| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Ho, Z Xiang, P Mukherjee, W Zhang, N De Jesus, M Mirjany, S Yemul, G M Pasinett. Gene expression profiling of the tau mutant (P301L) transgenic mouse brain. Neuroscience letters. vol 310. issue 1. 2001-10-25. PMID:11524143. |
to provide a global analysis of the influence of tau neuropathology at molecular level, we used cdna arrays representing 8832 genes to determine the mrna expression profile in transgenic mice expressing the most common frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17) tau mutation (p301l) (nat. |
2001-10-25 |
2023-08-12 |
mouse |
| A M Hartmann, D Rujescu, T Giannakouros, E Nikolakaki, M Goedert, E M Mandelkow, Q S Gao, A Andreadis, S Stam. Regulation of alternative splicing of human tau exon 10 by phosphorylation of splicing factors. Molecular and cellular neurosciences. vol 18. issue 1. 2001-09-27. PMID:11461155. |
mutations increasing the inclusion of exon 10 result in the production of tau protein which predominantly contains four microtubule-binding repeats and were shown to cause frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17). |
2001-09-27 |
2023-08-12 |
human |
| Z Arvanitakis, Z K Wszole. Recent advances in the understanding of tau protein and movement disorders. Current opinion in neurology. vol 14. issue 4. 2001-09-20. PMID:11470966. |
the accumulation of pathological tau is a major substrate of frontotemporal dementia and parkinsonism linked to chromosome 17, progressive supranuclear palsy, and corticobasal degeneration. |
2001-09-20 |
2023-08-12 |
Not clear |
| V M Lee, M Goedert, J Q Trojanowsk. Neurodegenerative tauopathies. Annual review of neuroscience. vol 24. 2001-09-13. PMID:11520930. |
prominent filamentous tau inclusions and brain degeneration in the absence of beta-amyloid deposits are also hallmarks of neurodegenerative tauopathies exemplified by sporadic corticobasal degeneration, progressive supranuclear palsy, and pick's disease, as well as by hereditary frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17). |
2001-09-13 |
2023-08-12 |
Not clear |
| J Göt. Tau and transgenic animal models. Brain research. Brain research reviews. vol 35. issue 3. 2001-08-30. PMID:11423157. |
tau filament formation, in the absence of abeta production, is also a feature of several additional neurodegenerative diseases including progressive supranuclear palsy, corticobasal degeneration, pick's disease, and frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17). |
2001-08-30 |
2023-08-12 |
mouse |
| J Götz, M Tolnay, R Barmettler, F Chen, A Probst, R M Nitsc. Oligodendroglial tau filament formation in transgenic mice expressing G272V tau. The European journal of neuroscience. vol 13. issue 11. 2001-08-23. PMID:11422454. |
genetic evidence indicates that several mutations in tau, including g272v, are linked to frontotemporal dementia with parkinsonism. |
2001-08-23 |
2023-08-12 |
mouse |
| M Ingelson, S F Fabre, L Lilius, C Andersen, M Viitanen, O Almkvist, L O Wahlund, L Lannfel. Increased risk for frontotemporal dementia through interaction between tau polymorphisms and apolipoprotein E epsilon4. Neuroreport. vol 12. issue 5. 2001-08-09. PMID:11303757. |
increased risk for frontotemporal dementia through interaction between tau polymorphisms and apolipoprotein e epsilon4. |
2001-08-09 |
2023-08-12 |
Not clear |
| M Ingelson, S F Fabre, L Lilius, C Andersen, M Viitanen, O Almkvist, L O Wahlund, L Lannfel. Increased risk for frontotemporal dementia through interaction between tau polymorphisms and apolipoprotein E epsilon4. Neuroreport. vol 12. issue 5. 2001-08-09. PMID:11303757. |
the tau gene has an important role in frontotemporal dementia (ftd) as pathogenic mutations have been found in hereditary forms of the disease. |
2001-08-09 |
2023-08-12 |
Not clear |
| N Lev, E Melame. Heredity in Parkinson's disease: new findings. The Israel Medical Association journal : IMAJ. vol 3. issue 6. 2001-07-26. PMID:11433638. |
abnormal tau protein was found to be the cause of familial frontotemporal dementia and parkinsonism. |
2001-07-26 |
2023-08-12 |
mouse |
| D S Knopma. An overview of common non-Alzheimer dementias. Clinics in geriatric medicine. vol 17. issue 2. 2001-07-12. PMID:11375136. |
at least some of the frontotemporal dementias, which in this article encompass the progressive aphasias, have mutations in the tau gene that account for some of the phenotypic variations. |
2001-07-12 |
2023-08-12 |
Not clear |
| M Hutto. Missense and splice site mutations in tau associated with FTDP-17: multiple pathogenic mechanisms. Neurology. vol 56. issue 11 Suppl 4. 2001-06-28. PMID:11402146. |
recent identification of mutations in the gene encoding the microtubule-associated protein tau in the inherited frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17) has demonstrated that tau dysfunction can lead to neurodegeneration. |
2001-06-28 |
2023-08-12 |
Not clear |
| M Sjögren, P Davidsson, M Tullberg, L Minthon, A Wallin, C Wikkelso, A K Granérus, H Vanderstichele, E Vanmechelen, K Blenno. Both total and phosphorylated tau are increased in Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 70. issue 5. 2001-06-21. PMID:11309456. |
[corrected] pathological tau protein concentrations in csf are found in both alzheimer's disease (ad) and frontotemporal dementia (ftd), but studies on brain tissue have suggested that the tau pathology in ad differs from that in ftd and that the difference may be related to the degree of phosphorylation. |
2001-06-21 |
2023-08-12 |
Not clear |
| R A Halverson, C B Chambers, N A Mum. Alternative splicing of amino-terminal Tau mRNA in rat spinal cord during development and following axonal injury. Experimental neurology. vol 169. issue 1. 2001-06-07. PMID:11312563. |
tau isoforms that include exon 10 are overexpressed in frontotemporal dementia and progressive supranuclear palsy. |
2001-06-07 |
2023-08-12 |
rat |
| M S Forman, V M Lee, J Q Trojanowsk. New insights into genetic and molecular mechanisms of brain degeneration in tauopathies. Journal of chemical neuroanatomy. vol 20. issue 3-4. 2001-05-24. PMID:11207421. |
the discovery of multiple tau gene mutations that are pathogenic for hereditary frontotemporal dementia and parkinsonism linked to chromosome 17 in many kindreds, as well as the demonstration that tau polymorphisms are genetic risk factors for sporadic tauopathies, directly implicate tau abnormalities in the onset/progression of neurodegenerative disease. |
2001-05-24 |
2023-08-12 |
Not clear |
| M Tolnay, A Probs. Frontotemporal lobar degeneration. An update on clinical, pathological and genetic findings. Gerontology. vol 47. issue 1. 2001-05-21. PMID:11244285. |
in contrast, pick's disease and familial frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17) are both characterized by abundant filamentous nerve cell inclusions made up of the microtubule-associated protein tau. |
2001-05-21 |
2023-08-12 |
Not clear |
| S F Fabre, C Forsell, M Viitanen, M Sjögren, A Wallin, K Blennow, M Blomberg, C Andersen, L O Wahlund, L Lannfel. Clinic-based cases with frontotemporal dementia show increased cerebrospinal fluid tau and high apolipoprotein E epsilon4 frequency, but no tau gene mutations. Experimental neurology. vol 168. issue 2. 2001-05-10. PMID:11259129. |
clinic-based cases with frontotemporal dementia show increased cerebrospinal fluid tau and high apolipoprotein e epsilon4 frequency, but no tau gene mutations. |
2001-05-10 |
2023-08-12 |
Not clear |
| S F Fabre, C Forsell, M Viitanen, M Sjögren, A Wallin, K Blennow, M Blomberg, C Andersen, L O Wahlund, L Lannfel. Clinic-based cases with frontotemporal dementia show increased cerebrospinal fluid tau and high apolipoprotein E epsilon4 frequency, but no tau gene mutations. Experimental neurology. vol 168. issue 2. 2001-05-10. PMID:11259129. |
frontotemporal dementia (ftd) belongs to a group of neurodegenerative disorders known as tauopathies, characterized by intracellular aggregation of hyperphosphorylated tau protein in the brain. |
2001-05-10 |
2023-08-12 |
Not clear |
| C Russ, S Lovestone, M Baker, S M Pickering-Brown, P M Andersen, R Furlong, D Mann, J F Powel. The extended haplotype of the microtubule associated protein tau gene is not associated with Pick's disease. Neuroscience letters. vol 299. issue 1-2. 2001-05-03. PMID:11166961. |
the tauopathy, familial frontotemporal dementia (ftd), is caused by mutations in the tau gene. |
2001-05-03 |
2023-08-12 |
Not clear |
| A C Ludolph, A Sperfeld, B M Collatz, A Storc. [Tauopathies--a new class of neurodegenerative diseases]. Der Nervenarzt. vol 72. issue 2. 2001-05-03. PMID:11256158. |
recently it was shown by several research groups that mutations in the gene encoding for the tau protein associated with microtubuli on chromosome 17 caused a distinct form of dementia named frontotemporal dementia and parkinsonism (ftdp-17). |
2001-05-03 |
2023-08-12 |
Not clear |
| E W Nagiec, K E Sampson, I Abraha. Mutated tau binds less avidly to microtubules than wildtype tau in living cells. Journal of neuroscience research. vol 63. issue 3. 2001-04-26. PMID:11170176. |
some forms of genetically inherited dementia, including frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17), are caused by mutations in tau. |
2001-04-26 |
2023-08-12 |
human |