| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S H Kim, R Vlkolinsky, N Cairns, G Lube. Decreased levels of complex III core protein 1 and complex V beta chain in brains from patients with Alzheimer's disease and Down syndrome. Cellular and molecular life sciences : CMLS. vol 57. issue 12. 2001-01-04. PMID:11130185. |
in this study, we applied the proteomic approach to investigate protein levels of complex iii core protein and complex v beta chain in brain regions of alzheimer's disease (ad) and down syndrome (ds) patients. |
2001-01-04 |
2023-08-12 |
Not clear |
| A Herman, Z Weinraub, E Dreazen, S Arieli, S Rozansky, I Bukovsky, R Maymo. Combined first trimester nuchal translucency and second trimester biochemical screening tests among normal pregnancies. Prenatal diagnosis. vol 20. issue 10. 2000-12-28. PMID:11038452. |
overlapping of screen-positive cases, of nt and tt, was determined by comparing mutual risks for down syndrome (ds) livebirth of > or = 1:380. |
2000-12-28 |
2023-08-12 |
Not clear |
| T Hallahan, D Krantz, F Orlandi, C Rossi, P Curcio, S Macri, J Larsen, P Buchanan, J Macr. First trimester biochemical screening for Down syndrome: free beta hCG versus intact hCG. Prenatal diagnosis. vol 20. issue 10. 2000-12-28. PMID:11038453. |
although distributions for free beta hcg (unaffected, 0.2157; ds, 0.2322) are wider than for intact hcg (unaffected, 0.1697; ds, 0.2158), overall 27% of down syndrome cases were above the 95th percentile for free beta hcg compared to 19% for intact hcg. |
2000-12-28 |
2023-08-12 |
Not clear |
| J W Taub, X Huang, Y Ge, J A Dutcher, M L Stout, R M Mohammad, Y Ravindranath, L H Matherl. Cystathionine-beta-synthase cDNA transfection alters the sensitivity and metabolism of 1-beta-D-arabinofuranosylcytosine in CCRF-CEM leukemia cells in vitro and in vivo: a model of leukemia in Down syndrome. Cancer research. vol 60. issue 22. 2000-12-22. PMID:11103808. |
the significantly higher event-free survival rates of down syndrome (ds) children with acute myeloid leukemia compared with non-ds children is linked to increased sensitivity of ds myeloblasts to 1-beta-d-arabinofuranosylcytosine (ara-c) and the enhanced metabolism of ara-c to ara-c triphosphate (j. w. taub et al., blood, 87: 3395-3403, 1996). |
2000-12-22 |
2023-08-12 |
mouse |
| P J Allison, M Hennequi. The oral assessment in Down syndrome questionnaire (OADS): development of an instrument to evaluate oral health problems in individuals with Down syndrome. Community dental health. vol 17. issue 3. 2000-12-22. PMID:11108405. |
to develop a french language instrument whose primary aim is the description of oral health status in down syndrome (ds) individuals. |
2000-12-22 |
2023-08-12 |
Not clear |
| G Calamandrei, E Alleva, F Cirulli, A Queyras, V Volterra, O Capirci, S Vicari, A Giannotti, P Turrini, L Alo. Serum NGF levels in children and adolescents with either Williams syndrome or Down syndrome. Developmental medicine and child neurology. vol 42. issue 11. 2000-12-14. PMID:11104346. |
serum ngf was measured in normally developing control children (n=26) and in individuals affected by congenital syndromes associated with learning disability: either williams syndrome (ws; n=12) or down syndrome (ds; n=21). |
2000-12-14 |
2023-08-12 |
human |
| A Nunomura, G Perry, M A Pappolla, R P Friedland, K Hirai, S Chiba, M A Smit. Neuronal oxidative stress precedes amyloid-beta deposition in Down syndrome. Journal of neuropathology and experimental neurology. vol 59. issue 11. 2000-12-07. PMID:11089579. |
the predictable chronological sequence of pathological events in down syndrome (ds) provides the opportunity to rigorously investigate the relationship between oxidative stress and amyloid-beta (abeta) deposition. |
2000-12-07 |
2023-08-12 |
Not clear |
| M Hennequin, P J Allison, J L Veyrun. Prevalence of oral health problems in a group of individuals with Down syndrome in France. Developmental medicine and child neurology. vol 42. issue 10. 2000-11-30. PMID:11085298. |
this cross-sectional study describes oral health problems in a sample of children with down syndrome (ds) compared with their siblings. |
2000-11-30 |
2023-08-12 |
Not clear |
| R Chrast, H S Scott, R Madani, L Huber, D P Wolfer, M Prinz, A Aguzzi, H P Lipp, S E Antonaraki. Mice trisomic for a bacterial artificial chromosome with the single-minded 2 gene (Sim2) show phenotypes similar to some of those present in the partial trisomy 16 mouse models of Down syndrome. Human molecular genetics. vol 9. issue 12. 2000-10-27. PMID:10915774. |
three copies of sim2 may contribute to some down syndrome (ds) phenotypes because of the mapping position function as transcriptional repressor, temporal and spatial expression pattern of mouse sim2, and the potentially analogous role of human sim2 to that of drosophila sim during neurogenesis. |
2000-10-27 |
2023-08-12 |
mouse |
| S H Kim, B C Yoo, J L Broers, N Cairns, G Lube. Neuroendocrine-specific protein C, a marker of neuronal differentiation, is reduced in brain of patients with Down syndrome and Alzheimer's disease. Biochemical and biophysical research communications. vol 276. issue 1. 2000-10-26. PMID:11006125. |
as the neuropathological findings in down syndrome (ds) includes deficits of differentiation, and we detected a downregulated sequence with 100% homology with nsp-c homolog mrna in temporal cortex of patients with ds as well as alzheimer's disease (ad) using differential display-polymerase chain reaction (dd-pcr), we decided to examine the protein levels of nsp-c in temporal, frontal cortex and cerebellum of ds and ad. |
2000-10-26 |
2023-08-12 |
Not clear |
| M J Wortelboer, B T De Wolf, C C Verschuuren-Bemelmans, J Reefhuis, A Mantingh, J R Beekhuis, M C Corne. Trends in live birth prevalence of down syndrome in the Northern Netherlands 1987-96: the impact of screening and prenatal diagnosis. Prenatal diagnosis. vol 20. issue 9. 2000-10-25. PMID:11015698. |
in the northern netherlands, we examined the live birth prevalence of down syndrome (ds) and the impact of maternal serum screening (mss) and prenatal cytogenetic diagnosis (pcd) during the period 1987-96. |
2000-10-25 |
2023-08-12 |
Not clear |
| M B Petersen, G Karadima, M Samaritaki, D Avramopoulos, D Vassilopoulos, M Mikkelse. Association between presenilin-1 polymorphism and maternal meiosis II errors in Down syndrome. American journal of medical genetics. vol 93. issue 5. 2000-10-24. PMID:10951459. |
several lines of evidence suggest a shared genetic susceptibility to down syndrome (ds) and alzheimer disease (ad). |
2000-10-24 |
2023-08-12 |
Not clear |
| K L Agarwala, S Nakamura, Y Tsutsumi, K Yamakaw. Down syndrome cell adhesion molecule DSCAM mediates homophilic intercellular adhesion. Brain research. Molecular brain research. vol 79. issue 1-2. 2000-10-04. PMID:10925149. |
down syndrome (ds) caused by trisomy 21 is the most common birth defect associated with mental retardation. |
2000-10-04 |
2023-08-12 |
mouse |
| D W Evans, F L Gra. Compulsive-like behavior in individuals with Down syndrome: its relation to mental age level, adaptive and maladaptive behavior. Child development. vol 71. issue 2. 2000-09-26. PMID:10834464. |
this study examined the nature of repetitive, ritualistic, and compulsive-like behaviors in 50 typically developing children and 50 individuals with down syndrome (ds), matched on mental age (ma; m = 59.72 months). |
2000-09-26 |
2023-08-12 |
human |
| C Schwab, A J DeMaggio, N Ghoshal, L I Binder, J Kuret, P L McGee. Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases. Neurobiology of aging. vol 21. issue 4. 2000-09-07. PMID:10924763. |
the distribution of casein kinase 1 delta (cki delta) was studied by immunohistochemistry and correlated with other pathological hallmarks in alzheimer's disease (ad), down syndrome (ds), progressive supranuclear palsy (psp), parkinsonism dementia complex of guam (pdc), pick's disease (pid), pallido-ponto-nigral degeneration (ppnd), parkinson's disease (pd), dementia with lewy bodies (dlb), amyotrophic lateral sclerosis (als), and elderly controls. |
2000-09-07 |
2023-08-12 |
Not clear |
| A J Anderson, S Stoltzner, F Lai, J Su, R A Nixo. Morphological and biochemical assessment of DNA damage and apoptosis in Down syndrome and Alzheimer disease, and effect of postmortem tissue archival on TUNEL. Neurobiology of aging. vol 21. issue 4. 2000-09-07. PMID:10924764. |
down syndrome (ds) is a neurodegenerative disorder that exhibits significant neuropathological parallels with ad. |
2000-09-07 |
2023-08-12 |
human |
| A Katada, S Hasegawa, D Ohira, T Kumagai, T Harashima, H Ozaki, H Suzuk. On chronological changes in the basic EEG rhythm in persons with Down syndrome - with special reference to slowing of alpha waves. Brain & development. vol 22. issue 4. 2000-08-24. PMID:10838108. |
the authors tried to know specificity of aging in persons with down syndrome (ds) from the aspect of electroencephalograph (eeg) frequency changes through the cross-sectional and longitudinal studies, in comparison with normal persons as well as those with mentally retardation except the down syndrome (non-ds mr). |
2000-08-24 |
2023-08-12 |
human |
| R Tazi-Ahnini, F S di Giovine, A J McDonagh, A G Messenger, C Amadou, A Cox, G W Duff, M J Cor. Structure and polymorphism of the human gene for the interferon-induced p78 protein (MX1): evidence of association with alopecia areata in the Down syndrome region. Human genetics. vol 106. issue 6. 2000-08-21. PMID:10942113. |
aa occurs in approximately 0.1% of the general population, but this is increased to 9% in down syndrome (ds). |
2000-08-21 |
2023-08-12 |
mouse |
| A Jyothy, K S Kumar, G N Rao, V B Rao, M Swarna, B U Devi, M Sujatha, C K Kumari, P P Redd. Cytogenetic studies of 1001 Down syndrome cases from Andhra Pradesh, India. The Indian journal of medical research. vol 111. 2000-08-17. PMID:10935320. |
cytogenetic data obtained from investigating 1001 patients of down syndrome (ds) and their parents over a period of 20 years (january 1979-january 1999) are presented. |
2000-08-17 |
2023-08-12 |
Not clear |
| E J Murphy, M B Schapiro, S I Rapoport, H U Shett. Phospholipid composition and levels are altered in Down syndrome brain. Brain research. vol 867. issue 1-2. 2000-08-04. PMID:10837793. |
phospholipid composition (mol %) and levels (nmol/mg protein) were determined in postmortem frontal cortical and cerebellar gray matter from older down syndrome (ds) patients (age range 38-68 years) and from control subjects. |
2000-08-04 |
2023-08-12 |
human |