| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fuad Lechin, Bertha van der Dijs, Betty Pardey-Maldonad. Insulin versus glucagon crosstalk: central plus peripheral mechanisms. American journal of therapeutics. vol 20. issue 4. 2014-02-19. PMID:23838633. |
finally, one of the showiest findings derived from our research work arises from the unbalance between the da versus 5-ht circulating parameters demonstrating that absolute predominance of the former is always paralleled by hypoglycemia (endogenous depression syndrome), whereas the opposite profile is registered in mammals affected by hyperglycemia (dysthymic depression and uncoping stress syndromes). |
2014-02-19 |
2023-08-12 |
Not clear |
| Hong-Mei Jia, Yu-Fei Feng, Yue-Tao Liu, Xing Chang, Lin Chen, Hong-Wu Zhang, Gang Ding, Zhong-Mei Zo. Integration of ¹H NMR and UPLC-Q-TOF/MS for a comprehensive urinary metabonomics study on a rat model of depression induced by chronic unpredictable mild stress. PloS one. vol 8. issue 5. 2014-02-18. PMID:23696839. |
moreover, the results of western blot analysis of aromatic l-amino acid decarboxylase (ddc) and indoleamine 2, 3-dioxygenase (ido) in the hippocampus of cums-treated rats indicated that depletion of 5-ht and tryptophan, production of 5-mt and altered expression of ddc and ido together played a key role in the initiation and progression of depression. |
2014-02-18 |
2023-08-12 |
rat |
| Atbin Djamshidian, Joseph H Friedma. Anxiety and depression in Parkinson's disease. Current treatment options in neurology. vol 16. issue 4. 2014-02-17. PMID:24532378. |
we favor the selective serotonin reuptake inhibitors (ssris) in general for both depression and anxiety because of their relative freedom from side effects but will often choose mirtazapine if insomnia or weight loss is a problem, clonazepam for anxiety without depression if an ssri is insufficient or if rem sleep behavior disorder is a problem, or a tricyclic antidepressant if drooling is troubling and the patient is not demented. |
2014-02-17 |
2023-08-12 |
human |
| Jae-Min Kim, Robert Stewart, Hee-Ju Kang, Sung-Wan Kim, Il-Seon Shin, Hye-Ran Kim, Myung-Geun Shin, Joon-Tae Kim, Man-Seok Park, Ki-Hyun Cho, Jin-Sang Yoo. A longitudinal study of SLC6A4 DNA promoter methylation and poststroke depression. Journal of psychiatric research. vol 47. issue 9. 2014-02-14. PMID:23702251. |
serotonin transporter gene (slc6a4) has been shown to play an important role in the pathophysiology of mood disorders including poststroke depression (psd). |
2014-02-14 |
2023-08-12 |
Not clear |
| Makiko Yamada, Yukie Kawahara, Fumi Kaneko, Yuki Kishikawa, Naoki Sotogaku, Wilfred J Poppinga, Joost H A Folgering, Eliyahu Dremencov, Hiroshi Kawahara, Akinori Nish. Upregulation of the dorsal raphe nucleus-prefrontal cortex serotonin system by chronic treatment with escitalopram in hyposerotonergic Wistar-Kyoto rats. Neuropharmacology. vol 72. 2014-02-11. PMID:23643754. |
dorsal raphe nucleus (drn) serotonin (5-ht) neurons projecting to the prefrontal cortex (pfc) comprise the important neurocircuitry underlying the pathophysiology of depression. |
2014-02-11 |
2023-08-12 |
rat |
| Makiko Yamada, Yukie Kawahara, Fumi Kaneko, Yuki Kishikawa, Naoki Sotogaku, Wilfred J Poppinga, Joost H A Folgering, Eliyahu Dremencov, Hiroshi Kawahara, Akinori Nish. Upregulation of the dorsal raphe nucleus-prefrontal cortex serotonin system by chronic treatment with escitalopram in hyposerotonergic Wistar-Kyoto rats. Neuropharmacology. vol 72. 2014-02-11. PMID:23643754. |
thus, the wky rat is an animal model of depression with low activity of the drn-pfc 5ht system. |
2014-02-11 |
2023-08-12 |
rat |
| Makiko Yamada, Yukie Kawahara, Fumi Kaneko, Yuki Kishikawa, Naoki Sotogaku, Wilfred J Poppinga, Joost H A Folgering, Eliyahu Dremencov, Hiroshi Kawahara, Akinori Nish. Upregulation of the dorsal raphe nucleus-prefrontal cortex serotonin system by chronic treatment with escitalopram in hyposerotonergic Wistar-Kyoto rats. Neuropharmacology. vol 72. 2014-02-11. PMID:23643754. |
the finding that chronic escit upregulates the 5-ht system in hyposerotonergic wky rats may contribute to improved understanding of mechanisms of action of antidepressants, especially in depression with 5-ht deficiency. |
2014-02-11 |
2023-08-12 |
rat |
| Jade M Franklin, Matt Mathew, Gonzalo A Carrasc. Cannabinoid-induced upregulation of serotonin 2A receptors in the hypothalamic paraventricular nucleus and anxiety-like behaviors in rats. Neuroscience letters. vol 548. 2014-02-07. PMID:23721787. |
recent behavioral reports suggest that repeated exposure to cannabis and synthetic cannabinoid agonists is linked with mental disorders associated with dysfunction of serotonin 2a (5-ht2a) receptor neurotransmission such as anxiety and depression. |
2014-02-07 |
2023-08-12 |
rat |
| Christinna V Jørgensen, Jacob P Jacobsen, Marc G Caron, Anders B Klein, Gitte M Knudsen, Jens D Mikkelse. Cerebral 5-HT2A receptor binding, but not mGluR2, is increased in tryptophan hydroxylase 2 decrease-of-function mice. Neuroscience letters. vol 555. 2014-01-31. PMID:24055299. |
transgenic mice with a knock-in (ki) of a tryptophan hydroxylase 2 (tph2) r439h mutation, analogous to the tph2 r441h single-nucleotide polymorphism originally identified in a late life depression cohort, have markedly reduced levels of 5-hydroxytryptamine (5-ht). |
2014-01-31 |
2023-08-12 |
mouse |
| Andrew J Bradley, Alan J Lenox-Smit. Does adding noradrenaline reuptake inhibition to selective serotonin reuptake inhibition improve efficacy in patients with depression? A systematic review of meta-analyses and large randomised pragmatic trials. Journal of psychopharmacology (Oxford, England). vol 27. issue 8. 2014-01-30. PMID:23832963. |
does adding noradrenaline reuptake inhibition to selective serotonin reuptake inhibition improve efficacy in patients with depression? |
2014-01-30 |
2023-08-12 |
Not clear |
| Andrew J Bradley, Alan J Lenox-Smit. Does adding noradrenaline reuptake inhibition to selective serotonin reuptake inhibition improve efficacy in patients with depression? A systematic review of meta-analyses and large randomised pragmatic trials. Journal of psychopharmacology (Oxford, England). vol 27. issue 8. 2014-01-30. PMID:23832963. |
selective serotonin reuptake inhibitors (ssris) are recommended as first-line pharmacological treatment for depression and are the most commonly prescribed class of antidepressants. |
2014-01-30 |
2023-08-12 |
Not clear |
| Andrew J Bradley, Alan J Lenox-Smit. Does adding noradrenaline reuptake inhibition to selective serotonin reuptake inhibition improve efficacy in patients with depression? A systematic review of meta-analyses and large randomised pragmatic trials. Journal of psychopharmacology (Oxford, England). vol 27. issue 8. 2014-01-30. PMID:23832963. |
this review aims to examine the evidence of including noradrenaline reuptake inhibition with serotonin reuptake inhibition with respect to increasing efficacy in the treatment of depression. |
2014-01-30 |
2023-08-12 |
Not clear |
| Andrew J Bradley, Alan J Lenox-Smit. Does adding noradrenaline reuptake inhibition to selective serotonin reuptake inhibition improve efficacy in patients with depression? A systematic review of meta-analyses and large randomised pragmatic trials. Journal of psychopharmacology (Oxford, England). vol 27. issue 8. 2014-01-30. PMID:23832963. |
evidence from meta-analysis of randomised controlled trials (rcts) and randomised pragmatic trials was found in support of greater efficacy of the serotonin noradrenaline reuptake inhibitors (snris), venlafaxine and duloxetine, in moderate to severe depression compared to ssris but no evidence was found for superiority of milnacipran. |
2014-01-30 |
2023-08-12 |
Not clear |
| Andrew J Bradley, Alan J Lenox-Smit. Does adding noradrenaline reuptake inhibition to selective serotonin reuptake inhibition improve efficacy in patients with depression? A systematic review of meta-analyses and large randomised pragmatic trials. Journal of psychopharmacology (Oxford, England). vol 27. issue 8. 2014-01-30. PMID:23832963. |
there is sufficient current evidence that demonstrates an increase in efficacy, when noradrenaline reuptake is added to serotonin (5-ht) reuptake, to suggest that patients with severe depression or those who have failed to reach remission with a ssri may benefit from treatment with a snri. |
2014-01-30 |
2023-08-12 |
Not clear |
| Lisette Binkhorst, Ron H J Mathijssen, Myrthe P P van Herk-Sukel, Marjolein Bannink, Agnes Jager, Erik A C Wiemer, Teun van Gelde. Unjustified prescribing of CYP2D6 inhibiting SSRIs in women treated with tamoxifen. Breast cancer research and treatment. vol 139. issue 3. 2014-01-27. PMID:23760858. |
selective serotonin reuptake inhibitors (ssris) and selective serotonin and norepinephrine reuptake inhibitors (snris) have been effectively used for the treatment of depression and hot flashes, both of which occur frequently in tamoxifen-treated women. |
2014-01-27 |
2023-08-12 |
Not clear |
| Richard Musil, Peter Zill, Florian Seemüller, Brigitta Bondy, Sebastian Meyer, Ilja Spellmann, Wolfram Bender, Mazda Adli, Isabella Heuser, Robert Fisher, Wolfgang Gaebel, Wolfgang Maier, Marcella Rietschel, Dan Rujescu, Rebecca Schennach, Hans-Jürgen Möller, Michael Riede. Genetics of emergent suicidality during antidepressive treatment--data from a naturalistic study on a large sample of inpatients with a major depressive episode. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 7. 2014-01-23. PMID:23063133. |
common polymorphisms involved in the tryptophan hydroxylase 1 (tph1) and 2 (tph2), serotonin transporter, monoamine oxidase a (maoa) and brain-derived neurotrophic factor (bdnf) were investigated in a naturalistic inpatient study of the german research network on depression. |
2014-01-23 |
2023-08-12 |
Not clear |
| Cesario Bellantuono, Francesca Bozzi, Laura Orsolini, Mario Catena-Dell'Oss. The safety of escitalopram during pregnancy and breastfeeding: a comprehensive review. Human psychopharmacology. vol 27. issue 6. 2014-01-21. PMID:23044635. |
escitalopram (esc) is considered one of the most effective selective serotonin reuptake inhibitors for the treatment of major depression. |
2014-01-21 |
2023-08-12 |
Not clear |
| Shan-Shan Qu, Yong Huang, Zhang-Jin Zhang, Jun-Qi Chen, Ren-Yong Lin, Chong-Qi Wang, Gan-Long Li, Hei Kiu Wong, Cang-Huan Zhao, Ji-Yang Pan, Shen-Chang Guo, Yan-Chi Zhan. A 6-week randomized controlled trial with 4-week follow-up of acupuncture combined with paroxetine in patients with major depressive disorder. Journal of psychiatric research. vol 47. issue 6. 2014-01-21. PMID:23498306. |
our study indicates that acupuncture can accelerate the clinical response to selective serotonin reuptake inhibitors (ssris) and prevent the aggravation of depression. |
2014-01-21 |
2023-08-12 |
Not clear |
| A E Lychkov. [Nervous regulation of thyroid function]. Vestnik Rossiiskoi akademii meditsinskikh nauk. issue 6. 2014-01-16. PMID:24340635. |
depression is accompanied by inhibition of the enzyme activity deiodinase type 2, thereby reducing the concentration of serotonin. |
2014-01-16 |
2023-08-12 |
Not clear |
| Simona Spinelli, Tanja Müller, Miriam Friedel, Hannes Sigrist, Klaus-Peter Lesch, Mark Henkelman, Markus Rudin, Erich Seifritz, Christopher R Pryc. Effects of repeated adolescent stress and serotonin transporter gene partial knockout in mice on behaviors and brain structures relevant to major depression. Frontiers in behavioral neuroscience. vol 7. 2014-01-15. PMID:24427124. |
effects of repeated adolescent stress and serotonin transporter gene partial knockout in mice on behaviors and brain structures relevant to major depression. |
2014-01-15 |
2023-08-12 |
mouse |