| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Goeder. Filamentous nerve cell inclusions in neurodegenerative diseases: tauopathies and alpha-synucleinopathies. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 354. issue 1386. 1999-08-26. PMID:10434313. |
the recent discovery of mutations in the tau gene in familial forms of frontotemporal dementia has provided a direct link between tau dysfunction and dementing disease. |
1999-08-26 |
2023-08-12 |
Not clear |
| M Goedert, R Jakes, R A Crowthe. Effects of frontotemporal dementia FTDP-17 mutations on heparin-induced assembly of tau filaments. FEBS letters. vol 450. issue 3. 1999-07-22. PMID:10359094. |
effects of frontotemporal dementia ftdp-17 mutations on heparin-induced assembly of tau filaments. |
1999-07-22 |
2023-08-12 |
Not clear |
| M Goedert, R Jakes, R A Crowthe. Effects of frontotemporal dementia FTDP-17 mutations on heparin-induced assembly of tau filaments. FEBS letters. vol 450. issue 3. 1999-07-22. PMID:10359094. |
missense mutations and intronic mutations in the gene for microtubule-associated protein tau cause frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17). |
1999-07-22 |
2023-08-12 |
Not clear |
| M Goedert, R Jakes, R A Crowthe. Effects of frontotemporal dementia FTDP-17 mutations on heparin-induced assembly of tau filaments. FEBS letters. vol 450. issue 3. 1999-07-22. PMID:10359094. |
these findings indicate that missense mutations in tau lead to frontotemporal dementia through potentially multiple mechanisms. |
1999-07-22 |
2023-08-12 |
Not clear |
| Y Mizuno, N Hattori, H Mor. Genetics of Parkinson's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 53. issue 3. 1999-07-21. PMID:10349506. |
in addition, the tau gene has been shown to be the disease gene for familial frontotemporal dementia and parkinsonism linked to chromosome 17. |
1999-07-21 |
2023-08-12 |
Not clear |
| N Matsumura, T Yamazaki, Y Ihar. Stable expression in Chinese hamster ovary cells of mutated tau genes causing frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). The American journal of pathology. vol 154. issue 6. 1999-07-14. PMID:10362789. |
stable expression in chinese hamster ovary cells of mutated tau genes causing frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17). |
1999-07-14 |
2023-08-12 |
Not clear |
| N Matsumura, T Yamazaki, Y Ihar. Stable expression in Chinese hamster ovary cells of mutated tau genes causing frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). The American journal of pathology. vol 154. issue 6. 1999-07-14. PMID:10362789. |
extensive neuronal loss and aggregation of tau as cytoplasmic inclusions in neurons and glial cells in selected cortical and subcortical regions is the most striking characteristic of frontotemporal dementia and parkinsonism linked to chromosome 17, which is caused by exonic or intronic mutations in the tau gene. |
1999-07-14 |
2023-08-12 |
Not clear |
| C Janke, M Beck, T Stahl, M Holzer, K Brauer, V Bigl, T Arend. Phylogenetic diversity of the expression of the microtubule-associated protein tau: implications for neurodegenerative disorders. Brain research. Molecular brain research. vol 68. issue 1-2. 1999-07-07. PMID:10320789. |
especially, the unique expression pattern of tau isoforms in the human central nervous system implicates a possible link to the particular vulnerability of humans to neurodegenerative disorders with tauopathy, namely alzheimer's disease, frontotemporal dementia and pick's disease. |
1999-07-07 |
2023-08-12 |
human |
| O Bugiani, J R Murrell, G Giaccone, M Hasegawa, G Ghigo, M Tabaton, M Morbin, A Primavera, F Carella, C Solaro, M Grisoli, M Savoiardo, M G Spillantini, F Tagliavini, M Goedert, B Ghett. Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau. Journal of neuropathology and experimental neurology. vol 58. issue 6. 1999-07-07. PMID:10374757. |
frontotemporal dementia and corticobasal degeneration in a family with a p301s mutation in tau. |
1999-07-07 |
2023-08-12 |
Not clear |
| O Bugiani, J R Murrell, G Giaccone, M Hasegawa, G Ghigo, M Tabaton, M Morbin, A Primavera, F Carella, C Solaro, M Grisoli, M Savoiardo, M G Spillantini, F Tagliavini, M Goedert, B Ghett. Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau. Journal of neuropathology and experimental neurology. vol 58. issue 6. 1999-07-07. PMID:10374757. |
one individual presented with frontotemporal dementia, whereas his son has corticobasal degeneration, demonstrating that the same primary gene defect in tau can lead to 2 distinct clinical phenotypes. |
1999-07-07 |
2023-08-12 |
Not clear |
| Z S Nasreddine, M Loginov, L N Clark, J Lamarche, B L Miller, A Lamontagne, V Zhukareva, V M Lee, K C Wilhelmsen, D H Geschwin. From genotype to phenotype: a clinical pathological, and biochemical investigation of frontotemporal dementia and parkinsonism (FTDP-17) caused by the P301L tau mutation. Annals of neurology. vol 45. issue 6. 1999-06-24. PMID:10360762. |
from genotype to phenotype: a clinical pathological, and biochemical investigation of frontotemporal dementia and parkinsonism (ftdp-17) caused by the p301l tau mutation. |
1999-06-24 |
2023-08-12 |
Not clear |
| Z S Nasreddine, M Loginov, L N Clark, J Lamarche, B L Miller, A Lamontagne, V Zhukareva, V M Lee, K C Wilhelmsen, D H Geschwin. From genotype to phenotype: a clinical pathological, and biochemical investigation of frontotemporal dementia and parkinsonism (FTDP-17) caused by the P301L tau mutation. Annals of neurology. vol 45. issue 6. 1999-06-24. PMID:10360762. |
mutational analysis of the tau coding region identified a c-to-t change in exon 10 that resulted in the conversion of proline to a leucine (p301l) that segregated with frontotemporal dementia in this family. |
1999-06-24 |
2023-08-12 |
Not clear |
| S Arawaka, M Usami, N Sahara, G D Schellenberg, G Lee, H Mor. The tau mutation (val337met) disrupts cytoskeletal networks of microtubules. Neuroreport. vol 10. issue 5. 1999-06-23. PMID:10321473. |
the missense point mutation found in the tau gene, which was segregated in a family with frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17), has proved to be the causal molecule for widely spread dementia diseases. |
1999-06-23 |
2023-08-12 |
Not clear |
| A J Green, R J Harvey, E J Thompson, M N Rosso. Increased tau in the cerebrospinal fluid of patients with frontotemporal dementia and Alzheimer's disease. Neuroscience letters. vol 259. issue 2. 1999-06-18. PMID:10025576. |
increased tau in the cerebrospinal fluid of patients with frontotemporal dementia and alzheimer's disease. |
1999-06-18 |
2023-08-12 |
human |
| A J Green, R J Harvey, E J Thompson, M N Rosso. Increased tau in the cerebrospinal fluid of patients with frontotemporal dementia and Alzheimer's disease. Neuroscience letters. vol 259. issue 2. 1999-06-18. PMID:10025576. |
levels of csf tau were measured in 17 patients with alzheimer's disease and 23 patients with frontotemporal dementia, and were compared to age-matched healthy controls. |
1999-06-18 |
2023-08-12 |
human |
| A J Green, R J Harvey, E J Thompson, M N Rosso. Increased tau in the cerebrospinal fluid of patients with frontotemporal dementia and Alzheimer's disease. Neuroscience letters. vol 259. issue 2. 1999-06-18. PMID:10025576. |
csf tau concentrations were significantly raised in patients with both alzheimer's disease and frontotemporal dementia when compared to healthy controls (802+/-381 pg/ml, p<0.001; 612+/-382 pg/ml, p<0.05, respectively). |
1999-06-18 |
2023-08-12 |
human |
| A J Green, R J Harvey, E J Thompson, M N Rosso. Increased tau in the cerebrospinal fluid of patients with frontotemporal dementia and Alzheimer's disease. Neuroscience letters. vol 259. issue 2. 1999-06-18. PMID:10025576. |
this study shows that csf tau is significantly raised in patients with frontotemporal dementia. |
1999-06-18 |
2023-08-12 |
human |
| I D'Souza, P Poorkaj, M Hong, D Nochlin, V M Lee, T D Bird, G D Schellenber. Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 10. 1999-06-17. PMID:10318930. |
missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative rna splicing regulatory elements. |
1999-06-17 |
2023-08-12 |
Not clear |
| I D'Souza, P Poorkaj, M Hong, D Nochlin, V M Lee, T D Bird, G D Schellenber. Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 10. 1999-06-17. PMID:10318930. |
frontotemporal dementia with parkinsonism, chromosome 17 type (ftdp-17) is caused by mutations in the tau gene, and the signature lesions of ftdp-17 are filamentous tau inclusions. |
1999-06-17 |
2023-08-12 |
Not clear |
| M Iijima, T Tabira, P Poorkaj, G D Schellenberg, J Q Trojanowski, V M Lee, M L Schmidt, K Takahashi, T Nabika, T Matsumoto, Y Yamashita, S Yoshioka, H Ishin. A distinct familial presenile dementia with a novel missense mutation in the tau gene. Neuroreport. vol 10. issue 3. 1999-06-10. PMID:10208578. |
we report a japanese family with early onset hereditary frontotemporal dementia and a novel missense mutation (ser305asn) in the tau gene. |
1999-06-10 |
2023-08-12 |
Not clear |