| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jane C F Chang, Paul Ciaccio, Patricia Schroeder, Lindsay Wright, Russell Westwood, Anna-Lena Ber. Pathology and Neurotoxicity in Dogs after Repeat Dose Exposure to a Serotonin 5-HT1B Inhibitor. Journal of toxicologic pathology. vol 27. issue 1. 2014-05-05. PMID:24791065. |
azd3783, a cationic amphiphilic drug and a potent inhibitor of the 5-hydroxytryptamine (5-ht1b) receptor, was explored as a potential treatment for depression. |
2014-05-05 |
2023-08-13 |
rat |
| Robert C Hilton, Manivel Rengasamy, Brandon Mansoor, Jiayan He, Taryn Mayes, Graham J Emslie, Giovanna Porta, Greg N Clarke, Karen Dineen Wagner, Boris Birmaher, Martin B Keller, Neal Ryan, Wael Shamseddeen, Joan Rosenbaum Asarnow, David A Bren. Impact of treatments for depression on comorbid anxiety, attentional, and behavioral symptoms in adolescents with selective serotonin reuptake inhibitor-resistant depression. Journal of the American Academy of Child and Adolescent Psychiatry. vol 52. issue 5. 2014-05-02. PMID:23622849. |
impact of treatments for depression on comorbid anxiety, attentional, and behavioral symptoms in adolescents with selective serotonin reuptake inhibitor-resistant depression. |
2014-05-02 |
2023-08-12 |
human |
| Ronald M Salomon, Ronald L Cowa. Oscillatory serotonin function in depression. Synapse (New York, N.Y.). vol 67. issue 11. 2014-05-01. PMID:23592367. |
oscillatory serotonin function in depression. |
2014-05-01 |
2023-08-12 |
Not clear |
| Ronald M Salomon, Ronald L Cowa. Oscillatory serotonin function in depression. Synapse (New York, N.Y.). vol 67. issue 11. 2014-05-01. PMID:23592367. |
recent data suggest that ultradian rhythms in serotonin (5ht) function also change in depression. |
2014-05-01 |
2023-08-12 |
Not clear |
| Ronald M Salomon, Ronald L Cowa. Oscillatory serotonin function in depression. Synapse (New York, N.Y.). vol 67. issue 11. 2014-05-01. PMID:23592367. |
dysfunctional 5ht rhythms in depression may be a common endpoint and biomarker for depression, linking dysfunction of slow brain network oscillators to 5ht mechanisms affected by commonly available treatments. |
2014-05-01 |
2023-08-12 |
Not clear |
| Ronald M Salomon, Ronald L Cowa. Oscillatory serotonin function in depression. Synapse (New York, N.Y.). vol 67. issue 11. 2014-05-01. PMID:23592367. |
further studies of 5ht oscillations in depression are indicated. |
2014-05-01 |
2023-08-12 |
Not clear |
| Martin J Lan, Natalie Hesselgrave, Adam Ciarleglio, R Todd Ogden, Gregory M Sullivan, J John Mann, Ramin V Parse. Higher pretreatment 5-HT1A receptor binding potential in bipolar disorder depression is associated with treatment remission: a naturalistic treatment pilot PET study. Synapse (New York, N.Y.). vol 67. issue 11. 2014-05-01. PMID:23720414. |
our group reported previously that brain serotonin 1a (5-ht(1a)) receptor binding measured by positron emission tomography (pet) is higher in bipolar depression. |
2014-05-01 |
2023-08-12 |
Not clear |
| Martin J Lan, Natalie Hesselgrave, Adam Ciarleglio, R Todd Ogden, Gregory M Sullivan, J John Mann, Ramin V Parse. Higher pretreatment 5-HT1A receptor binding potential in bipolar disorder depression is associated with treatment remission: a naturalistic treatment pilot PET study. Synapse (New York, N.Y.). vol 67. issue 11. 2014-05-01. PMID:23720414. |
higher pretreatment brain 5-ht(1a) receptor binding was associated with remission after 3 months of pharmacological treatment in bipolar depression. |
2014-05-01 |
2023-08-12 |
Not clear |
| Jinling Liu, Jiangchuan Dong, Lei Wang, Ying Su, Peng Yan, Shenggang Su. Comparative efficacy and acceptability of antidepressants in Parkinson's disease: a network meta-analysis. PloS one. vol 8. issue 10. 2014-04-29. PMID:24098546. |
there are many kinds of antidepressants being used, such as tricyclic antidepressants (tcas), selective serotonin reuptake inhibitors (ssris), serotonin and norepinephrine reuptake inhibitors (snris), and dopamine agonists which are suggested as alternative antidepressants for the treatment of depression in pd. |
2014-04-29 |
2023-08-12 |
Not clear |
| Erika Comasco, Cecilia Åslund, Lars Oreland, Kent W Nilsso. Three-way interaction effect of 5-HTTLPR, BDNF Val66Met, and childhood adversity on depression: a replication study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 10. 2014-04-24. PMID:23481907. |
both the serotonin transporter linked promoter region (5-httlpr) and the brain-derived neurotrophic factor (bdnf) val66met polymorphisms have been shown to interact with unfavourable environment in relation to depression symptoms and to depression diagnosis. |
2014-04-24 |
2023-08-12 |
Not clear |
| Philip Cowen, Ann C Sherwoo. The role of serotonin in cognitive function: evidence from recent studies and implications for understanding depression. Journal of psychopharmacology (Oxford, England). vol 27. issue 7. 2014-04-24. PMID:23535352. |
the role of serotonin in cognitive function: evidence from recent studies and implications for understanding depression. |
2014-04-24 |
2023-08-12 |
Not clear |
| Philip Cowen, Ann C Sherwoo. The role of serotonin in cognitive function: evidence from recent studies and implications for understanding depression. Journal of psychopharmacology (Oxford, England). vol 27. issue 7. 2014-04-24. PMID:23535352. |
drugs that potentiate serotonin (5-ht) function, such as selective serotonin reuptake inhibitors (ssris), are the mainstay of treatment for depression. |
2014-04-24 |
2023-08-12 |
Not clear |
| J Xu, Y Q Cheng, B Chen, R Bai, S Li, X F Xu, L Xu, J F Wen, Z P Lu, X F Zen. Depression in systemic lupus erythematosus patients is associated with link-polymorphism but not methylation status of the 5HTT promoter region. Lupus. vol 22. issue 10. 2014-04-24. PMID:23893825. |
depression in systemic lupus erythematosus patients is associated with link-polymorphism but not methylation status of the 5htt promoter region. |
2014-04-24 |
2023-08-12 |
human |
| J Xu, Y Q Cheng, B Chen, R Bai, S Li, X F Xu, L Xu, J F Wen, Z P Lu, X F Zen. Depression in systemic lupus erythematosus patients is associated with link-polymorphism but not methylation status of the 5HTT promoter region. Lupus. vol 22. issue 10. 2014-04-24. PMID:23893825. |
the present study was conducted to explore whether the polymorphism and methylation status of the serotonin transporter gene (5htt) promoter region (pr-5htt) contribute to depression in sle patients from both genetic and epigenetic perspectives. |
2014-04-24 |
2023-08-12 |
human |
| María Dolores Martín-de-Saavedra, Josiane Budni, Mauricio P Cunha, Vanessa Gómez-Rangel, Silvia Lorrio, Laura Del Barrio, Isabel Lastres-Becker, Esther Parada, Rosa María Tordera, Ana Lùcia S Rodrigues, Antonio Cuadrado, Manuela G Lópe. Nrf2 participates in depressive disorders through an anti-inflammatory mechanism. Psychoneuroendocrinology. vol 38. issue 10. 2014-04-22. PMID:23623252. |
in this study, we have observed that nrf2 deletion in mice results in: (i) a depressive-like behavior evaluated as an increase in the immobility time in the tail-suspension test and by a decrease in the grooming time in the splash test, (ii) reduced levels of dopamine and serotonin and increased levels of glutamate in the prefrontal cortex, (iii) altered levels of proteins associated to depression such as vegf and synaptophysin and (iv) microgliosis. |
2014-04-22 |
2023-08-12 |
mouse |
| Alan L Pehrson, Thomas Cremers, Cecile Bétry, Marieke G C van der Hart, Laerke Jørgensen, Mathias Madsen, Nasser Haddjeri, Bjarke Ebert, Connie Sanche. Lu AA21004, a novel multimodal antidepressant, produces regionally selective increases of multiple neurotransmitters--a rat microdialysis and electrophysiology study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 2. 2014-04-21. PMID:22612991. |
preclinical research suggests that 5-ht receptor subtypes, including 5-ht1a, 5-ht1b, 5-ht3, and 5-ht7 receptors as well as the 5-ht transporter (sert), may have important roles in treating depression. |
2014-04-21 |
2023-08-12 |
rat |
| Ling-ling Lu, Xiao-Heng Shen, Jing-xian Che. [Xuefu zhuyu oral liquid intervened stress-stimulated depression model rats]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 33. issue 5. 2014-04-18. PMID:23905383. |
to observe effects of xuefu zhuyu oral liquid (xzol) on the brain behavior and monoamine neurotransmitter 5-ht, and brain derived neurotrophic factor (bdnf) content on depression model rats. |
2014-04-18 |
2023-08-12 |
rat |
| Huai-wu Yuan, Ning Zhang, Chun-xue Wang, Yu-zhi Shi, Dong Qi, Ben-yan Luo, Yong-jun Wan. [The association between plasma neurotransmitters levels and depression in acute hemorrhagic stroke]. Zhonghua nei ke za zhi. vol 52. issue 8. 2014-04-17. PMID:24199885. |
to explore the relation between plasma neurotransmitters (glutamic acid, gaa; γ-aminobutyric acid, gaba; 5-hydroxytryptamine, 5-ht; and noradrenaline, ne) and depression in acute hemorrhagic stroke. |
2014-04-17 |
2023-08-12 |
Not clear |
| Yubo Li, Yuxiu Sun, Xueling Ma, Xiaoxing Xue, Wenting Zhang, Zhiqian Wu, Yulin Ouyang, Jianxin Chen, Weiming Wang, Shuzhen Guo, Wei Wan. Effects of Sini San used alone and in combination with fluoxetine on central and peripheral 5-HT levels in a rat model of depression. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. vol 33. issue 5. 2014-04-15. PMID:24660595. |
effects of sini san used alone and in combination with fluoxetine on central and peripheral 5-ht levels in a rat model of depression. |
2014-04-15 |
2023-08-12 |
rat |
| Yubo Li, Yuxiu Sun, Xueling Ma, Xiaoxing Xue, Wenting Zhang, Zhiqian Wu, Yulin Ouyang, Jianxin Chen, Weiming Wang, Shuzhen Guo, Wei Wan. Effects of Sini San used alone and in combination with fluoxetine on central and peripheral 5-HT levels in a rat model of depression. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. vol 33. issue 5. 2014-04-15. PMID:24660595. |
to investigate the effects of sini san and fluoxetine on the levels of central and peripheral 5-ht in a rat model of depression, and provide new insight into the treatment of depression with integrated chinese-western medicine. |
2014-04-15 |
2023-08-12 |
rat |