| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J J Fuentes, M Dierssen, C Pucharcós, C Fillat, C Casas, X Estivill, M Pritchar. Application of Alu-splice PCR on chromosome 21: DSCR1 and Intersectin. Journal of neural transmission. Supplementum. vol 57. 2000-04-12. PMID:10666688. |
down syndrome (ds) is a major cause of mental retardation and congenital heart defects, with an overall incidence of one in 700 live births. |
2000-04-12 |
2023-08-12 |
human |
| R Maymon, I K Sehmi, A Herman, R G Jones, D Sherman, H Cuckl. Serum inhibin A levels in pregnant women with systemic lupus erythematosus or antiphospholipid syndrome. Prenatal diagnosis. vol 20. issue 1. 2000-03-27. PMID:10701844. |
maternal serum inhibin a levels are increased on average in pregnancies affected by down syndrome (ds). |
2000-03-27 |
2023-08-12 |
Not clear |
| A Amano, T Kishima, S Kimura, M Takiguchi, T Ooshima, S Hamada, I Morisak. Periodontopathic bacteria in children with Down syndrome. Journal of periodontology. vol 71. issue 2. 2000-03-22. PMID:10711615. |
it is widely known that individuals with down syndrome (ds) often develop severe early-onset periodontal diseases. |
2000-03-22 |
2023-08-12 |
Not clear |
| A M da Nóbrega, H G Nunesmaia, N de O Viana, M A Filgueira. [Electroencephalographic modification in Down syndrome]. Arquivos de neuro-psiquiatria. vol 57. issue 3A. 2000-03-09. PMID:10667280. |
the frequency of epilepsy in down syndrome (ds) has been reported in literature varying from 6 to 17%. |
2000-03-09 |
2023-08-12 |
Not clear |
| S Vicari, S Bellucci, G A Carlesim. Implicit and explicit memory: a functional dissociation in persons with Down syndrome. Neuropsychologia. vol 38. issue 3. 2000-03-08. PMID:10678691. |
this study aimed at investigating implicit and explicit long-term memory functioning in subjects with down syndrome (ds) compared to mental-age (ma) matched normal children. |
2000-03-08 |
2023-08-12 |
human |
| N Angelopoulou, C Matziari, V Tsimaras, A Sakadamis, V Souftas, K Mandrouka. Bone mineral density and muscle strength in young men with mental retardation (with and without Down syndrome). Calcified tissue international. vol 66. issue 3. 2000-02-29. PMID:10666490. |
the objective of this study was to compare the bone mineral density (bmd) of men with down syndrome (ds) to otherwise mentally retarded (mr) men and to investigate whether leg muscle strength of these patients is related to bmd. |
2000-02-29 |
2023-08-12 |
Not clear |
| L L Baxter, T H Moran, J T Richtsmeier, J Troncoso, R H Reeve. Discovery and genetic localization of Down syndrome cerebellar phenotypes using the Ts65Dn mouse. Human molecular genetics. vol 9. issue 2. 2000-02-28. PMID:10607830. |
down syndrome (ds) is the most common genetic cause of mental retardation and affects many aspects of brain development. |
2000-02-28 |
2023-08-12 |
mouse |
| J Tyrrell, M Cosgrave, J McPherson, Z Hawi, V Trulock, J Calvert, B Lawlor, M Gil. Presenilin 1 and alpha-1-antichymotrypsin polymorphisms in Down syndrome: no effect on the presence of dementia. American journal of medical genetics. vol 88. issue 6. 2000-02-24. PMID:10581479. |
as people with down syndrome (ds) age, they are at greater risk for alzheimer disease (ad) than the general population. |
2000-02-24 |
2023-08-12 |
Not clear |
| N Hoshi, R Hattori, K Hanatani, K Okuyama, H Yamada, T Kishida, T Yamada, T Sagawa, Y Sumiyoshi, S Fujimot. Recent trends in the prevalence of Down syndrome in Japan, 1980-1997. American journal of medical genetics. vol 84. issue 4. 2000-02-18. PMID:10340648. |
the aims of the present study were to determine recent trends in the prevalence of down syndrome (ds) in japan, and to determine whether recent changes in demographic and social habits and access to prenatal diagnosis have influenced the livebirth rates of ds. |
2000-02-18 |
2023-08-12 |
Not clear |
| K Brugge, S Nichols, T Saitoh, D Traune. Correlations of glutathione peroxidase activity with memory impairment in adults with Down syndrome. Biological psychiatry. vol 46. issue 12. 2000-02-08. PMID:10624550. |
down syndrome (ds) is a genetic disorder (trisomy 21 in 96% of cases), associated with an excess of a key enzyme involved with free radical metabolism (frm), superoxide dismutase-1 (sod-1), that is encoded by a gene on chromosome 21. |
2000-02-08 |
2023-08-12 |
Not clear |
| K A Chang, S H Kim, Y Sakaki, H S Kim, C W Park, Y H Su. Inhibition of the NGF and IL-1beta-induced expression of Alzheimer's amyloid precursor protein by antisense oligonucleotides. Journal of molecular neuroscience : MN. vol 12. issue 1. 2000-02-03. PMID:10636471. |
the overexpression of app is known to be a risk factor for abeta deposit in ad and in down syndrome (ds). |
2000-02-03 |
2023-08-12 |
Not clear |
| E Alleva, F Cirulli, G Calamandrei, C Rondinini, O Capirci, L Aloe, V Volterr. [Williams syndrome]. Annali dell'Istituto superiore di sanita. vol 35. issue 2. 2000-02-03. PMID:10645654. |
a cognitive profile of the ws individuals is defined and compared to down syndrome (ds) and autism cognitive profiles. |
2000-02-03 |
2023-08-12 |
human |
| A C Costa, K Walsh, M T Davisso. Motor dysfunction in a mouse model for Down syndrome. Physiology & behavior. vol 68. issue 1-2. 2000-01-31. PMID:10627083. |
motor deficits are among the most frequently occurring features of down syndrome (ds). |
2000-01-31 |
2023-08-12 |
mouse |
| T Wiltshire, M Pletcher, S E Cole, M Villanueva, B Birren, J Lehoczky, K Dewar, R H Reeve. Perfect conserved linkage across the entire mouse chromosome 10 region homologous to human chromosome 21. Genome research. vol 9. issue 12. 2000-01-27. PMID:10613844. |
the new genes identified here may be involved in down syndrome (ds) or in several genetic diseases that map to this conserved region of hsa21. |
2000-01-27 |
2023-08-12 |
mouse |
| W Cusick, A M Vintzileo. Fetal Down syndrome screening: a cost effectiveness analysis of alternative screening programs. The Journal of maternal-fetal medicine. vol 8. issue 6. 2000-01-07. PMID:10582856. |
to compare the efficacy and cost effectiveness of different screening programs for fetal down syndrome (ds). |
2000-01-07 |
2023-08-12 |
Not clear |
| J Strovel, J Stamberg, P J Yarowsk. Interphase FISH for rapid identification of a down syndrome animal model. Cytogenetics and cell genetics. vol 86. issue 3-4. 2000-01-06. PMID:10575227. |
mouse models of down syndrome (trisomy 21, ds) have been developed to study the consequences of triplication of regions syntenic to distal human chromosome 21. |
2000-01-06 |
2023-08-12 |
mouse |
| A Ognibene, R Ciuti, P Tozzi, G Messer. Maternal serum superoxide dismutase (SOD): a possible marker for screening Down syndrome affected pregnancies. Prenatal diagnosis. vol 19. issue 11. 2000-01-06. PMID:10589060. |
superoxide dismutase (sod: ec1.15.1.1) has been shown to increase in down syndrome (ds) subjects and in amniotic fluid from ds affected pregnancies. |
2000-01-06 |
2023-08-12 |
human |
| M B Schapiro, K F Berman, G E Alexander, D R Weinberger, S I Rapopor. Regional cerebral blood flow in Down syndrome adults during the Wisconsin Card Sorting Test: exploring cognitive activation in the context of poor performance. Biological psychiatry. vol 45. issue 9. 2000-01-05. PMID:10331111. |
prior studies have indicated abnormal frontal lobes in down syndrome (ds). |
2000-01-05 |
2023-08-12 |
Not clear |
| P D Mehta, B A Patrick, A J Dalton, P S Aisen, M E Emmerling, E A Sersen, H M Wisniewsk. Increased levels of tau-like protein in patients with Down syndrome. Neuroscience letters. vol 275. issue 3. 2000-01-04. PMID:10580699. |
tau-like protein levels from 40 down syndrome (ds) persons (31-70 years old), 40 non-ds age-matched normal controls, 18 non-ds mentally retarded (mr) persons (26-91 years old), 25 probable alzheimer disease (ad) patients (55-99 years old) and 24 non-demented elderly controls (54-79 years old) were measured using a sandwich enzyme linked immunosorbent assay. |
2000-01-04 |
2023-08-12 |
Not clear |
| M I van Allen, J Fung, S B Jurenk. Health care concerns and guidelines for adults with Down syndrome. American journal of medical genetics. vol 89. issue 2. 1999-12-28. PMID:10559765. |
down syndrome (ds) is the most common cause of mental retardation in north america, yet little information is available on the natural history of ds in adults. |
1999-12-28 |
2023-08-12 |
Not clear |