| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joseph B Rayma. Focusing on oligomeric tau as a therapeutic target in Alzheimer's disease and other tauopathies. Expert opinion on therapeutic targets. 2023-05-04. PMID:37140480. |
tau pathology is a hallmark of primary tauopathies, such as progressive supranuclear palsy (psp), corticobasal syndrome (cbs), and subtypes of frontotemporal dementia (ftd), as well as secondary tauopathies, such as alzheimer's disease (ad). |
2023-05-04 |
2023-08-14 |
Not clear |
| Luigi Fiondella, Priya Gami-Patel, Christian A Blok, Annemieke J M Rozemuller, Jeroen J M Hoozemans, Yolande A L Pijnenburg, Marta Scarioni, Anke A Dijkstr. Movement disorders are linked to TDP-43 burden in the substantia nigra of FTLD-TDP brain donors. Acta neuropathologica communications. vol 11. issue 1. 2023-04-12. PMID:37046309. |
they are also present in frontotemporal dementia (ftd), where md have been linked to frontotemporal lobar degeneration with tau pathology (ftld-tau). |
2023-04-12 |
2023-08-14 |
Not clear |
| Aleksandra Parka, Christiane Volbracht, Benjamin Hall, Jesper F Bastlund, Maiken Nedergaard, Bettina Laursen, Paolo Botta, Florence Sott. Visual Evoked Potentials as an Early-Stage Biomarker in the rTg4510 Tauopathy Mouse Model. Journal of Alzheimer's disease : JAD. 2023-04-03. PMID:37005884. |
tauopathies such as alzheimer's disease (ad) and frontotemporal dementia (ftd) are characterized by formation of neurofibrillary tangles consisting of hyperphosphorylated tau protein. |
2023-04-03 |
2023-08-14 |
mouse |
| Sumaiya Khan, Md Imtaiyaz Hassan, Mohammad Shahid, Asimul Isla. Nature's Toolbox Against Tau Aggregation: An Updated Review of Current Research. Ageing research reviews. 2023-04-02. PMID:37004844. |
tau aggregation is a hallmark of several neurodegenerative disorders, such as alzheimer's disease (ad), frontotemporal dementia, and progressive supranuclear palsy. |
2023-04-02 |
2023-08-14 |
Not clear |
| Dailu Chen, Sofia Bali, Ruhar Singh, Aleksandra Wosztyl, Vishruth Mullapudi, Jaime Vaquer-Alicea, Parvathy Jayan, Shamiram Melhem, Harro Seelaar, John C van Swieten, Marc I Diamond, Lukasz A Joachimia. FTD-tau S320F mutation stabilizes local structure and allosterically promotes amyloid motif-dependent aggregation. Nature communications. vol 14. issue 1. 2023-03-24. PMID:36959205. |
in frontotemporal dementia with abnormal tau (ftd-tau), missense mutations in tau enhance its aggregation propensity. |
2023-03-24 |
2023-08-14 |
Not clear |
| Alexis M Johnson, John R Luken. The innate immune response in tauopathies. European journal of immunology. 2023-03-18. PMID:36932726. |
tauopathies, which include frontotemporal dementia, alzheimer's disease, and chronic traumatic encephalopathy, are a class of neurological disorders resulting from pathogenic tau aggregates. |
2023-03-18 |
2023-08-14 |
Not clear |
| Aurélie Bussy, Jake P Levy, Tristin Best, Raihaan Patel, Lani Cupo, Tim Van Langenhove, Jørgen E Nielsen, Yolande Pijnenburg, Maria Landqvist Waldö, Anne M Remes, Matthias L Schroeter, Isabel Santana, Florence Pasquier, Markus Otto, Adrian Danek, Johannes Levin, Isabelle Le Ber, Rik Vandenberghe, Matthis Synofzik, Fermin Moreno, Alexandre de Mendonça, Raquel Sanchez-Valle, Robert Laforce, Tobias Langheinrich, Alexander Gerhard, Caroline Graff, Chris R Butler, Sandro Sorbi, Lize Jiskoot, Harro Seelaar, John C van Swieten, Elizabeth Finger, Maria Carmela Tartaglia, Mario Masellis, Pietro Tiraboschi, Daniela Galimberti, Barbara Borroni, James B Rowe, Martina Bocchetta, Jonathan D Rohrer, Gabriel A Devenyi, M Mallar Chakravarty, Simon Ducharm. Cerebellar and subcortical atrophy contribute to psychiatric symptoms in frontotemporal dementia. Human brain mapping. 2023-03-10. PMID:36895129. |
recent studies have reported early cerebellar and subcortical impact in the disease progression of genetic frontotemporal dementia (ftd) due to microtubule-associated protein tau (mapt), progranulin (grn) and chromosome 9 open reading frame 72 (c9orf72). |
2023-03-10 |
2023-08-14 |
human |
| Vasilios C Constantinides, George P Paraskevas, Fotini Boufidou, Mara Bourbouli, Efstratios-Stylianos Pyrgelis, Leonidas Stefanis, Elisabeth Kapak. CSF Aβ42 and Aβ42/Aβ40 Ratio in Alzheimer's Disease and Frontotemporal Dementias. Diagnostics (Basel, Switzerland). vol 13. issue 4. 2023-02-25. PMID:36832271. |
alzheimer's disease dementia (add) may manifest with atypical phenotypes, resembling behavioral variant frontotemporal dementia (bvftd) and corticobasal syndrome (cbs), phenotypes which typically have an underlying frontotemporal lobar degeneration with tau proteinopathy (ftld-tau), such as pick's disease, corticobasal degeneration (cbd), progressive supranuclear palsy (psp), or ftld with tdp-43 proteinopathy (ftld-tdp). |
2023-02-25 |
2023-08-14 |
Not clear |
| Claira Sohn, Jiacheng Ma, William J Ray, Bess Fros. Pathogenic tau decreases nuclear tension in cultured neurons. Frontiers in aging. vol 4. 2023-02-09. PMID:36756194. |
we first find that tau-dependent nuclear envelope invagination and relocalization of linker of nucleoskeleton and cytoskeleton (linc) complex components are conserved in a newly-developed neuroblastoma cell line that features doxycycline-inducible expression of a tau mutant associated with autosomal dominant frontotemporal dementia. |
2023-02-09 |
2023-08-14 |
human |
| Aleksandra Parka, Caroline Degel, Jakob Dreyer, Ulrike Richter, Benjamin Hall, Jesper F Bastlund, Bettina Laursen, Maiken Nedergaard, Florence Sotty, Paolo Bott. Early impairments of visually-driven neuronal ensemble dynamics in the rTg4510 tauopathy mouse model. Neurobiology of disease. vol 178. 2023-01-25. PMID:36696792. |
tau protein pathology is a hallmark of many neurodegenerative diseases, including alzheimer's disease or frontotemporal dementia. |
2023-01-25 |
2023-08-14 |
mouse |
| Deonne Taylor, Andrew Kneynsberg, Marloes van Roijen, Jürgen Göt. Tyrosine phosphatase STEP Molecular brain. vol 16. issue 1. 2023-01-13. PMID:36639708. |
tyrosine phosphatase step synaptic degeneration is a precursor of synaptic and neuronal loss in neurodegenerative diseases such as alzheimer's disease (ad) and frontotemporal dementia with tau pathology (ftd-tau), a group of primary tauopathies. |
2023-01-13 |
2023-08-14 |
Not clear |
| Esen Saka Topçuoğlu, Ümit Özgür Akdemir, Lütfiye Özlem Ata. What is New in Nuclear Medicine Imaging for Dementia. Noro psikiyatri arsivi. vol 59. issue Suppl 1. 2022-12-29. PMID:36578980. |
amyloid positron emission tomography (pet) and tau pet, which are molecular imaging methods, [f18]fluorodeoxyglucose (fdg) pet showing the glucose metabolism pattern in the brain, dopamine transporter single photon emission computerized tomography (spect) that marks dopaminergic terminals are valuable tools for early recognition and differentiation of ad and its atypical variants, frontotemporal dementias and dementia with lewy bodies. |
2022-12-29 |
2023-08-14 |
Not clear |
| Itzhak Fische. Evolutionary perspective of Big tau structure: 4a exon variants of MAPT. Frontiers in molecular neuroscience. vol 15. 2022-12-19. PMID:36533137. |
tau plays important roles in modulating microtubule dynamics, axonal transport, synaptic plasticity, and dna repair, and has also been associated with neurodegenerative diseases (tauopathies) including alzheimer's disease and frontotemporal dementia. |
2022-12-19 |
2023-08-14 |
human |
| Karthikeyan Selvarasu, Abhay Kumar Singh, Ashok Iyaswamy, Sravan Gopalkrishnashetty Sreenivasmurthy, Senthilkumar Krishnamoorthi, Amal Kanti Bera, Jian-Dong Huang, Siva Sundara Kumar Durairaja. Reduction of kinesin I heavy chain decreases tau hyperphosphorylation, aggregation, and memory impairment in Alzheimer's disease and tauopathy models. Frontiers in molecular biosciences. vol 9. 2022-11-17. PMID:36387285. |
many neurodegenerative diseases, such as alzheimer's disease (ad) and frontotemporal dementia with parkinsonism linked to chromosome 17, are characterized by tau pathology. |
2022-11-17 |
2023-08-14 |
mouse |
| Priyanka Rawat, Ujala Sehar, Jasbir Bisht, Ashley Selman, John Culberson, P Hemachandra Redd. Phosphorylated Tau in Alzheimer's Disease and Other Tauopathies. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36361631. |
tauopathies, including pick's disease, frontotemporal dementia, corticobasal degeneration, alzheimer's disease, argyrophilic grain disease, progressive supranuclear palsy, and huntington's disease, are the result of misprocessing and accumulation of tau within the neuronal and glial cells. |
2022-11-11 |
2023-08-14 |
Not clear |
| Javier Andrés Muñiz, Carolina Lucía Facal, Leandro Urrutia, Ramiro Clerici-Delville, Ana Damianich, Juan E Ferrario, Germán Falasco, María Elena Aval. SMaRT modulation of tau isoforms rescues cognitive and motor impairments in a preclinical model of tauopathy. Frontiers in bioengineering and biotechnology. vol 10. 2022-10-24. PMID:36277399. |
abnormal tau metabolism leads to neurodegenerative diseases named tauopathies, such as alzheimer's disease and frontotemporal dementia. |
2022-10-24 |
2023-08-14 |
human |
| R Babapour Mofrad, M Del Campo, C F W Peeters, L H H Meeter, H Seelaar, M Koel-Simmelink, I H G B Ramakers, H A M Middelkoop, P P De Deyn, J A H R Claassen, J C van Swieten, C Bridel, J J M Hoozemans, P Scheltens, W M van der Flier, Y A L Pijnenburg, Charlotte E Teunisse. Plasma proteome profiling identifies changes associated to AD but not to FTD. Acta neuropathologica communications. vol 10. issue 1. 2022-10-23. PMID:36273219. |
frontotemporal dementia (ftd) is caused by frontotemporal lobar degeneration (ftld), characterized mainly by inclusions of tau (ftld-tau) or tar dna binding43 (ftld-tdp) proteins. |
2022-10-23 |
2023-08-14 |
Not clear |
| Ki-Ryeong Kim, Sang Eun Park, Ji-Ye Hong, Jae-Young Koh, Dong-Hyung Cho, Jung Jin Hwang, Yang-Hee Ki. Zinc enhances autophagic flux and lysosomal function through transcription factor EB activation and V-ATPase assembly. Frontiers in cellular neuroscience. vol 16. 2022-10-17. PMID:36246521. |
finally, considering that p301l mutation in tau protein causes frontotemporal dementia through aggressive tau accumulation, we investigated whether zinc reduces the accumulation of protein aggregates in sk-n-be(2)-c neuroblastoma cells expressing wild-type tau or mutant p301l-tau. |
2022-10-17 |
2023-08-14 |
mouse |
| Helena Gossye, Sara Van Mossevelde, Anne Sieben, Maria Bjerke, Elisabeth Hendrickx Van de Craen, Julie van der Zee, Peter P De Deyn, Jan De Bleecker, Jan Versijpt, Jenneke van den Ende, Olivier Deryck, Paul Bourgeois, Jean Christophe Bier, Maarten Goethals, Rik Vandenberghe, Sebastiaan Engelborghs, Christine Van Broeckhove. Patients carrying the mutation p.R406W in MAPT present with non-conforming phenotypic spectrum. Brain : a journal of neurology. 2022-09-29. PMID:36171642. |
postmortem brain analysis of one p.r406w patient with behavioral variant frontotemporal dementia revealed frontotemporal lobar degeneration with tau pathology. |
2022-09-29 |
2023-08-14 |
Not clear |
| Simanta Sarani Paul, Aaron Lyons, Russell Kirchner, Michael T Woodsid. Quantifying Oligomer Populations in Real Time during Protein Aggregation Using Single-Molecule Mass Photometry. ACS nano. 2022-09-20. PMID:36126253. |
by applying the approach to tau protein, whose aggregates are linked to diseases including alzheimer's and frontotemporal dementia, we found that tau existed in an equilibrium between monomers, dimers, and trimers before aggregation was triggered. |
2022-09-20 |
2023-08-14 |
Not clear |