| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Novo, M I García, J Lavergn. Nonspecific immunity in Down syndrome: a study of chemotaxis, phagocytosis, oxidative metabolism, and cell surface marker expression of polymorphonuclear cells. American journal of medical genetics. vol 46. issue 4. 1993-09-23. PMID:7689298. |
we have investigated several aspects of nonspecific immunity in down syndrome (ds), utilizing peripheral polymorphonuclear leukocytes (pmnl), obtained from 12 children aged 8-16, diagnosed as trisomy 21, and their healthy matched controls. |
1993-09-23 |
2023-08-12 |
Not clear |
| G Lu, A J Altman, P A Ben. Review of the cytogenetic changes in acute megakaryoblastic leukemia: one disease or several? Cancer genetics and cytogenetics. vol 67. issue 2. 1993-08-17. PMID:8330276. |
the karyotypes of 116 cases of acute megakaryoblastic leukemia (amkl) were reviewed, including 43 pediatric patients with down syndrome (ds) and 73 non-ds patients. |
1993-08-17 |
2023-08-12 |
Not clear |
| R Gerlai, W Friend, L Becker, D O'Hanlon, A Marks, J Rode. Female transgenic mice carrying multiple copies of the human gene for S100 beta are hyperactive. Behavioural brain research. vol 55. issue 1. 1993-08-13. PMID:8329126. |
down syndrome (ds) (trisomy 21) is the most frequent genetic cause of mental retardation in man. |
1993-08-13 |
2023-08-12 |
mouse |
| N J Roizen, A P Amaros. Hematologic abnormalities in children with Down syndrome. American journal of medical genetics. vol 46. issue 5. 1993-07-30. PMID:8322810. |
we compared the hematologic parameters of 18 otherwise healthy children with down syndrome (ds) in the age range of 2-6 years to those of 18 healthy non-ds controls matched for age and gender. |
1993-07-30 |
2023-08-12 |
human |
| N Hayashi, K Iijima, M Higurash. [Attitudes toward handicapped children--a study comparing parents of handicapped children and others, in the case of Down syndrome]. [Nihon koshu eisei zasshi] Japanese journal of public health. vol 40. issue 3. 1993-07-27. PMID:8518432. |
eighty-four parents of down syndrome children (ds) and 118 controls including housewives, female office workers, and students were surveyed. |
1993-07-27 |
2023-08-12 |
Not clear |
| M Murphy, R M Insoft, L Pike-Nobile, K S Derbin, L B Epstei. Overexpression of LFA-1 and ICAM-1 in Down syndrome thymus. Implications for abnormal thymocyte maturation. Journal of immunology (Baltimore, Md. : 1950). vol 150. issue 12. 1993-07-20. PMID:8099939. |
consequently, we examined the constitutive expression of lfa-1 and icam-1 in postnatal human thymus from children with down syndrome (trisomy 21, ds) and age-matched control children. |
1993-07-20 |
2023-08-12 |
human |
| W Fuhrmann, K Altland, V Jovanovic, W Holzgreve, P Miny, D Wenger, R Rauskol. First-trimester alpha-fetoprotein screening for Down syndrome. Prenatal diagnosis. vol 13. issue 3. 1993-07-02. PMID:7685089. |
although in this sample msafp tended to be lower in down syndrome (ds) pregnancies than in pregnancies with a chromosomally normal fetus, at this early gestational age neither a fixed cut-off level of 0.5 multiples of the normal median (mom) nor one of 0.6 mom was suitable for identifying pregnancies at higher risk for ds. |
1993-07-02 |
2023-08-12 |
Not clear |
| M J Cremers, H J Beije. No relation between general laxity and atlantoaxial instability in children with Down syndrome. Journal of pediatric orthopedics. vol 13. issue 3. 1993-06-21. PMID:8496364. |
atlantoaxial instability in children with down syndrome (ds) may be caused by laxity of the transverse ligament. |
1993-06-21 |
2023-08-12 |
Not clear |
| V K Singh, R P Warren, J D Odell, W L Warren, P Col. Antibodies to myelin basic protein in children with autistic behavior. Brain, behavior, and immunity. vol 7. issue 1. 1993-05-14. PMID:7682457. |
this result in autistics was significantly (p < or = .0001) different from the controls (8 of 88 or only 9% positive), which included age-matched children with normal health, idiopathic mental retardation (mr) and down syndrome (ds), and normal adults of 20 to 40 years of age. |
1993-05-14 |
2023-08-12 |
Not clear |
| H Vaziri, F Schächter, I Uchida, L Wei, X Zhu, R Effros, D Cohen, C B Harle. Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. American journal of human genetics. vol 52. issue 4. 1993-04-23. PMID:8460632. |
since lymphocytes have a limited replicative capacity and since blood cells were previously shown to lose telomeric dna during aging in vivo, we wished to determine: (a) whether accelerated telomere loss is associated with the premature immunosenescence of lymphocytes in individuals with down syndrome (ds) and (b) whether telomeric dna is also lost during aging of lymphocytes in vitro. |
1993-04-23 |
2023-08-12 |
human |
| M I de Michelena, E Burstein, J R Lama, J C Vásque. Paternal age as a risk factor for Down syndrome. American journal of medical genetics. vol 45. issue 6. 1993-04-22. PMID:8456845. |
although the effect of maternal age as a risk factor for down syndrome (ds) is well known, the role of paternal age in the cause of ds has not been clearly established. |
1993-04-22 |
2023-08-12 |
Not clear |
| M E Percy, V D Markovic, A J Dalton, D R McLachlan, J M Berg, A C Rusk, M J Somerville, B Chodakowski, D F Andrew. Age-associated chromosome 21 loss in Down syndrome: possible relevance to mosaicism and Alzheimer disease. American journal of medical genetics. vol 45. issue 5. 1993-04-16. PMID:8456829. |
we previously observed low level mosaicism (2-4% normal cells) in phytohemagglutinin-stimulated peripheral blood lymphocytes (pbl) in 29% of a small group of elderly persons with down syndrome (ds). |
1993-04-16 |
2023-08-12 |
Not clear |
| I Barnes-Kedar, A Amiel, O Maor, M Fejgi. Elevated human chorionic gonadotropin levels in pregnancies with sex chromosome abnormalities. American journal of medical genetics. vol 45. issue 3. 1993-03-17. PMID:8434623. |
numerous reports have dealt with the usefulness of the maternal serum alpha-fetoprotein marker (msafp) and human chorionic gonadotropin (mshcg) levels in the detection of down syndrome (ds) and other autosomal trisomies. |
1993-03-17 |
2023-08-12 |
human |
| M Herrou, N Leporrier, P Leymari. Screening for fetal Down syndrome with maternal serum hCG and oestriol: a prospective study. Prenatal diagnosis. vol 12. issue 11. 1993-03-05. PMID:1494541. |
we report the preliminary results of a prospective study aimed at evaluating the effectiveness of down syndrome (ds) screening using second-trimester measurement of maternal serum human chorionic gonadotrophin (hcg) and unconjugated oestriol (ue3) together with maternal age. |
1993-03-05 |
2023-08-11 |
human |
| T L Jernigan, U Bellugi, E Sowell, S Doherty, J R Hesselin. Cerebral morphologic distinctions between Williams and Down syndromes. Archives of neurology. vol 50. issue 2. 1993-03-05. PMID:8431138. |
neurobehavioral studies of williams syndrome (ws) and down syndrome (ds) have revealed distinct profiles of cognitive strengths and weaknesses. |
1993-03-05 |
2023-08-12 |
human |
| M B Schapiro, J V Haxby, C L Grad. Nature of mental retardation and dementia in Down syndrome: study with PET, CT, and neuropsychology. Neurobiology of aging. vol 13. issue 6. 1993-02-26. PMID:1491738. |
down syndrome (ds), trisomy 21, is a genetic disorder in which an extra portion of chromosome 21 leads to mental retardation, short stature, and phenotypic abnormalities. |
1993-02-26 |
2023-08-11 |
human |
| Y Ono, H Yoshida, Y Momotani, F Yoshimasu, Y Higash. Age-related changes in occipital alpha rhythm of adults with Down syndrome. The Japanese journal of psychiatry and neurology. vol 46. issue 3. 1993-02-22. PMID:1487850. |
a power spectral analysis was performed on occipital eegs recorded from 36 down syndrome (ds) subjects aged 15 to 54 and compared with two control groups; 47 healthy volunteers (control) and 42 mentally retarded people without ds (mr). |
1993-02-22 |
2023-08-11 |
human |
| M M Marcell, S Cohe. Hearing abilities of Down syndrome and other mentally handicapped adolescents. Research in developmental disabilities. vol 13. issue 6. 1993-02-11. PMID:1480804. |
down syndrome (ds) individuals are prone to auditory processing difficulties in a variety of audiological, short-term memory, and language tasks. |
1993-02-11 |
2023-08-11 |
human |
| H Suzuki, A Iso, M Ishikaw. [Incidence rates of cerebral palsy, severe mental and motor retardation, and Down syndrome in the city of Kokubunji in suburban Tokyo]. No to hattatsu = Brain and development. vol 25. issue 1. 1993-01-28. PMID:8416690. |
the number of children with down syndrome (ds) was 11 and the incidence rate was 2.01/1,000 which was higher than the previous rates. |
1993-01-28 |
2023-08-12 |
Not clear |
| N V Kovalev. [Age and chromosome nondisjunction]. Genetika. vol 28. issue 10. 1993-01-25. PMID:1468638. |
the parental age in 77 families of down syndrome (ds) children with the known origin of extra chromosome 21 and in 12 families of ds children resulting from de novo translocation (more probable than not in 2 meiotic division) was studied. |
1993-01-25 |
2023-08-11 |
Not clear |