| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chizu Wada, Itaru Toyoshim. [Clinical symptoms and speech disturbance in frontotemporal dementia and parkinsonism linked to chromosome 17 with tau mutation]. No to shinkei = Brain and nerve. vol 54. issue 3. 2002-04-30. PMID:11968813. |
[clinical symptoms and speech disturbance in frontotemporal dementia and parkinsonism linked to chromosome 17 with tau mutation]. |
2002-04-30 |
2023-08-12 |
Not clear |
| Shintaro Hayashi, Yasuko Toyoshima, Masato Hasegawa, Yuri Umeda, Koichi Wakabayashi, Susumu Tokiguchi, Takeshi Iwatsubo, Hitoshi Takahash. Late-onset frontotemporal dementia with a novel exon 1 (Arg5His) tau gene mutation. Annals of neurology. vol 51. issue 4. 2002-04-18. PMID:11921059. |
late-onset frontotemporal dementia with a novel exon 1 (arg5his) tau gene mutation. |
2002-04-18 |
2023-08-12 |
Not clear |
| Y Yoshiyama, V M Lee, J Q Trojanowsk. Frontotemporal dementia and tauopathy. Current neurology and neuroscience reports. vol 1. issue 5. 2002-04-09. PMID:11898551. |
the discovery of mutations in the tau gene in frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17) constitutes convincing evidence that tau proteins play a key role in the pathogenesis of neurodegenerative disorders. |
2002-04-09 |
2023-08-12 |
mouse |
| Y Yoshiyama, V M Lee, J Q Trojanowsk. Frontotemporal dementia and tauopathy. Current neurology and neuroscience reports. vol 1. issue 5. 2002-04-09. PMID:11898551. |
moreover, it now is known that the most common form of sporadic frontotemporal dementia (ftd), which is characterized by frontotemporal neuron loss, gliosis, and microvacuolar change, also is a tauopathy caused by a loss of tau protein expression. |
2002-04-09 |
2023-08-12 |
mouse |
| Patrice Delobel, Stéphane Flament, Malika Hamdane, Ross Jakes, Arlette Rousseau, André Delacourte, Jean-Pierre Vilain, Michel Goedert, Luc Bué. Functional characterization of FTDP-17 tau gene mutations through their effects on Xenopus oocyte maturation. The Journal of biological chemistry. vol 277. issue 11. 2002-04-05. PMID:11756436. |
tau gene mutations cause frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17). |
2002-04-05 |
2023-08-12 |
xenopus_laevis |
| Hirotaka Yoshida, R Anthony Crowther, Michel Goeder. Functional effects of tau gene mutations deltaN296 and N296H. Journal of neurochemistry. vol 80. issue 3. 2002-04-04. PMID:11906000. |
mutations in the tau gene cause frontotemporal dementia and parkinsonism linked to chromosome-17 (ftdp-17). |
2002-04-04 |
2023-08-12 |
Not clear |
| Magnus Sjögren, Pia Davidsson, Anders Wallin, Ann-Kathrine Granérus, Eva Grundström, Håkan Askmark, Eugeen Vanmechelen, Kaj Blenno. Decreased CSF-beta-amyloid 42 in Alzheimer's disease and amyotrophic lateral sclerosis may reflect mismetabolism of beta-amyloid induced by disparate mechanisms. Dementia and geriatric cognitive disorders. vol 13. issue 2. 2002-04-01. PMID:11844893. |
both tau and beta-amyloid 42 (abeta42) have been implicated in alzheimer's disease (ad) and tau alone in frontotemporal dementia (ftd) and amyotrophic lateral sclerosis (als). |
2002-04-01 |
2023-08-12 |
Not clear |
| H R Morris, R Katzenschlager, J C Janssen, J M Brown, M Ozansoy, N Quinn, T Revesz, M N Rossor, S E Daniel, N W Wood, A J Lee. Sequence analysis of tau in familial and sporadic progressive supranuclear palsy. Journal of neurology, neurosurgery, and psychiatry. vol 72. issue 3. 2002-03-28. PMID:11861703. |
recently familial frontotemporal dementia linked to chromosome 17 (ftdp-17) has been shown to be due to mutations in tau and there may be a clinical and pathological overlap between psp and ftdp-17. |
2002-03-28 |
2023-08-12 |
Not clear |
| Sonia M Rosso, Esther van Herpen, Wout Deelen, Wouter Kamphorst, Lies-Anne Severijnen, Rob Willemsen, Rivka Ravid, Martinus F Niermeijer, Dennis Dooijes, Michael J Smith, Michel Goedert, Peter Heutink, John C van Swiete. A novel tau mutation, S320F, causes a tauopathy with inclusions similar to those in Pick's disease. Annals of neurology. vol 51. issue 3. 2002-03-28. PMID:11891833. |
mutations in the tau gene cause familial frontotemporal dementia and parkinsonism linked to chromosome 17. |
2002-03-28 |
2023-08-12 |
Not clear |
| M Goedert, M G Spillantini, L C Serpell, J Berriman, M J Smith, R Jakes, R A Crowthe. From genetics to pathology: tau and alpha-synuclein assemblies in neurodegenerative diseases. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 356. issue 1406. 2002-03-20. PMID:11260802. |
importantly, the discovery of mutations in the tau gene in familial forms of frontotemporal dementia and of mutations in the alpha-synuclein gene in familial forms of parkinson's disease has established that dysfunction of tau protein and alpha-synuclein can cause neurodegeneration. |
2002-03-20 |
2023-08-12 |
human |
| T G Mack, R Dayanandan, M Van Slegtenhorst, A Whone, M Hutton, S Lovestone, B H Anderto. Tau proteins with frontotemporal dementia-17 mutations have both altered expression levels and phosphorylation profiles in differentiated neuroblastoma cells. Neuroscience. vol 108. issue 4. 2002-03-14. PMID:11738505. |
the inherited form of frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17) has been attributed to mutations in the tau gene. |
2002-03-14 |
2023-08-12 |
Not clear |
| G Heidary, M E Fortin. Identification and characterization of the Drosophila tau homolog. Mechanisms of development. vol 108. issue 1-2. 2002-03-05. PMID:11578871. |
the identification of mutations in the tau locus in patients with familial frontotemporal dementia and parkinsonism linked to chromosome 17 has demonstrated that mutations in tau are sufficient to cause neurodegenerative disease (poorkaj et al., ann. |
2002-03-05 |
2023-08-12 |
human |
| K Tanemura, T Akagi, M Murayama, N Kikuchi, O Murayama, T Hashikawa, Y Yoshiike, J M Park, K Matsuda, S Nakao, X Sun, S Sato, H Yamaguchi, A Takashim. Formation of filamentous tau aggregations in transgenic mice expressing V337M human tau. Neurobiology of disease. vol 8. issue 6. 2002-02-21. PMID:11741399. |
these mice contain a tau gene with a mutation of the frontotemporal dementia parkinsonism (ftdp-17) type, in which valine is substituted with methionine residue 337. |
2002-02-21 |
2023-08-12 |
mouse |
| F Lim, F Hernández, J J Lucas, P Gómez-Ramos, M A Morán, J Avil. FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and Tau filaments in forebrain. Molecular and cellular neurosciences. vol 18. issue 6. 2002-02-21. PMID:11749044. |
the tauopathies, which include alzheimer's disease (ad) and frontotemporal dementias, are a group of neurodegenerative disorders characterized by filamentous tau aggregates. |
2002-02-21 |
2023-08-12 |
mouse |
| F Lim, F Hernández, J J Lucas, P Gómez-Ramos, M A Morán, J Avil. FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and Tau filaments in forebrain. Molecular and cellular neurosciences. vol 18. issue 6. 2002-02-21. PMID:11749044. |
that tau dysfunction can cause neurodegeneration is indicated by pathogenic tau mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17). |
2002-02-21 |
2023-08-12 |
mouse |
| Christopher D Syme, Ewan W Blanch, Carl Holt, Ross Jakes, Michel Goedert, Lutz Hecht, Laurence D Barro. A Raman optical activity study of rheomorphism in caseins, synucleins and tau. New insight into the structure and behaviour of natively unfolded proteins. European journal of biochemistry. vol 269. issue 1. 2002-02-21. PMID:11784308. |
new insight into the structures of these proteins has been provided by a raman optical activity study, supplemented with differential scanning calorimetry, of bovine beta- and kappa-casein, recombinant human alpha-, beta- and gamma-synuclein, together with the a30p and a53t mutants of alpha-synuclein associated with familial cases of parkinson's disease, and recombinant human tau 46 together with the tau 46 p301l mutant associated with inherited frontotemporal dementia. |
2002-02-21 |
2023-08-12 |
human |
| Kentaro Tanemura, Miyuki Murayama, Takumi Akagi, Tsutomu Hashikawa, Takashi Tominaga, Michinori Ichikawa, Haruyasu Yamaguchi, Akihiko Takashim. Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 1. 2002-02-04. PMID:11756496. |
we have developed a transgenic (tg) mouse expressing mutant human tau (v337m), derived from frontotemporal dementia parkinsonism-17. |
2002-02-04 |
2023-08-12 |
mouse |
| M von Bergen, S Barghorn, L Li, A Marx, J Biernat, E M Mandelkow, E Mandelko. Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure. The Journal of biological chemistry. vol 276. issue 51. 2002-01-31. PMID:11606569. |
mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure. |
2002-01-31 |
2023-08-12 |
Not clear |
| M von Bergen, S Barghorn, L Li, A Marx, J Biernat, E M Mandelkow, E Mandelko. Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure. The Journal of biological chemistry. vol 276. issue 51. 2002-01-31. PMID:11606569. |
we also show that two of the tau mutations found in hereditary frontotemporal dementias, deltak280 and p301l, have a much stronger tendency for phf aggregation which correlates with their high propensity for beta-structure around the hexapeptide motifs. |
2002-01-31 |
2023-08-12 |
Not clear |
| E Iseki, T Matsumura, W Marui, H Hino, T Odawara, N Sugiyama, K Suzuki, H Sawada, T Arai, K Kosak. Familial frontotemporal dementia and parkinsonism with a novel N296H mutation in exon 10 of the tau gene and a widespread tau accumulation in the glial cells. Acta neuropathologica. vol 102. issue 3. 2002-01-24. PMID:11585254. |
familial frontotemporal dementia and parkinsonism with a novel n296h mutation in exon 10 of the tau gene and a widespread tau accumulation in the glial cells. |
2002-01-24 |
2023-08-12 |
Not clear |