| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Inoue, T Shinohara, S Takehara, J Inoue, H Kamino, H Kugoh, M Oshimur. Specific impairment of cardiogenesis in mouse ES cells containing a human chromosome 21. Biochemical and biophysical research communications. vol 273. issue 1. 2000-07-27. PMID:10873590. |
down syndrome (ds) leads to cardiac defects which are common and significant in babies with ds. |
2000-07-27 |
2023-08-12 |
mouse |
| H U Shetty, R J Siarey, Z Galdzicki, J Stoll, S I Rapopor. Ts65Dn mouse, a Down syndrome model, exhibits elevated myo-inositol in selected brain regions and peripheral tissues. Neurochemical research. vol 25. issue 4. 2000-07-18. PMID:10823574. |
myo-inositol is elevated in the down syndrome (ds; trisomy 21) brain and may play a role in mental retardation. |
2000-07-18 |
2023-08-12 |
mouse |
| S Fisman, L Wolf, D Ellison, T Freema. A longitudinal study of siblings of children with chronic disabilities. Canadian journal of psychiatry. Revue canadienne de psychiatrie. vol 45. issue 4. 2000-07-14. PMID:10813071. |
to examine the unaffected siblings of 2 different groups with chronic disabilities, pervasive developmental disorder (pdd) and down syndrome (ds), over 3 years, comparing their adjustment with each other and with the siblings of a nondisabled group. |
2000-07-14 |
2023-08-12 |
Not clear |
| J Ganiban, D Barnett, D Cicchett. Negative reactivity and attachment: Down syndrome's contribution to the attachment-temperament debate. Development and psychopathology. vol 12. issue 1. 2000-07-11. PMID:10774593. |
this longitudinal study investigated the relation between negative reactivity and attachment in children with down syndrome (ds). |
2000-07-11 |
2023-08-12 |
Not clear |
| S Moalem, M E Percy, D F Andrews, T P Kruck, S Wong, A J Dalton, P Mehta, B Fedor, A C Warre. Are hereditary hemochromatosis mutations involved in Alzheimer disease? American journal of medical genetics. vol 93. issue 1. 2000-07-10. PMID:10861683. |
we screened dna samples from patients with familial alzheimer disease (fad) (n = 26), adults with down syndrome (ds) (n = 50), and older (n = 41) and younger (n = 52) healthy normal individuals, for two hhc point mutations-c282y and h63d. |
2000-07-10 |
2023-08-12 |
Not clear |
| D Gómez, E Solsona, M Guitart, N Baena, E Gabau, J Egozcue, M R Caballí. Origin of trisomy 21 in Down syndrome cases from a Spanish population registry. Annales de genetique. vol 43. issue 1. 2000-06-30. PMID:10818217. |
we have carried out a population-based study on the origin of the extra chromosome 21 in 38 families with down syndrome (ds) offspring in el vallès (spain). |
2000-06-30 |
2023-08-12 |
human |
| S B Freeman, Q Yang, K Allran, L F Taft, S L Sherma. Women with a reduced ovarian complement may have an increased risk for a child with Down syndrome. American journal of human genetics. vol 66. issue 5. 2000-06-28. PMID:10733467. |
advanced maternal age is the only well-established risk factor for trisomy 21 down syndrome (ds), but the basis of the maternal-age effect is not known. |
2000-06-28 |
2023-08-12 |
Not clear |
| V Dimitrova, T Chernev, S Savova, M Stoianov. [The attitude of pregnant women to the possibilities for the prenatal screening and diagnosis of Down's syndrome in the 2nd trimester]. Akusherstvo i ginekologiia. vol 39. issue 1. 2000-06-20. PMID:10826326. |
the aim of the study was to assess pregnant women's attitude and receptivity for second trimester prenatal screening and diagnostic tests for fetal down syndrome [ds], factors that influence attitude formation, sufficiency of patients' information, advisability of introduction of these tests in routine prenatal care interviews with 129 pregnant women were conducted after they had received written information concerning prenatal ds screening and diagnostic tests five questions to the point of the matter as well as 14 related to the personal characteristics of the interviewed were included. |
2000-06-20 |
2023-08-12 |
Not clear |
| T F Haydar, R S Nowakowski, P J Yarowsky, B K Kruege. Role of founder cell deficit and delayed neuronogenesis in microencephaly of the trisomy 16 mouse. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 11. 2000-06-15. PMID:10818151. |
development of the neocortex of the trisomy 16 (ts16) mouse, an animal model of down syndrome (ds), is characterized by a transient delay in the radial expansion of the cortical wall and a persistent reduction in cortical volume. |
2000-06-15 |
2023-08-12 |
mouse |
| B Y Azizeh, E Head, M A Ibrahim, R Torp, A J Tenner, R C Kim, I T Lott, C W Cotma. Molecular dating of senile plaques in the brains of individuals with Down syndrome and in aged dogs. Experimental neurology. vol 163. issue 1. 2000-06-13. PMID:10785449. |
beta-amyloid (abeta) is a constituent of senile plaques found with increasing age in individuals with down syndrome (ds) and in the canine model of aging. |
2000-06-13 |
2023-08-12 |
dog |
| M M Blann, D L Morgan, M Oblender, B Heinen, J Williams, V S Ton. Duplication of 1q in a child with down syndrome and myelodysplastic syndrome. Cancer genetics and cytogenetics. vol 119. issue 1. 2000-06-08. PMID:10812176. |
cytogenetic analysis of bone marrow cells was performed on a 2-year-old african-american male with down syndrome (ds) and myelodysplastic syndrome (mds), specifically refractory anemia with excess blasts in transformation (raeb-t). |
2000-06-08 |
2023-08-12 |
Not clear |
| J T Richtsmeier, L L Baxter, R H Reeve. Parallels of craniofacial maldevelopment in Down syndrome and Ts65Dn mice. Developmental dynamics : an official publication of the American Association of Anatomists. vol 217. issue 2. 2000-05-25. PMID:10706138. |
ts65dn mice are at dosage imbalance for many of the same genes duplicated in trisomy 21 or down syndrome (ds), the most common live-born human aneuploidy. |
2000-05-25 |
2023-08-12 |
mouse |
| D Paladini, A Tartaglione, A Agangi, A Teodoro, F Forleo, A Borghese, P Martinell. The association between congenital heart disease and Down syndrome in prenatal life. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. vol 15. issue 2. 2000-05-25. PMID:10775990. |
to assess the relationship between congenital heart disease (chd) and down syndrome (ds) in utero. |
2000-05-25 |
2023-08-12 |
Not clear |
| W Huang, Z Galdzicki, P van Gelderen, A Balbo, E G Chikhale, M B Schapiro, S I Rapopor. Brain myo-inositol level is elevated in Ts65Dn mouse and reduced after lithium treatment. Neuroreport. vol 11. issue 3. 2000-05-18. PMID:10718292. |
the segmental trisomy ts65dn mouse is a novel model of down syndrome (ds). |
2000-05-18 |
2023-08-12 |
mouse |
| P Kusumakumary, T S Vats, R Ankathil, H R Gattamaneni, M K Nai. Malignancies in Down syndrome. Indian journal of pediatrics. vol 64. issue 6. 2000-05-17. PMID:10771932. |
down syndrome (ds) is associated with an increased incidence of malignancies, especially leukaemias. |
2000-05-17 |
2023-08-12 |
Not clear |
| P Vergani, A Locatelli, M G Piccoli, E Mariani, N Strobelt, J C Pezzullo, A Ghidin. Critical reappraisal of the utility of sonographic fetal femur length in the prediction of trisomy 21. Prenatal diagnosis. vol 20. issue 3. 2000-05-11. PMID:10719323. |
measurement of femur length (fl) has been advocated as part of a genetic sonogram for the prediction of down syndrome (ds). |
2000-05-11 |
2023-08-12 |
human |
| R Räty, A Virtanen, P Koskinen, P Laitinen, J Forsström, R Salonen, P Mörsky, U Ekbla. Maternal midtrimester serum AFP and free beta-hCG levels in in vitro fertilization twin pregnancies. Prenatal diagnosis. vol 20. issue 3. 2000-05-11. PMID:10719325. |
the data were collected from down syndrome (ds) screening programmes in four university catchment areas in finland between 1994-98. |
2000-05-11 |
2023-08-12 |
Not clear |
| A Egeo, R Di Lisi1, C Sandri, M Mazzocco, M Lapide, S Schiaffino, P Scartezzin. Developmental expression of the SH3BGR gene, mapping to the Down syndrome heart critical region. Mechanisms of development. vol 90. issue 2. 2000-04-27. PMID:10640719. |
the sh3bgr gene has been recently isolated and mapped to chromosome 21 within the down syndrome (ds) congenital heart disease (chd) minimal region. |
2000-04-27 |
2023-08-12 |
mouse |
| E Pastore, B Marino, A Calzolari, M C Digilio, A Giannotti, A Turchett. Clinical and cardiorespiratory assessment in children with Down syndrome without congenital heart disease. Archives of pediatrics & adolescent medicine. vol 154. issue 4. 2000-04-26. PMID:10768682. |
to assess the clinical and functional status of a young down syndrome (ds) population without congenital heart disease. |
2000-04-26 |
2023-08-12 |
Not clear |
| S Vicari, M C Caselli, F Tonucc. Asynchrony of lexical and morphosyntactic development in children with Down Syndrome. Neuropsychologia. vol 38. issue 5. 2000-04-25. PMID:10689040. |
fifteen children with down syndrome (ds) (from 4 to 7 years) and fifteen normal controls matched on mental age participated in this study. |
2000-04-25 |
2023-08-12 |
Not clear |