| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elise Morice, Laura C Andreae, Sam F Cooke, Lesley Vanes, Elizabeth M C Fisher, Victor L J Tybulewicz, Timothy V P Blis. Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome. Learning & memory (Cold Spring Harbor, N.Y.). vol 15. issue 7. 2008-10-02. PMID:18626093. |
down syndrome (ds) is a genetic disorder arising from the presence of a third copy of the human chromosome 21 (hsa21). |
2008-10-02 |
2023-08-12 |
mouse |
| In-Hyun Park, Natasha Arora, Hongguang Huo, Nimet Maherali, Tim Ahfeldt, Akiko Shimamura, M William Lensch, Chad Cowan, Konrad Hochedlinger, George Q Dale. Disease-specific induced pluripotent stem cells. Cell. vol 134. issue 5. 2008-09-29. PMID:18691744. |
here we describe the generation of induced pluripotent stem (ips) cells from patients with a variety of genetic diseases with either mendelian or complex inheritance; these diseases include adenosine deaminase deficiency-related severe combined immunodeficiency (ada-scid), shwachman-bodian-diamond syndrome (sbds), gaucher disease (gd) type iii, duchenne (dmd) and becker muscular dystrophy (bmd), parkinson disease (pd), huntington disease (hd), juvenile-onset, type 1 diabetes mellitus (jdm), down syndrome (ds)/trisomy 21, and the carrier state of lesch-nyhan syndrome. |
2008-09-29 |
2023-08-12 |
human |
| Tyler K Best, Madelaine Cho-Clark, Richard J Siarey, Zygmunt Galdzick. Speeding of miniature excitatory post-synaptic currents in Ts65Dn cultured hippocampal neurons. Neuroscience letters. vol 438. issue 3. 2008-09-26. PMID:18490108. |
down syndrome (ds) is the leading non-heritable cause of mental retardation and is due to the effects of an extra chromosome 21. |
2008-09-26 |
2023-08-12 |
mouse |
| Alberto C S Costa, Jonah J Scott-McKean, Melissa R Stask. Acute injections of the NMDA receptor antagonist memantine rescue performance deficits of the Ts65Dn mouse model of Down syndrome on a fear conditioning test. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 7. 2008-09-24. PMID:17700645. |
individuals with down syndrome (ds) and ts65dn mice (a major animal model of ds) carry an extra copy of the dscr1 (down syndrome critical region 1) gene, which encodes for a protein that inhibits calcineurin. |
2008-09-24 |
2023-08-12 |
mouse |
| Fei Liu, Zhihou Liang, Jerzy Wegiel, Yu-Wen Hwang, Khalid Iqbal, Inge Grundke-Iqbal, Narayan Ramakrishna, Cheng-Xin Gon. Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 22. issue 9. 2008-09-24. PMID:18509201. |
adults with down syndrome (ds) develop alzheimer neurofibrillary degeneration in the brain, but the underlying molecular mechanism is unknown. |
2008-09-24 |
2023-08-12 |
mouse |
| J M Biselli, E M Goloni-Bertollo, R Haddad, M N Eberlin, E C Pavarino-Bertell. The MTR A2756G polymorphism is associated with an increase of plasma homocysteine concentration in Brazilian individuals with Down syndrome. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 41. issue 1. 2008-09-22. PMID:18060320. |
individuals with down syndrome (ds) present decreased homocysteine (hcy) concentration, reflecting a functional folate deficiency secondary to overexpression of the cystathionine ss-synthase gene. |
2008-09-22 |
2023-08-12 |
Not clear |
| Markus Neuhäuser, Sven Kracko. Adaptive-filtering of trisomy 21: risk of Down syndrome depends on family size and age of previous child. Die Naturwissenschaften. vol 94. issue 2. 2008-09-17. PMID:17028887. |
the neonatal incidence rate of down syndrome (ds) is well-known to accelerate strongly with maternal age. |
2008-09-17 |
2023-08-12 |
Not clear |
| Hefziba Lifshitz, Joav Merrick, Mohammed Mora. Health status and ADL functioning of older persons with intellectual disability: community residence versus residential care centers. Research in developmental disabilities. vol 29. issue 4. 2008-09-15. PMID:17618082. |
ten percent had down syndrome (ds), 16% had cerebral palsy (cp) and the rest had id with no specific etiology (nsid). |
2008-09-15 |
2023-08-12 |
human |
| Maurizio Arico, Ottavio Ziino, Maria Grazia Valsecchi, Giovanni Cazzaniga, Carlo Baronci, Chiara Messina, Andrea Pession, Nicola Santoro, Giuseppe Basso, Valentino Conte. Acute lymphoblastic leukemia and Down syndrome: presenting features and treatment outcome in the experience of the Italian Association of Pediatric Hematology and Oncology (AIEOP). Cancer. vol 113. issue 3. 2008-09-10. PMID:18521927. |
the presenting features and treatment outcome of 120 patients with down syndrome (ds) and childhood acute lymphoblastic leukemia (all) were compared with 6237 non-ds patients treated in the same years. |
2008-09-10 |
2023-08-12 |
Not clear |
| Karen Fung, Herenia Lawrence, Paul Alliso. A paired analysis of correlates of dental restorative care in siblings with and without Down syndrome. Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry. vol 28. issue 3. 2008-09-08. PMID:18489654. |
this study examined the hypothesis that age-matched siblings with and without down syndrome (ds) have the same risk of ever having had a tooth restored. |
2008-09-08 |
2023-08-12 |
human |
| Mari Eli Leonelli de Moraes, Jefferson Luis Oshiro Tanaka, Luis Cesar de Moraes, Edmundo Medici Filho, Julio Cezar de Melo Castilh. Skeletal age of individuals with Down syndrome. Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry. vol 28. issue 3. 2008-09-08. PMID:18489657. |
the aim of this study was to assess the skeletal age of brazilian individuals with down syndrome (ds) using the method of greulich and pyle. |
2008-09-08 |
2023-08-12 |
human |
| Aldo Rosano, Elisabetta Del Bufalo, Alessandra Burgi. [Socioeconomic status and risk of congenital malformations]. Epidemiologia e prevenzione. vol 32. issue 1. 2008-09-04. PMID:18488950. |
to analyse the relationship between socioeconomic factors and the prevalence at birth of a selected group of congenital malformations (cm): neural tube defects (ntd), orofacial clefts (ofc), down syndrome (ds). |
2008-09-04 |
2023-08-12 |
Not clear |
| Sheng-Wen Shaw, Jenn-Jeih Hsu, Chien-Nan Lee, Ching-Hua Hsiao, Chih-Ping Chen, T'sang-T'ang Hsieh, Po-Jen Chen. First- and second-trimester Down syndrome screening: current strategies and clinical guidelines. Taiwanese journal of obstetrics & gynecology. vol 47. issue 2. 2008-09-04. PMID:18603499. |
down syndrome (ds) is the most common human disease caused by a structural chromosome defect. |
2008-09-04 |
2023-08-12 |
human |
| Erika Roat, Nicole Prada, Enrico Lugli, Milena Nasi, Roberta Ferraresi, Leonarda Troiano, Chiara Giovenzana, Marcello Pinti, Ornella Biagioni, Mauro Mariotti, Angelo Di Iorio, Ugo Consolo, Fiorella Balli, Andrea Cossarizz. Homeostatic cytokines and expansion of regulatory T cells accompany thymic impairment in children with Down syndrome. Rejuvenation research. vol 11. issue 3. 2008-08-21. PMID:18386990. |
down syndrome (ds), the most common chromosomal abnormality in humans, is characterized by precocious immunologic aging that results, among other things, in alterations of b and t lymphocyte subsets and natural killer cells, defective phagocytosis, and chemotaxis of polymorphonuclear leukocytes. |
2008-08-21 |
2023-08-12 |
Not clear |
| Aneek Das Bhowmik, Samikshan Dutta, Swagata Sinha, Anindita Chattopadhyay, Kanchan Mukhopadhya. Lack of association between down syndrome and polymorphisms in dopamine receptor D4 and serotonin transporter genes. Neurochemical research. vol 33. issue 7. 2008-08-20. PMID:18270821. |
down syndrome (ds) patients suffer from cognitive dysfunction, depression, hyperactivity, irritability etc. |
2008-08-20 |
2023-08-12 |
Not clear |
| Michael Christiansen, Tina Lindvig Sørensen, Severin Olesen Larsen, Bent Nørgaard-Pederse. First-trimester maternal serum progesterone in aneuploid pregnancies. Prenatal diagnosis. vol 28. issue 4. 2008-08-18. PMID:18317998. |
first-trimester maternal serum screening for down syndrome (ds) can be improved by the use of additional serum markers. |
2008-08-18 |
2023-08-12 |
Not clear |
| Naznin Virji-Babul, Alexander Moiseev, Teresa Cheung, Daniel Weeks, Douglas Cheyne, Urs Ribar. Changes in mu rhythm during action observation and execution in adults with Down syndrome: implications for action representation. Neuroscience letters. vol 436. issue 2. 2008-08-13. PMID:18394804. |
in order to examine this issue we examined the recruitment of the mirror neuron system, as reflected in mu rhythm suppression in a population of adults with down syndrome (ds) with known strengths in imitation but with impairments in perceptual-motor coupling. |
2008-08-13 |
2023-08-12 |
human |
| S de Falco, G Esposito, P Venuti, M H Bornstei. Fathers' play with their Down Syndrome children. Journal of intellectual disability research : JIDR. vol 52. issue Pt 6. 2008-08-07. PMID:18373561. |
in children with down syndrome (ds), as in other groups of special needs children, development depends crucially on the degree to which parents provide appropriate stimulation and effective support. |
2008-08-07 |
2023-08-12 |
Not clear |
| Zhihou Liang, Fei Liu, Khalid Iqbal, Inge Grundke-Iqbal, Jerzy Wegiel, Cheng-Xin Gon. Decrease of protein phosphatase 2A and its association with accumulation and hyperphosphorylation of tau in Down syndrome. Journal of Alzheimer's disease : JAD. vol 13. issue 3. 2008-08-07. PMID:18430997. |
virtually all individuals with down syndrome (ds) develop neurofibrillary tangles, a characteristic brain lesion of alzheimer's disease (ad), when they reach the fourth decade of life. |
2008-08-07 |
2023-08-12 |
Not clear |
| Marie-Noëlle Mazille, Alain Woda, Emmanuel Nicolas, Marie-Agnès Peyron, Martine Hennequi. Effect of occlusal appliance wear on chewing in persons with Down syndrome. Physiology & behavior. vol 93. issue 4-5. 2008-07-31. PMID:18234243. |
the effects of down syndrome (ds) include orofacial dysmorphology with neuro-motor difficulties and inter-maxillary discrepancy. |
2008-07-31 |
2023-08-12 |
human |