| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aaron Block, Md Mahiuddin Ahmed, A Ranjitha Dhanasekaran, Suhong Tong, Katheleen J Gardine. Sex differences in protein expression in the mouse brain and their perturbations in a model of Down syndrome. Biology of sex differences. vol 6. 2015-11-11. PMID:26557979. |
down syndrome (ds) is the most common genetic cause of id and is due to trisomy of human chromosome 21 (hsa21) and the resulting increased expression of hsa21-encoded genes. |
2015-11-11 |
2023-08-13 |
mouse |
| Cem Karadeniz, Rahmi Ozdemir, Fikri Demir, Yılmaz Yozgat, Mehmet Küçük, Talia Oner, Utku Karaarslan, Timur Meşe, Nurettin Una. Increased P-wave and QT dispersions necessitate long-term follow-up evaluation of Down syndrome patients with congenitally normal hearts. Pediatric cardiology. vol 35. issue 8. 2015-11-09. PMID:24859169. |
reports state that down syndrome (ds) patients with congenitally normal hearts might experience the development of cardiac abnormalities such as cardiac autonomic dysfunction, valvular lesions, bradycardia, and atrioventricular block. |
2015-11-09 |
2023-08-13 |
human |
| b' J Muchov\\xc3\\xa1, I \\xc5\\xbdit\\xc5\\x88anov\\xc3\\xa1, Z \\xc4\\x8eura\\xc4\\x8dkov\\xc3\\xa. Oxidative stress and Down syndrome. Do antioxidants play a role in therapy? Physiological research. vol 63. issue 5. 2015-11-09. PMID:24908086.' |
oxidative stress in individuals with down syndrome (ds) has been associated with trisomy of the 21st chromosome resulting in ds phenotype as well as with various morphological abnormalities, immune disorders, intellectual disability, premature aging and other biochemical abnormalities. |
2015-11-09 |
2023-08-13 |
Not clear |
| M H Tanaka, T O Rodrigues, L S Finoti, S R L Teixeira, M P A Mayer, R M Scarel-Caminaga, E M A Gir. The effect of conventional mechanical periodontal treatment on red complex microorganisms and clinical parameters in Down syndrome periodontitis patients: a pilot study. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. vol 34. issue 3. 2015-11-09. PMID:25367612. |
down syndrome (ds) individuals demonstrate a high prevalence of pd compared with those who are otherwise chromosomally normal (euploids). |
2015-11-09 |
2023-08-13 |
human |
| Fabio Di Domenico, Gilda Pupo, Cesare Mancuso, Eugenio Barone, Francesca Paolini, Andrea Arena, Carla Blarzino, Frederick A Schmitt, Elizabeth Head, D Allan Butterfield, Marzia Perluig. Bach1 overexpression in Down syndrome correlates with the alteration of the HO-1/BVR-a system: insights for transition to Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 44. issue 4. 2015-11-09. PMID:25391381. |
since oxidative stress is an early event in down syndrome (ds) and might contribute to the development of multiple deleterious ds phenotypes, including alzheimer's disease (ad) pathology, we investigated the status of the bach1/ho-1/bvr-a axis in ds and its possible implications for the development of ad. |
2015-11-09 |
2023-08-13 |
mouse |
| Judith L S Budd, Elizabeth S Draper, Robyn R Lotto, Laura E Berry, Lucy K Smit. Socioeconomic inequalities in pregnancy outcome associated with Down syndrome: a population-based study. Archives of disease in childhood. Fetal and neonatal edition. vol 100. issue 5. 2015-11-09. PMID:26071456. |
to investigate socioeconomic inequalities in outcome of pregnancy associated with down syndrome (ds) compared with other congenital anomalies screened for during pregnancy. |
2015-11-09 |
2023-08-13 |
Not clear |
| Yasuhiro Kazuki, Yuwna Yakura, Satoshi Abe, Mitsuhiko Osaki, Naoyo Kajitani, Kanako Kazuki, Shoko Takehara, Kazuhisa Honma, Hirofumi Suemori, Satoshi Yamazaki, Tetsushi Sakuma, Tsutomu Toki, Ritsuko Shimizu, Hiromitsu Nakauchi, Takashi Yamamoto, Mitsuo Oshimur. Down syndrome-associated haematopoiesis abnormalities created by chromosome transfer and genome editing technologies. Scientific reports. vol 4. 2015-11-05. PMID:25159877. |
infants with down syndrome (ds) are at a high risk of developing transient abnormal myelopoiesis (tam). |
2015-11-05 |
2023-08-13 |
human |
| Jillian L Shaw, Shixing Zhang, Karen T Chan. Bidirectional Regulation of Amyloid Precursor Protein-Induced Memory Defects by Nebula/DSCR1: A Protein Upregulated in Alzheimer's Disease and Down Syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 32. 2015-11-05. PMID:26269644. |
aging individuals with down syndrome (ds) have an increased risk of developing alzheimer's disease (ad), a neurodegenerative disorder characterized by impaired memory. |
2015-11-05 |
2023-08-13 |
drosophila_melanogaster |
| Jillian L Shaw, Shixing Zhang, Karen T Chan. Bidirectional Regulation of Amyloid Precursor Protein-Induced Memory Defects by Nebula/DSCR1: A Protein Upregulated in Alzheimer's Disease and Down Syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 32. 2015-11-05. PMID:26269644. |
this study examines the functional interactions between down syndrome critical region 1 (dscr1) and amyloid-precursor protein (app), proteins upregulated in both ds and ad, in regulating memory. |
2015-11-05 |
2023-08-13 |
drosophila_melanogaster |
| Nancy Raitano Lee, Payal Anand, Elizabeth Will, Elizabeth I Adeyemi, Liv S Clasen, Jonathan D Blumenthal, Jay N Giedd, Lisa A Daunhauer, Deborah J Fidler, Jamie O Edgi. Everyday executive functions in Down syndrome from early childhood to young adulthood: evidence for both unique and shared characteristics compared to youth with sex chromosome trisomy (XXX and XXY). Frontiers in behavioral neuroscience. vol 9. 2015-11-05. PMID:26539087. |
executive functions (ef) are thought to be impaired in down syndrome (ds) and sex chromosome trisomy (klinefelter and trisomy x syndromes; +1x). |
2015-11-05 |
2023-08-13 |
human |
| Benoit Souchet, Fayçal Guedj, Zsuza Penke-Verdier, Fabrice Daubigney, Arnaud Duchon, Yann Herault, Jean-Charles Bizot, Nathalie Janel, Nicole Créau, Benoit Delatour, Jean M Delaba. Pharmacological correction of excitation/inhibition imbalance in Down syndrome mouse models. Frontiers in behavioral neuroscience. vol 9. 2015-11-05. PMID:26539088. |
cognitive impairment in down syndrome (ds) has been linked to increased synaptic inhibition. |
2015-11-05 |
2023-08-13 |
mouse |
| Xun Yu Choong, Justin L Tosh, Laura J Pulford, Elizabeth M C Fishe. Dissecting Alzheimer disease in Down syndrome using mouse models. Frontiers in behavioral neuroscience. vol 9. 2015-11-03. PMID:26528151. |
down syndrome (ds) is a common genetic condition caused by the presence of three copies of chromosome 21 (trisomy 21). |
2015-11-03 |
2023-08-13 |
mouse |
| Tanja A Gruber, James R Downin. The biology of pediatric acute megakaryoblastic leukemia. Blood. vol 126. issue 8. 2015-11-02. PMID:26186939. |
amkl in children with down syndrome (ds) is characterized by a founding gata1 mutation that cooperates with trisomy 21, followed by the acquisition of additional somatic mutations. |
2015-11-02 |
2023-08-13 |
Not clear |
| D B Victorino, M F Godoy, E M Goloni-Bertollo, E C Pavarin. Meta-analysis of Methylenetetrahydrofolate reductase maternal gene in Down syndrome: increased susceptibility in women carriers of the MTHFR 677T allele. Molecular biology reports. vol 41. issue 8. 2015-10-29. PMID:24913031. |
because a number of data studies include some controversial results about methylenetetrahydrofolate reductase (mthfr) polymorphisms and down syndrome (ds), we performed a meta-analysis to determine a more precise estimation of this association. |
2015-10-29 |
2023-08-13 |
Not clear |
| Fiorenza Stagni, Andrea Giacomini, Sandra Guidi, Elisabetta Ciani, Renata Bartesagh. Timing of therapies for Down syndrome: the sooner, the better. Frontiers in behavioral neuroscience. vol 9. 2015-10-27. PMID:26500515. |
intellectual disability (id) is the unavoidable hallmark of down syndrome (ds), with a heavy impact on public health. |
2015-10-27 |
2023-08-13 |
mouse |
| Tiffany Renee Oliver, Candace D Middlebrooks, Stuart W Tinker, Emily Graves Allen, Lora J H Bean, Ferdouse Begum, Eleanor Feingold, Reshmi Chowdhury, Vivian Cheung, Stephanie L Sherma. An examination of the relationship between hotspots and recombination associated with chromosome 21 nondisjunction. PloS one. vol 9. issue 6. 2015-10-26. PMID:24926858. |
trisomy 21, resulting in down syndrome (ds), is the most common autosomal trisomy among live-born infants and is caused mainly by nondisjunction of chromosome 21 within oocytes. |
2015-10-26 |
2023-08-13 |
human |
| Sohier Yahia, Mohamed El-Hadidy, Abdel-Hady El-Gilany, Dina Amdel-Hady, Yahya Wahba, Mohammad Al-Hagga. Disruptive behavior in Down syndrome children: a cross-sectional comparative study. Annals of Saudi medicine. vol 34. issue 6. 2015-10-26. PMID:25971826. |
down syndrome (ds) is associated with intellectual disability, and patients with ds show significant psychopathology. |
2015-10-26 |
2023-08-13 |
Not clear |
| Saadia Shahza. JOURNEY OF A WORKING MOTHER AND HER SON WITH DOWN SYNDROME. Journal of Ayub Medical College, Abbottabad : JAMC. vol 27. issue 2. 2015-10-26. PMID:26411153. |
trisomy 21, chromosomal disorder related with down syndrome (ds), is the most common cause leading to learning disability among all races and all human population. |
2015-10-26 |
2023-08-13 |
human |
| Silvia Lanfranchi, Irene C Mammarella, Barbara Carrett. Spatial-simultaneous working memory and selective interference in Down syndrome. Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence. vol 21. issue 4. 2015-10-21. PMID:24814650. |
several studies have suggested that individuals with down syndrome (ds) have impairments in some aspects of the visuospatial domain. |
2015-10-21 |
2023-08-13 |
human |
| Glynis Laws, Josie Briscoe, Su-Yin Ang, Heather Brown, Ehab Hermena, Anna Kapikia. Receptive vocabulary and semantic knowledge in children with SLI and children with Down syndrome. Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence. vol 21. issue 4. 2015-10-21. PMID:24830646. |
receptive vocabulary and associated semantic knowledge were compared within and between groups of children with specific language impairment (sli), children with down syndrome (ds), and typically developing children. |
2015-10-21 |
2023-08-13 |
Not clear |