| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peter Bentham, Roger T Staff, Bjoern O Schelter, Helen Shiells, Charles R Harrington, Claude M Wischi. Long-Term Hydromethylthionine Treatment Is Associated with Delayed Clinical Onset and Slowing of Cerebral Atrophy in a Pre-Symptomatic P301S MAPT Mutation Carrier. Journal of Alzheimer's disease : JAD. vol 83. issue 3. 2021-11-19. PMID:34366349. |
one of the mutations in the microtubule-associated protein tau, p301s, is causative for dominantly inherited frontotemporal dementia characterized by extensive tau pathology for which no licensed treatment is available. |
2021-11-19 |
2023-08-13 |
Not clear |
| Fabian Kreilaus, Rebecca Masanetz, Georgia Watt, Magdalena Przybyla, Arne Ittner, Lars Ittner, Tim Kar. The behavioural phenotype of 14-month-old female TAU58/2 transgenic mice. Behavioural brain research. vol 397. 2021-11-15. PMID:33017638. |
frontotemporal dementia (ftd) and alzheimer's disease (ad) exhibit intracellular inclusions [neurofibrillary tangles (nft's)] of microtubule-associated protein tau that contributes to neuronal dysfunction and death. |
2021-11-15 |
2023-08-13 |
mouse |
| Yuxing Xia, Lith Nasif, Benoit I Giasso. Pathogenic MAPT mutations Q336H and Q336R have isoform-dependent differences in aggregation propensity and microtubule dysfunction. Journal of neurochemistry. vol 158. issue 2. 2021-11-12. PMID:33772783. |
mutations in the microtubule-associated protein tau (mapt) gene lead to familial forms of frontotemporal dementia. |
2021-11-12 |
2023-08-13 |
Not clear |
| Yuxing Xia, Lith Nasif, Benoit I Giasso. Pathogenic MAPT mutations Q336H and Q336R have isoform-dependent differences in aggregation propensity and microtubule dysfunction. Journal of neurochemistry. vol 158. issue 2. 2021-11-12. PMID:33772783. |
q336h and q336r mapt mutations also cause early onset frontotemporal dementia with pick bodies, which are mostly composed of 3r tau isoforms. |
2021-11-12 |
2023-08-13 |
Not clear |
| Nicholas M Kanaan, Tessa Grabinsk. Neuronal and Glial Distribution of Tau Protein in the Adult Rat and Monkey. Frontiers in molecular neuroscience. vol 14. 2021-11-12. PMID:33986642. |
additionally, tau is a central player in the pathogenesis of several diseases such as alzheimer's disease and several frontotemporal dementias. |
2021-11-12 |
2023-08-13 |
rat |
| Tuan D Samdin, Adam G Kreutzer, James S Nowic. Exploring amyloid oligomers with peptide model systems. Current opinion in chemical biology. vol 64. 2021-11-11. PMID:34229162. |
the assembly of amyloidogenic peptides and proteins, such as the β-amyloid peptide, α-synuclein, huntingtin, tau, and islet amyloid polypeptide, into amyloid fibrils and oligomers is directly linked to amyloid diseases, such as alzheimer's, parkinson's, and huntington's diseases, frontotemporal dementias, and type ii diabetes. |
2021-11-11 |
2023-08-13 |
Not clear |
| Ben Boyarko, Vivian Hoo. Human Tau Isoforms and Proteolysis for Production of Toxic Tau Fragments in Neurodegeneration. Frontiers in neuroscience. vol 15. 2021-11-10. PMID:34744602. |
the human tau protein is implicated in a wide range of neurodegenerative "tauopathy" diseases, consisting of alzheimer's disease (ad) and frontotemporal lobar degeneration which includes progressive supranuclear palsy, corticobasal degeneration, pick's disease, and ftld-tau (frontotemporal dementia with parkinsonism caused by mapt mutations). |
2021-11-10 |
2023-08-13 |
human |
| Sara Oberrauch, Jeremy A Metha, Maddison L Brian, Samuel A Barnes, Travis J Featherby, Andrew J Lawrence, Daniel Hoyer, Carsten Murawski, Laura H Jacobso. Reward motivation and cognitive flexibility in tau null-mutation mice. Neurobiology of aging. vol 100. 2021-11-08. PMID:33524848. |
the reduction of tau or hyperphosphorylated tau (p-tau) has been proposed as a therapeutic strategy for alzheimer's disease (ad) and frontotemporal dementia (ftd). |
2021-11-08 |
2023-08-13 |
mouse |
| Yuwa Oka, Hidemoto Saiki, Yasumasa Hashimoto, Yuta Terada, Takashi Nakamura, Takashi Ayaki, Satoshi Orimo, Sadayuki Matsumot. Japanese Familial Cases of Frontotemporal Dementia and Parkinsonism with N279K Tau Gene Mutation. Movement disorders clinical practice. vol 8. issue 1. 2021-11-05. PMID:33426168. |
japanese familial cases of frontotemporal dementia and parkinsonism with n279k tau gene mutation. |
2021-11-05 |
2023-08-13 |
Not clear |
| Yuwa Oka, Hidemoto Saiki, Yasumasa Hashimoto, Yuta Terada, Takashi Nakamura, Takashi Ayaki, Satoshi Orimo, Sadayuki Matsumot. Japanese Familial Cases of Frontotemporal Dementia and Parkinsonism with N279K Tau Gene Mutation. Movement disorders clinical practice. vol 8. issue 1. 2021-11-05. PMID:33426168. |
mutations in the tau gene linked to chromosome 17 cause frontotemporal dementia and parkinsonism (ftdp-17). |
2021-11-05 |
2023-08-13 |
Not clear |
| Attila Somogyi, Ervin Wol. Increased Signal Delays and Unaltered Synaptic Input Pattern Recognition in Layer III Neocortical Pyramidal Neurons of the rTg4510 Mouse Model of Tauopathy: A Computer Simulation Study With Passive Membrane. Frontiers in neuroscience. vol 15. 2021-11-05. PMID:34733131. |
transgenic rtg4510 mice express high levels of human tau protein with p301l mutation linked to chromosome 17 that has been associated with frontotemporal dementia with parkinsonism. |
2021-11-05 |
2023-08-13 |
mouse |
| Chialin Cheng, Surya A Reis, Emily T Adams, Daniel M Fass, Steven P Angus, Timothy J Stuhlmiller, Jared Richardson, Hailey Olafson, Eric T Wang, Debasis Patnaik, Roberta L Beauchamp, Danielle A Feldman, M Catarina Silva, Mriganka Sur, Gary L Johnson, Vijaya Ramesh, Bruce L Miller, Sally Temple, Kenneth S Kosik, Bradford C Dickerson, Stephen J Haggart. High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy. Scientific reports. vol 11. issue 1. 2021-11-04. PMID:34426604. |
mutations in mapt (microtubule-associated protein tau) cause frontotemporal dementia (ftd). |
2021-11-04 |
2023-08-13 |
human |
| Yuxing Xia, Brach M Bell, Benoit I Giasso. Tau K321/K353 pseudoacetylation within KXGS motifs regulates tau-microtubule interactions and inhibits aggregation. Scientific reports. vol 11. issue 1. 2021-11-01. PMID:34426645. |
the insidious accumulation of brain tau inclusions is also involved in a group of neurodegenerative diseases termed frontotemporal dementias. |
2021-11-01 |
2023-08-13 |
Not clear |
| Mario Torso, Gerard R Ridgway, Mark Jenkinson, Steven Chanc. Intracortical diffusion tensor imaging signature of microstructural changes in frontotemporal lobar degeneration. Alzheimer's research & therapy. vol 13. issue 1. 2021-10-28. PMID:34686217. |
frontotemporal lobar degeneration (ftld) is a neuropathological construct with multiple clinical presentations, including the behavioural variant of frontotemporal dementia (bvftd), primary progressive aphasia-both non-fluent variant (nfvppa) and semantic variant (svppa)-progressive supranuclear palsy (psp) and corticobasal syndrome (cbs), characterised by the deposition of abnormal tau protein in the brain. |
2021-10-28 |
2023-08-13 |
Not clear |
| Ines Moreno-Gonzalez, George A Edwards, Omar Hasan, Nazaret Gamez, Jonathan E Schulz, Juan Jose Fernandez-Valenzuela, Antonia Gutierrez, Claudio Soto, Paul E Schul. Longitudinal Assessment of Tau-Associated Pathology by Diagnostics (Basel, Switzerland). vol 11. issue 10. 2021-10-26. PMID:34679572. |
in alzheimer's disease (ad), nfts are accompanied by extracellular amyloid-beta (aβ), but primary tauopathy disorders are marked by the accumulation of tau protein alone, including forms of frontotemporal dementia (ftd), corticobasal degeneration (cbd), and progressive supranuclear palsy (psp), among others. |
2021-10-26 |
2023-08-13 |
Not clear |
| Z Jaunmuktane, S Brandne. Invited Review: The role of prion-like mechanisms in neurodegenerative diseases. Neuropathology and applied neurobiology. vol 46. issue 6. 2021-10-25. PMID:31868945. |
there is increasing evidence that other neurodegenerative diseases, most notably alzheimer's disease (aβ and tau), parkinson's disease (α-synuclein), frontotemporal dementia (tdp43, tau or fus) and motor neurone disease (tdp43), exhibit at least some of the misfolded prion protein properties. |
2021-10-25 |
2023-08-13 |
Not clear |
| Mauro Montalbano, Salome McAllen, Filippa Lo Cascio, Urmi Sengupta, Stephanie Garcia, Nemil Bhatt, Anna Ellsworth, Eric A Heidelman, Omar D Johnson, Samantha Doskocil, Rakez Kaye. TDP-43 and Tau Oligomers in Alzheimer's Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia. Neurobiology of disease. vol 146. 2021-10-25. PMID:33065281. |
tdp-43 and tau oligomers in alzheimer's disease, amyotrophic lateral sclerosis, and frontotemporal dementia. |
2021-10-25 |
2023-08-13 |
human |
| Fiona J Baird, Craig L Bennet. Microtubule defects & Neurodegeneration. Journal of genetic syndromes & gene therapy. vol 4. 2021-10-21. PMID:24563812. |
the importance of mt dynamics and stability is underscored by the critical role tau protein plays in mt-associated stabilization versus the dysfunction seen in alzheimer's disease, frontotemporal dementia and other tauopathies. |
2021-10-21 |
2023-08-12 |
mouse |
| Wendy Noble, Amy M Pooler, Diane P Hange. Advances in tau-based drug discovery. Expert opinion on drug discovery. vol 6. issue 8. 2021-10-20. PMID:22003359. |
introduction: tauopathies, including alzheimer's disease (ad) and some frontotemporal dementias, are neurodegenerative diseases characterised by pathological lesions comprised of tau protein. |
2021-10-20 |
2023-08-12 |
Not clear |
| Jake P Levy, Gleb Bezgin, Melissa Savard, Tharick A Pascoal, Elizabeth Finger, Robert Laforce, Joshua A Sonnen, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Neto, Simon Ducharm. 18F-MK-6240 tau-PET in genetic frontotemporal dementia. Brain : a journal of neurology. 2021-10-19. PMID:34664612. |
tau is one of several proteins associated with frontotemporal dementia (ftd). |
2021-10-19 |
2023-08-13 |
human |