| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alun Hughes, David Mann, Stuart Pickering-Brow. Tau haplotype frequency in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Experimental neurology. vol 181. issue 1. 2003-05-19. PMID:12710929. |
these data are consistent with the hypothesis that the tau gene, or nearby gene on the h1 haplotype, is a risk factor for frontotemporal dementia. |
2003-05-19 |
2023-08-12 |
Not clear |
| Armand Savioz, Beat M Riederer, Peter Heutink, Patrizia Rizzu, Markus Tolnay, Enikö Kövari, Alphonse Probst, I rène M Riederer, Constantin Bouras, Geneviève Leub. Tau and neurofilaments in a family with frontotemporal dementia unlinked to chromosome 17q21-22. Neurobiology of disease. vol 12. issue 1. 2003-05-09. PMID:12609488. |
tau and neurofilaments in a family with frontotemporal dementia unlinked to chromosome 17q21-22. |
2003-05-09 |
2023-08-12 |
Not clear |
| Gail V W Johnson, Craig D C Baile. Tau, where are we now? Journal of Alzheimer's disease : JAD. vol 4. issue 5. 2003-04-04. PMID:12446970. |
these findings, along with the fact that mutations in the tau gene cause a group of diseases collectively known as frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17), clearly demonstrate that tau dysfunction results in neuronal dysfunction and death. |
2003-04-04 |
2023-08-12 |
Not clear |
| Y Tsuboi, R J Uitti, M Baker, M L Hutton, Z K Wszole. Clinical features of frontotemporal dementia due to the intronic tau 10(+16) mutation. Neurology. vol 60. issue 3. 2003-02-27. PMID:12578950. |
clinical features of frontotemporal dementia due to the intronic tau 10(+16) mutation. |
2003-02-27 |
2023-08-12 |
Not clear |
| William P Cheshire, Yoshio Tsuboi, Zbigniew K Wszole. Physiologic assessment of autonomic dysfunction in pallidopontonigral degeneration with N279K mutation in the tau gene on chromosome 17. Autonomic neuroscience : basic & clinical. vol 102. issue 1-2. 2003-01-31. PMID:12492138. |
autonomic function was investigated in five affected and five at-risk members of a single kinship of pallidopontonigral degeneration (ppnd), which is a progressive syndrome of parkinsonism and frontotemporal dementia resulting from a mutation in the n279k tau gene on chromosome 17. |
2003-01-31 |
2023-08-12 |
human |
| Khalid Iqbal, Alejandra del C Alonso, Ezzat El-Akkad, Cheng-Xin Gong, Niloufar Haque, Sabiha Khatoon, Jin-Jing Pei, Ichiro Tsujio, Jian-Zhi Wang, Inge Grundke-Iqba. Significance and mechanism of Alzheimer neurofibrillary degeneration and therapeutic targets to inhibit this lesion. Journal of molecular neuroscience : MN. vol 19. issue 1-2. 2003-01-28. PMID:12212801. |
the cosegregation of tau mutations with disease in inherited cases of frontotemporal dementia has confirmed that abnormalities in this protein can be a primary cause of neurodegeneration. |
2003-01-28 |
2023-08-12 |
Not clear |
| Henry G Tomasiewicz, Denise B Flaherty, J P Soria, John G Woo. Transgenic zebrafish model of neurodegeneration. Journal of neuroscience research. vol 70. issue 6. 2003-01-24. PMID:12444595. |
in addition, and importantly, mutations in the genes encoding human tau have recently been implicated in a variety of hereditary dementias, collectively termed frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17). |
2003-01-24 |
2023-08-12 |
human |
| Markus Tolnay, Alphonse Probs. Frontotemporal lobar degeneration--tau as a pied piper? Neurogenetics. vol 4. issue 2. 2003-01-23. PMID:12481984. |
the underlying neuropathology can be classified into disorders with tau pathology (including pick disease, corticobasal degeneration, progressive supranuclear palsy, and familial frontotemporal dementia with parkinsonism linked to chromosome 17 - ftdp-17), and into disorders that lack tau abnormalities (including dementia lacking distinctive histology and motor neuron disease inclusion dementia). |
2003-01-23 |
2023-08-12 |
Not clear |
| Anna Kowalska, Masato Hasegawa, Katsuichi Miyamoto, Ichiro Akiguchi, Akito Ikemoto, Keikichi Takahashi, Wataru Araki, Takeshi Tabir. A novel mutation at position +11 in the intron following exon 10 of the tau gene in FTDP-17. Journal of applied genetics. vol 43. issue 4. 2003-01-22. PMID:12441638. |
mutations in the microtubule-associated tau gene are responsible for frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17). |
2003-01-22 |
2023-08-12 |
Not clear |
| Anna Kowalska, Masato Hasegawa, Katsuichi Miyamoto, Ichiro Akiguchi, Akito Ikemoto, Keikichi Takahashi, Wataru Araki, Takeshi Tabir. A novel mutation at position +11 in the intron following exon 10 of the tau gene in FTDP-17. Journal of applied genetics. vol 43. issue 4. 2003-01-22. PMID:12441638. |
here, we describe a new mutation of the tau gene, a t --> c transition at position +11 of the intron following exon 10 (t --> c 3'e10 +11) in the family showing frontotemporal dementia with very early age of onset (the first decade of proband's life). |
2003-01-22 |
2023-08-12 |
Not clear |
| Li Li, Martin von Bergen, Eva-Maria Mandelkow, Eckhard Mandelko. Structure, stability, and aggregation of paired helical filaments from tau protein and FTDP-17 mutants probed by tryptophan scanning mutagenesis. The Journal of biological chemistry. vol 277. issue 44. 2003-01-17. PMID:12198126. |
the stability increases with the number of repeats and with tau mutants promoting beta-structure, arguing for a gain of toxic function in frontotemporal dementias. |
2003-01-17 |
2023-08-12 |
Not clear |
| Gerardo Morfini, Gustavo Pigino, Uwe Beffert, Jorge Busciglio, Scott T Brad. Fast axonal transport misregulation and Alzheimer's disease. Neuromolecular medicine. vol 2. issue 2. 2003-01-03. PMID:12428805. |
pathological alterations in the microtubule-associated protein (map) tau are well-established in a number of neurodegenerative disorders, including alzheimer's disease (ad), frontotemporal dementia (ftd), progressive supranuclear palsy (psp), and others. |
2003-01-03 |
2023-08-12 |
Not clear |
| Rohan de Silva, John Hardy, Julia Crook, Naheed Khan, Elizabeth A Graham, Christopher M Morris, Nicholas W Wood, Andrew J Lee. The tau locus is not significantly associated with pathologically confirmed sporadic Parkinson's disease. Neuroscience letters. vol 330. issue 2. 2002-12-17. PMID:12231446. |
mutations of the tau gene in frontotemporal dementia with parkinsonism and genetic association of the tau locus with progressive supranuclear palsy and corticobasal degeneration directly implicate the tau gene in the aetiology of these tauopathies. |
2002-12-17 |
2023-08-12 |
Not clear |
| Maho Morishima-Kawashima, Yasuo Ihar. Alzheimer's disease: beta-Amyloid protein and tau. Journal of neuroscience research. vol 70. issue 3. 2002-12-13. PMID:12391602. |
the genetic analysis of frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17) revealed the presence of mutations in the tau gene in affected members. |
2002-12-13 |
2023-08-12 |
Not clear |
| Yoshitaka Tatebayashi, Tomohiro Miyasaka, De-Hua Chui, Takumi Akagi, Ken-ichi Mishima, Katsunori Iwasaki, Michihiro Fujiwara, Kentaro Tanemura, Miyuki Murayama, Koichi Ishiguro, Emmanuel Planel, Shinji Sato, Tsutomu Hashikawa, Akihiko Takashim. Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau. Proceedings of the National Academy of Sciences of the United States of America. vol 99. issue 21. 2002-12-04. PMID:12368474. |
the r406w tau mutation found in frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17) causes a hereditary tauopathy clinically resembling alzheimer's disease. |
2002-12-04 |
2023-08-12 |
mouse |
| P K Panegyres, K Zafiris-Toufexi. Polymorphisms in the tau gene in sporadic frontotemporal dementia and other neurodegenerative disorders. European journal of neurology. vol 9. issue 5. 2002-11-26. PMID:12220379. |
polymorphisms in the tau gene in sporadic frontotemporal dementia and other neurodegenerative disorders. |
2002-11-26 |
2023-08-12 |
Not clear |
| P K Panegyres, K Zafiris-Toufexi. Polymorphisms in the tau gene in sporadic frontotemporal dementia and other neurodegenerative disorders. European journal of neurology. vol 9. issue 5. 2002-11-26. PMID:12220379. |
mutations in tau are found in familial frontotemporal dementia (ftd) and the a0/a0 genotype associated with progressive supranuclear palsy (psp). |
2002-11-26 |
2023-08-12 |
Not clear |
| Bridget Allen, Esther Ingram, Masaki Takao, Michael J Smith, Ross Jakes, Kanwar Virdee, Hirotaka Yoshida, Max Holzer, Molly Craxton, Piers C Emson, Cristiana Atzori, Antonio Migheli, R Anthony Crowther, Bernardino Ghetti, Maria Grazia Spillantini, Michel Goeder. Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 21. 2002-11-25. PMID:12417659. |
the identification of mutations in the tau gene in frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17) has made it possible to express human tau protein with pathogenic mutations in transgenic animals. |
2002-11-25 |
2023-08-12 |
mouse |
| Michael DeTure, Li-Wen Ko, Colin Easson, Shu-Hui Ye. Tau assembly in inducible transfectants expressing wild-type or FTDP-17 tau. The American journal of pathology. vol 161. issue 5. 2002-11-22. PMID:12414518. |
conditional expression systems for 4-repeat wild-type (wt) tau or the corresponding mutants v337m and r406w were established in human neuroglioma h4 cells to study the effect of tau mutations on the physicochemical properties of tau, and to develop a cellular model for the formation of filamentous tau characteristic of frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17) and alzheimer's disease. |
2002-11-22 |
2023-08-12 |
human |
| A Takashim. [Analysis of mouse model exhibiting neurofibrillary changes]. Rinsho shinkeigaku = Clinical neurology. vol 41. issue 12. 2002-11-08. PMID:12235811. |
in frontotemporal dementia parkinsonism 17 (ftdp17), genetic studies indicated that tau is a causative gene, and mutation is found in exons and introns of tau gene. |
2002-11-08 |
2023-08-12 |
mouse |