| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Helena Gossye, Sara Van Mossevelde, Anne Sieben, Maria Bjerke, Elisabeth Hendrickx Van de Craen, Julie van der Zee, Peter P De Deyn, Jan De Bleecker, Jan Versijpt, Jenneke van den Ende, Olivier Deryck, Paul Bourgeois, Jean Christophe Bier, Maarten Goethals, Rik Vandenberghe, Sebastiaan Engelborghs, Christine Van Broeckhove. Patients carrying the mutation p.R406W in MAPT present with non-conforming phenotypic spectrum. Brain : a journal of neurology. 2022-09-29. PMID:36171642. |
postmortem brain analysis of one p.r406w patient with behavioral variant frontotemporal dementia revealed frontotemporal lobar degeneration with tau pathology. |
2022-09-29 |
2023-08-14 |
Not clear |
| Simanta Sarani Paul, Aaron Lyons, Russell Kirchner, Michael T Woodsid. Quantifying Oligomer Populations in Real Time during Protein Aggregation Using Single-Molecule Mass Photometry. ACS nano. 2022-09-20. PMID:36126253. |
by applying the approach to tau protein, whose aggregates are linked to diseases including alzheimer's and frontotemporal dementia, we found that tau existed in an equilibrium between monomers, dimers, and trimers before aggregation was triggered. |
2022-09-20 |
2023-08-14 |
Not clear |
| Stella M K Glasauer, Susan K Goderie, Jennifer N Rauch, Elmer Guzman, Morgane Audouard, Taylor Bertucci, Shona Joy, Emma Rommelfanger, Gabriel Luna, Erica Keane-Rivera, Steven Lotz, Susan Borden, Aaron M Armando, Oswald Quehenberger, Sally Temple, Kenneth S Kosi. Human tau mutations in cerebral organoids induce a progressive dyshomeostasis of cholesterol. Stem cell reports. 2022-08-19. PMID:35985329. |
mutations in the mapt gene that encodes tau lead to frontotemporal dementia (ftd) with pathology evident in both cerebral neurons and glia. |
2022-08-19 |
2023-08-14 |
human |
| Oscar Ramos-Campoy, Albert Lladó, Beatriz Bosch, Mireia Ferrer, Agnès Pérez-Millan, Miguel Vergara, Laura Molina-Porcel, Laura Fort-Aznar, Ricardo Gonzalo, Fermín Moreno-Izco, Guadalupe Fernandez-Villullas, Mircea Balasa, Raquel Sánchez-Valle, Anna Antonel. Differential Gene Expression in Sporadic and Genetic Forms of Alzheimer's Disease and Frontotemporal Dementia in Brain Tissue and Lymphoblastoid Cell Lines. Molecular neurobiology. 2022-08-12. PMID:35962298. |
frontotemporal dementia (ftd) causes early-onset dementia associated to tau or tdp43 protein deposits. |
2022-08-12 |
2023-08-14 |
human |
| Yanaika S Hok-A-Hin, Anke A Dijkstra, Alberto Rábano, Jeroen J Hoozemans, Lucía Castillo, Haro Seelaar, John C van Swieten, Yolande A L Pijnenburg, Charlotte E Teunissen, Marta Del Camp. Apolipoprotein L1 is increased in frontotemporal lobar degeneration post-mortem brain but not in ante-mortem cerebrospinal fluid. Neurobiology of disease. 2022-07-12. PMID:35820647. |
frontotemporal dementia (ftd) is caused by frontal-temporal lobar degeneration (ftld), characterized mainly by brain protein aggregates of tau (ftld-tau) or tdp-43 (ftld-tdp). |
2022-07-12 |
2023-08-14 |
Not clear |
| Song Mi Han, Yu Jung Jang, Eun Young Kim, Sun Ah Par. The Change in Circadian Rhythms in P301S Transgenic Mice is Linked to Variability in Hsp70-related Tau Disaggregation. Experimental neurobiology. vol 31. issue 3. 2022-07-05. PMID:35786641. |
circadian disruption often involves a neurodegenerative disorder, such as alzheimer's disease or frontotemporal dementia, which are characterized by intraneuronal tau accumulations. |
2022-07-05 |
2023-08-14 |
mouse |
| David J Ingham, Kelsey M Hillyer, Madison J McGuire, Truman C Gambli. Biochemistry. 2022-06-22. PMID:35731895. |
in addition, mutations in the gene that encodes for tau protein expression have been associated with a group of tauopathies known as frontotemporal dementias with parkinsonism linked to chromosome 17 (ftdp-17 or familial frontotemporal dementia). |
2022-06-22 |
2023-08-14 |
Not clear |
| Ishani Pidara, Koyuki Yamad. The Structure of Tau Proteins and Its Role in Neurodegenerative Disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35553522. |
while there are many tauopathies, such as frontotemporal dementia with parkinsonism-17 and pick disease, alzheimer's is one of the most prevalent and studied diseases associated with tau (gao et al., 2018). |
2022-05-13 |
2023-08-13 |
Not clear |
| Mauro Montalbano, Elizabeth Jaworski, Stephanie Garcia, Anna Ellsworth, Salome McAllen, Andrew Routh, Rakez Kaye. Tau modulates mRNA transcription, alternative polyadenylation (APA) profiles of hnRNPs, chromatin remodeling and spliceosome complexes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35560478. |
tau protein is a known contributor in several neurodegenerative diseases, including alzheimer 's disease (ad) and frontotemporal dementia (ftd). |
2022-05-13 |
2023-08-13 |
human |
| Karla Villalobos-Nova, Sebastián Monroy-Moya, Joaquín Maulen-Peñaloza, Gabriela Costa Maia Pinto, Alberto Cornej. Bringing the Spotlight to tau and TDP-43 in Frontotemporal Dementia: A Review of Promising Chemical Compounds. Current medicinal chemistry. 2022-05-09. PMID:35532254. |
bringing the spotlight to tau and tdp-43 in frontotemporal dementia: a review of promising chemical compounds. |
2022-05-09 |
2023-08-13 |
Not clear |
| Gurpreet Singh, Peng Liu, Katherine R Yao, Jessica M Strasser, Chris Hlynialuk, Kailee Leinonen-Wright, Peter J Teravskis, Jessica M Choquette, Junaid Ikramuddin, Merlin Bresinsky, Kathryn M Nelson, Dezhi Liao, Karen H Ashe, Michael A Walters, Steffen Pocke. Caspase-2 Inhibitor Blocks Tau Truncation and Restores Excitatory Neurotransmission in Neurons Modeling FTDP-17 Tauopathy. ACS chemical neuroscience. 2022-05-06. PMID:35522720. |
synaptic and cognitive deficits mediated by a severe reduction in excitatory neurotransmission caused by a disproportionate accumulation of the neuronal protein tau in dendritic spines is a fundamental mechanism that has been found repeatedly in models of tauopathies, including alzheimer's disease, lewy body dementia, frontotemporal dementia, and traumatic brain injury. |
2022-05-06 |
2023-08-13 |
Not clear |
| Elizabeth L Steuer, Lisa J Kemper, Chris J W Hlynialuk, Kailee Leinonen-Wright, Michelle L Montonye, Ian P Lapcinski, Colleen L Forster, Karen H Ashe, Peng Li. Blocking site-specific cleavage of human tau delays progression of disease-related phenotypes in genetically matched tau-transgenic mice modeling frontotemporal dementia. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-05-04. PMID:35508385. |
blocking site-specific cleavage of human tau delays progression of disease-related phenotypes in genetically matched tau-transgenic mice modeling frontotemporal dementia. |
2022-05-04 |
2023-08-13 |
mouse |
| Elizabeth L Steuer, Lisa J Kemper, Chris J W Hlynialuk, Kailee Leinonen-Wright, Michelle L Montonye, Ian P Lapcinski, Colleen L Forster, Karen H Ashe, Peng Li. Blocking site-specific cleavage of human tau delays progression of disease-related phenotypes in genetically matched tau-transgenic mice modeling frontotemporal dementia. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-05-04. PMID:35508385. |
studies have recently demonstrated that a caspase-2-mediated cleavage of human tau (htau) at asparate-314 (d314) is responsible for cognitive deficits and neurodegeneration in mice modeling frontotemporal dementia (ftd). |
2022-05-04 |
2023-08-13 |
mouse |
| Eleonora Virgilio, Fabiola De Marchi, Elena Contaldi, Umberto Dianzani, Roberto Cantello, Letizia Mazzini, Cristoforo Com. The Role of Tau beyond Alzheimer's Disease: A Narrative Review. Biomedicines. vol 10. issue 4. 2022-04-23. PMID:35453510. |
cerebrospinal fluid and serum tau have been extensively investigated in several neurodegenerative disorders, from classically defined proteinopathy, e.g., amyotrophic lateral sclerosis (als), frontotemporal dementia (ftd), and parkinson's disease (pd), but also in inflammatory conditions such as multiple sclerosis (ms), as a marker of axonal damage. |
2022-04-23 |
2023-08-13 |
Not clear |
| Cristina Villa, Giacomina Rossi, Ilaria Bizzozero, Sara Prioni, Chiara Boiocchi, Federica Agosta, Elisa Canu, Massimo Filippi, Giorgio Giaccone, Paola Caropp. MAPT Q336H mutation: Intrafamilial phenotypic heterogeneity in a new Italian family. European journal of neurology. vol 29. issue 5. 2022-04-12. PMID:35020237. |
q336h is a rare mapt mutation, previously found in a single patient with behavioral variant frontotemporal dementia and tau pathology (pick bodies). |
2022-04-12 |
2023-08-16 |
Not clear |
| Arabella Bouzigues, Lucy L Russell, Georgia Peakman, Martina Bocchetta, Caroline V Greaves, Rhian S Convery, Emily Todd, James B Rowe, Barbara Borroni, Daniela Galimberti, Pietro Tiraboschi, Mario Masellis, Maria Carmela Tartaglia, Elizabeth Finger, John C van Swieten, Harro Seelaar, Lize Jiskoot, Sandro Sorbi, Chris R Butler, Caroline Graff, Alexander Gerhard, Tobias Langheinrich, Robert Laforce, Raquel Sanchez-Valle, Alexandre de Mendonça, Fermin Moreno, Matthis Synofzik, Rik Vandenberghe, Simon Ducharme, Isabelle Le Ber, Johannes Levin, Adrian Danek, Markus Otto, Florence Pasquier, Isabel Santana, Jonathan D Rohre. Anomia is present pre-symptomatically in frontotemporal dementia due to MAPT mutations. Journal of neurology. 2022-03-29. PMID:35348856. |
a third of frontotemporal dementia (ftd) is caused by an autosomal-dominant genetic mutation in one of three genes: microtubule-associated protein tau (mapt), chromosome 9 open reading frame 72 (c9orf72) and progranulin (grn). |
2022-03-29 |
2023-08-13 |
Not clear |
| M Catarina Silva, Ghata Nandi, Katherine A Donovan, Quan Cai, Bethany C Berry, Radoslaw P Nowak, Eric S Fischer, Nathanael S Gray, Fleur M Ferguson, Stephen J Haggart. Discovery and Optimization of Tau Targeted Protein Degraders Enabled by Patient Induced Pluripotent Stem Cells-Derived Neuronal Models of Tauopathy. Frontiers in cellular neuroscience. vol 16. 2022-03-23. PMID:35317195. |
an important class of these are tauopathies, such as frontotemporal dementia (ftd) and alzheimer's disease (ad), associated with accumulation of aberrant forms of tau protein in the brain. |
2022-03-23 |
2023-08-13 |
human |
| Nora Lemke, Ahmed H El-Khatib, Teodor Tchipilov, Norbert Jakubowski, Michael G Weller, Jochen Vog. Procedure providing SI-traceable results for the calibration of protein standards by sulfur determination and its application on tau. Analytical and bioanalytical chemistry. 2022-03-22. PMID:35316347. |
finally, the developed procedure was applied to the tau protein, which is a biomarker for a group of neurodegenerative diseases denoted "tauopathies" including, e.g., alzheimer's disease and frontotemporal dementia. |
2022-03-22 |
2023-08-13 |
mouse |
| Fabian Kreilaus, Magdalena Przybyla, Lars Ittner, Tim Kar. Cannabidiol (CBD) treatment improves spatial memory in 14-month-old female TAU58/2 transgenic mice. Behavioural brain research. 2022-02-24. PMID:35202719. |
frontotemporal dementia (ftd) and alzheimer's disease (ad) share the pathological hallmark of intracellular neurofibrillary tangles, which result from the hyperphosphorylation of microtubule associated protein tau. |
2022-02-24 |
2023-08-13 |
mouse |
| Shaqayeq Roqanian, Shahin Ahmadian, Seyed Masood Nabavi, Hossein Pakdaman, Mahshid Shafiezadeh, Ghazaleh Goudarzi, Koorosh Shahpasan. Tau nuclear translocation is a leading step in tau pathology process through P53 stabilization and nucleolar dispersion. Journal of neuroscience research. 2022-02-16. PMID:35170061. |
in tau-overexpressing shsy5y cells and ipsc-derived neuron models of frontotemporal dementia (ftd), axonal tau translocates into the nuclear compartment, resulting in neuronal dysfunction. |
2022-02-16 |
2023-08-13 |
mouse |