| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Bozinovski, D Poenaru, W Paterson, I Kama. Esophageal aperistalsis following fundoplication in a patient with trisomy 21. Pediatric surgery international. vol 15. issue 7. 1999-11-16. PMID:10525912. |
gastrointestinal abnormalities are frequent in patients with down syndrome (ds), gastroesophageal reflux (ger) being prominent among them. |
1999-11-16 |
2023-08-12 |
Not clear |
| R Maymon, E Dreazen, S Rozinsky, I Bukovsky, Z Weinraub, A Herma. Comparison of nuchal translucency measurement and second-trimester triple serum screening in twin versus singleton pregnancies. Prenatal diagnosis. vol 19. issue 8. 1999-11-09. PMID:10451516. |
maternal serum screening for down syndrome (ds) in twin pregnancies poses difficulties due to a lack of precise biochemical information about each co-twin. |
1999-11-09 |
2023-08-12 |
Not clear |
| G J Van Buggenhout, J C Trommelen, A Schoenmaker, C De Bal, J J Verbeek, D F Smeets, H H Ropers, K Devriendt, B C Hamel, J P Fryn. Down syndrome in a population of elderly mentally retarded patients: genetic-diagnostic survey and implications for medical care. American journal of medical genetics. vol 85. issue 4. 1999-10-20. PMID:10398264. |
ninety-six adults with down syndrome (ds) from an institutional setting of 591 mentally retarded were investigated systematically with respect to cytogenetic diagnosis, mental functioning and dementia, ophthalmological and audiological abnormalities, and thyroid function. |
1999-10-20 |
2023-08-12 |
Not clear |
| L Averbuch-Heller, L F Dell'Osso, J B Jacobs, B F Remle. Latent and congenital nystagmus in Down syndrome. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society. vol 19. issue 3. 1999-10-20. PMID:10494944. |
although nystagmus has been reported in down syndrome (ds), it has been poorly characterized, because most investigators have relied on clinical observations rather than on eye movement recordings. |
1999-10-20 |
2023-08-12 |
Not clear |
| C Lopes, M Rachidi, S Gassanova, P M Sinet, J M Delaba. Developmentally regulated expression of mtprd, the murine ortholog of tprd, a gene from the Down syndrome chromosomal region 1. Mechanisms of development. vol 84. issue 1-2. 1999-10-12. PMID:10473140. |
the gene tprd, which contains three tetratricopeptide domains, has been recently localized in the down syndrome (ds) chromosomal region 1. |
1999-10-12 |
2023-08-12 |
mouse |
| F E Ali, W A al-Busairi, F A al-Mull. Treatment of hyperthyroidism in Down syndrome: case report and review of the literature. Research in developmental disabilities. vol 20. issue 4. 1999-10-08. PMID:10425657. |
thyroid disorders are common in individuals with down syndrome (ds). |
1999-10-08 |
2023-08-12 |
Not clear |
| M Heath, D Elliot. Cerebral specialization for speech production in persons with Down syndrome. Brain and language. vol 69. issue 2. 1999-10-05. PMID:10447990. |
the study of cerebral specialization in persons with down syndrome (ds) has revealed an anomalous pattern of organization. |
1999-10-05 |
2023-08-12 |
human |
| D Duflos-Delaplace, J L Laï, B Nelken, F Genevieve, A S Defachelles, M Zandeck. Transient leukemoid disorder in a newborn with Down syndrome followed 19 months later by an acute myeloid leukemia: demonstration of the same structural change in both instances with clonal evolution. Cancer genetics and cytogenetics. vol 113. issue 2. 1999-09-28. PMID:10484985. |
a transient leukemoid disorder (tld) was observed in a newborn with down syndrome (ds), demonstrating a clonal abnormality: 47,xx,der(x;15)(p10;q10),+21(c). |
1999-09-28 |
2023-08-12 |
Not clear |
| F Lai, E Kammann, G W Rebeck, A Anderson, Y Chen, R A Nixo. APOE genotype and gender effects on Alzheimer disease in 100 adults with Down syndrome. Neurology. vol 53. issue 2. 1999-09-21. PMID:10430422. |
alzheimer disease (ad) neuropathology is present in down syndrome (ds) after age 35, but dementia onset varies from ages 40 to 70 years. |
1999-09-21 |
2023-08-12 |
Not clear |
| J W Taub, X Huang, L H Matherly, M L Stout, S A Buck, G V Massey, D L Becton, M N Chang, H J Weinstein, Y Ravindranat. Expression of chromosome 21-localized genes in acute myeloid leukemia: differences between Down syndrome and non-Down syndrome blast cells and relationship to in vitro sensitivity to cytosine arabinoside and daunorubicin. Blood. vol 94. issue 4. 1999-09-07. PMID:10438727. |
the high event-free survival rates of down syndrome (ds) children with acute myeloid leukemia (aml) are due, in part, to increased in vitro sensitivity of ds myeloblasts to cytosine arabinoside (ara-c) and daunorubicin and the greater generation of ara-c triphosphate (ara-ctp) from ara-c compared with myeloblasts from non-ds patients (taub et al, blood 87:3395, 1996). |
1999-09-07 |
2023-08-12 |
Not clear |
| A D Carothers, C A Hecht, E B Hoo. International variation in reported livebirth prevalence rates of Down syndrome, adjusted for maternal age. Journal of medical genetics. vol 36. issue 5. 1999-08-24. PMID:10353785. |
reported livebirth prevalence of down syndrome (ds) may be affected by the maternal age distribution of the population, completeness of ascertainment, accuracy of diagnosis, extent of selective prenatal termination of affected pregnancies, and as yet unidentified genetic and environmental factors. |
1999-08-24 |
2023-08-12 |
human |
| A Petroni. Alzheimer's disease and down syndrome: from meiosis to dementia. Experimental neurology. vol 158. issue 2. 1999-08-24. PMID:10415146. |
several molecular and clinical similarities have been detected in alzheimer's disease (ad) and down syndrome (ds). |
1999-08-24 |
2023-08-12 |
Not clear |
| K Yasui, K Shinozaki, T Nakazawa, K Agematsu, A Komiyam. Presenility of granulocytes in Down syndrome individuals. American journal of medical genetics. vol 84. issue 5. 1999-08-23. PMID:10360394. |
neutrophil function defects occur in individuals with down syndrome (ds). |
1999-08-23 |
2023-08-12 |
human |
| K Carlstedt, G Annerén, J Huggare, T Modéer, G Dahllö. The effect of growth hormone therapy on craniofacial growth and dental maturity in children with Down syndrome. Journal of craniofacial genetics and developmental biology. vol 19. issue 1. 1999-08-18. PMID:10378144. |
craniofacial growth was evaluated 3 years after termination of growth hormone (gh) therapy in ten down syndrome (ds) children. |
1999-08-18 |
2023-08-12 |
Not clear |
| J Guimera, C Casas, X Estivill, M Pritchar. Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome. Genomics. vol 57. issue 3. 1999-08-02. PMID:10329007. |
the human homologue (mnbh/dyrk1) of the drosophila minibrain gene maps to human chromosome 21 within the down syndrome (ds) critical region and is within the region minimally deleted in chromosome 21-linked microcephaly. |
1999-08-02 |
2023-08-12 |
mouse |
| S Greber, G Lubec, N Cairns, M Fountoulaki. Decreased levels of synaptosomal associated protein 25 in the brain of patients with Down syndrome and Alzheimer's disease. Electrophoresis. vol 20. issue 4-5. 1999-07-29. PMID:10344268. |
in down syndrome (ds) brain, it is abnormally developed from early life, and brain pathology becomes even more pronounced when alzheimer's disease (ad) develops in the fourth decade. |
1999-07-29 |
2023-08-12 |
Not clear |
| C A Lemere, T J Grenfell, D J Selko. The AMY antigen co-occurs with abeta and follows its deposition in the amyloid plaques of Alzheimer's disease and down syndrome. The American journal of pathology. vol 155. issue 1. 1999-07-26. PMID:10393833. |
in a temporal series of 29 down syndrome (ds) brains from patients aged 12 to 73 years, the earliest amy ir was detected in some plaques at age 15, following the earliest appearance of abeta plaques (age 12 years), and then accrued within a subset of abeta deposits, namely, the more spherical, compacted plaques. |
1999-07-26 |
2023-08-12 |
mouse |
| T Bussière, P R Hof, C Mailliot, C D Brown, M L Caillet-Boudin, D P Perl, L Buée, A Delacourt. Phosphorylated serine422 on tau proteins is a pathological epitope found in several diseases with neurofibrillary degeneration. Acta neuropathologica. vol 97. issue 3. 1999-06-30. PMID:10090668. |
by using biochemical and immunohistochemical methods, we confirmed that it is not found on tau proteins from biopsy- or autopsy-derived control samples, and we investigated the presence of this epitope on tau proteins in several neurodegenerative disorders, including ad, down syndrome (ds), guamanian amyotrophic lateral sclerosis/parkinsonism-dementia complex (als/pdc), corticobasal degeneration (cbd), progressive supranuclear palsy (psp), postencephalitic parkinsonism (pep) and pick's disease (pid). |
1999-06-30 |
2023-08-12 |
Not clear |
| A Levanon, A Tarasiuk, A Ta. Sleep characteristics in children with Down syndrome. The Journal of pediatrics. vol 134. issue 6. 1999-06-29. PMID:10356146. |
obstructive sleep apnea syndrome is common in children with down syndrome (ds). |
1999-06-29 |
2023-08-12 |
Not clear |
| D Hernandez, P J Mee, J E Martin, V L Tybulewicz, E M Fishe. Transchromosomal mouse embryonic stem cell lines and chimeric mice that contain freely segregating segments of human chromosome 21. Human molecular genetics. vol 8. issue 5. 1999-06-23. PMID:10196383. |
trisomy 21, which results in down syndrome (ds), is the most frequent aneuploidy in humans (1 in 600 live births, up to 1 in 150 pregnancies world-wide) and is the most common known genetic cause of mental retardation. |
1999-06-23 |
2023-08-12 |
mouse |