| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J R Beekhuis, J M Van Lith, B T De Wolf, A Manting. Increased maternal serum alpha-fetoprotein and human chorionic gonadotropin in compromised pregnancies other than for neural tube defects or Down syndrome. Prenatal diagnosis. vol 12. issue 8. 1992-12-23. PMID:1279656. |
intrauterine fetal death occurred in four women who were 'screen-positive' in a screening programme for neural tube defects (ntds) and down syndrome (ds). |
1992-12-23 |
2023-08-11 |
human |
| T Mito, L E Becke. Vascular dysplasia in Down syndrome: a possible relationship to moyamoya disease. Brain & development. vol 14. issue 4. 1992-12-02. PMID:1443405. |
the brain of a child with down syndrome (ds) and vascular abnormalities is described. |
1992-12-02 |
2023-08-11 |
Not clear |
| M J Khoury, J D Erickso. Can maternal risk factors influence the presence of major birth defects in infants with Down syndrome? American journal of medical genetics. vol 43. issue 6. 1992-11-13. PMID:1415327. |
although the manifestations of down syndrome (ds) are well known, certain major birth defects such as duodenal atresia and endocardial cushion defects are present in some infants but not others, suggesting the possible role of other genetic or environmental factors interacting with the trisomy genotype. |
1992-11-13 |
2023-08-11 |
Not clear |
| M J Khoury, J D Erickso. Can maternal risk factors influence the presence of major birth defects in infants with Down syndrome? American journal of medical genetics. vol 43. issue 6. 1992-11-13. PMID:1415327. |
in addition to searching for a genetic basis for the ds phenotype, we suggest that the role of environmental factors and maternal exposures be specifically explored in clarifying the genesis of various birth defects in down syndrome. |
1992-11-13 |
2023-08-11 |
Not clear |
| M Murphy, W Hyun, B Hunte, A D Levine, L B Epstei. A role for tumor necrosis factor-alpha and interferon-gamma in the regulation of interleukin-4-induced human thymocyte proliferation in vitro. Heightened sensitivity in the Down syndrome (trisomy 21) thymus. Pediatric research. vol 32. issue 3. 1992-11-09. PMID:1408461. |
the influence of recombinant interferon-gamma (ifn-gamma) and tumor necrosis factor-alpha (tnf) on il-4-induced proliferation of postnatal human thymocytes from eight children with down syndrome (ds, trisomy 21) and 18 control children was evaluated. |
1992-11-09 |
2023-08-11 |
human |
| A Jeziorowska, G E Houck, X L Yao, S L Sklower-Brooks, K E Wisniewski, E C Jenkins, H M Wisniewsk. Reassessment of a chromosome 12q+ marker by fluorescent in situ hybridization (FISH). Clinical genetics. vol 42. issue 3. 1992-11-06. PMID:1395083. |
(1983) as atypical down syndrome (ds). |
1992-11-06 |
2023-08-11 |
human |
| A Zipursky, A Poon, J Doyl. Leukemia in Down syndrome: a review. Pediatric hematology and oncology. vol 9. issue 2. 1992-10-22. PMID:1388043. |
the incidence of leukemia is higher in children with down syndrome (ds) than in normals. |
1992-10-22 |
2023-08-11 |
Not clear |
| M Murphy, D S Friend, L Pike-Nobile, L B Epstei. Tumor necrosis factor-alpha and IFN-gamma expression in human thymus. Localization and overexpression in Down syndrome (trisomy 21). Journal of immunology (Baltimore, Md. : 1950). vol 149. issue 7. 1992-10-20. PMID:1388194. |
in paired experiments, we examined frozen sections of postnatal human thymus from four control children and four age-matched children with down syndrome (ds) (trisomy 21) for tnf-alpha and ifn-gamma mrna expression using in situ hybridization. |
1992-10-20 |
2023-08-11 |
human |
| H Suzuki, A Is. [Incidence rates of cerebral palsy, severe mental and motor retardation, and Down syndrome in the city of Higashiyamato in suburban Tokyo]. No to hattatsu = Brain and development. vol 24. issue 4. 1992-10-15. PMID:1387793. |
the number of patients with down syndrome (ds) was 7 and the incidence rate was 1.8/1,000. |
1992-10-15 |
2023-08-11 |
Not clear |
| D Zagzag, D C Miller, J Cangiarella, J C Allen, M A Grec. Brainstem glioma after radiation therapy for acute myeloblastic leukemia in a child with Down syndrome. Possible pathogenetic mechanisms. Cancer. vol 70. issue 5. 1992-10-07. PMID:1387583. |
a 13-year-old boy with down syndrome (ds) had a brainstem glioma confirmed at autopsy, 10 years after receiving prophylactic cranial irradiation for acute myeloblastic leukemia. |
1992-10-07 |
2023-08-11 |
Not clear |
| K H Pitetti, M Climstein, M J Mays, P J Barret. Isokinetic arm and leg strength of adults with Down syndrome: a comparative study. Archives of physical medicine and rehabilitation. vol 73. issue 9. 1992-10-01. PMID:1387522. |
this study compared isokinetic arm (elbow flexion and extension) and leg (knee flexion and extension) strength of individuals with down syndrome (ds), with mental retardation without ds (nds), and sedentary young adults with no mental retardation (nmr). |
1992-10-01 |
2023-08-11 |
human |
| M G Wilson, L S Chan, W S Herber. Birth prevalence of Down syndrome in a predominantly Latino population: a 15-year study. Teratology. vol 45. issue 3. 1992-08-14. PMID:1385907. |
the birth prevalence of down syndrome (ds), although decreasing in parts of the world, is not known in many specific subpopulations. |
1992-08-14 |
2023-08-11 |
Not clear |
| G S Yeo, A A Al. The effect of prenatal diagnosis on the incidence of Down syndrome livebirths in the Singapore General Hospital. Singapore medical journal. vol 33. issue 1. 1992-07-06. PMID:1534635. |
during a 3-year-period between january 1988 and december 1990, there were 12 down syndrome (ds) livebirths out of 13,794 livebirths at the department of obstetrics and gynaecology, singapore general hospital, giving an incidence of 1 in 1,150 livebirths or 0.87 per thousand. |
1992-07-06 |
2023-08-11 |
Not clear |
| C I McQuillan, K H Cho. Comparison of total cellular DNA, mRNA, and rRNA levels between normals and Down syndrome patients. Journal of inherited metabolic disease. vol 15. issue 1. 1992-06-17. PMID:1374821. |
two recent studies have suggested that the absolute cellular rna and/or dna levels in down syndrome (ds) may be unusual compared to normals and may be linked to phenotypic expression (pash et al., 1990; dahl et al. |
1992-06-17 |
2023-08-11 |
Not clear |
| J Shapira, A Stabholz, D Schurr, M N Sela, J Man. Caries levels, Streptococcus mutans counts, salivary pH, and periodontal treatment needs of adult Down syndrome patients. Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry. vol 11. issue 6. 1992-06-15. PMID:1839941. |
the prevalence of dental caries and periodontal treatment needs in an institutionalized down syndrome (ds) population was examined as well as the relationship between caries prevalence, salivary ph and salivary levels of streptococcus mutans. |
1992-06-15 |
2023-08-11 |
Not clear |
| T Takeshita, C Ariizumi-Shibusawa, K Shimizu, H Hoshino, Z Yamagata, S Iijima, A Asaka, M Higurash. The effect of aging on cell-cycle kinetics and X-ray-induced chromosome aberrations in cultured lymphocytes from patients with Down syndrome. Mutation research. vol 275. issue 1. 1992-04-30. PMID:1372684. |
to evaluate the effects of aging on cytogenetic characteristics of lymphocytes from down syndrome (ds), cell-cycle kinetics after pha stimulation and chromosome-type aberration frequencies after x-ray exposure were investigated in vitro in the lymphocytes derived from 4 (or 3 for x-ray treatment) age groups of ds patients and age-matched controls. |
1992-04-30 |
2023-08-11 |
Not clear |
| K H Pitetti, M Climstein, K D Campbell, P J Barrett, J A Jackso. The cardiovascular capacities of adults with Down syndrome: a comparative study. Medicine and science in sports and exercise. vol 24. issue 1. 1992-04-23. PMID:1532223. |
the purpose of this study was to compare the cardiovascular capacities of individuals with down syndrome (ds) to individuals without down syndrome who are mentally retarded. |
1992-04-23 |
2023-08-11 |
human |
| D M Holtzman, R M Bayney, Y W Li, H Khosrovi, C N Berger, C J Epstein, W C Moble. Dysregulation of gene expression in mouse trisomy 16, an animal model of Down syndrome. The EMBO journal. vol 11. issue 2. 1992-03-31. PMID:1371464. |
in humans, trisomy 21 results in a specific phenotype known as down syndrome (ds). |
1992-03-31 |
2023-08-11 |
mouse |
| C A Colton, J Yao, R E Taffs, J E Keri, M L Oster-Granit. Abnormal production of interleukin-1 by microglia from trisomy 16 mice. Neuroscience letters. vol 132. issue 2. 1992-03-18. PMID:1723792. |
the production of interleukin-1 (il-1) was examined in cultured cns microglia obtained from trisomy 16 (ts16) fetal mouse brain, a model system for studies relevant to down syndrome (ds). |
1992-03-18 |
2023-08-11 |
mouse |
| C L Crown, S Feldstein, M D Jasnow, B Beebe, J Jaff. Down's syndrome and infant gaze. Gaze behavior of Down's syndrome and nondelayed infants in interactions with their mothers. Acta paedopsychiatrica. vol 55. issue 1. 1992-03-05. PMID:1310371. |
the study reported here compared the gaze behavior of infants with down syndrome (ds) and nondelayed infants during interactions with their mothers. |
1992-03-05 |
2023-08-11 |
human |