| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S R Shot. Down syndrome: analysis of airway size and a guide for appropriate intubation. The Laryngoscope. vol 110. issue 4. 2000-04-24. PMID:10764002. |
the purpose of this study is to prospectively evaluate the airway size of children with down syndrome (ds). |
2000-04-24 |
2023-08-12 |
Not clear |
| G Lubec, O Labudova, N Cairns, P Berndt, H Langen, M Fountoulaki. Reduced aldehyde dehydrogenase levels in the brain of patients with Down syndrome. Journal of neural transmission. Supplementum. vol 57. 2000-04-12. PMID:10666666. |
subtractive hybridization studies in down syndrome (ds) fetal brain showed that mrna for aldh are downregulated. |
2000-04-12 |
2023-08-12 |
human |
| B L Shapir. The Down syndrome critical region. Journal of neural transmission. Supplementum. vol 57. 2000-04-12. PMID:10666667. |
since the early 1970's numerous attempts have been made to learn whether specific segments of chromosome 21, when triplicated, are responsible for the clinical condition down syndrome (ds). |
2000-04-12 |
2023-08-12 |
Not clear |
| S Greber-Platzer, B Balcz, N Cairns, G Lube. c-fos expression in brains of patients with Down syndrome. Journal of neural transmission. Supplementum. vol 57. 2000-04-12. PMID:10666669. |
we therefore decided to determine this transcription factor in control and down syndrome (ds) brain with the rationale that c-fos may be linked to brain damage in ds. |
2000-04-12 |
2023-08-12 |
Not clear |
| E Kitzmueller, O Labudova, H Rink, N Cairns, G Lube. Altered gene expression in fetal Down syndrome brain as revealed by the gene hunting technique of subtractive hybridization. Journal of neural transmission. Supplementum. vol 57. 2000-04-12. PMID:10666671. |
information on gene expression in brain of patients with down syndrome (ds, trisomy 21) is limited and molecular biological research is focussing on mapping and sequencing chromosome 21. |
2000-04-12 |
2023-08-12 |
Not clear |
| O Labudova, E Kitzmueller, H Rink, N Cairns, G Lube. Gene expression in fetal Down syndrome brain as revealed by subtractive hybridization. Journal of neural transmission. Supplementum. vol 57. 2000-04-12. PMID:10666672. |
information on gene expression in brain of patients with down syndrome (ds, trisomy 21) is limited and molecular biological research is focussing on mapping and sequencing chromosome 21. |
2000-04-12 |
2023-08-12 |
Not clear |
| F W van Leeuwen, E M Ho. Molecular misreading of genes in Down syndrome as a model for the Alzheimer type of neurodegeneration. Journal of neural transmission. Supplementum. vol 57. 2000-04-12. PMID:10666673. |
the occurrence of +1 frameshifted proteins, such as amyloid precursor protein (app+1) and ubiquitin-b (ubb+1) in down syndrome (ds) has been linked to the onset of alzheimer's disease (ad). |
2000-04-12 |
2023-08-12 |
Not clear |
| G Lubec, M Nonaka, K Krapfenbauer, M Gratzer, N Cairns, M Fountoulaki. Expression of the dihydropyrimidinase related protein 2 (DRP-2) in Down syndrome and Alzheimer's disease brain is downregulated at the mRNA and dysregulated at the protein level. Journal of neural transmission. Supplementum. vol 57. 2000-04-12. PMID:10666674. |
deteriorated migration, axonal pathfinding and wiring of the brain is a main neuropathological feature of down syndrome (ds). |
2000-04-12 |
2023-08-12 |
Not clear |
| K Krapfenbauer, B C Yoo, N Cairns, G Lube. Differential display reveals deteriorated mRNA levels of NADH3 (complex I) in cerebellum of patients with Down syndrome. Journal of neural transmission. Supplementum. vol 57. 2000-04-12. PMID:10666677. |
although gene hunting has been carried out in down syndrome (ds) cells, information on expressional differences in ds brain is limited. |
2000-04-12 |
2023-08-12 |
Not clear |
| R Seidl, S T Kaehler, H Prast, N Singewald, N Cairns, M Gratzer, G Lube. Serotonin (5-HT) in brains of adult patients with Down syndrome. Journal of neural transmission. Supplementum. vol 57. 2000-04-12. PMID:10666678. |
down syndrome (ds) is a genetic disease with developmental brain abnormalities resulting in early mental retardation and precocious, age dependent alzheimer-type neurodegeneration. |
2000-04-12 |
2023-08-12 |
Not clear |
| O Labudova, N Cairns, E Kitzmüller, G Lube. Impaired brain glucose metabolism in patients with Down syndrome. Journal of neural transmission. Supplementum. vol 57. 2000-04-12. PMID:10666680. |
a series of impaired metabolic functions in down syndrome (ds) including glucose handling has been described. |
2000-04-12 |
2023-08-12 |
Not clear |
| R Seidl, M Bajo, K Böhm, E C LaCasse, A E MacKenzie, N Cairns, G Lube. Neuronal apoptosis inhibitory protein (NAIP)-like immunoreactivity in brains of adult patients with Down syndrome. Journal of neural transmission. Supplementum. vol 57. 2000-04-12. PMID:10666683. |
in down syndrome (ds), enhanced apoptosis (programmed cell death) may play a role in the pathogenesis of characteristic early mental retardation and precocious neurodegeneration of alzheimer-type. |
2000-04-12 |
2023-08-12 |
human |
| M A Pritchard, I Kol. The "gene dosage effect" hypothesis versus the "amplified developmental instability" hypothesis in Down syndrome. Journal of neural transmission. Supplementum. vol 57. 2000-04-12. PMID:10666684. |
two hypotheses exist to explain the down syndrome (ds) phenotype. |
2000-04-12 |
2023-08-12 |
Not clear |
| K Yeghiazaryan, D Turhani-Schatzmann, O Labudova, E Schuller, E N Olson, N Cairns, G Lube. Downregulation of the transcription factor scleraxis in brain of patients with Down syndrome. Journal of neural transmission. Supplementum. vol 57. 2000-04-12. PMID:10666685. |
performing gene hunting in fetal down syndrome (ds) brain, we found a downregulated sequence with 100% homology to the basic-helix-loop-helix transcription factor (tf) scleraxis (scl). |
2000-04-12 |
2023-08-12 |
human |
| B C Yoo, R Seidl, N Cairns, G Lube. Heat-shock protein 70 levels in brain of patients with Down syndrome and Alzheimer's disease. Journal of neural transmission. Supplementum. vol 57. 2000-04-12. PMID:10666686. |
the aim of our study was to demonstrate the presence of hsp70--immunoreactive protein in brain of controls, patients with ad and down syndrome (ds) in individual brain regions. |
2000-04-12 |
2023-08-12 |
Not clear |
| M Fountoulakis, N Cairns, G Lube. Increased levels of 14-3-3 gamma and epsilon proteins in brain of patients with Alzheimer's disease and Down syndrome. Journal of neural transmission. Supplementum. vol 57. 2000-04-12. PMID:10666687. |
performing protein mapping by 2d electrophoresis in human brain we identified two isoforms, 14-3-3 gamma and epsilon and decided to determine these two multifunctional proteins in several brain regions of aged patients with alzheimer's disease (ad) and down syndrome (ds) with ad neuropathology in comparison with control brains. |
2000-04-12 |
2023-08-12 |
human |
| J J Fuentes, M Dierssen, C Pucharcós, C Fillat, C Casas, X Estivill, M Pritchar. Application of Alu-splice PCR on chromosome 21: DSCR1 and Intersectin. Journal of neural transmission. Supplementum. vol 57. 2000-04-12. PMID:10666688. |
down syndrome (ds) is a major cause of mental retardation and congenital heart defects, with an overall incidence of one in 700 live births. |
2000-04-12 |
2023-08-12 |
human |
| R Maymon, I K Sehmi, A Herman, R G Jones, D Sherman, H Cuckl. Serum inhibin A levels in pregnant women with systemic lupus erythematosus or antiphospholipid syndrome. Prenatal diagnosis. vol 20. issue 1. 2000-03-27. PMID:10701844. |
maternal serum inhibin a levels are increased on average in pregnancies affected by down syndrome (ds). |
2000-03-27 |
2023-08-12 |
Not clear |
| A Amano, T Kishima, S Kimura, M Takiguchi, T Ooshima, S Hamada, I Morisak. Periodontopathic bacteria in children with Down syndrome. Journal of periodontology. vol 71. issue 2. 2000-03-22. PMID:10711615. |
it is widely known that individuals with down syndrome (ds) often develop severe early-onset periodontal diseases. |
2000-03-22 |
2023-08-12 |
Not clear |
| A M da Nóbrega, H G Nunesmaia, N de O Viana, M A Filgueira. [Electroencephalographic modification in Down syndrome]. Arquivos de neuro-psiquiatria. vol 57. issue 3A. 2000-03-09. PMID:10667280. |
the frequency of epilepsy in down syndrome (ds) has been reported in literature varying from 6 to 17%. |
2000-03-09 |
2023-08-12 |
Not clear |