| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Gerlai, A Marks, J Rode. T-maze spontaneous alternation rate is decreased in S100 beta transgenic mice. Behavioral neuroscience. vol 108. issue 1. 1994-06-27. PMID:8192834. |
s100 beta levels are elevated in down syndrome (ds), and the gene for s100 beta is located on chromosome 21, which is duplicated in ds. |
1994-06-27 |
2023-08-12 |
mouse |
| J R Korenberg, X N Chen, R Schipper, Z Sun, R Gonsky, S Gerwehr, N Carpenter, C Daumer, P Dignan, C Distech. Down syndrome phenotypes: the consequences of chromosomal imbalance. Proceedings of the National Academy of Sciences of the United States of America. vol 91. issue 11. 1994-06-27. PMID:8197171. |
down syndrome (ds) is a major cause of mental retardation and congenital heart disease. |
1994-06-27 |
2023-08-12 |
human |
| J Pincheira, M Rodriguez, M Bravo, M H Navarrete, J F Lopez-Sae. Defective G2 repair in Down syndrome: effect of caffeine, adenosine and niacinamide in control and X-ray irradiated lymphocytes. Clinical genetics. vol 45. issue 1. 1994-05-10. PMID:8149648. |
lymphocytes from both down syndrome (ds) patients and age-matched control donors have been investigated to identify a possible disturbance in chromosomal g2 repair. |
1994-05-10 |
2023-08-12 |
Not clear |
| M A Carskadon, S M Pueschel, R P Millma. Sleep-disordered breathing and behavior in three risk groups: preliminary findings from parental reports. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. vol 9. issue 8. 1994-04-08. PMID:8124671. |
adenotonsillar enlargement (at) is known to be a significant risk factor for these disorders, which have also been reported in several patients with down syndrome (ds). |
1994-04-08 |
2023-08-12 |
Not clear |
| G Annerén, B Edma. Down syndrome--a gene dosage disease caused by trisomy of genes within a small segment of the long arm of chromosome 21, exemplified by the study of effects from the superoxide-dismutase type 1 (SOD-1) gene. APMIS. Supplementum. vol 40. 1994-03-23. PMID:8311993. |
down syndrome (ds), the most common postnatally viable human autosomal chromosomal abnormality is caused by trisomy for chromosome 21. |
1994-03-23 |
2023-08-12 |
human |
| J E Allanson, P O'Hara, L G Farkas, R C Nai. Anthropometric craniofacial pattern profiles in Down syndrome. American journal of medical genetics. vol 47. issue 5. 1994-01-25. PMID:8267006. |
a series of 21 anthropometric craniofacial measurements was performed on 199 individuals with down syndrome (ds), age 6 months to 61 years. |
1994-01-25 |
2023-08-12 |
human |
| D M Holtzman, Y Li, K Chen, F H Gage, C J Epstein, W C Moble. Nerve growth factor reverses neuronal atrophy in a Down syndrome model of age-related neurodegeneration. Neurology. vol 43. issue 12. 1994-01-13. PMID:8255474. |
since all individuals with down syndrome (ds) develop ad neuropathology by the 4th decade, we reasoned that a genetic model of ds, the trisomy 16 (ts 16) mouse, may provide an animal model to study the neurodegeneration in ad. |
1994-01-13 |
2023-08-12 |
mouse |
| M S Watson, A J Carroll, J J Shuster, C P Steuber, M J Borowitz, F G Behm, D J Pullen, V J Lan. Trisomy 21 in childhood acute lymphoblastic leukemia: a Pediatric Oncology Group study (8602). Blood. vol 82. issue 10. 1993-12-22. PMID:8219201. |
of these 33, 14 had down syndrome (ds). |
1993-12-22 |
2023-08-12 |
Not clear |
| B T Lamb, S S Sisodia, A M Lawler, H H Slunt, C A Kitt, W G Kearns, P L Pearson, D L Price, J D Gearhar. Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected]. Nature genetics. vol 5. issue 1. 1993-12-09. PMID:8220418. |
overexpression of the gene encoding the beta-amyloid precursor protein (app) may have a key role in the pathogenesis of both alzheimer's disease (ad) and down syndrome (ds). |
1993-12-09 |
2023-08-12 |
mouse |
| B T Hyman, K Marzloff, P V Arriagad. The lack of accumulation of senile plaques or amyloid burden in Alzheimer's disease suggests a dynamic balance between amyloid deposition and resolution. Journal of neuropathology and experimental neurology. vol 52. issue 6. 1993-12-08. PMID:8229078. |
we have studied temporal neocortex of normal elderly subjects, ad patients, and elderly down syndrome (ds) patients to determine whether a beta accumulates with age or with increasing duration of illness. |
1993-12-08 |
2023-08-12 |
human |
| K K Sanford, R Parshad, F M Price, R E Tarone, M B Schapir. X-ray-induced chromatid damage in cells from Down syndrome and Alzheimer disease patients in relation to DNA repair and cancer proneness. Cancer genetics and cytogenetics. vol 70. issue 1. 1993-12-07. PMID:8221609. |
frequencies of chromatid aberrations in response to g2-phase x-irradiation were compared in pha-stimulated blood lymphocytes from healthy control subjects, down syndrome (ds) patients, and alzheimer disease (ad) patients. |
1993-12-07 |
2023-08-12 |
human |
| Y On. EEG changes with aging in adults with Down syndrome. The Japanese journal of psychiatry and neurology. vol 47. issue 1. 1993-11-16. PMID:8411794. |
the eegs of 40 subjects with down syndrome (ds) aged 15 to 54 were investigated and compared with those of 42 mentally retarded subjects without ds (mr) and 47 healthy volunteers. |
1993-11-16 |
2023-08-12 |
human |
| E Sikora, E Radziszewska, T Kmieć, D Maślińsk. The impaired transcription factor AP-1 DNA binding activity in lymphocytes derived from subjects with some symptoms of premature aging. Acta biochimica Polonica. vol 40. issue 2. 1993-11-04. PMID:8212965. |
down syndrome (ds) and neuronal ceroid-lypofuscinosis (ncl) are clinically characterized by the premature onset of numerous features normally associated with human aging. |
1993-11-04 |
2023-08-12 |
human |
| P D Mehta, A J Dalton, S P Mehta, M E Percy, E A Sersen, H M Wisniewsk. Immunoglobulin G subclasses in older persons with Down syndrome. Journal of the neurological sciences. vol 117. issue 1-2. 1993-11-01. PMID:8410055. |
igg subclasses were measured in sera from 33 persons with down syndrome (ds) (mean age 55 +/- 7 years) and 33 age- and sex-matched control individuals using a mouse monoclonal antibody based sandwich enzyme linked immunosorbent assay. |
1993-11-01 |
2023-08-12 |
mouse |
| M Oda, R Hakamada, K Ono, M Higurash. A seroimmunological analysis of Down syndrome. Gerontology. vol 39 Suppl 1. 1993-10-07. PMID:8365667. |
down syndrome (ds) was studied in terms of immunological function and serological aspects. |
1993-10-07 |
2023-08-12 |
Not clear |
| C G Palmer, C Cronk, S M Pueschel, K E Wisniewski, R Laxova, A C Crocker, R M Paul. Head circumference of children with Down syndrome (0-36 months) American journal of medical genetics. vol 42. issue 1. 1993-09-27. PMID:1308367. |
head circumference of children with down syndrome (0-36 months) this study provides statistically appropriate head circumference reference curves for males and females with down syndrome (ds) from birth to 36 months of age. |
1993-09-27 |
2023-08-11 |
Not clear |
| E Novo, M I García, J Lavergn. Nonspecific immunity in Down syndrome: a study of chemotaxis, phagocytosis, oxidative metabolism, and cell surface marker expression of polymorphonuclear cells. American journal of medical genetics. vol 46. issue 4. 1993-09-23. PMID:7689298. |
we have investigated several aspects of nonspecific immunity in down syndrome (ds), utilizing peripheral polymorphonuclear leukocytes (pmnl), obtained from 12 children aged 8-16, diagnosed as trisomy 21, and their healthy matched controls. |
1993-09-23 |
2023-08-12 |
Not clear |
| G Lu, A J Altman, P A Ben. Review of the cytogenetic changes in acute megakaryoblastic leukemia: one disease or several? Cancer genetics and cytogenetics. vol 67. issue 2. 1993-08-17. PMID:8330276. |
the karyotypes of 116 cases of acute megakaryoblastic leukemia (amkl) were reviewed, including 43 pediatric patients with down syndrome (ds) and 73 non-ds patients. |
1993-08-17 |
2023-08-12 |
Not clear |
| R Gerlai, W Friend, L Becker, D O'Hanlon, A Marks, J Rode. Female transgenic mice carrying multiple copies of the human gene for S100 beta are hyperactive. Behavioural brain research. vol 55. issue 1. 1993-08-13. PMID:8329126. |
down syndrome (ds) (trisomy 21) is the most frequent genetic cause of mental retardation in man. |
1993-08-13 |
2023-08-12 |
mouse |
| N J Roizen, A P Amaros. Hematologic abnormalities in children with Down syndrome. American journal of medical genetics. vol 46. issue 5. 1993-07-30. PMID:8322810. |
we compared the hematologic parameters of 18 otherwise healthy children with down syndrome (ds) in the age range of 2-6 years to those of 18 healthy non-ds controls matched for age and gender. |
1993-07-30 |
2023-08-12 |
human |