| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ian Mahar, Francis Rodriguez Bambico, Naguib Mechawar, José N Nobreg. Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects. Neuroscience and biobehavioral reviews. vol 38. 2014-08-08. PMID:24300695. |
stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects. |
2014-08-08 |
2023-08-12 |
Not clear |
| Ronise M Santiago, Janaína Barbiero, Raisa W Gradowski, Suelen Bochen, Marcelo M S Lima, Cláudio Da Cunha, Roberto Andreatini, Maria A B F Vita. Induction of depressive-like behavior by intranigral 6-OHDA is directly correlated with deficits in striatal dopamine and hippocampal serotonin. Behavioural brain research. vol 259. 2014-08-04. PMID:24183944. |
the neurotransmitter deficiency hypothesis of pd considers that low serotonin (5-hydroxytryptamine [5-ht]) activity in the brain in pd patients is a risk factor for depression. |
2014-08-04 |
2023-08-12 |
rat |
| Claire Gauthier, Christine Hassler, Lama Mattar, Jean-Marie Launay, Jacques Callebert, Howard Steiger, Jean-Claude Melchior, Bruno Falissard, Sylvie Berthoz, Virginie Mourier-Soleillant, François Lang, Marc Delorme, Xavier Pommereau, Priscille Gerardin, Stephanie Bioulac, Manuel Bouvard, Nathalie Godar. Symptoms of depression and anxiety in anorexia nervosa: links with plasma tryptophan and serotonin metabolism. Psychoneuroendocrinology. vol 39. 2014-07-31. PMID:24135616. |
symptoms of depression and anxiety in anorexia nervosa: links with plasma tryptophan and serotonin metabolism. |
2014-07-31 |
2023-08-12 |
human |
| Claire Gauthier, Christine Hassler, Lama Mattar, Jean-Marie Launay, Jacques Callebert, Howard Steiger, Jean-Claude Melchior, Bruno Falissard, Sylvie Berthoz, Virginie Mourier-Soleillant, François Lang, Marc Delorme, Xavier Pommereau, Priscille Gerardin, Stephanie Bioulac, Manuel Bouvard, Nathalie Godar. Symptoms of depression and anxiety in anorexia nervosa: links with plasma tryptophan and serotonin metabolism. Psychoneuroendocrinology. vol 39. 2014-07-31. PMID:24135616. |
in addition, there was a positive correlation between serotonin levels and symptoms of both anxiety and depression at discharge. |
2014-07-31 |
2023-08-12 |
human |
| Enric Alvarez, Victor Perez, Francesc Artiga. Pharmacology and clinical potential of vortioxetine in the treatment of major depressive disorder. Neuropsychiatric disease and treatment. vol 10. 2014-07-30. PMID:25075188. |
when active comparators were included in the study design, no significant differences were found except in one study in which the efficacy of vortioxetine was superior to the comparator (agomelatine) in depression resistant to selective serotonin reuptake inhibitors (ssri)/serotonin-norepinephrine reuptake inhibitors (snri) treatment. |
2014-07-30 |
2023-08-13 |
Not clear |
| Rudolf Uhe. Gene-environment interactions in common mental disorders: an update and strategy for a genome-wide search. Social psychiatry and psychiatric epidemiology. vol 49. issue 1. 2014-07-28. PMID:24323294. |
specific and complementary roles of genetic factors have been delineated: a common functional length polymorphism in the serotonin transporter gene (5-httlpr) moderated the effect of childhood maltreatment on chronic depression in adulthood, but did not substantially influence the effects of adult stressful life events on the onset of new depressive episodes; in contrast, a common functional polymorphism in the brain-derived neurotrophic factor gene (bdnf) moderated the effect of stressful life events in adulthood in triggering new depressive episodes, but did not influence the effects of childhood maltreatment. |
2014-07-28 |
2023-08-12 |
Not clear |
| Liang-Jen Wang, Chih-Ken Chen, Heng-Jung Hsu, I-Wen Wu, Chiao-Yin Sun, Chin-Chan Le. Depression, 5HTTLPR and BDNF Val66Met polymorphisms, and plasma BDNF levels in hemodialysis patients with chronic renal failure. Neuropsychiatric disease and treatment. vol 10. 2014-07-21. PMID:25045267. |
this cross-sectional study investigated whether depression in hemodialysis patients is associated with the polymorphism of the 5' flanking transcriptional region (5-httlpr) of the serotonin transporter gene, the valine (val)-to-methionine (met) substitution at codon 66 (val66met) polymorphism of the brain-derived neurotrophic factor (bdnf) gene, or plasma bdnf levels. |
2014-07-21 |
2023-08-13 |
Not clear |
| Koji Ohira, Rika Takeuchi, Tsuyoshi Iwanaga, Tsuyoshi Miyakaw. Chronic fluoxetine treatment reduces parvalbumin expression and perineuronal nets in gamma-aminobutyric acidergic interneurons of the frontal cortex in adult mice. Molecular brain. vol 6. 2014-07-15. PMID:24228616. |
the selective serotonin reuptake inhibitor fluoxetine (flx) is widely used to treat depression and anxiety disorders, but cellular mechanisms underlying the antidepressant effect of flx remain largely unknown. |
2014-07-15 |
2023-08-12 |
mouse |
| Rebecca Lyddon, Andrew J Dwork, Mehdi Keddache, Larry J Siever, Stella Drachev. Serotonin 2c receptor RNA editing in major depression and suicide. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 14. issue 8. 2014-07-14. PMID:22404657. |
serotonin 2c receptor rna editing in major depression and suicide. |
2014-07-14 |
2023-08-12 |
Not clear |
| James J Li, Michele S Berk, Steve S Le. Differential susceptibility in longitudinal models of gene-environment interaction for adolescent depression. Development and psychopathology. vol 25. issue 4 Pt 1. 2014-07-10. PMID:24229544. |
we tested the association of the 44 base pair polymorphism in the serotonin transporter linked promoter region gene (5-httlpr), family support (i.e., cohesion, communication, and warmth), and their interaction with self-reported depression symptoms and risk for suicide in 1,030 caucasian adolescents and young adults from the national longitudinal study of adolescent health. |
2014-07-10 |
2023-08-12 |
Not clear |
| Jonathan Y Tso. Depression and suicide are natural kinds: implications for physician-assisted suicide. International journal of law and psychiatry. vol 36. issue 5-6. 2014-07-01. PMID:23838294. |
in particular, depression and suicide are neurobiological kinds characterized by disturbances in serotonin functioning that affect various brain areas (i.e., the amygdala, anterior cingulate, prefrontal cortex, and hippocampus). |
2014-07-01 |
2023-08-12 |
Not clear |
| Franco De Crescenzo, Federica Perelli, Marco Armando, Stefano Vicar. Selective serotonin reuptake inhibitors (SSRIs) for post-partum depression (PPD): a systematic review of randomized clinical trials. Journal of affective disorders. vol 152-154. 2014-06-30. PMID:24139299. |
selective serotonin reuptake inhibitors (ssris) for post-partum depression (ppd): a systematic review of randomized clinical trials. |
2014-06-30 |
2023-08-12 |
Not clear |
| Franco De Crescenzo, Federica Perelli, Marco Armando, Stefano Vicar. Selective serotonin reuptake inhibitors (SSRIs) for post-partum depression (PPD): a systematic review of randomized clinical trials. Journal of affective disorders. vol 152-154. 2014-06-30. PMID:24139299. |
the treatment of postpartum depression with selective serotonin reuptake inhibitors (ssris) has been claimed to be both efficacious and well tolerated, but no recent systematic reviews have been conducted. |
2014-06-30 |
2023-08-12 |
Not clear |
| Nicole Lichtblau, Frank M Schmidt, Robert Schumann, Kenneth C Kirkby, Hubertus Himmeric. Cytokines as biomarkers in depressive disorder: current standing and prospects. International review of psychiatry (Abingdon, England). vol 25. issue 5. 2014-06-26. PMID:24151804. |
cytokines such as il-1ß, tnf-α and ifn-γ seem to contribute to the pathophysiology of depression by activating monoamine reuptake, stimulating the hypothalamic-pituitary-adrenocortical (hpa) axis and decreasing production of serotonin due to increased activity of indolamine-2,3-dioxygenase (ido). |
2014-06-26 |
2023-08-12 |
Not clear |
| Flavia Macchi, Judith R Homberg, Francesca Calabrese, Claudia Zecchillo, Giorgio Racagni, Marco A Riva, Raffaella Molten. Altered inflammatory responsiveness in serotonin transporter mutant rats. Journal of neuroinflammation. vol 10. 2014-06-25. PMID:24050835. |
in order to characterize the link between depression and inflammation, we aimed to investigate whether an altered inflammatory system is present in a genetic model of vulnerability for depression, namely rats with partial or total deletion of the serotonin transporter (sert) gene. |
2014-06-25 |
2023-08-12 |
rat |
| Marlene S William. Platelets and depression in cardiovascular disease: A brief review of the current literature. World journal of psychiatry. vol 2. issue 6. 2014-06-24. PMID:24175177. |
to date studies show increased serotonin response, increased platelet serotonin receptor density, decreased serotonin transporter binding, and decreased platelet serotonin levels in individuals with depression. |
2014-06-24 |
2023-08-12 |
Not clear |
| Marlene S William. Platelets and depression in cardiovascular disease: A brief review of the current literature. World journal of psychiatry. vol 2. issue 6. 2014-06-24. PMID:24175177. |
the direction of future research in platelet functional changes in depression and coronary artery disease should continue to focus on serotonin specific pathways with emphasis on potential mechanisms of specific pathway changes. |
2014-06-24 |
2023-08-12 |
Not clear |
| Jeremy D Coplan, Srinath Gopinath, Chadi G Abdallah, Benjamin R Berr. A neurobiological hypothesis of treatment-resistant depression - mechanisms for selective serotonin reuptake inhibitor non-efficacy. Frontiers in behavioral neuroscience. vol 8. 2014-06-24. PMID:24904340. |
a neurobiological hypothesis of treatment-resistant depression - mechanisms for selective serotonin reuptake inhibitor non-efficacy. |
2014-06-24 |
2023-08-13 |
Not clear |
| Jeremy D Coplan, Srinath Gopinath, Chadi G Abdallah, Benjamin R Berr. A neurobiological hypothesis of treatment-resistant depression - mechanisms for selective serotonin reuptake inhibitor non-efficacy. Frontiers in behavioral neuroscience. vol 8. 2014-06-24. PMID:24904340. |
first-line treatment of major depression includes administration of a selective serotonin reuptake inhibitor (ssri), yet studies suggest that remission rates following two trials of an ssri are <50%. |
2014-06-24 |
2023-08-13 |
Not clear |
| Paul R Albert, Faranak Vahid-Ansari, Christine Luckhar. Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre- and post-synaptic 5-HT1A receptor expression. Frontiers in behavioral neuroscience. vol 8. 2014-06-24. PMID:24936175. |
further studies to specifically test the roles and regulation of pyramidal vs. interneuronal populations of 5-ht receptors are needed better understand the role of serotonin in anxiety and depression and to devise more effective targeted therapeutic approaches. |
2014-06-24 |
2023-08-13 |
mouse |