| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Palka, M Ciccotelli, G Sabatino, G Calabrese, P Guanciali Franchi, L Stuppia, G Parruti, C Di Virgilio, O Di Sant. Cytogenetic study of the heterochromatic polymorphisms in 100 subjects with Down syndrome and their parents. American journal of medical genetics. Supplement. vol 7. 1991-04-16. PMID:2149948. |
we report on a cytogenetic study of 100 subjects with down syndrome (ds), diagnosed from 1980 to 1988, and their parents. |
1991-04-16 |
2023-08-11 |
human |
| A G Ugazio, R Maccario, L D Notarangelo, G R Burgi. Immunology of Down syndrome: a review. American journal of medical genetics. Supplement. vol 7. 1991-04-16. PMID:2149949. |
subjects with down syndrome (ds) have a high mortality due to infections and a high risk of developing malignancies. |
1991-04-16 |
2023-08-11 |
human |
| A Cossarizza, D Monti, G Montagnani, C Ortolani, M Masi, M Zannotti, C Francesch. Precocious aging of the immune system in Down syndrome: alteration of B lymphocytes, T-lymphocyte subsets, and cells with natural killer markers. American journal of medical genetics. Supplement. vol 7. 1991-04-16. PMID:2149950. |
phenotype and proliferative ability of peripheral blood lymphocytes from 15 noninstitutionalized children affected with down syndrome (ds), in apparently good health, were studied and compared with those of 16 healthy control children of the same age. |
1991-04-16 |
2023-08-11 |
human |
| P Musiani, S Valitutti, F Castellino, L M Larocca, N Maggiano, M Piantell. Intrathymic deficient expansion of T cell precursors in Down syndrome. American journal of medical genetics. Supplement. vol 7. 1991-04-16. PMID:2149951. |
to correlate the intrinsic cellular immunodeficiency, which is a major cause of increased susceptibility to polytopic infections in down syndrome (ds) patients, with the histologic abnormalities observed in the thymus of these patients, we have studied thymus fragments and thymocyte cell suspensions from 15 non-institutionalized ds subjects. |
1991-04-16 |
2023-08-11 |
human |
| L M Larocca, L Lauriola, F O Ranelletti, M Piantelli, N Maggiano, R Ricci, A Capell. Morphological and immunohistochemical study of Down syndrome thymus. American journal of medical genetics. Supplement. vol 7. 1991-04-16. PMID:2149952. |
the incidence and severity of various histologic changes were studied in the thymuses from 35 down syndrome (ds) patients. |
1991-04-16 |
2023-08-11 |
Not clear |
| M Murphy, M J Lempert, L B Epstei. Decreased level of T cell receptor expression by Down syndrome (trisomy 21) thymocytes. American journal of medical genetics. Supplement. vol 7. 1991-04-16. PMID:2149954. |
individuals with down syndrome (ds) have an enhanced susceptibility to viral and bacterial infections. |
1991-04-16 |
2023-08-11 |
Not clear |
| R T Zori, D A Schatz, H Ostrer, C A Williams, R Spillar, W J Rile. Relationship of autoimmunity to thyroid dysfunction in children and adults with Down syndrome. American journal of medical genetics. Supplement. vol 7. 1991-04-16. PMID:2149955. |
the extent to which autoimmunity contributes to thyroid dysfunction in down syndrome (ds) individuals has not been clarified. |
1991-04-16 |
2023-08-11 |
human |
| F Licastro, C Melotti, R Parente, L J Davis, M Chiricolo, M Zannotti, F Barbon. Derangement of non-specific immunity in Down syndrome subjects: low leukocyte chemiluminescence activity after phagocytic activation. American journal of medical genetics. Supplement. vol 7. 1991-04-16. PMID:2149956. |
metabolic activation of peripheral blood leukocytes (chemiluminescence) from 27 children with down syndrome (ds) and 23 age and sex-matched control children after phagocytic stimulation by opsonized zymosan particles was investigated through a chemiluminescence assay. |
1991-04-16 |
2023-08-11 |
human |
| G W Dewald, J L Diez-Martin, S L Steffen, R B Jenkins, P J Stupca, E O Burger. Hematologic disorders in 13 patients with acquired trisomy 21 and 13 individuals with Down syndrome. American journal of medical genetics. Supplement. vol 7. 1991-04-16. PMID:2149957. |
to study the role of trisomy 21 in hematologic malignancies, we investigated the hematologic disorders of 13 patients with acquired trisomy 21 and 13 individuals with down syndrome (ds). |
1991-04-16 |
2023-08-11 |
Not clear |
| T S Papas, D K Watson, N Sacchi, S Fujiwara, A K Seth, R J Fisher, N K Bhat, G Mavrothalassitis, S Koizumi, C L Jorcy. ETS family of genes in leukemia and Down syndrome. American journal of medical genetics. Supplement. vol 7. 1991-04-16. PMID:2149958. |
these genes are located on chromosome 21 and molecular genetic analysis of down syndrome (ds) patients with partial trisomy 21 suggested that ets2 may be a gene within the minimal ds genetic region. |
1991-04-16 |
2023-08-11 |
mouse |
| F Mitelman, S Heim, N Mandah. Trisomy 21 in neoplastic cells. American journal of medical genetics. Supplement. vol 7. 1991-04-16. PMID:2149959. |
the 52 leukemic down syndrome (ds) cases account for 1.4% of the total acute leukemias, an overrepresentation that parallels the generally increased risk of leukemia development in ds. |
1991-04-16 |
2023-08-11 |
human |
| D K Kalwinsky, S C Raimondi, N J Bunin, D Fairclough, C H Pui, M V Relling, R Ribeiro, G K River. Clinical and biological characteristics of acute lymphocytic leukemia in children with Down syndrome. American journal of medical genetics. Supplement. vol 7. 1991-04-16. PMID:2149960. |
twenty-eight children with down syndrome (ds) and acute lymphocytic leukemia (all) were compared to non-ds control leukemics matched by age, white blood cell (wbc) count, and treatment protocol to evaluate presenting manifestations, toxicity, and outcome. |
1991-04-16 |
2023-08-11 |
Not clear |
| G Gerli, L Zenoni, G F Locatelli, R Mongiat, F Piattoni, G B Orsini, A Montagnani, M R Gueli, V Gualandr. Erythrocyte antioxidant system in Down syndrome. American journal of medical genetics. Supplement. vol 7. 1991-04-16. PMID:2149961. |
it has been emphasized that an increased oxidative damage can exist in down syndrome (ds), and that superoxide dismutase (sod-1) seems to play a role in the pathogenesis of this disorder. |
1991-04-16 |
2023-08-11 |
Not clear |
| K E Wisniewsk. Down syndrome children often have brain with maturation delay, retardation of growth, and cortical dysgenesis. American journal of medical genetics. Supplement. vol 7. 1991-04-16. PMID:2149962. |
all down syndrome (ds) children have different degrees of developmental disabilities, developmental delay, and developmental brain abnormalities associated with cns maturation delay and cortical dysgenesis. |
1991-04-16 |
2023-08-11 |
Not clear |
| L C Cor. Neuropathology of Down syndrome and Alzheimer disease. American journal of medical genetics. Supplement. vol 7. 1991-04-16. PMID:2149963. |
patients with down syndrome (ds) over 40 years of age, prematurely and consistently develop neurofibrillary tangles (nft), intracytoplasmic inclusions of highly insoluble straight or paired helical 12-16 nm filaments, and senile plaques (sp) composed of abnormal neurites surrounding a core of beta amyloid. |
1991-04-16 |
2023-08-11 |
Not clear |
| C Romano, A Tiné, G Fazio, R Rizzo, R M Colognola, G Sorge, P Bergonzi, L Pavon. Seizures in patients with trisomy 21. American journal of medical genetics. Supplement. vol 7. 1991-04-16. PMID:2149964. |
we report on the incidence of seizures in 113 patients with down syndrome (ds), 43 coming from the oasi institute for research on mental retardation and brain aging, troina, and 70 from the outpatient clinic of the department of pediatrics, university of catania. |
1991-04-16 |
2023-08-11 |
Not clear |
| J Flórez, C del Arco, A González, J Pascual, A Pazo. Autoradiographic studies of neurotransmitter receptors in the brain of newborn infants with Down syndrome. American journal of medical genetics. Supplement. vol 7. 1991-04-16. PMID:2149965. |
the autoradiographic pattern of cholinergic muscarinic receptors in the brain of two newborn infants with down syndrome (ds) (stillbirths, 31 and 39 gestational weeks), were compared with that of age-matched control fetuses. |
1991-04-16 |
2023-08-11 |
Not clear |
| N Saviolo-Negrin, S Soresi, C Baccichetti, G Pozzan, E Trevisa. Observations on the visual-perceptual abilities and adaptive behavior in adults with Down syndrome. American journal of medical genetics. Supplement. vol 7. 1991-04-16. PMID:2149967. |
in this research, we consider some psychological, social, and clinical implications of premature aging in persons with down syndrome (ds). |
1991-04-16 |
2023-08-11 |
human |
| A Gat. Down syndrome children and their families. American journal of medical genetics. Supplement. vol 7. 1991-04-16. PMID:2149969. |
the philosophy of community care means that responsibility for the care of children with down syndrome (ds) remains still more firmly with the families. |
1991-04-16 |
2023-08-11 |
Not clear |
| T M Schroeder-Kurth, G Schaffert, W Koeckritz, M Kernic. Quality of life of adults with trisomy 21 living in mental retardation homes compared with those staying under parental care. American journal of medical genetics. Supplement. vol 7. 1991-04-16. PMID:2149970. |
genetic counseling today includes providing information about the probability of future behavior and state of health of surviving patients with down syndrome (ds). |
1991-04-16 |
2023-08-11 |
Not clear |