| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S H Kim, N Cairns, M Fountoulakisc, G Lube. Decreased brain histamine-releasing factor protein in patients with Down syndrome and Alzheimer's disease. Neuroscience letters. vol 300. issue 1. 2001-05-10. PMID:11172935. |
based upon deranged histamine metabolism in brain of patients with ad and down syndrome (ds), we aimed to study hrf in brain of ad and ds. |
2001-05-10 |
2023-08-12 |
Not clear |
| R J Palisano, S D Walter, D J Russell, P L Rosenbaum, M Gémus, B E Galuppi, L Cunningha. Gross motor function of children with down syndrome: creation of motor growth curves. Archives of physical medicine and rehabilitation. vol 82. issue 4. 2001-05-10. PMID:11295010. |
to create gross motor function growth curves for children with down syndrome (ds) and to estimate the probability that motor functions are achieved by different ages. |
2001-05-10 |
2023-08-12 |
Not clear |
| R Seidl, N Cairns, N Singewald, S T Kaehler, G Lube. Differences between GABA levels in Alzheimer's disease and Down syndrome with Alzheimer-like neuropathology. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 2. 2001-05-03. PMID:11218066. |
down syndrome (ds) is a genetic disease with developmental brain abnormalities resulting in early mental retardation and precocious, age-dependent alzheimer-type neurodegeneration. |
2001-05-03 |
2023-08-12 |
human |
| R Seidl, N Cairns, N Singewald, S T Kaehler, G Lube. Differences between GABA levels in Alzheimer's disease and Down syndrome with Alzheimer-like neuropathology. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 2. 2001-05-03. PMID:11218066. |
a number of amino acids [glutamate, aspartate, gamma-aminobutyrate (gaba), glycine, taurine, glutamine, serine, arginine] were investigated in post-mortem tissue samples from temporal, occipital cortex, thalamus, caudate nucleus, and cerebellum of adult patients with down syndrome (ds) exhibiting alzheimer-like neuropatholgy, alzheimer's disease (ad) and from controls by use of high performance liquid chromatography (hplc). |
2001-05-03 |
2023-08-12 |
human |
| B C Yoo, M Fountoulakis, N Cairns, G Lube. Changes of voltage-dependent anion-selective channel proteins VDAC1 and VDAC2 brain levels in patients with Alzheimer's disease and Down syndrome. Electrophoresis. vol 22. issue 1. 2001-04-26. PMID:11197169. |
we determined protein levels of vdacs in individual post-mortem brain regions of patients with down syndrome (ds) and alzheimer's disease (ad) using two-dimensional electrophoresis (2-de) and matrix-assisted laser desorption/ionization-mass spectroscopy (maldi-ms). |
2001-04-26 |
2023-08-12 |
Not clear |
| R Seidl, O Labudova, K Krapfenbauer, E W Henriksson, J Craft, D Turhani-Schatzmann, T Achsel, B Bidmon, G J Pruijn, N Cairns, G Lube. Deficient brain snRNP70K in patients with Down syndrome. Electrophoresis. vol 22. issue 1. 2001-04-26. PMID:11197177. |
applying subtractive hybridization, we found a sequence with 100% identity to snrnp absent in fetal down syndrome (ds) brain. |
2001-04-26 |
2023-08-12 |
human |
| S R Soares, C Templado, J Blanco, J Egozcue, F Vida. Numerical chromosome abnormalities in the spermatozoa of the fathers of children with trisomy 21 of paternal origin: generalised tendency to meiotic non-disjunction. Human genetics. vol 108. issue 2. 2001-04-12. PMID:11281452. |
the purpose of this study was the evaluation of aneuploidy frequencies in the spermatozoa of two fathers (dp-4 and dp-5) who had children with down syndrome (ds) of paternal origin and in whom a previous sperm analysis by fluoresence in situ hybridisation (fish) had suggested a generalised tendency to meiotic non-disjunction. |
2001-04-12 |
2023-08-12 |
Not clear |
| R H Reeves, L L Baxter, J T Richtsmeie. Too much of a good thing: mechanisms of gene action in Down syndrome. Trends in genetics : TIG. vol 17. issue 2. 2001-03-29. PMID:11173117. |
the molecular mechanisms underlying the specific traits in individuals with down syndrome (ds) have been postulated to derive either from nonspecific perturbation of balanced genetic programs, or from the simple, mendelian-like influence of a small subset of genes on chromosome 21. |
2001-03-29 |
2023-08-12 |
mouse |
| U Langenbeck, G Herzberger, S Kümmerl. Parent-offspring resemblance of palmar and plantar dermatoglyphic patterns in Down syndrome. Cytogenetics and cell genetics. vol 91. issue 1-4. 2001-03-29. PMID:11173849. |
with the aim of investigating the influence of trisomy 21 on the expression of heritable morphological features, we recorded the palmar and plantar dermatoglyphic patterns in 48 children with down syndrome (ds), in both their parents, and, as a control, in 57 of their siblings. |
2001-03-29 |
2023-08-12 |
Not clear |
| F S Yao, M T Caserta, A M Wyrwic. In vitro 1H and 31P NMR spectroscopic evidence of multiple aberrant biochemical pathways in murine trisomy 16 brain development. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 18. issue 8. 2001-03-22. PMID:11154853. |
nuclear magnetic resonance (nmr) spectroscopy was used to evaluate cytosolic compounds and membrane phospholipids simultaneously in trisomy 16 (ts16) and euploid (control) murine brain at fetal day 15 in order to examine the cellular biochemistry that underlies the neurodevelopmental consequences of chromosome triplication in this model of down syndrome (ds). |
2001-03-22 |
2023-08-12 |
Not clear |
| T Gulesserian, R Seidl, R Hardmeier, N Cairns, G Lube. Superoxide dismutase SOD1, encoded on chromosome 21, but not SOD2 is overexpressed in brains of patients with Down syndrome. Journal of investigative medicine : the official publication of the American Federation for Clinical Research. vol 49. issue 1. 2001-03-22. PMID:11217146. |
the antioxidant enzyme cu/zn-superoxide dismutase-1 (sod1) gene is localized to chromosome 21q22.1 and catalyzes the dismutation of superoxide anions to hydrogen peroxide, which may lead to the increased production of active oxygen species in down syndrome (ds), trisomy 21. |
2001-03-22 |
2023-08-12 |
Not clear |
| S W Maluf, B Erdtman. Genomic instability in Down syndrome and Fanconi anemia assessed by micronucleus analysis and single-cell gel electrophoresis. Cancer genetics and cytogenetics. vol 124. issue 1. 2001-03-01. PMID:11165325. |
cytokinesis-block micronucleus (cb-mn) assay and single-cell gel electrophoresis (scge) were employed to analyze leukocytes from 14 fanconi anemia (fa) patients, 30 down syndrome (ds) patients, and 30 control individuals, to examine the sensitivity of these techniques to detect genomic instability in these 2 diseases. |
2001-03-01 |
2023-08-12 |
Not clear |
| P J Allison, M Hennequin, D Faulk. Dental care access among individuals with Down syndrome in France. Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry. vol 20. issue 1. 2001-03-01. PMID:11203873. |
the aim of this study was to compare levels of dental care utilization, receipt of dental services, and oral hygiene habits between a sample of individuals with down syndrome (ds) and their siblings. |
2001-03-01 |
2023-08-12 |
Not clear |
| S Cavani, A Tamaoka, A Moretti, L Marinelli, G Angelini, S Di Stefano, G Piombo, V Cazzulo, S Matsuno, S Shoji, Y Furiya, D Zaccheo, F Dagna-Bricarelli, M Tabaton, H Mor. Plasma levels of amyloid beta 40 and 42 are independent from ApoE genotype and mental retardation in Down syndrome. American journal of medical genetics. vol 95. issue 3. 2001-02-22. PMID:11102927. |
in down syndrome (ds) brain an early, selective accumulation of amyloid beta (abeta) peptides ending at residue 42 (abeta42) occurs. |
2001-02-22 |
2023-08-12 |
human |
| J W Husseman, D Nochlin, I Vincen. Mitotic activation: a convergent mechanism for a cohort of neurodegenerative diseases. Neurobiology of aging. vol 21. issue 6. 2001-02-15. PMID:11124425. |
our results demonstrate that neurons containing characteristic lesions in a subset of diseases including down syndrome (ds), frontotemporal dementia linked to chromosome 17 (ftd-17), progressive supranuclear palsy (psp), corticobasal degeneration (cbd), parkinson-amyotrophic lateral sclerosis of guam (gp-als), niemann pick disease type c (npdc), and pick's disease, display mitotic indices, implicating diverse etiologies in mitotic activation. |
2001-02-15 |
2023-08-12 |
Not clear |
| R Chrast, H S Scott, M P Papasavvas, C Rossier, E S Antonarakis, C Barras, M T Davisson, C Schmidt, X Estivill, M Dierssen, M Pritchard, S E Antonaraki. The mouse brain transcriptome by SAGE: differences in gene expression between P30 brains of the partial trisomy 16 mouse model of Down syndrome (Ts65Dn) and normals. Genome research. vol 10. issue 12. 2001-02-08. PMID:11116095. |
trisomy 21, or down syndrome (ds), is the most common genetic cause of mental retardation. |
2001-02-08 |
2023-08-12 |
mouse |
| T Gulesserian, E Engidawork, N Cairns, G Lube. Increased protein levels of serotonin transporter in frontal cortex of patients with Down syndrome. Neuroscience letters. vol 296. issue 1. 2001-02-02. PMID:11099832. |
a large body of evidence exists on altered platelet serotonin uptake and metabolism in down syndrome (ds). |
2001-02-02 |
2023-08-12 |
Not clear |
| C G Csizmadia, M L Mearin, A Oren, A Kromhout, J B Crusius, B M von Blomberg, A S Peña, M N Wiggers, J P Vandenbrouck. Accuracy and cost-effectiveness of a new strategy to screen for celiac disease in children with Down syndrome. The Journal of pediatrics. vol 137. issue 6. 2001-01-26. PMID:11113830. |
to investigate the best approach to screen for celiac disease (cd) in patients with down syndrome (ds). |
2001-01-26 |
2023-08-12 |
Not clear |
| M J Baptista, U L Fairbrother, C M Howard, M J Farrer, G E Davies, D Trikka, K Maratou, A Redington, G Greve, P R Njølstad, A M Kesslin. Heterotrisomy, a significant contributing factor to ventricular septal defect associated with Down syndrome? Human genetics. vol 107. issue 5. 2001-01-18. PMID:11140945. |
down syndrome (ds; trisomy 21) is associated with a wide range of variable clinical features, one of the most common being congenital heart defects (chd). |
2001-01-18 |
2023-08-12 |
Not clear |
| D A Devenny, S J Krinsky-McHale, G Sersen, W P Silverma. Sequence of cognitive decline in dementia in adults with Down's syndrome. Journal of intellectual disability research : JIDR. vol 44 ( Pt 6). 2001-01-04. PMID:11115020. |
out of the individuals who showed declines, 10 adults with ds were classified as having 'questionable' decline based on the presence of memory impairment, and five and seven adults with ds were classified as in the 'early stage' and 'middle stage' of dat, respectively, based on the presence of memory impairment, score on the dementia scale for down syndrome and a physician's diagnosis. |
2001-01-04 |
2023-08-12 |
human |