| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Diana Rosas, Lydia R Lewis, Nathaniel D Mercaldo, Shahin Nasr, Adam M Brickman, Viviana Siless, Michael Yassa, Mithra Sathishkumar, Ira Lott, Nicole Schupf, Wayne Silverman, Florence La. Altered connectivity of the default mode network in cognitively stable adults with Down syndrome: "Accelerated aging" or a prelude to Alzheimer's disease? Alzheimer's & dementia (Amsterdam, Netherlands). vol 13. issue 1. 2021-05-26. PMID:34027014. |
most individuals with down syndrome (ds) have the neuropathological changes of alzheimer's disease (ad) by age 40 and will have developed dementia by age 60. |
2021-05-26 |
2023-08-13 |
Not clear |
| Tatsunori Takahashi, Noriaki Sakai, Tomonori Iwasaki, Timothy C Doyle, William C Mobley, Seiji Nishin. Detailed evaluation of the upper airway in the Dp(16)1Yey mouse model of Down syndrome. Scientific reports. vol 10. issue 1. 2021-05-21. PMID:33288820. |
a high prevalence of obstructive sleep apnea (osa) has been reported in down syndrome (ds) owing to the coexistence of multiple predisposing factors related to its genetic abnormality, posing a challenge for the management of osa. |
2021-05-21 |
2023-08-13 |
mouse |
| O Esteban, C Marcuello, M Martinez, L Lavilla, S Marco, F J Ascas. Macular and choroidal thickness in Down syndrome by swept-source optical coherence tomography (SS-OCT). Archivos de la Sociedad Espanola de Oftalmologia. 2021-05-20. PMID:33715915. |
down syndrome (ds) is associated with certain structural and functional disorders in the whole visual system. |
2021-05-20 |
2023-08-13 |
human |
| Wenbo Ma, Yanna Liu, Houshi Ma, Zhaorui Ren, Jingbin Ya. Cis-acting: A pattern of lncRNAs for gene regulation in induced pluripotent stem cells from patients with Down syndrome determined by integrative analysis of lncRNA and mRNA profiling data. Experimental and therapeutic medicine. vol 22. issue 1. 2021-05-20. PMID:34007310. |
down syndrome (ds), caused by the trisomy of chromosome 21, is one of the common chromosomal disorders, the main clinical manifestations of which are delayed nervous development and intellectual disability. |
2021-05-20 |
2023-08-13 |
Not clear |
| Jean A Ronda. From the lab to the people: major challenges in the biological treatment of Down syndrome. AIMS neuroscience. vol 8. issue 2. 2021-05-19. PMID:33709029. |
down syndrome (ds) refers to a genetic condition due to the triplication of human chromosome 21. |
2021-05-19 |
2023-08-13 |
mouse |
| Emilia Roy-Vallejo, José María Galván-Román, Fernando Moldenhauer, Diego Real de Asú. Adults with Down syndrome challenge another paradigm: When aging no longer entails arterial hypertension. Journal of clinical hypertension (Greenwich, Conn.). vol 22. issue 7. 2021-05-18. PMID:32644285. |
though trisomy 21 (t21) and its phenotypic expression, down syndrome (ds), are conditions that involve premature aging, the cardiovascular system of adults with ds appears to be particularly spared from this early senescence. |
2021-05-18 |
2023-08-13 |
Not clear |
| b' Ver\\xc3\\xb3nica Vidal, Susana Garc\\xc3\\xada-Cerro, Noem\\xc3\\xad Rueda, Alba Puente, Renata Bartesaghi, Carmen Mart\\xc3\\xadnez-Cu\\xc3\\xa. Early postnatal oleic acid administration enhances synaptic development and cognitive abilities in the Ts65Dn mouse model of Down syndrome. Nutritional neuroscience. 2021-05-18. PMID:33345728.' |
the brains of individuals with down syndrome (ds) present defects in neurogenesis and synaptogenesis during prenatal and early postnatal stages that are partially responsible for their cognitive disabilities. |
2021-05-18 |
2023-08-13 |
mouse |
| James A Hendrix, David C Airey, Angela Britton, Anna D Burke, George T Capone, Ronelyn Chavez, Jacqueline Chen, Brian Chicoine, Alberto C S Costa, Jeffrey L Dage, Eric Doran, Anna Esbensen, Casey L Evans, Kelley M Faber, Tatiana M Foroud, Sarah Hart, Kelsey Haugen, Elizabeth Head, Suzanne Hendrix, Hampus Hillerstrom, Priya S Kishnani, Kavita Krell, Duvia Lara Ledesma, Florence Lai, Ira Lott, Cesar Ochoa-Lubinoff, Jennifer Mason, Jessie Nicodemus-Johnson, Nicholas Kyle Proctor, Margaret B Pulsifer, Carolyn Revta, H Diana Rosas, Tracie C Rosser, Stephanie Santoro, Kim Schafer, Thomas Scheidemantel, Frederick Schmitt, Brian G Skotko, Melissa R Stasko, Amy Talboy, Amy Torres, Kristi Wilmes, Jason Woodward, Jennifer A Zimmer, Howard H Feldman, William Moble. Cross-Sectional Exploration of Plasma Biomarkers of Alzheimer's Disease in Down Syndrome: Early Data from the Longitudinal Investigation for Enhancing Down Syndrome Research (LIFE-DSR) Study. Journal of clinical medicine. vol 10. issue 9. 2021-05-18. PMID:33924960. |
with improved healthcare, the down syndrome (ds) population is both growing and aging rapidly. |
2021-05-18 |
2023-08-13 |
human |
| Carla M Startin, Hana D'Souza, George Ball, Sarah Hamburg, Rosalyn Hithersay, Kate M O Hughes, Esha Massand, Annette Karmiloff-Smith, Michael S C Thomas, Andre Strydo. Health comorbidities and cognitive abilities across the lifespan in Down syndrome. Journal of neurodevelopmental disorders. vol 12. issue 1. 2021-05-17. PMID:31973697. |
down syndrome (ds) is associated with variable intellectual disability and multiple health and psychiatric comorbidities. |
2021-05-17 |
2023-08-13 |
Not clear |
| Laura Del Hoyo Soriano, Angela John Thurman, Danielle Harvey, Sara T Kover, Leonard Abbedut. Expressive language development in adolescents with Down syndrome and fragile X syndrome: change over time and the role of family-related factors. Journal of neurodevelopmental disorders. vol 12. issue 1. 2021-05-17. PMID:32593286. |
it is well known that individuals with down syndrome (ds) or fragile x syndrome (fxs) demonstrate expressive language difficulties beginning early in childhood. |
2021-05-17 |
2023-08-13 |
Not clear |
| Sarah Kim-Hellmuth, Matthias Hermann, Julia Eilenberger, Julia Ley-Zaporozhan, Marcus Fischer, Fabian Hauck, Christoph Klein, Nikolaus Haas, Matthias Kappler, Johannes Huebner, André Jakob, Ulrich von Bot. SARS-CoV-2 Triggering Severe Acute Respiratory Distress Syndrome and Secondary Hemophagocytic Lymphohistiocytosis in a 3-Year-Old Child With Down Syndrome. Journal of the Pediatric Infectious Diseases Society. vol 10. issue 4. 2021-05-17. PMID:33188394. |
down syndrome (ds) predisposes to severe immunologic reaction secondary to infectious triggers. |
2021-05-17 |
2023-08-13 |
Not clear |
| Rachel Culp-Hill, Connie Zheng, Julie A Reisz, Keith Smith, Angela Rachubinski, Travis Nemkov, Eric Butcher, Ross Granrath, Kirk C Hansen, Joaquín M Espinosa, Angelo D'Alessandr. Red blood cell metabolism in Down syndrome: hints on metabolic derangements in aging. Blood advances. vol 1. issue 27. 2021-05-14. PMID:29296929. |
trisomy 21 (t21), the etiological factor of down syndrome (ds), has been shown to cause chronic autoinflammation, promoting alterations in rbc life span, size (macrocytosis), and redox homeostasis. |
2021-05-14 |
2023-08-13 |
human |
| Niamh Lagan, Dean Huggard, Fiona Mc Grane, Timothy Ronan Leahy, Orla Franklin, Edna Roche, David Webb, Aengus O' Marcaigh, Des Cox, Afif El-Khuffash, Peter Greally, Joanne Balfe, Eleanor J Mollo. Multiorgan involvement and management in children with Down syndrome. Acta paediatrica (Oslo, Norway : 1992). vol 109. issue 6. 2021-05-14. PMID:31899550. |
to review multiorgan involvement and management in children with down syndrome (ds). |
2021-05-14 |
2023-08-13 |
Not clear |
| Garrick A Priebe, Mark M Kanzaw. Reducing the progression of Alzheimer's disease in Down syndrome patients with micro-dose lithium. Medical hypotheses. vol 137. 2021-05-14. PMID:31986471. |
an early-onset variant of the disease is a substantial source of morbidity in individuals with trisomy 21, the main cause of down syndrome (ds), with clinical evidence of the disease seen in roughly one-half of those 50 years and older. |
2021-05-14 |
2023-08-13 |
human |
| Garrick A Priebe, Mark M Kanzaw. Reducing the progression of Alzheimer's disease in Down syndrome patients with micro-dose lithium. Medical hypotheses. vol 137. 2021-05-14. PMID:31986471. |
furthermore, the specific factors that make those with down syndrome prone to developing ad, including enhanced ability to synthesize beta-amyloid, mitochondrial dysfunction, and elevated oxidative stress, correlate quite well with the model by which lithium is thought to disrupt alzheimer's pathogenesis, making the ds population ideally suited to study this intervention. |
2021-05-14 |
2023-08-13 |
human |
| Julia S Benoit, Ayeswarya Ravikumar, Jason D Marsack, Heather A Anderso. Understanding the Impact of Individual Perceived Image Quality Features on Visual Performance. Translational vision science & technology. vol 9. issue 5. 2021-05-14. PMID:32821479. |
this study aimed to quantify the impact of blur, contrast, and ghosting on perceived overall image quality (iq) as well as resultant predicted visual acuity, utilizing simulated acuity charts from objective refraction among eyes of individuals with down syndrome (ds). |
2021-05-14 |
2023-08-13 |
Not clear |
| Megan Lam, Charis Lai, Nouf Almuhanna, Raed Alhusaye. Hidradenitis suppurativa and Down syndrome: A systematic review and meta-analysis. Pediatric dermatology. vol 37. issue 6. 2021-05-14. PMID:32892406. |
several follicular disorders have also been associated with down syndrome (ds), a common chromosomal disorder, including hs, although studies on this topic are limited. |
2021-05-14 |
2023-08-13 |
Not clear |
| Amir Emami, Fatemeh Javanmardi, Ali Akbari, Ali A Asadi-Pooy. COVID-19 in patients with Down syndrome. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 42. issue 5. 2021-05-14. PMID:33523318. |
the aim of the current study was to determine whether covid-19 is associated with a different presenting clinical picture or a more severe course of illness in people with down syndrome (ds). |
2021-05-14 |
2023-08-13 |
Not clear |
| Csaba Szab. The re-emerging pathophysiological role of the cystathionine-β-synthase - hydrogen sulfide system in Down syndrome. The FEBS journal. vol 287. issue 15. 2021-05-13. PMID:31955501. |
down syndrome (ds) is associated with significant perturbances in many morphological and biochemical features. |
2021-05-13 |
2023-08-13 |
Not clear |
| Stamatis Agiovlasitis, Jooyeon Jin, Joonkoo Yu. Age-Group Differences in Body Mass Index, Weight, and Height in Adults With Down Syndrome and Adults With Intellectual Disability From the United States. Adapted physical activity quarterly : APAQ. vol 38. issue 1. 2021-05-12. PMID:33310929. |
the authors examined if body mass index (bmi), weight, and height across age groups differ between adults with down syndrome (ds) and adults with intellectual disability but without ds. |
2021-05-12 |
2023-08-13 |
Not clear |