| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M L Garcia, D W Clevelan. Going new places using an old MAP: tau, microtubules and human neurodegenerative disease. Current opinion in cell biology. vol 13. issue 1. 2001-04-12. PMID:11163132. |
missense and splice-site mutations in the human tau gene are now known to be causes of inherited frontotemporal dementia and parkinsonism linked to chromosome 17, a cognitive disorder of aging. |
2001-04-12 |
2023-08-12 |
human |
| N Hattori, H Shimura, S Kubo, M Wang, N Shimizu, K Tanaka, Y Mizun. Importance of familial Parkinson's disease and parkinsonism to the understanding of nigral degeneration in sporadic Parkinson's disease. Journal of neural transmission. Supplementum. issue 60. 2001-04-12. PMID:11205133. |
furthermore, ubiquitin carboxy terminal hydrolase l1 gene is responsible for an autosomal dominant form of typical pd, although only a single family has so far been identified with a mutation of this gene, and tau has been identified as a causative gene for frontotemporal dementia and parkinsonism. |
2001-04-12 |
2023-08-12 |
Not clear |
| P Poorkaj, M Grossman, E Steinbart, H Payami, A Sadovnick, D Nochlin, T Tabira, J Q Trojanowski, S Borson, D Galasko, S Reich, B Quinn, G Schellenberg, T D Bir. Frequency of tau gene mutations in familial and sporadic cases of non-Alzheimer dementia. Archives of neurology. vol 58. issue 3. 2001-04-05. PMID:11255441. |
mutations in the tau gene have been reported in families with frontotemporal dementia (ftd) linked to chromosome 17. |
2001-04-05 |
2023-08-12 |
Not clear |
| V Zhukareva, V Vogelsberg-Ragaglia, V M Van Deerlin, J Bruce, T Shuck, M Grossman, C M Clark, S E Arnold, E Masliah, D Galasko, J Q Trojanowski, V M Le. Loss of brain tau defines novel sporadic and familial tauopathies with frontotemporal dementia. Annals of neurology. vol 49. issue 2. 2001-03-29. PMID:11220736. |
loss of brain tau defines novel sporadic and familial tauopathies with frontotemporal dementia. |
2001-03-29 |
2023-08-12 |
Not clear |
| P Pastor, E Pastor, C Carnero, R Vela, T García, G Amer, E Tolosa, R Oliv. Familial atypical progressive supranuclear palsy associated with homozigosity for the delN296 mutation in the tau gene. Annals of neurology. vol 49. issue 2. 2001-03-29. PMID:11220749. |
heterozygous missense and splice-site mutations in the tau gene have been previously identified in familial frontotemporal dementia with autosomal dominant inheritance. |
2001-03-29 |
2023-08-12 |
Not clear |
| P Rizzu, M Joosse, R Ravid, A Hoogeveen, W Kamphorst, J C van Swieten, R Willemsen, P Heutin. Mutation-dependent aggregation of tau protein and its selective depletion from the soluble fraction in brain of P301L FTDP-17 patients. Human molecular genetics. vol 9. issue 20. 2001-02-22. PMID:11115852. |
mutations in the gene for the microtubule-associated protein tau are associated with frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17). |
2001-02-22 |
2023-08-12 |
Not clear |
| R Tanaka, T Kobayashi, Y Motoi, M Anno, Y Mizuno, H Mor. A case of frontotemporal dementia with tau P301L mutation in the Far East. Journal of neurology. vol 247. issue 9. 2001-02-15. PMID:11081811. |
a case of frontotemporal dementia with tau p301l mutation in the far east. |
2001-02-15 |
2023-08-12 |
Not clear |
| J Götz, F Chen, R Barmettler, R M Nitsc. Tau filament formation in transgenic mice expressing P301L tau. The Journal of biological chemistry. vol 276. issue 1. 2001-02-08. PMID:11013246. |
mutations in the microtubule-associated protein tau, including p301l, are genetically coupled to hereditary frontotemporal dementia with parkinsonism linked to chromosome 17. |
2001-02-08 |
2023-08-12 |
mouse |
| V Vogelsberg-Ragaglia, J Bruce, C Richter-Landsberg, B Zhang, M Hong, J Q Trojanowski, V M Le. Distinct FTDP-17 missense mutations in tau produce tau aggregates and other pathological phenotypes in transfected CHO cells. Molecular biology of the cell. vol 11. issue 12. 2001-02-08. PMID:11102510. |
multiple tau gene mutations are pathogenic for hereditary frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17), with filamentous tau aggregates as the major lesions in the cns of these patients. |
2001-02-08 |
2023-08-12 |
Not clear |
| C Mailliot, T Bussière, M Hamdane, N Sergeant, M L Caillet, A Delacourte, L Bué. Pathological tau phenotypes. The weight of mutations, polymorphisms, and differential neuronal vulnerabilities. Annals of the New York Academy of Sciences. vol 920. 2001-02-08. PMID:11193138. |
finally, recent findings provide a direct link between a genetic defect in tau and its abnormal aggregation into filaments in frontotemporal dementia with parkinsonism linked to chromosome 17. |
2001-02-08 |
2023-08-12 |
human |
| S M Rosso, W Kamphorst, R Ravid, J C van Swiete. Coexistent tau and amyloid pathology in hereditary frontotemporal dementia with tau mutations. Annals of the New York Academy of Sciences. vol 920. 2001-02-08. PMID:11193139. |
coexistent tau and amyloid pathology in hereditary frontotemporal dementia with tau mutations. |
2001-02-08 |
2023-08-12 |
Not clear |
| S M Rosso, W Kamphorst, R Ravid, J C van Swiete. Coexistent tau and amyloid pathology in hereditary frontotemporal dementia with tau mutations. Annals of the New York Academy of Sciences. vol 920. 2001-02-08. PMID:11193139. |
hereditary frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17) is associated with different mutations in the microtubule-associated protein (map) tau gene. |
2001-02-08 |
2023-08-12 |
Not clear |
| J Götz, R Barmettler, A Ferrari, M Goedert, A Probst, R M Nitsc. In vivo analysis of wild-type and FTDP-17 tau transgenic mice. Annals of the New York Academy of Sciences. vol 920. 2001-02-08. PMID:11193141. |
mutations in the coding and intronic regions of the tau gene cause frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17). |
2001-02-08 |
2023-08-12 |
mouse |
| M Hutto. Molecular genetics of chromosome 17 tauopathies. Annals of the New York Academy of Sciences. vol 920. 2001-02-08. PMID:11193178. |
the identification of mutations in the gene encoding the microtubule associated protein tau in frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17) demonstrated that tau dysfunction can lead to neurodegeneration. |
2001-02-08 |
2023-08-12 |
Not clear |
| M Goedert, B Ghetti, M G Spillantin. Tau gene mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Their relevance for understanding the neurogenerative process. Annals of the New York Academy of Sciences. vol 920. 2001-02-08. PMID:11193179. |
tau gene mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17). |
2001-02-08 |
2023-08-12 |
human |
| M Goedert, B Ghetti, M G Spillantin. Tau gene mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Their relevance for understanding the neurogenerative process. Annals of the New York Academy of Sciences. vol 920. 2001-02-08. PMID:11193179. |
filamentous tau protein deposits are also the defining characteristic of other neurodegenerative diseases, many of which are frontotemporal dementias or movement disorders, such as pick's disease, progressive supranuclear palsy, and corticobasal degeneration. |
2001-02-08 |
2023-08-12 |
human |
| M Goedert, B Ghetti, M G Spillantin. Tau gene mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Their relevance for understanding the neurogenerative process. Annals of the New York Academy of Sciences. vol 920. 2001-02-08. PMID:11193179. |
this has now changed with the discovery of more than 15 mutations in the tau gene in frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17). |
2001-02-08 |
2023-08-12 |
human |
| Z K Wszolek, Y Tsuboi, R J Uitti, L Ree. Two brothers with frontotemporal dementia and parkinsonism with an N279K mutation of the tau gene. Neurology. vol 55. issue 12. 2001-02-01. PMID:11134413. |
two brothers with frontotemporal dementia and parkinsonism with an n279k mutation of the tau gene. |
2001-02-01 |
2023-08-12 |
Not clear |
| K Spittaels, C Van den Haute, J Van Dorpe, H Geerts, M Mercken, K Bruynseels, R Lasrado, K Vandezande, I Laenen, T Boon, J Van Lint, J Vandenheede, D Moechars, R Loos, F Van Leuve. Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice. The Journal of biological chemistry. vol 275. issue 52. 2001-01-26. PMID:11007782. |
protein tau filaments in brain of patients suffering from alzheimer's disease, frontotemporal dementia, and other tauopathies consist of protein tau that is hyperphosphorylated. |
2001-01-26 |
2023-08-12 |
mouse |
| C F Lippa, V Zhukareva, T Kawarai, K Uryu, M Shafiq, L E Nee, J Grafman, Y Liang, P H St George-Hyslop, J Q Trojanowski, V M Le. Frontotemporal dementia with novel tau pathology and a Glu342Val tau mutation. Annals of neurology. vol 48. issue 6. 2001-01-11. PMID:11117541. |
frontotemporal dementia with novel tau pathology and a glu342val tau mutation. |
2001-01-11 |
2023-08-12 |
Not clear |