| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Smigielska-Kuzia, W Sobanie. Brain metabolic profile obtained by proton magnetic resonance spectroscopy HMRS in children with Down syndrome. Advances in medical sciences. vol 52 Suppl 1. 2008-03-04. PMID:18229661. |
down syndrome (ds), or trisomia 21, is one of the most common autosomal mutations, with mental impairment as the constant symptom. |
2008-03-04 |
2023-08-12 |
Not clear |
| Machiko Kawamura, Hidefumi Kaku, Takeshi Taketani, Tomohiko Taki, Akira Shimada, Yasuhide Hayash. Mutations of GATA1, FLT3, MLL-partial tandem duplication, NRAS, and RUNX1 genes are not found in a 7-year-old Down syndrome patient with acute myeloid leukemia (FAB-M2) having a good prognosis. Cancer genetics and cytogenetics. vol 180. issue 1. 2008-02-26. PMID:18068539. |
the prognosis of leukemia developed in down syndrome (ds) patients has improved markedly. |
2008-02-26 |
2023-08-12 |
Not clear |
| Ming-Hua Chen, Shyh-Jye Chen, Li-Ying Su, Winnie Yan. Thyroid dysfunction in patients with Down syndrome. Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi. vol 48. issue 4. 2008-02-26. PMID:18265539. |
the close relationship between thyroid disorder and down syndrome (ds) had been widely reported in the literature. |
2008-02-26 |
2023-08-12 |
Not clear |
| M Lumbreras, C Baamonde, C Martínez-Cué, G Lubec, N Cairns, J Sallés, M Dierssen, J Flóre. Brain G protein-dependent signaling pathways in Down syndrome and Alzheimer's disease. Amino acids. vol 31. issue 4. 2008-02-19. PMID:16583316. |
premature aging and neuropathological features of alzheimer's disease (ad) are commonly observed in down syndrome (ds). |
2008-02-19 |
2023-08-12 |
mouse |
| Maureen M O'Brien, Jeffrey W Taub, Myron N Chang, Gita V Massey, Kimo C Stine, Susana C Raimondi, David Becton, Yaddanapudi Ravindranath, Gary V Dah. Cardiomyopathy in children with Down syndrome treated for acute myeloid leukemia: a report from the Children's Oncology Group Study POG 9421. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. vol 26. issue 3. 2008-02-14. PMID:18202418. |
to determine the outcomes, with particular attention to toxicity, of children with down syndrome (ds) and acute myeloid leukemia (aml) treated on pediatric oncology group (pog) protocol 9421. |
2008-02-14 |
2023-08-12 |
Not clear |
| Eun-Sil Park, So-Young Kim, Jung-Suk Yeom, Jae-Young Lim, Chan-Hoo Park, Hee-Shang You. Extreme thrombocytosis associated with transient myeloproliferative disorder with Down Syndrome with t(11;17)(q13;q21). Pediatric blood & cancer. vol 50. issue 3. 2008-02-12. PMID:16941648. |
a female patient with down syndrome (ds) had neonatal thrombocytosis with platelet counts exceeding 2,000 x 10(3)/microl and transient myeloproliferative disorder (tmd). |
2008-02-12 |
2023-08-12 |
Not clear |
| H E Lockstone, L W Harris, J E Swatton, M T Wayland, A J Holland, S Bah. Gene expression profiling in the adult Down syndrome brain. Genomics. vol 90. issue 6. 2008-02-11. PMID:17950572. |
the mechanisms by which trisomy 21 leads to the characteristic down syndrome (ds) phenotype are unclear. |
2008-02-11 |
2023-08-12 |
human |
| Nagwa A Meguid, Ahmed A Dardir, Mohamed Khass, Lamia El Hossieny, Afaf Ezzat, Mostafa K El Awad. MTHFR genetic polymorphism as a risk factor in Egyptian mothers with Down syndrome children. Disease markers. vol 24. issue 1. 2008-02-07. PMID:18057532. |
recent reports linking down syndrome (ds) to maternal polymorphisms at the methylenetetrahydrofolate reductase (mthfr) gene locus have generated great interest among investigators in the field. |
2008-02-07 |
2023-08-12 |
Not clear |
| Dale A Ulrich, Meghann C Lloyd, Chad W Tiernan, Julia E Looper, Rosa M Angulo-Barros. Effects of intensity of treadmill training on developmental outcomes and stepping in infants with Down syndrome: a randomized trial. Physical therapy. vol 88. issue 1. 2008-02-05. PMID:17940103. |
infants with down syndrome (ds) are consistently late walkers. |
2008-02-05 |
2023-08-12 |
Not clear |
| Afua Mensah, Claire Mulligan, Jackie Linehan, Sandra Ruf, Aideen O'Doherty, Beata Grygalewicz, Janet Shipley, Juergen Groet, Victor Tybulewicz, Elizabeth Fisher, Sebastian Brandner, Dean Nizeti. An additional human chromosome 21 causes suppression of neural fate of pluripotent mouse embryonic stem cells in a teratoma model. BMC developmental biology. vol 7. 2008-02-04. PMID:18047653. |
down syndrome (ds), caused by trisomy of human chromosome 21 (hsa21), is the most common genetic cause of mental retardation in humans. |
2008-02-04 |
2023-08-12 |
mouse |
| Lilah M Besser, Mikyong Shin, James E Kucik, Adolfo Corre. Prevalence of down syndrome among children and adolescents in metropolitan Atlanta. Birth defects research. Part A, Clinical and molecular teratology. vol 79. issue 11. 2008-01-29. PMID:17990336. |
down syndrome (ds) prevalence estimates beyond infancy are needed to assess health service needs among those with ds. |
2008-01-29 |
2023-08-12 |
Not clear |
| Mikyong Shin, James E Kucik, Adolfo Corre. Causes of death and case fatality rates among infants with down syndrome in metropolitan Atlanta. Birth defects research. Part A, Clinical and molecular teratology. vol 79. issue 11. 2008-01-29. PMID:17990337. |
there is limited population-based information on the extent of underreporting of congenital heart defects (chd) as a cause of death among infants with down syndrome (ds) and on the variation in case fatality by presence of chd and age at death. |
2008-01-29 |
2023-08-12 |
Not clear |
| Min Hoan Moon, Jeong Yeon Cho, Yu Mi Lee, Sung Il Jung, Jae Hyug Yang, Moon Young Kim, Hyun-Mee Ryu, Jin Hoon Chung, Seong Ho Par. First-trimester screening for Down syndrome; the role of nasal bone assessment in the Korean population. Prenatal diagnosis. vol 27. issue 9. 2008-01-15. PMID:17605156. |
the aim of this study was to evaluate the role of nasal bone assessment in first-trimester screening for down syndrome (ds) in the korean population. |
2008-01-15 |
2023-08-12 |
Not clear |
| Jean Maurice Delabar, Revital Aflalo-Rattenbac, Nicole Créa. Developmental defects in trisomy 21 and mouse models. TheScientificWorldJournal. vol 6. 2008-01-14. PMID:17205199. |
this review focuses on the developmental defects of murine models of a prototype human aneuploidy: trisomy 21 (down syndrome, ds, t21). |
2008-01-14 |
2023-08-12 |
mouse |
| Mohammed Rachidi, Carmela Lope. Mental retardation in Down syndrome: from gene dosage imbalance to molecular and cellular mechanisms. Neuroscience research. vol 59. issue 4. 2008-01-11. PMID:17897742. |
down syndrome (ds), the most frequent genetic disorder leading to mental retardation (mr), is caused by three copies of human chromosome 21 (hc21). |
2008-01-11 |
2023-08-12 |
mouse |
| Hillevi Englund, Göran Annerén, Jan Gustafsson, Ulrika Wester, Jens Wiltfang, Lars Lannfelt, Kaj Blennow, Kina Höglun. Increase in beta-amyloid levels in cerebrospinal fluid of children with Down syndrome. Dementia and geriatric cognitive disorders. vol 24. issue 5. 2008-01-10. PMID:17914261. |
individuals with down syndrome (ds) invariably develop alzheimer's disease (ad) during their life span. |
2008-01-10 |
2023-08-12 |
Not clear |
| Joongkyu Park, Eun Jin Yang, Joo Heon Yoon, Kwang Chul Chun. Dyrk1A overexpression in immortalized hippocampal cells produces the neuropathological features of Down syndrome. Molecular and cellular neurosciences. vol 36. issue 2. 2008-01-09. PMID:17720532. |
down syndrome (ds) is the most common genetic disorder, characterized by mental retardation, congenital heart abnormalities, and susceptibility to alzheimer's disease (ad). |
2008-01-09 |
2023-08-12 |
human |
| Elias Zintzara. Maternal gene polymorphisms involved in folate metabolism and risk of Down syndrome offspring: a meta-analysis. Journal of human genetics. vol 52. issue 11. 2008-01-09. PMID:17934692. |
studies investigating the association between gene polymorphisms involved in homocysteine/folate metabolism and down syndrome (ds) have reported contradictory or inconclusive results. |
2008-01-09 |
2023-08-12 |
Not clear |
| Ivan Zatsepin, Pierre Verger, Elisabeth Robert-Gnansia, Bertrand Gagnière, Margot Tirmarche, Rostislav Khmel, Irina Babicheva, Gennady Lazju. Down syndrome time-clustering in January 1987 in Belarus: link with the Chernobyl accident? Reproductive toxicology (Elmsford, N.Y.). vol 24. issue 3-4. 2008-01-08. PMID:17706919. |
we analyzed the time trends of down syndrome (ds) in belarus to evaluate whether either brief exposure at high dose rates during the plume passage or continuous exposure at low doses and dose rates of the residents of contaminated areas had any detectable impact on ds prevalence at birth. |
2008-01-08 |
2023-08-12 |
Not clear |
| Michel E Weijerman, A Marceline van Furth, Antonie Vonk Noordegraaf, Jacobus P van Wouwe, Chantal J M Broers, Reinoud J B J Gemk. Prevalence, neonatal characteristics, and first-year mortality of Down syndrome: a national study. The Journal of pediatrics. vol 152. issue 1. 2008-01-07. PMID:18154890. |
to determine the prevalence, neonatal characteristics, and first-year mortality in down syndrome (ds) among children in the netherlands. |
2008-01-07 |
2023-08-12 |
Not clear |