| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Buée, T Bussière, V Buée-Scherrer, A Delacourte, P R Ho. Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain research. Brain research reviews. vol 33. issue 1. 2000-09-28. PMID:10967355. |
the recent discovery of tau gene mutations in frontotemporal dementia with parkinsonism linked to chromosome 17 has reinforced the predominant role attributed to tau proteins in the pathogenesis of neurodegenerative disorders, and underlined the fact that distinct sets of tau isoforms expressed in different neuronal populations could lead to different pathologies. |
2000-09-28 |
2023-08-12 |
human |
| M Goedert, M G Spillantin. Tau mutations in frontotemporal dementia FTDP-17 and their relevance for Alzheimer's disease. Biochimica et biophysica acta. vol 1502. issue 1. 2000-09-25. PMID:10899436. |
tau mutations in frontotemporal dementia ftdp-17 and their relevance for alzheimer's disease. |
2000-09-25 |
2023-08-12 |
Not clear |
| M Goedert, M G Spillantin. Tau mutations in frontotemporal dementia FTDP-17 and their relevance for Alzheimer's disease. Biochimica et biophysica acta. vol 1502. issue 1. 2000-09-25. PMID:10899436. |
the discovery of mutations in the tau gene in familial frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17) has provided a direct link between tau dysfunction and dementing disease. |
2000-09-25 |
2023-08-12 |
Not clear |
| M Tolnay, M Grazia Spillantini, C Rizzini, D Eccles, J Lowe, D Elliso. A new case of frontotemporal dementia and parkinsonism resulting from an intron 10 +3-splice site mutation in the tau gene: clinical and pathological features. Neuropathology and applied neurobiology. vol 26. issue 4. 2000-09-19. PMID:10931371. |
a new case of frontotemporal dementia and parkinsonism resulting from an intron 10 +3-splice site mutation in the tau gene: clinical and pathological features. |
2000-09-19 |
2023-08-12 |
Not clear |
| M Tolnay, M Grazia Spillantini, C Rizzini, D Eccles, J Lowe, D Elliso. A new case of frontotemporal dementia and parkinsonism resulting from an intron 10 +3-splice site mutation in the tau gene: clinical and pathological features. Neuropathology and applied neurobiology. vol 26. issue 4. 2000-09-19. PMID:10931371. |
hereditary frontotemporal dementia and parkinsonism (ftdp) linked to chromosome 17 (ftdp-17) constitutes a new form of tauopathy, and mutations in the tau gene have recently been reported in some affected families. |
2000-09-19 |
2023-08-12 |
Not clear |
| J Lewis, E McGowan, J Rockwood, H Melrose, P Nacharaju, M Van Slegtenhorst, K Gwinn-Hardy, M Paul Murphy, M Baker, X Yu, K Duff, J Hardy, A Corral, W L Lin, S H Yen, D W Dickson, P Davies, M Hutto. Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nature genetics. vol 25. issue 4. 2000-08-28. PMID:10932182. |
mutations in the gene (mtapt) encoding tau protein cause frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17), thereby proving that tau dysfunction can directly result in neurodegeneration. |
2000-08-28 |
2023-08-12 |
mouse |
| E Vanmechelen, H Vanderstichele, P Davidsson, E Van Kerschaver, B Van Der Perre, M Sjögren, N Andreasen, K Blenno. Quantification of tau phosphorylated at threonine 181 in human cerebrospinal fluid: a sandwich ELISA with a synthetic phosphopeptide for standardization. Neuroscience letters. vol 285. issue 1. 2000-08-22. PMID:10788705. |
in every diagnostic group, a highly significant correlation was found between total tau and phospho-tau (alzheimer's disease, r(2)=0.73; frontotemporal dementia, r(2)=0.43; control, r(2)=0.42), suggesting that the degree of phosphorylation of csf-tau changes in different clinical conditions. |
2000-08-22 |
2023-08-12 |
human |
| K Kodama, S Okada, E Iseki, A Kowalska, T Tabira, N Hosoi, N Yamanouchi, S Noda, N Komatsu, M Nakazato, C Kumakiri, M Yazaki, T Sat. Familial frontotemporal dementia with a P301L tau mutation in Japan. Journal of the neurological sciences. vol 176. issue 1. 2000-08-21. PMID:10865093. |
familial frontotemporal dementia with a p301l tau mutation in japan. |
2000-08-21 |
2023-08-12 |
Not clear |
| I D'Souza, G D Schellenber. Determinants of 4-repeat tau expression. Coordination between enhancing and inhibitory splicing sequences for exon 10 inclusion. The Journal of biological chemistry. vol 275. issue 23. 2000-07-20. PMID:10748133. |
mutations in the tau gene are pathogenic causing autosomal dominant frontotemporal dementia with parkinsonism-chromosome 17 type (ftdp-17). |
2000-07-20 |
2023-08-12 |
Not clear |
| A Probst, J Götz, K H Wiederhold, M Tolnay, C Mistl, A L Jaton, M Hong, T Ishihara, V M Lee, J Q Trojanowski, R Jakes, R A Crowther, M G Spillantini, K Bürki, M Goeder. Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein. Acta neuropathologica. vol 99. issue 5. 2000-07-17. PMID:10805089. |
coding region and intronic mutations in the tau gene cause frontotemporal dementia and parkinsonism linked to chromosome 17. |
2000-07-17 |
2023-08-12 |
mouse |
| Z Jiang, J Cote, J M Kwon, A M Goate, J Y W. Aberrant splicing of tau pre-mRNA caused by intronic mutations associated with the inherited dementia frontotemporal dementia with parkinsonism linked to chromosome 17. Molecular and cellular biology. vol 20. issue 11. 2000-07-06. PMID:10805746. |
aberrant splicing of tau pre-mrna caused by intronic mutations associated with the inherited dementia frontotemporal dementia with parkinsonism linked to chromosome 17. |
2000-07-06 |
2023-08-12 |
human |
| Z Jiang, J Cote, J M Kwon, A M Goate, J Y W. Aberrant splicing of tau pre-mRNA caused by intronic mutations associated with the inherited dementia frontotemporal dementia with parkinsonism linked to chromosome 17. Molecular and cellular biology. vol 20. issue 11. 2000-07-06. PMID:10805746. |
frontotemporal dementia with parkinsonism linked to chromosome 17 is associated with either exonic or intronic mutations in the tau gene. |
2000-07-06 |
2023-08-12 |
human |
| J M Kwon, P Nowotny, P K Shah, S Chakraverty, J Norton, J C Morris, A M Goat. Tau polymorphisms are not associated with Alzheimer's disease. Neuroscience letters. vol 284. issue 1-2. 2000-07-03. PMID:10771166. |
alzheimer's disease (ad) is one of a number of neurodegenerative conditions including frontotemporal dementia and progressive supranuclear palsy that are associated with abnormal tau protein aggregates in neurons. |
2000-07-03 |
2023-08-12 |
Not clear |
| J M Kwon, P Nowotny, P K Shah, S Chakraverty, J Norton, J C Morris, A M Goat. Tau polymorphisms are not associated with Alzheimer's disease. Neuroscience letters. vol 284. issue 1-2. 2000-07-03. PMID:10771166. |
mutations in the tau gene cause familial forms of frontotemporal dementia and alleles of the tau gene have been associated with risk for progressive supranuclear palsy. |
2000-07-03 |
2023-08-12 |
Not clear |
| T C Gamblin, M E King, H Dawson, M P Vitek, J Kuret, R W Berry, L I Binde. In vitro polymerization of tau protein monitored by laser light scattering: method and application to the study of FTDP-17 mutants. Biochemistry. vol 39. issue 20. 2000-06-21. PMID:10821687. |
laser light scattering was then used to measure the efficiency with which the mutant tau proteins found in frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17) form filamentous structures. |
2000-06-21 |
2023-08-12 |
Not clear |
| M G Spillantini, M Goeder. Tau mutations in familial frontotemporal dementia. Brain : a journal of neurology. vol 123 ( Pt 5). 2000-06-06. PMID:10775532. |
tau mutations in familial frontotemporal dementia. |
2000-06-06 |
2023-08-12 |
Not clear |
| P M Stanford, G M Halliday, W S Brooks, J B Kwok, C E Storey, H Creasey, J G Morris, M J Fulham, P R Schofiel. Progressive supranuclear palsy pathology caused by a novel silent mutation in exon 10 of the tau gene: expansion of the disease phenotype caused by tau gene mutations. Brain : a journal of neurology. vol 123 ( Pt 5). 2000-06-06. PMID:10775534. |
genetic mutations in the tau gene on chromosome 17 are known to cause frontotemporal dementias. |
2000-06-06 |
2023-08-12 |
human |
| M Sjögren, L Rosengren, L Minthon, P Davidsson, K Blennow, A Walli. Cytoskeleton proteins in CSF distinguish frontotemporal dementia from AD. Neurology. vol 54. issue 10. 2000-06-06. PMID:10822437. |
to investigate the csf levels of tau and the light neurofilament protein (nfl) in patients with frontotemporal dementia (ftd) and other common dementia disorders as well as normal control subjects. |
2000-06-06 |
2023-08-12 |
human |
| N Sahara, T Tomiyama, H Mor. Missense point mutations of tau to segregate with FTDP-17 exhibit site-specific effects on microtubule structure in COS cells: a novel action of R406W mutation. Journal of neuroscience research. vol 60. issue 3. 2000-06-02. PMID:10797541. |
missense and splicing point mutations have been found in the tau gene in families with frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17). |
2000-06-02 |
2023-08-12 |
Not clear |
| P Heutin. Untangling tau-related dementia. Human molecular genetics. vol 9. issue 6. 2000-05-31. PMID:10767321. |
abundant cytoplasmic inclusions consisting of aggregated hyperphosphorylated protein tau are a characteristic pathological observation in several neurodegenerative disorders such as alzheimer's disease, pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. |
2000-05-31 |
2023-08-12 |
Not clear |