| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giovanni Pagano, Giuseppe Castell. Oxidative stress and mitochondrial dysfunction in Down syndrome. Advances in experimental medicine and biology. vol 724. 2012-04-10. PMID:22411251. |
down syndrome (ds) or trisomy 21 is the genetic disease with highest prevalence displaying phenotypic features that both include neurologic deficiencies and a number of clinical outcomes. |
2012-04-10 |
2023-08-12 |
mouse |
| Véronique Brault, Benoît Martin, Nathalie Costet, Jean-Charles Bizot, Yann Héraul. Characterization of PTZ-induced seizure susceptibility in a down syndrome mouse model that overexpresses CSTB. PloS one. vol 6. issue 11. 2012-04-09. PMID:22140471. |
down syndrome (ds) is a complex genetic syndrome characterized by intellectual disability, dysmorphism and variable additional physiological traits. |
2012-04-09 |
2023-08-12 |
mouse |
| Karen R Rabin, Justin Smith, Claudia A Kozinet. Myelosuppression and infectious complications in children with Down syndrome and acute lymphoblastic leukemia. Pediatric blood & cancer. vol 58. issue 4. 2012-04-06. PMID:22106003. |
children with down syndrome (ds) bear an increased risk of acute lymphoblastic leukemia (all) and treatment complications. |
2012-04-06 |
2023-08-12 |
Not clear |
| Jenny Abanto, Ana Lidia Ciamponi, Elizabeth Francischini, Christiana Murakami, Nathalie Pepe Medeiros de Rezende, Marina Gallottin. Medical problems and oral care of patients with Down syndrome: a literature review. Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry. vol 31. issue 6. 2012-04-04. PMID:22070358. |
when planning the dental treatment of patients with down syndrome (ds), dental practitioners should always consider their general health, in order to achieve a holistic and interdisciplinary approach. |
2012-04-04 |
2023-08-12 |
Not clear |
| Amanda Faith Casey, Claudia Eme. The effects of swim training on respiratory aspects of speech production in adolescents with down syndrome. Adapted physical activity quarterly : APAQ. vol 28. issue 4. 2012-04-03. PMID:21914905. |
reduced respiratory muscle strength in individuals with down syndrome (ds) may affect speech respiratory variables such as maximum phonation duration (mpd), initiation volume, and expired mean airflow. |
2012-04-03 |
2023-08-12 |
human |
| Arnaud Duchon, Matthieu Raveau, Claire Chevalier, Valérie Nalesso, Andrew J Sharp, Yann Heraul. Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling Down syndrome. Mammalian genome : official journal of the International Mammalian Genome Society. vol 22. issue 11-12. 2012-04-03. PMID:21953411. |
down syndrome (ds) is the most frequent genetic disorder leading to intellectual disabilities and is caused by three copies of human chromosome 21. |
2012-04-03 |
2023-08-12 |
mouse |
| Ji Hyae Lim, Shin Young Kim, So Yeon Park, Shin Yeong Lee, Mi Jin Kim, You Jung Han, Si Won Lee, Jin Hoon Chung, Moon Young Kim, Jae Hyug Yang, Hyun Mee Ry. Non-invasive epigenetic detection of fetal trisomy 21 in first trimester maternal plasma. PloS one. vol 6. issue 11. 2012-04-02. PMID:22132128. |
down syndrome (ds) is the most common known aneuploidy, caused by an extra copy of all or part of chromosome 21. |
2012-04-02 |
2023-08-12 |
Not clear |
| Cara J Westmark, Pamela R Westmark, Kenneth J O'Riordan, Brian C Ray, Crystal M Hervey, M Shahriar Salamat, Sara H Abozeid, Kelsey M Stein, Levi A Stodola, Michael Tranfaglia, Corinna Burger, Elizabeth M Berry-Kravis, James S Malte. Reversal of fragile X phenotypes by manipulation of AβPP/Aβ levels in Fmr1KO mice. PloS one. vol 6. issue 10. 2012-03-26. PMID:22046307. |
cleavage of aβpp can produce β-amyloid (aβ), a 39-43 amino acid peptide mis-expressed in alzheimer's disease (ad) and down syndrome (ds). |
2012-03-26 |
2023-08-12 |
mouse |
| Ana C Xavier, Holly Edwards, Alan A Dombkowski, Tugce B Balci, Jason N Berman, Graham Dellaire, Chengzhi Xie, Steven A Buck, Larry H Matherly, Yubin Ge, Jeffrey W Tau. A unique role of GATA1s in Down syndrome acute megakaryocytic leukemia biology and therapy. PloS one. vol 6. issue 11. 2012-03-26. PMID:22110660. |
acute megakaryocytic leukemia (amkl) in down syndrome (ds) children is uniformly associated with somatic gata1 mutations, which result in the synthesis of a shorter protein (gata1s) with altered transactivation activity compared to the wild-type gata1. |
2012-03-26 |
2023-08-12 |
Not clear |
| Tyler K Best, Nathan P Cramer, Lina Chakrabarti, Tarik F Haydar, Zygmunt Galdzick. Dysfunctional hippocampal inhibition in the Ts65Dn mouse model of Down syndrome. Experimental neurology. vol 233. issue 2. 2012-03-26. PMID:22178330. |
gabaergic dysfunction is implicated in hippocampal deficits of the ts65dn mouse model of down syndrome (ds). |
2012-03-26 |
2023-08-12 |
mouse |
| Laureanne Pilar E Lorenzo, Haiyan Chen, Kristen E Shatynski, Sarah Clark, Rong Yuan, David E Harrison, Paul J Yarowsky, Mark S William. Defective hematopoietic stem cell and lymphoid progenitor development in the Ts65Dn mouse model of Down syndrome: potential role of oxidative stress. Antioxidants & redox signaling. vol 15. issue 8. 2012-03-21. PMID:21504363. |
down syndrome (ds), a genetic disease caused by a triplication of chromosome 21, is characterized by increased markers of oxidative stress. |
2012-03-21 |
2023-08-12 |
mouse |
| b' Ivana Babi\\xc4\\x87 Bo\\xc5\\xbeovi\\xc4\\x87, Jadranka Vranekovi\\xc4\\x87, Nada Star\\xc4\\x8devi\\xc4\\x87 Cizmarevi\\xc4\\x87, Vesna Mahulja-Stamenkovi\\xc4\\x87, Igor Prpi\\xc4\\x87, Bojana Brajenovi\\xc4\\x87-Mili\\xc4\\x8. MTHFR C677T and A1298C polymorphisms as a risk factor for congenital heart defects in Down syndrome. Pediatrics international : official journal of the Japan Pediatric Society. vol 53. issue 4. 2012-03-20. PMID:21159028.' |
congenital heart defects (chd) are present in most, but not all, cases of down syndrome (ds). |
2012-03-20 |
2023-08-12 |
Not clear |
| Alan S Gamis, Todd A Alonzo, Robert B Gerbing, Joanne M Hilden, April D Sorrell, Mukta Sharma, Thomas W Loew, Robert J Arceci, Dorothy Barnard, John Doyle, Gita Massey, John Perentesis, Yaddanapudi Ravindranath, Jeffrey Taub, Franklin O Smit. Natural history of transient myeloproliferative disorder clinically diagnosed in Down syndrome neonates: a report from the Children's Oncology Group Study A2971. Blood. vol 118. issue 26. 2012-03-20. PMID:21849481. |
prospective enrollment (n = 135) elucidated the natural history in down syndrome (ds) patients diagnosed with tmd via the use of uniform monitoring and intervention guidelines. |
2012-03-20 |
2023-08-12 |
Not clear |
| b' Noem\\xc3\\xad Rueda, Jes\\xc3\\xbas Fl\\xc3\\xb3rez, Carmen Mart\\xc3\\xadnez-Cu\\xc3\\xa. The Ts65Dn mouse model of Down syndrome shows reduced expression of the Bcl-X(L) antiapoptotic protein in the hippocampus not accompanied by changes in molecular or cellular markers of cell death. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 29. issue 7. 2012-03-19. PMID:21684326.' |
the ts65dn (ts) mouse, the most widely used model of down syndrome (ds), has a partial trisomy of a segment of chromosome 16 that is homologous to the distal part of human chromosome 21. |
2012-03-19 |
2023-08-12 |
mouse |
| Patrick M Cowley, Lori L Ploutz-Snyder, Tracy Baynard, Kevin S Heffernan, Sae Young Jae, Sharon Hsu, Miyoung Lee, Kenneth H Pitetti, Michael P Reiman, Bo Fernhal. The effect of progressive resistance training on leg strength, aerobic capacity and functional tasks of daily living in persons with Down syndrome. Disability and rehabilitation. vol 33. issue 23-24. 2012-03-16. PMID:21446859. |
the purpose of this study was to examine the effect of progressive resistance training on leg strength, aerobic capacity and physical function in persons with down syndrome (ds). |
2012-03-16 |
2023-08-12 |
Not clear |
| A Soler Marín, J Ma Xandri Grauper. Nutritional status of intellectual disabled persons with Down syndrome. Nutricion hospitalaria. vol 26. issue 5. 2012-03-12. PMID:22072353. |
to evaluate the nutritional status in young adults with down syndrome (ds). |
2012-03-12 |
2023-08-12 |
Not clear |
| Rodrigo Guzmán, Carlos Campos, Encarnación López-Fernández, Angela Casad. Biomarkers of age effect on renal function in Down syndrome. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. vol 16. issue 8. 2012-03-09. PMID:22023562. |
to assess differences in kidney function between down syndrome (ds) individuals and a control group related to aging. |
2012-03-09 |
2023-08-12 |
Not clear |
| Ming-Horng Tsai, Jia-Woei Hou, Chao-Ping Yang, Pong-Hong Yang, Shih-Ming Chu, Jen-Fu Hsu, Ming-Chou Chiang, Hsuan-Rong Huan. Transient myeloproliferative disorder and GATA1 mutation in neonates with and without Down syndrome. Indian journal of pediatrics. vol 78. issue 7. 2012-03-08. PMID:21287369. |
to report clinical experiences and cytogenetic findings of transient myeloproliferative disorder (tmd) in neonates with and without down syndrome (ds). |
2012-03-08 |
2023-08-12 |
Not clear |
| Himara Mohamad Lópe. Transfer of the amyloid β and/or of β-amyloid precursor protein of the fetus with trisomy 21 to the maternal blood stream and its possible contribution to the pathogenesis of the maternal Alzheimer's Disease. Medical hypotheses. vol 77. issue 6. 2012-03-06. PMID:21944886. |
down syndrome (ds) is the most frequent genetic pathology. |
2012-03-06 |
2023-08-12 |
Not clear |
| Kelly W Malone. Acute lymphoblastic leukaemia in children with Down syndrome: an updated review. British journal of haematology. vol 155. issue 4. 2012-03-01. PMID:21933171. |
down syndrome (ds) is the most common chromosomal abnormality in children and also carries a marked increased incidence of acute leukaemia. |
2012-03-01 |
2023-08-12 |
Not clear |