Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
R Gaggero, P T Donati, R Curia, M De Negr. Occlusion of unilateral carotid artery in Down syndrome. Brain & development. vol 18. issue 1. 1997-03-07. PMID:8907351. |
the association between moyamoya phenomena and down syndrome (ds) is reported in the literature. |
1997-03-07 |
2023-08-12 |
Not clear |
C L Olsen, P K Cross, L J Gensburg, J P Hughe. The effects of prenatal diagnosis, population ageing, and changing fertility rates on the live birth prevalence of Down syndrome in New York State, 1983-1992. Prenatal diagnosis. vol 16. issue 11. 1997-03-06. PMID:8953632. |
the incidence of down syndrome (ds) at conception is highly dependent on the maternal age distribution and age-specific pregnancy rates. |
1997-03-06 |
2023-08-12 |
Not clear |
B Källén, P Mastroiacovo, E Rober. Major congenital malformations in Down syndrome. American journal of medical genetics. vol 65. issue 2. 1997-02-19. PMID:8911611. |
we studied major malformations in 5,581 infants with down syndrome (ds) from three registers of congenital malformations. |
1997-02-19 |
2023-08-12 |
Not clear |
J Kuromitsu, H Yamashita, H Kataoka, T Takahara, M Muramatsu, T Sekine, N Okamoto, Y Furuichi, Y Hayashizak. A unique downregulation of h2-calponin gene expression in Down syndrome: a possible attenuation mechanism for fetal survival by methylation at the CpG island in the trisomic chromosome 21. Molecular and cellular biology. vol 17. issue 2. 1997-02-18. PMID:9001224. |
to understand the effect of trisomic chromosome 21 on the cause of down syndrome (ds), dna methylation in the cpg island, which regulates the expression of adjacent genes, was investigated with the dnas of chromosome 21 isolated from ds patients and their parents. |
1997-02-18 |
2023-08-12 |
Not clear |
S L Klein, L J Kriegsfeld, J E Hairston, V Rau, R J Nelson, P J Yarowsk. Characterization of sensorimotor performance, reproductive and aggressive behaviors in segmental trisomic 16 (Ts65Dn) mice. Physiology & behavior. vol 60. issue 4. 1997-02-05. PMID:8884947. |
in the present study, segmental trisomy 16 (ts65dn) mice, an animal model of down syndrome (ds), were examined for sensorimotor, reproductive, and aggression abnormalities associated with ds. |
1997-02-05 |
2023-08-12 |
mouse |
E Arvat, L Gianotti, L Ragusa, M R Valetto, M Cappa, G Aimaretti, J Ramunni, S Grottoli, F Camanni, E Ghig. The enhancing effect of pyridostigmine on the GH response to GHRH undergoes an accelerated age-related reduction in Down syndrome. Dementia (Basel, Switzerland). vol 7. issue 5. 1997-01-10. PMID:8872421. |
as in down syndrome (ds) neural alterations have been reported similar to those in aging, including cholinergic impairment, we verified the gh response to ghrh (1 microgram/kg i.v. |
1997-01-10 |
2023-08-12 |
human |
J Guimerá, C Casas, C Pucharcòs, A Solans, A Domènech, A M Planas, J Ashley, M Lovett, X Estivill, M A Pritchar. A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region. Human molecular genetics. vol 5. issue 9. 1997-01-08. PMID:8872470. |
trisomy 21 or down syndrome (ds) is the most frequent human birth defect. |
1997-01-08 |
2023-08-12 |
mouse |
J Guimerá, C Casas, C Pucharcòs, A Solans, A Domènech, A M Planas, J Ashley, M Lovett, X Estivill, M A Pritchar. A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region. Human molecular genetics. vol 5. issue 9. 1997-01-08. PMID:8872470. |
a region on human chromosome 21 has been designated the down syndrome critical region (dscr) and when present in three copies, this is responsible for many of the characteristic features of ds, including mental retardation. |
1997-01-08 |
2023-08-12 |
mouse |
D M Holtzman, D Santucci, J Kilbridge, J Chua-Couzens, D J Fontana, S E Daniels, R M Johnson, K Chen, Y Sun, E Carlson, E Alleva, C J Epstein, W C Moble. Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 23. 1996-12-30. PMID:8917591. |
to study the pathogenesis of central nervous system abnormalities in down syndrome (ds), we have analyzed a new genetic model of ds, the partial trisomy 16 (ts65dn) mouse. |
1996-12-30 |
2023-08-12 |
mouse |
D E Cabin, K Gardiner, R H Reeve. Molecular genetic characterization and comparative mapping of the human PCP4 gene. Somatic cell and molecular genetics. vol 22. issue 3. 1996-12-18. PMID:8914602. |
to further characterize pcp4 and its possible contribution to cerebellar hypoplasia in trisomy 21, or down syndrome (ds), we cloned and sequenced the full length human cdna, isolated a yac which carries the entire gene, determined the gene structure, and characterized its expression. |
1996-12-18 |
2023-08-12 |
mouse |
M E Coussons-Read, L S Crni. Behavioral assessment of the Ts65Dn mouse, a model for Down syndrome: altered behavior in the elevated plus maze and open field. Behavior genetics. vol 26. issue 1. 1996-12-17. PMID:8852727. |
the ts65dn mouse carries a partial trisomy for mouse chromosome 16 in a region that has high homology to the down syndrome (ds) region of human chromosome 21 and is, thus, a potential animal model of ds. |
1996-12-17 |
2023-08-12 |
mouse |
D Risser, Z B You, N Cairns, M Herrera-Marschitz, R Seidl, C Schneider, L Terenius, G Lube. Endogenous opioids in frontal cortex of patients with Down syndrome. Neuroscience letters. vol 203. issue 2. 1996-12-09. PMID:8834106. |
the main purpose of this study was to investigate differences regarding endogenous opioids in post-mortem frontal cortex of adult patients with down syndrome (ds), patients with alzheimer disease (ad) and neurologically healthy persons, respectively, using specific radioimmunoassays. |
1996-12-09 |
2023-08-12 |
Not clear |
M B Schapiro, D G Murphy, R J Hagerman, N P Azari, G E Alexander, C M Miezejeski, V J Hinton, B Horwitz, J V Haxby, A Kuma. Adult fragile X syndrome: neuropsychology, brain anatomy, and metabolism. American journal of medical genetics. vol 60. issue 6. 1996-12-05. PMID:8825884. |
controls for the ct studies were 20 healthy males (age range 21-37 yr), controls for the pet studies were 9 healthy males (age range 22-31 yr), and controls for the neuropsychological tests were 10 young adult, male down syndrome (ds) subjects (age range 22-31 yr). |
1996-12-05 |
2023-08-12 |
human |
R M Viner, N Shimura, B D Brown, A J Green, I A Hughe. Down syndrome in association with features of the androgen insensitivity syndrome. Journal of medical genetics. vol 33. issue 7. 1996-12-03. PMID:8818943. |
three cases of down syndrome (ds) are reported in association with features of the androgen insensitivity syndrome (ais). |
1996-12-03 |
2023-08-12 |
Not clear |
M David, R Merksamer, N Israel, H Da. Unconjugated estriol as maternal serum marker for the detection of Down syndrome pregnancies. Fetal diagnosis and therapy. vol 11. issue 2. 1996-12-03. PMID:8838765. |
the effectiveness of unconjugated estriol (ue3) as a serum marker for the detection of down syndrome (ds) during the 2nd trimester of pregnancy was evaluated. |
1996-12-03 |
2023-08-12 |
human |
A L Politoff, R P Stadter, N Monson, P Has. Cognition-related EEG abnormalities in nondemented Down syndrome subjects. Dementia (Basel, Switzerland). vol 7. issue 2. 1996-12-03. PMID:8866678. |
down syndrome (ds) subjects develop alzheimer disease (ad) histopathology before they develop dementia. |
1996-12-03 |
2023-08-12 |
human |
A Marks, D O'Hanlon, M Lei, M E Percy, L E Becke. Accumulation of S100 beta mRNA and protein in cerebellum during infancy in Down syndrome and control subjects. Brain research. Molecular brain research. vol 36. issue 2. 1996-12-03. PMID:8965656. |
in order to investigate the effect of trisomy 21 on s100 beta gene expression, we performed southern, northern and western blot analysis on dna, rna and protein, respectively, extracted from the cerebellum of control and down syndrome (ds) subjects aged 1-18 months. |
1996-12-03 |
2023-08-12 |
human |
A L Christianson, J G Kromber. Maternal non-recognition of Down syndrome in black South African infants. Clinical genetics. vol 49. issue 3. 1996-11-22. PMID:8737979. |
down syndrome (ds), one of the commonest causes of mental retardation in caucasoids, has only rarely been described in africa. |
1996-11-22 |
2023-08-12 |
Not clear |
J Wegiel, H M Wisniewski, J Dziewiatkowski, E R Popovitch, M Tarnawsk. Differential susceptibility to neurofibrillary pathology among patients with Down syndrome. Dementia (Basel, Switzerland). vol 7. issue 3. 1996-11-07. PMID:8740627. |
individual differences in the development of neurofibrillary changes were examined in eight cortical regions in the brains of 43 subjects with down syndrome (ds; age range, 15-69 years) using sections stained with monoclonal antibodies (mab) tau-1 and 3-39. |
1996-11-07 |
2023-08-12 |
human |
J Wegiel, H M Wisniewski, J Dziewiatkowski, E R Popovitch, M Tarnawsk. Differential susceptibility to neurofibrillary pathology among patients with Down syndrome. Dementia (Basel, Switzerland). vol 7. issue 3. 1996-11-07. PMID:8740627. |
comparison of these three groups of down syndrome subjects representing high, moderate, and low susceptibility to neurofibrillary changes with the general population suggests that the risk of alzheimer disease is similar but the onset of pathological changes is earlier in ds. |
1996-11-07 |
2023-08-12 |
human |