| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jose J Ferrero, Ahnaf R Hassan, Zelin Yu, Zifang Zhao, Liang Ma, Cynthia Wu, Shan Shao, Takeshi Kawano, Judah Engel, Werner Doyle, Orrin Devinsky, Dion Khodagholy, Jennifer N Gelina. Closed-loop electrical stimulation to prevent focal epilepsy progression and long-term memory impairment. bioRxiv : the preprint server for biology. 2024-02-26. PMID:38405990. |
we show in a model of progressive hippocampal epilepsy that ieds produce pathological oscillatory coupling which is associated with prolonged, hypersynchronous neural spiking in synaptically connected cortex and expands the brain territory capable of generating ieds. |
2024-02-26 |
2024-02-28 |
human |
| Rui Mao, Mengsha Hu, Xuan Liu, Lei Ye, Bingsong Xu, Min Sun, Siyi Xu, Wenxuan Shao, Yi Tan, Yun Xu, Feng Bai, Shu Sh. Impairments of GABAergic transmission in hippocampus mediate increased susceptibility of epilepsy in the early stage of Alzheimer's disease. Cell communication and signaling : CCS. vol 22. issue 1. 2024-02-23. PMID:38388921. |
impairments of gabaergic transmission in hippocampus mediate increased susceptibility of epilepsy in the early stage of alzheimer's disease. |
2024-02-23 |
2024-02-25 |
Not clear |
| Shuo Zhang, Shengyang Xie, Yang Zheng, Zhong Chen, Cenglin X. Current advances in rodent drug-resistant temporal lobe epilepsy models: Hints from laboratory studies. Neurochemistry international. 2024-02-21. PMID:38382810. |
temporal lobe epilepsy (tle), a common type of epilepsy usually associated with hippocampal sclerosis (hs), shares the highest proportion of drug resistance (approximately 70%). |
2024-02-21 |
2024-02-24 |
Not clear |
| Erik H Middlebrooks, Vivek Gupta, Amit K Agarwal, Brin E Freund, Steven A Messina, William O Tatum, David S Sabsevitz, Anteneh M Feyissa, Seyed M Mirsattari, Fernando N Galan, Alfredo Quinones-Hinojosa, Sanjeet S Grewal, John V Murra. Radiologic Classification of Hippocampal Sclerosis in Epilepsy. AJNR. American journal of neuroradiology. 2024-02-21. PMID:38383054. |
radiologic classification of hippocampal sclerosis in epilepsy. |
2024-02-21 |
2024-02-24 |
Not clear |
| Erik H Middlebrooks, Vivek Gupta, Amit K Agarwal, Brin E Freund, Steven A Messina, William O Tatum, David S Sabsevitz, Anteneh M Feyissa, Seyed M Mirsattari, Fernando N Galan, Alfredo Quinones-Hinojosa, Sanjeet S Grewal, John V Murra. Radiologic Classification of Hippocampal Sclerosis in Epilepsy. AJNR. American journal of neuroradiology. 2024-02-21. PMID:38383054. |
temporal lobe epilepsy is a common form of epilepsy that is often associated with hippocampal sclerosis (hs). |
2024-02-21 |
2024-02-24 |
Not clear |
| Erik H Middlebrooks, Vivek Gupta, Amit K Agarwal, Brin E Freund, Steven A Messina, William O Tatum, David S Sabsevitz, Anteneh M Feyissa, Seyed M Mirsattari, Fernando N Galan, Alfredo Quinones-Hinojosa, Sanjeet S Grewal, John V Murra. Radiologic Classification of Hippocampal Sclerosis in Epilepsy. AJNR. American journal of neuroradiology. 2024-02-21. PMID:38383054. |
this framework will not only benefit current clinical evaluations, but also enhance future studies involving high-resolution mri in temporal lobe epilepsy.abbreviations: ca = cornu ammonis; dg = dentate gyrus; hs = hippocampal sclerosis; ilae = international league against epilepsy; srlm = strata radiatum, lacunosum, and moleculare layers; tle = temporal lobe epilepsy. |
2024-02-21 |
2024-02-24 |
Not clear |
| Jonas M Hebel, Michael Lanz, Thomas Malina, Stefan R G Stodieck, Michel Le Van Quye. Effects of midazolam on high-frequency oscillations in amygdala and hippocampus of epilepsy patients. Epilepsia. 2024-02-17. PMID:38366848. |
effects of midazolam on high-frequency oscillations in amygdala and hippocampus of epilepsy patients. |
2024-02-17 |
2024-02-19 |
Not clear |
| Supratim Mondal, Abhijit Nandy, Geetha Dande, Krishna Prabhu, Rajesh Ramanna Valmiki, Debasish Koner, Shibdas Banerje. Mass Spectrometric Imaging of Anionic Phospholipids Desorbed from Human Hippocampal Sections: Discrimination between Temporal and Nontemporal Lobe Epilepsies. ACS chemical neuroscience. 2024-02-14. PMID:38355427. |
mass spectrometric imaging of anionic phospholipids desorbed from human hippocampal sections: discrimination between temporal and nontemporal lobe epilepsies. |
2024-02-14 |
2024-02-17 |
human |
| Supratim Mondal, Abhijit Nandy, Geetha Dande, Krishna Prabhu, Rajesh Ramanna Valmiki, Debasish Koner, Shibdas Banerje. Mass Spectrometric Imaging of Anionic Phospholipids Desorbed from Human Hippocampal Sections: Discrimination between Temporal and Nontemporal Lobe Epilepsies. ACS chemical neuroscience. 2024-02-14. PMID:38355427. |
to examine the lipid profile, 39 fresh frozen sections of the human hippocampus obtained from epilepsy surgery for tle ( |
2024-02-14 |
2024-02-17 |
human |
| Alfredo Lucas, Sofia Mouchtaris, Ashley Tranquille, Nishant Sinha, Ryan Gallagher, Marissa Mojena, Joel M Stein, Sandhitsu Das, Kathryn A Davi. Mapping hippocampal and thalamic atrophy in epilepsy: A 7-T magnetic resonance imaging study. Epilepsia. 2024-02-12. PMID:38345348. |
mapping hippocampal and thalamic atrophy in epilepsy: a 7-t magnetic resonance imaging study. |
2024-02-12 |
2024-02-15 |
Not clear |
| Alfredo Lucas, Sofia Mouchtaris, Ashley Tranquille, Nishant Sinha, Ryan Gallagher, Marissa Mojena, Joel M Stein, Sandhitsu Das, Kathryn A Davi. Mapping hippocampal and thalamic atrophy in epilepsy: A 7-T magnetic resonance imaging study. Epilepsia. 2024-02-12. PMID:38345348. |
in this work, we leverage ultra-high-field 7-t structural magnetic resonance imaging (mri) to characterize volumetric atrophy patterns across hippocampal subfields and thalamic nuclei in drug-resistant focal epilepsy. |
2024-02-12 |
2024-02-15 |
Not clear |
| Daria Ponomareva, Anton Ivanov, Piotr Bregestovsk. Analysis of the Effects of Pentose Phosphate Pathway Inhibition on the Generation of Reactive Oxygen Species and Epileptiform Activity in Hippocampal Slices. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38339211. |
using the specific g6pd inhibitor g6pdi-1, we assessed its effects on mouse hippocampal slices, examining intracellular ros, glucose/oxygen consumption, the nad(p)h level and ros production during synaptic stimulation and in the 4ap epilepsy model. |
2024-02-10 |
2024-02-12 |
mouse |
| Navyashree Krishnashastry Srinivasa, Rajeeb Kumar Mishra, Varadarajan Bhadrinarayan, Karthik Kulanthaivel. Hippocampal volume and recovery profile following propofol sedation in children undergoing magnetic resonance imaging: An exploratory study. Saudi journal of anaesthesia. vol 18. issue 1. 2024-02-05. PMID:38313727. |
reduction in the hippocampal volume may contribute to agitated and delayed emergence after anesthesia in epilepsy surgery. |
2024-02-05 |
2024-02-07 |
Not clear |
| Dominique Leitner, Geoffrey Pires, Tomas Kavanagh, Evgeny Kanshin, Manor Askenazi, Beatrix Ueberheide, Orrin Devinsky, Thomas Wisniewski, Eleanor Drummon. Similar brain proteomic signatures in Alzheimer's disease and epilepsy. Acta neuropathologica. vol 147. issue 1. 2024-01-30. PMID:38289539. |
we observed a highly significant overlap in protein differences in epilepsy and ad: 89% (689/777) of proteins altered in the hippocampus of epilepsy patients were significantly altered in advanced ad. |
2024-01-30 |
2024-02-01 |
Not clear |
| Dominique Leitner, Geoffrey Pires, Tomas Kavanagh, Evgeny Kanshin, Manor Askenazi, Beatrix Ueberheide, Orrin Devinsky, Thomas Wisniewski, Eleanor Drummon. Similar brain proteomic signatures in Alzheimer's disease and epilepsy. Acta neuropathologica. vol 147. issue 1. 2024-01-30. PMID:38289539. |
immunohistochemistry for aβ and multiple phosphorylated tau species (ptau396/404, ptau217, ptau231) showed a trend for increased intraneuronal ptau217 and ptau231 but no phosphorylated tau aggregates or amyloid plaques in epilepsy hippocampal sections. |
2024-01-30 |
2024-02-01 |
Not clear |
| Jerome Clasadonte, Tania Deprez, Gabriel S Stephens, Georges Mairet-Coello, Pierre-Yves Cortin, Maxime Boutier, Aurore Frey, Jeannie Chin, Marek Rajma. ΔFosB is part of a homeostatic mechanism that protects the epileptic brain from further deterioration. Frontiers in molecular neuroscience. vol 16. 2024-01-29. PMID:38283700. |
in this study, Δfosb was specifically downregulated by delivering aav-shrna into the hippocampus of chronically epileptic mice using the drug-resistant pilocarpine model of mesial temporal epilepsy (mtle). |
2024-01-29 |
2024-01-31 |
mouse |
| Chia-Hsuan Fu, Jason C You, Carrie Mohila, Robert A Rissman, Daniel Yoshor, Angela N Viaene, Jeannie Chi. Hippocampal ΔFosB expression is associated with cognitive impairment in a subgroup of patients with childhood epilepsies. Frontiers in neurology. vol 14. 2024-01-26. PMID:38274865. |
to test whether dg Δfosb expression is indicative of cognitive impairment in epilepsies with different etiologies, we assessed Δfosb expression in surgically-resected hippocampal tissue from 33 patients with childhood epilepsies who had undergone wechsler intelligence scale for children (wisc) testing prior to surgery. |
2024-01-26 |
2024-01-28 |
human |
| Chia-Hsuan Fu, Jason C You, Carrie Mohila, Robert A Rissman, Daniel Yoshor, Angela N Viaene, Jeannie Chi. Hippocampal ΔFosB expression is associated with cognitive impairment in a subgroup of patients with childhood epilepsies. Frontiers in neurology. vol 14. 2024-01-26. PMID:38274865. |
hippocampal Δfosb expression is associated with cognitive impairment in a subgroup of patients with childhood epilepsies. |
2024-01-26 |
2024-01-28 |
human |
| Omar Mamad, Mona Heiland, Andreas U Lindner, Thomas D M Hill, Ronan M Ronroy, Kilian Rentrup, Amaya Sanz-Rodriguez, Elena Langa, Janosch P Heller, Oscar Moreno, Jordi Llop, Anindya Bhattacharya, James A Palmer, Marc Ceusters, Tobias Engel, David C Henshal. Anti-seizure effects of JNJ-54175446 in the intra-amygdala kainic acid model of drug-resistant temporal lobe epilepsy in mice. Frontiers in pharmacology. vol 14. 2024-01-23. PMID:38259288. |
previous studies in mice reported that the p2x7 receptor antagonist jnj-47965567 suppressed spontaneous seizures in the intraamygdala kainic acid model of epilepsy and reduced attendant gliosis in the hippocampus. |
2024-01-23 |
2024-01-25 |
mouse |
| Jan Sroubek, Lenka Kramska, Tomas Cesak, Jana Amlerova, Jiri Keller, Zdenek Vojtec. Ultrasound-Navigated Multiple Hippocampal Transections: An Anatomical Study. Journal of neurological surgery. Part A, Central European neurosurgery. 2024-01-22. PMID:38253328. |
during mht, the longitudinal fibers of the hippocampus, implicated in epilepsy spreading, are interrupted, while the transverse memory circuits are spared. |
2024-01-22 |
2024-01-25 |
Not clear |