| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Patrick Vagenknecht, Artur Luzgin, Maiko Ono, Bin Ji, Makoto Higuchi, Daniela Noain, Cinzia A Maschio, Jens Sobek, Zhenyue Chen, Uwe Konietzko, Juan A Gerez, Roland Riek, Daniel Razansky, Jan Klohs, Roger M Nitsch, Xose Luis Dean-Ben, Ruiqing N. Non-invasive imaging of tau-targeted probe uptake by whole brain multi-spectral optoacoustic tomography. European journal of nuclear medicine and molecular imaging. 2022-02-07. PMID:35128565. |
abnormal tau accumulation within the brain plays an important role in tauopathies such as alzheimer's disease and frontotemporal dementia. |
2022-02-07 |
2023-08-13 |
Not clear |
| María Pagnon de la Vega, Carl Näslund, RoseMarie Brundin, Lars Lannfelt, Malin Löwenmark, Lena Kilander, Martin Ingelsson, Vilmantas Giedraiti. Mutation analysis of disease causing genes in patients with early onset or familial forms of Alzheimer's disease and frontotemporal dementia. BMC genomics. vol 23. issue 1. 2022-02-05. PMID:35120450. |
mutations in the tau gene (mapt) lead to frontotemporal dementia (ftd), whereas mutations in the genes for the amyloid-β precursor protein (app) and the presenilins (psen1, psen2) cause early-onset, dominantly inherited forms of alzheimer's disease (ad). |
2022-02-05 |
2023-08-13 |
Not clear |
| Yvette Akwa, Chiara Di Malta, Elise Gondard, Anne Boiret, Andres M Lozano, Thomas Vaccari, Carmine Settembre, Etienne E Baulieu, Davide Tampellin. Synaptic stimulation induces tau clearance by enhancing autophagosomal/lysosomal degradation. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108923. |
we have demonstrated that synaptic stimulation, via dbs or other methods, is protective in mouse models of ad and frontotemporal dementia (ftd) by enhancing autophagy and lysosomal degradation of pathologic tau, and by protecting synapses (akwa et al., 2018; mann et al., 2018). |
2022-02-03 |
2023-08-13 |
mouse |
| Iain James Hartnell, Manon Graffeuil, Luke Mason, Pavan Marwaha, Declan Woodhouse, William Jasper, David Blum, James Ar Nicoll, Guillaume Dorothee, Delphine Boch. Tau pathology, neuroinflammation and adaptive immune cells in human primary tauopathies. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109059. |
frontotemporal lobar degeneration with tau (ftld-tau) is a tauopathy that underlies ∼50% of cases of frontotemporal dementia (ftd). |
2022-02-03 |
2023-08-13 |
mouse |
| Justin R Welden, Giorgi Margvelani, Chi Jing Leow, Jessica Blackburn, Peter T Nelson, Stefan Stam. Proteins translated from tau circular RNAs as drivers for Alzheimer's disease and frontotemporal dementia. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109060. |
proteins translated from tau circular rnas as drivers for alzheimer's disease and frontotemporal dementia. |
2022-02-03 |
2023-08-13 |
mouse |
| Sidhartha Mahali, Rita Martinez, Miwei Hu, Jacob Marsh, Sally Temple, Celeste M Karc. Defective proteostasis in patient-derived iPSC astrocytes and neurons carrying a MAPT IVS10+16 mutation. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109114. |
in a subset of frontotemporal dementia (ftd) cases, mutations in the microtubule-associated protein tau (mapt) that alter the relative levels of tau isoforms are sufficient to cause tau inclusions in neurons and astroglia and neurodegeneration without the presence of mutated protein (e.g. |
2022-02-03 |
2023-08-13 |
Not clear |
| Tara E Tracy, Jesus Madero-Pérez, Danielle L Swaney, Timothy S Chang, Michelle Moritz, Csaba Konrad, Michael E Ward, Erica Stevenson, Ruth Hüttenhain, Grant Kauwe, Maria Mercedes, Lauren Sweetland-Martin, Xu Chen, Sue-Ann Mok, Man Ying Wong, Maria Telpoukhovskaia, Sang-Won Min, Chao Wang, Peter Dongmin Sohn, Jordie Martin, Yungui Zhou, Wenjie Luo, John Q Trojanowski, Virginia M Y Lee, Shiaoching Gong, Giovanni Manfredi, Giovanni Coppola, Nevan J Krogan, Daniel H Geschwind, Li Ga. Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration. Cell. 2022-01-22. PMID:35063084. |
to dissect the underlying mechanisms, we combined an engineered ascorbic acid peroxidase (apex) approach with quantitative affinity purification mass spectrometry (ap-ms) followed by proximity ligation assay (pla) to characterize tau interactomes modified by neuronal activity and mutations that cause frontotemporal dementia (ftd) in human induced pluripotent stem cell (ipsc)-derived neurons. |
2022-01-22 |
2023-08-13 |
human |
| Daniel T Ohm, Katheryn A Q Cousins, Sharon X Xie, Claire Peterson, Corey T McMillan, Lauren Massimo, Katya Raskovsky, David A Wolk, Vivianna M Van Deerlin, Lauren Elman, Meredith Spindler, Andres Deik, John Q Trojanowski, Edward B Lee, Murray Grossman, David J Irwi. Signature laminar distributions of pathology in frontotemporal lobar degeneration. Acta neuropathologica. 2022-01-08. PMID:34997851. |
frontotemporal lobar degeneration (ftld) with either tau (ftld-tau) or tdp-43 (ftld-tdp) inclusions are distinct proteinopathies that frequently cause similar frontotemporal dementia (ftd) clinical syndromes. |
2022-01-08 |
2023-08-13 |
Not clear |
| Huimin Cai, Yana Pang, Longfei Ji. Generation of an induced pluripotent stem cell line (ICNDXHi001-A) from a patient with frontotemporal dementia carrying a heterozygous mutation c.796C > G (p.L266V) in MAPT. Stem cell research. vol 59. 2022-01-07. PMID:34995843. |
frontotemporal dementia (ftd) caused by microtubule-associated protein tau (mapt) mutations is not rare and is almost fully penetrant. |
2022-01-07 |
2023-08-13 |
human |
| Georgie Lines, Charles Arber, Elisavet Preza, Claire Alexandra Leckey, Natura Myeku, Jackie M Casey, Michael Perkinton, Selina Wra. Investigating changes in the proteostasis capabilities of iPSC-neurons during development and in FTD using iPSC-neurons with MAPT mutations. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 2. 2021-12-31. PMID:34971145. |
mutations in microtubule-associated protein tau (mapt) gene are causative of frontotemporal dementia (ftd). |
2021-12-31 |
2023-08-13 |
Not clear |
| Sidhartha Mahali, Celeste Karc. Defective proteostasis in patient-derived iPSC-astrocytes and neurons carrying a MAPT IVS10+16 mutation. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 2. 2021-12-31. PMID:34971182. |
in a subset of frontotemporal dementia (ftd) cases, mutations in the microtubule-associated protein tau (mapt) that alter the relative levels of specific tau isoforms are sufficient to cause tau inclusions in neurons and astroglia and neurodegeneration without the presence of mutated protein (e.g. |
2021-12-31 |
2023-08-13 |
Not clear |
| Sushma, Amal Chandra Monda. Immunotherapeutic Approaches for the Treatment of Neurodegenerative Diseases: Challenges and Outcomes. CNS & neurological disorders drug targets. 2021-12-29. PMID:34963438. |
these proteins are amyloid-β peptide, tau, α-synuclein, and mhtt, which cause alzheimer's disease, frontotemporal dementia, corticobasal degeneration, progressive supranuclear palsy, parkinson's disease, multiple system atrophy, dementia with lewy-body and huntington's disease. |
2021-12-29 |
2023-08-13 |
Not clear |
| Mauro Montalbano, Elizabeth Jaworski, Stephanie Garcia, Anna Ellsworth, Salome McAllen, Andrew Routh, Rakez Kaye. Tau Modulates mRNA Transcription, Alternative Polyadenylation Profiles of hnRNPs, Chromatin Remodeling and Spliceosome Complexes. Frontiers in molecular neuroscience. vol 14. 2021-12-20. PMID:34924950. |
tau protein is a known contributor in several neurodegenerative diseases, including alzheimer's disease (ad) and frontotemporal dementia (ftd). |
2021-12-20 |
2023-08-13 |
human |
| Enrique Luengo, Paula Trigo-Alonso, Cristina Fernández-Mendívil, Ángel Nuñez, Marta Del Campo, César Porrero, Nuria García-Magro, Pilar Negredo, Sergio Senar, Cristina Sánchez-Ramos, Juan A Bernal, Alberto Rábano, Jeroen Hoozemans, Ana I Casas, Harald H H W Schmidt, Manuela G Lópe. Implication of type 4 NADPH oxidase (NOX4) in tauopathy. Redox biology. vol 49. 2021-12-18. PMID:34922273. |
aggregates of the microtubule-associated protein tau are a common marker of neurodegenerative diseases collectively termed as tauopathies, such as alzheimer's disease (ad) and frontotemporal dementia. |
2021-12-18 |
2023-08-13 |
mouse |
| Rebekka Kühn, Aayushi Mahajan, Peter Canoll, Gunnar Hargu. Human Induced Pluripotent Stem Cell Models of Frontotemporal Dementia With Tau Pathology. Frontiers in cell and developmental biology. vol 9. 2021-12-04. PMID:34858989. |
human induced pluripotent stem cell models of frontotemporal dementia with tau pathology. |
2021-12-04 |
2023-08-13 |
human |
| Kathryn R Bowles, M Catarina Silva, Kristen Whitney, Taylor Bertucci, Joshua E Berlind, Jesse D Lai, Jacob C Garza, Nathan C Boles, Sidhartha Mahali, Kevin H Strang, Jacob A Marsh, Cynthia Chen, Derian A Pugh, Yiyuan Liu, Ronald E Gordon, Susan K Goderie, Rebecca Chowdhury, Steven Lotz, Keith Lane, John F Crary, Stephen J Haggarty, Celeste M Karch, Justin K Ichida, Alison M Goate, Sally Templ. ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids. Cell. vol 184. issue 17. 2021-12-03. PMID:34314701. |
frontotemporal dementia (ftd) because of mapt mutation causes pathological accumulation of tau and glutamatergic cortical neuronal death by unknown mechanisms. |
2021-12-03 |
2023-08-13 |
human |
| Sally Kelliny, Jing Xiong, Larisa Bobrovskaya, Xin-Fu Zho. Preclinical validation of a novel oral Edaravone formulation for treatment of frontotemporal dementia. Neurotoxicity research. vol 39. issue 6. 2021-12-03. PMID:34599751. |
herein, we aimed to study the effect of edr on tau pathology in p301l mice; an animal model of frontotemporal dementia (ftd), at two age time points representing the early and late stages of the disease. |
2021-12-03 |
2023-08-13 |
mouse |
| Karima Schwab, Valeria Melis, Charles R Harrington, Claude M Wischik, Mandy Magbagbeolu, Franz Theuring, Gernot Riede. Proteomic Analysis of Hydromethylthionine in the Line 66 Model of Frontotemporal Dementia Demonstrates Actions on Tau-Dependent and Tau-Independent Networks. Cells. vol 10. issue 8. 2021-11-29. PMID:34440931. |
abnormal aggregation of tau is the pathological hallmark of tauopathies including frontotemporal dementia (ftd). |
2021-11-29 |
2023-08-13 |
mouse |
| Mar Pacheco-Herrero, Luis O Soto-Rojas, Heidy Reyes-Sabater, Linda Garcés-Ramirez, Fidel de la Cruz López, Ignacio Villanueva-Fierro, José Luna-Muño. Current Status and Challenges of Stem Cell Treatment for Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 84. issue 3. 2021-11-29. PMID:34633316. |
neurodegenerative diseases called tauopathies, such as alzheimer's disease (ad), frontotemporal dementia, progressive supranuclear palsy, and parkinson's disease, among others, are characterized by the pathological processing and accumulation of tau protein. |
2021-11-29 |
2023-08-13 |
Not clear |
| Jerrik Rydbom, Halea Kohl, Vanesa R Hyde, Kelly M Loh. Altered Gut Microbial Load and Immune Activation in a Frontiers in neuroscience. vol 15. 2021-11-23. PMID:34803581. |
in the family of neurodegenerative diseases known as tauopathies, including alzheimer's disease (ad), frontotemporal dementia (ftd), and chronic traumatic encephalopathy (cte), abnormal tau aggregation destabilizes microtubule structure, contributing to a cascade of cellular processes leading to neuronal cell death. |
2021-11-23 |
2023-08-13 |
Not clear |