Abellan-Vidal, Javier Mallada, Jaume Olives, Neus Falgàs, Rafael Oliva, Albert Lladó, Raquel Sánchez-Vall. Novel P397S MAPT variant associated with late onset and slow progressive frontotemporal dementia. Annals of clinical and translational neurology. vol 6. issue 8. 2020-05-29. PMID:31402617. |
mutations in the mapt gene cause frontotemporal dementia with tau deposits. |
2020-05-29 |
2023-08-13 |
human |