| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yongzhi Shan, Hongxing Wang, Yanfeng Yang, Jiahao Wang, Wenfeng Zhao, Yuda Huang, Huang Wang, Bing Han, Na Pan, Xiukun Jin, Xiaotong Fan, Yunyun Liu, Jun Wang, Changming Wang, Huaqiang Zhang, Sichang Chen, Ting Liu, Tianyi Yan, Tianmei Si, Lu Yin, Xinmin Li, Fiammetta Cosci, Xiangyang Zhang, Guanghao Zhang, Keming Gao, Guoguang Zha. Evidence of a large current of transcranial alternating current stimulation directly to deep brain regions. Molecular psychiatry. 2023-07-19. PMID:37468529. |
here, we directly recorded local field potentials (lfps) in the hippocampus, insula and amygdala at different current strengths (1 to 15 ma) in 11 adult patients with drug-resistant epilepsy implanted with stereoelectroencephalography (seeg) electrodes who received tacs at 77.5 hz from 1 ma to 15 ma at 77.5 hz for five minutes at each current for a total of 40 min. |
2023-07-19 |
2023-08-14 |
human |
| Mona Heiland, Niamh M C Connolly, Omar Mamad, Ngoc T Nguyen, Jaideep C Kesavan, Elena Langa, Kevin Fanning, Albert Sanfeliu, Yan Yan, Junyi Su, Morten T Venø, Lara S Costard, Valentin Neubert, Tobias Engel, Thomas D M Hill, Thomas M Freiman, Arun Mahesh, Vijay K Tiwari, Felix Rosenow, Sebastian Bauer, Jørgen Kjems, Gareth Morris, David C Henshal. MicroRNA-335-5p suppresses voltage-gated sodium channel expression and may be a target for seizure control. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 30. 2023-07-18. PMID:37463203. |
here we show that genome-wide mirna screening of hippocampal tissue from a rat epilepsy model, mice treated with the antiseizure medicine cannabidiol, and plasma from patients with treatment-resistant epilepsy, converge on a single target-mir-335-5p. |
2023-07-18 |
2023-08-14 |
mouse |
| Maureen Cassady, Gaston Basle. Dissociation in patients with epilepsy and functional seizures: A narrative review of the literature. Seizure. vol 110. 2023-07-11. PMID:37433243. |
ictal symptoms, especially in focal epilepsy of temporal lobe origin, may include dissociative-like experiences such as déjà vu/jamais vu, depersonalization, derealization and what has been described as a "dreamy state". these descriptions are common in the setting of seizures that originate from mesial temporal lobe epilepsy and may involve the amygdala and hippocampus. |
2023-07-11 |
2023-08-14 |
Not clear |
| Manolia R Ghouli, Carrie R Jonak, Rajan Sah, Todd A Fiacco, Devin K Binde. Regulation of the Volume-Regulated Anion Channel Pore-Forming Subunit LRRC8A in the Intrahippocampal Kainic Acid Model of Mesial Temporal Lobe Epilepsy. ASN neuro. vol 15. 2023-07-06. PMID:37410995. |
the timepoint-dependent upregulation of total hippocampal lrrc8a and the possible subsequent increased efflux of glutamate in the epileptic hippocampus suggest that the dysregulation of astrocytic vrac may play an important role in the development of epilepsy. |
2023-07-06 |
2023-08-14 |
Not clear |
| Walter F De La Cruz Ramirez, Denisse E Chacón Zuñiga, Sofía S Sánchez Boluarte, Carlos M Vasquez Perez, Liza Núñez Del Prado Murillo, Jose C Delgado Rio. Postsurgical outcomes in a cohort of patients with hippocampal sclerosis. Initial experience in a referral epilepsy center in Peru. Epilepsia open. 2023-07-03. PMID:37394997. |
we performed a retrospective observational study included 91 patients with mesial temporal lobe epilepsy and hippocampal sclerosis who had undergone anterior temporal lobectomy between 2012 and 2020 at a surgical epilepsy center located in lima, peru. |
2023-07-03 |
2023-08-14 |
human |
| Duilio Deangeli, Francisco Iarussi, Hernán Külsgaard, Delfina Braggio, Juan Pablo Princich, Mariana Bendersky, Emmanuel Iarussi, Ignacio Larrabide, José Ignacio Orland. NORHA: A NORmal Hippocampal Asymmetry Deviation Index Based on One-Class Novelty Detection and 3D Shape Features. Brain topography. 2023-06-29. PMID:37382838. |
radiologists routinely analyze hippocampal asymmetries in magnetic resonance (mr) images as a biomarker for neurodegenerative conditions like epilepsy and alzheimer's disease. |
2023-06-29 |
2023-08-14 |
human |
| Ke Zhao, Yinchao Li, Xiaofeng Yang, Liemin Zho. The Impact of Altered HCN1 Expression on Brain Function and Its Relationship with Epileptogenesis. Current neuropharmacology. 2023-06-27. PMID:37366350. |
hyperpolarization-activated cyclic nucleotide-gated cation channel 1 (hcn1) is predominantly expressed in neurons from the neocortex and hippocampus, two important regions related to epilepsy. |
2023-06-27 |
2023-08-14 |
Not clear |
| Ying-Cai Zhao, Cheng-Cheng Wang, Xiao-Yue Li, Dan-Dan Wang, Yu-Ming Wang, Chang-Hu Xue, Min Wen, Tian-Tian Zhan. Supplementation of n-3 PUFAs in Adulthood Attenuated Susceptibility to Pentylenetetrazol Induced Epilepsy in Mice Fed with n-3 PUFAs Deficient Diet in Early Life. Marine drugs. vol 21. issue 6. 2023-06-27. PMID:37367679. |
notably, nutritional supplementation with n-3 pufas in adulthood for 17 days could significantly recover the brain n-3 fatty acid and alleviate the epilepsy susceptibility as well as raise seizure threshold to different levels by mediating the neurotransmitter disturbance and mitochondria-dependent apoptosis, demyelination, and neuroinflammation status of the hippocampus. |
2023-06-27 |
2023-08-14 |
mouse |
| Michael Rebsamen, Baudouin Zongxin Jin, Tomas Klail, Sophie De Beukelaer, Rike Barth, Beata Rezny-Kasprzak, Uzeyir Ahmadli, Serge Vulliemoz, Margitta Seeck, Kaspar Schindler, Roland Wiest, Piotr Radojewski, Christian Rumme. Clinical Evaluation of a Quantitative Imaging Biomarker Supporting Radiological Assessment of Hippocampal Sclerosis. Clinical neuroradiology. 2023-06-26. PMID:37358608. |
to evaluate the influence of quantitative reports (qreports) on the radiological assessment of hippocampal sclerosis (hs) from mri of patients with epilepsy in a setting mimicking clinical reality. |
2023-06-26 |
2023-08-14 |
Not clear |
| Ya He, Hongxia Zhang, Limin Ma, Jingang Li, Fei Wang, Hui Zhou, Guangliang Zhang, Yuetao We. Identification of TIMP1 as an inflammatory biomarker associated with temporal lobe epilepsy based on integrated bioinformatics and experimental analyses. Journal of neuroinflammation. vol 20. issue 1. 2023-06-26. PMID:37365625. |
temporal lobe epilepsy (tle) is the most common epilepsy subtype, and previous studies have reported that hippocampal inflammation is an important mechanism associated with the occurrence and development of tle. |
2023-06-26 |
2023-08-14 |
Not clear |
| Pingyang Ke, Juan Gu, Jing Liu, Yan Liu, Xin Tian, Yuanlin Ma, Yuan Meng, Fei Xia. Syntabulin regulates neuronal excitation/inhibition balance and epileptic seizures by transporting syntaxin 1B. Cell death discovery. vol 9. issue 1. 2023-06-22. PMID:37349285. |
in summary, syntabulin plays a protective role in epilepsy by maintaining a proper e/i balance in the hippocampus. |
2023-06-22 |
2023-08-14 |
Not clear |
| Yuanxin Huang Huang, Dai Shi, Guofeng Wu, Likun Wang, Siying Re. Low-frequency Electrical Stimulation of the Hippocampus Plays a Role in the Treatment of Pharmacoresistant Epilepsy by Blocking the PKA-CREB Pathway. Current neurovascular research. 2023-06-15. PMID:37317906. |
low-frequency electrical stimulation of the hippocampus plays a role in the treatment of pharmacoresistant epilepsy by blocking the pka-creb pathway. |
2023-06-15 |
2023-08-14 |
Not clear |
| Mingkun Gong, Ke Xu, Yongzhi Shan, Yihe Wang, Chao Zhang, Xiongfei Wang, Jian Zhou, Yuguang Guan, Tianfu Li, Guoming Lua. Protocol of a prospective multicenter randomized controlled trial of robot-assisted stereotactic lesioning in the treatment of focal drug-resistant epilepsy. Trials. vol 24. issue 1. 2023-06-11. PMID:37296479. |
typical causes of focal epilepsy include hippocampal sclerosis and focal cortical dysplasia. |
2023-06-11 |
2023-08-14 |
Not clear |
| Dipan C Patel, Nathaniel Swift, Bhanu P Tewari, Jack L Browning, Courtney Prim, Lata Chaunsali, Ian Kimbrough, Michelle L Olsen, Harald Sontheime. Infection-induced epilepsy is caused by increased expression of chondroitin sulfate proteoglycans in hippocampus and amygdala. bioRxiv : the preprint server for biology. 2023-06-09. PMID:37292901. |
infection-induced epilepsy is caused by increased expression of chondroitin sulfate proteoglycans in hippocampus and amygdala. |
2023-06-09 |
2023-08-14 |
Not clear |
| Junzi Chen, Yu Wang, Cong Chen, Qingyang Zhang, Shuang Wang, Yi Wang, Jiajia Fang, Ying Wan. Activation of medial septum cholinergic neurons restores cognitive function in temporal lobe epilepsy. Neural regeneration research. vol 18. issue 11. 2023-06-07. PMID:37282477. |
furthermore, selective apoptosis of medial septum cholinergic neurons mimicked the cognitive deficits in epileptic mice, and activation of medial septum cholinergic neurons enhanced hippocampal acetylcholine release and restored cognitive function in both kainic acid- and kindling-induced epilepsy models. |
2023-06-07 |
2023-08-14 |
mouse |
| Yuanming Lu, Wanshi Wang, Yanping Ma, Zilian Fan, Lan Xiong, Junhao Zhao, Yongwen He, Chao Li, Anjie Wang, Nanping Xiao, Tianxun Wan. miR-10a induces inflammatory responses in epileptic hippocampal neurons of rats via PI3K/Akt/mTOR signaling pathway. Neuroreport. vol 34. issue 10. 2023-06-04. PMID:37270844. |
the mir-10a may promote inflammatory responses in rat hippocampal neurons by inhibiting the pi3k/akt/mtor pathway, suggesting that mir-10a may be one of the target therapeutic molecules for epilepsy treatment. |
2023-06-04 |
2023-08-14 |
rat |
| Zi Ye, Xiaomin Guan, Wenyuan Shan, Baojun M. OIP5-AS1 accelerates apoptosis of hippocampal neurons in cell models of epilepsy by modulating MiR-128-3p/BAX axis. Preventive medicine. 2023-06-02. PMID:37268172. |
oip5-as1 accelerates apoptosis of hippocampal neurons in cell models of epilepsy by modulating mir-128-3p/bax axis. |
2023-06-02 |
2023-08-14 |
Not clear |
| Zhaofei Dong, Fuli Min, Sai Zhang, Huili Zhang, Tao Zen. EGR1-Driven METTL3 Activation Curtails VIM-Mediated Neuron Injury in Epilepsy. Neurochemical research. 2023-06-02. PMID:37268752. |
egr1 activated mettl3 and reduced vim expression, thereby impairing hippocampal neuron injury and apoptosis, preventing epilepsy progression. |
2023-06-02 |
2023-08-14 |
mouse |
| Daniela de Andrade Morange, Magali Teresópolis Reis Amaral, Martha Silvia Martinez-Silveira, Agnès Trébucho. Rhinal and hippocampal event-related potentials as epileptogenic zone markers in the pre-surgical evaluation of temporal epilepsies: a systematic review. Arquivos de neuro-psiquiatria. vol 81. issue 5. 2023-05-31. PMID:37257470. |
rhinal and hippocampal event-related potentials as epileptogenic zone markers in the pre-surgical evaluation of temporal epilepsies: a systematic review. |
2023-05-31 |
2023-08-14 |
Not clear |
| Yuemei Luo, Juan Yang, Lijia Zhang, Zhenzhen Tai, Hao Huang, Haiqing Zhang, Zucai X. PGK1 succinylation modulates epileptic seizures and the blood-brain barrier. Experimental animals. 2023-05-31. PMID:37258131. |
the expression of the succinylation of pgk1 was decreased in a rat model of lithium-pilocarpine-induced acute epilepsy compared with the normal rats in the hippocampus. |
2023-05-31 |
2023-08-14 |
rat |