| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Justyna Jasionowska, Maria Filip, Monika Talarowska, Piotr Gałeck. [The importance of the kynurenine pathway in depressive disorders]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. vol 45. issue 266. 2018-11-20. PMID:30240376. |
it is indicated that in patients with depression there are disorders of tryptophan metabolism, ie the redirection of tryptophan from the serotonin synthesis pathway to the kynurenine pathway, which is the source of neuroactive compounds in the central nervous system, so-called. |
2018-11-20 |
2023-08-13 |
human |
| Ryan M Walsh, Erica Y Shen, Rosemary C Bagot, Anthony Anselmo, Yan Jiang, Behnam Javidfar, Gregory J Wojtkiewicz, Jennifer Cloutier, John W Chen, Ruslan Sadreyev, Eric J Nestler, Schahram Akbarian, Konrad Hochedlinge. Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice. Nature communications. vol 8. 2018-11-14. PMID:28485378. |
our results clarify the functional role of phf8 in mammalian development and behaviour and establish a direct link between phf8 expression and serotonin signalling, identifying this histone demethylase as a potential target for the treatment of anxiety and depression. |
2018-11-14 |
2023-08-13 |
mouse |
| Yong-Ping Zhang, Hao-Yin Wang, Cai Zhang, Bai-Ping Liu, Zhi-Lan Peng, Yu-Yu Li, Feng-Ming Liu, Cai Son. Mifepristone attenuates depression-like changes induced by chronic central administration of interleukin-1β in rats. Behavioural brain research. vol 347. 2018-11-13. PMID:29580890. |
increased proinflammatory cytokines, such as interleukin (il)-1β, may play an important role in the etiology of depression because they cause the hypothalamic-pituitary-adrenal axis to release glucocorticoids (gc) and induce dysfunction of serotonin and norepinephrine neurotransmission. |
2018-11-13 |
2023-08-13 |
rat |
| Shu-Juan Pan, Yun-Long Tan, Shang-Wu Yao, Yu Xin, Xuan Yang, Jing Liu, Jing Xion. Fluoxetine induces lipid metabolism abnormalities by acting on the liver in patients and mice with depression. Acta pharmacologica Sinica. vol 39. issue 9. 2018-11-07. PMID:30150788. |
fluoxetine (flx) is the first selective serotonin reuptake inhibitor to be widely available for the treatment of depression. |
2018-11-07 |
2023-08-13 |
mouse |
| Yu P Sivola. [Serotonin neurotrasmission and treatment options for depression]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 117. issue 11. 2018-11-01. PMID:29265105. |
[serotonin neurotrasmission and treatment options for depression]. |
2018-11-01 |
2023-08-13 |
Not clear |
| Yu P Sivola. [Serotonin neurotrasmission and treatment options for depression]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 117. issue 11. 2018-11-01. PMID:29265105. |
the medicines with serotonergic properties include trazodone, which is intermediate between tricyclic antidepressants with their powerful antidepressive effect and selective serotonin reuptake inhibitors, as first-line agents in the treatment of depression and anxiety disorders. |
2018-11-01 |
2023-08-13 |
Not clear |
| Pradeep Phadnis, Purnima Dey Sarkar, Mithun Singh Rajpu. Improved serotonergic neurotransmission by genistein pretreatment regulates symptoms of obsessive-compulsive disorder in streptozotocin-induced diabetic mice. Journal of basic and clinical physiology and pharmacology. vol 29. issue 4. 2018-10-23. PMID:29561730. |
an isoflavonoid phytoestrogen, genistein, has been recognized as of great pharmacological value especially for protecting neurodegeneration, depression (serotonin regulation), and diabetes. |
2018-10-23 |
2023-08-13 |
mouse |
| Ernest Dallé, Musa V Mabandl. Early Life Stress, Depression And Parkinson's Disease: A New Approach. Molecular brain. vol 11. issue 1. 2018-10-22. PMID:29551090. |
here, we propose that a medication designed to address a deficiency in serotonin is more likely to influence motor symptoms of pd associated with depression. |
2018-10-22 |
2023-08-13 |
Not clear |
| Dasiel O Borroto-Escuela, Manuel Narváez, Patrizia Ambrogini, Luca Ferraro, Ismel Brito, Wilber Romero-Fernandez, Yuniesky Andrade-Talavera, Antonio Flores-Burgess, Carmelo Millon, Belen Gago, Jose Angel Narvaez, Yuji Odagaki, Miklos Palkovits, Zaida Diaz-Cabiale, Kjell Fux. Receptor⁻Receptor Interactions in Multiple 5-HT1A Heteroreceptor Complexes in Raphe-Hippocampal 5-HT Transmission and Their Relevance for Depression and Its Treatment. Molecules (Basel, Switzerland). vol 23. issue 6. 2018-10-22. PMID:29865267. |
receptor⁻receptor interactions in multiple 5-ht1a heteroreceptor complexes in raphe-hippocampal 5-ht transmission and their relevance for depression and its treatment. |
2018-10-22 |
2023-08-13 |
rat |
| Dasiel O Borroto-Escuela, Manuel Narváez, Patrizia Ambrogini, Luca Ferraro, Ismel Brito, Wilber Romero-Fernandez, Yuniesky Andrade-Talavera, Antonio Flores-Burgess, Carmelo Millon, Belen Gago, Jose Angel Narvaez, Yuji Odagaki, Miklos Palkovits, Zaida Diaz-Cabiale, Kjell Fux. Receptor⁻Receptor Interactions in Multiple 5-HT1A Heteroreceptor Complexes in Raphe-Hippocampal 5-HT Transmission and Their Relevance for Depression and Its Treatment. Molecules (Basel, Switzerland). vol 23. issue 6. 2018-10-22. PMID:29865267. |
a number of serotonin 5-ht1a heteroreceptor complexes were recently found to be linked to the ascending 5-ht pathways known to have a significant role in depression. |
2018-10-22 |
2023-08-13 |
rat |
| Li-Jun Zhang, Mei-Yan Liu, Radhika Rastogi, Jessie N Din. Psychocardiological disorder and brain serotonin after comorbid myocardial infarction and depression: an experimental study. Neurological research. vol 40. issue 6. 2018-10-15. PMID:29577822. |
psychocardiological disorder and brain serotonin after comorbid myocardial infarction and depression: an experimental study. |
2018-10-15 |
2023-08-13 |
rat |
| Li-Jun Zhang, Mei-Yan Liu, Radhika Rastogi, Jessie N Din. Psychocardiological disorder and brain serotonin after comorbid myocardial infarction and depression: an experimental study. Neurological research. vol 40. issue 6. 2018-10-15. PMID:29577822. |
objectives we investigated whether trimetazidine pretreatment can regulate central and peripheral serotonin (5-ht) in rats of myocardial infarction (mi) combined with depression. |
2018-10-15 |
2023-08-13 |
rat |
| Li-Jun Zhang, Mei-Yan Liu, Radhika Rastogi, Jessie N Din. Psychocardiological disorder and brain serotonin after comorbid myocardial infarction and depression: an experimental study. Neurological research. vol 40. issue 6. 2018-10-15. PMID:29577822. |
conclusions trimetazidine pretreatment can increase serum and platelet 5-ht levels in rats with mi and depression and decrease 5-ht levels in brain tissue. |
2018-10-15 |
2023-08-13 |
rat |
| Elżbieta Żmudzka, Kinga Sałaciak, Jacek Sapa, Karolina Pytk. Serotonin receptors in depression and anxiety: Insights from animal studies. Life sciences. vol 210. 2018-10-15. PMID:30144453. |
serotonin receptors in depression and anxiety: insights from animal studies. |
2018-10-15 |
2023-08-13 |
Not clear |
| Frances L Wang, Laurie Chassin, John E Bates, Danielle Dick, Jennifer E Lansford, Gregory S Pettit, Kenneth A Dodg. Serotonin functioning and adolescents' alcohol use: A genetically informed study examining mechanisms of risk. Development and psychopathology. vol 30. issue 1. 2018-10-10. PMID:28534453. |
however, adolescents with higher levels of 5-ht polygenic risk showed greater depression and aggression/antisociality. |
2018-10-10 |
2023-08-13 |
Not clear |
| Kadri Andre, Olli Kampman, Merja Viikki, Eija Setälä-Soikkeli, Ari Illi, Nina Mononen, Terho Lehtimäki, Esa Leinone. BDNF and NRG1 polymorphisms and temperament in selective serotonin reuptake inhibitor-treated patients with major depression. Acta neuropsychiatrica. vol 30. issue 3. 2018-10-05. PMID:29310728. |
bdnf and nrg1 polymorphisms and temperament in selective serotonin reuptake inhibitor-treated patients with major depression. |
2018-10-05 |
2023-08-13 |
human |
| Kadri Andre, Olli Kampman, Merja Viikki, Eija Setälä-Soikkeli, Ari Illi, Nina Mononen, Terho Lehtimäki, Esa Leinone. BDNF and NRG1 polymorphisms and temperament in selective serotonin reuptake inhibitor-treated patients with major depression. Acta neuropsychiatrica. vol 30. issue 3. 2018-10-05. PMID:29310728. |
we investigated the separate effects of and possible interactions between the functional polymorphisms of brain-derived neurotrophic factor (bdnf) rs11030101, bdnf rs61888800, and neuregulin-1 (nrg1) rs3924999 and nrg1 rs6994992 on change of temperament scores in a clinical sample of subjects with major depression (mdd), who received selective serotonin reuptake inhibitor treatment for a period of 6 weeks. |
2018-10-05 |
2023-08-13 |
human |
| Ariana Gatt, Antigoni Ekonomou, Alyma Somani, Sandrine Thuret, David Howlett, Anne Corbett, Mary Johnson, Elaine Perry, Johannes Attems, Paul Francis, Dag Aarsland, Clive Ballar. Importance of Proactive Treatment of Depression in Lewy Body Dementias: The Impact on Hippocampal Neurogenesis and Cognition in a Post-Mortem Study. Dementia and geriatric cognitive disorders. vol 44. issue 5-6. 2018-09-25. PMID:29393203. |
to examine the impact of selective serotonin reuptake inhibitors (ssris) and depression on neurogenesis and cognition in dementia with lewy bodies (dlb) and parkinson disease dementia (pdd). |
2018-09-25 |
2023-08-13 |
Not clear |
| Weibin Zha, Horace T B Ho, Tao Hu, Mary F Hebert, Joanne Wan. Serotonin transporter deficiency drives estrogen-dependent obesity and glucose intolerance. Scientific reports. vol 7. issue 1. 2018-09-18. PMID:28442777. |
depression and use of antidepressant medications are both associated with increased risk of obesity, potentially attributed to a reduced serotonin transporter (sert) function. |
2018-09-18 |
2023-08-13 |
Not clear |
| Sara Poletti, Aye Mu Myint, Gregor Schüetze, Irene Bollettini, Elena Mazza, Doris Grillitsch, Clara Locatelli, Markus Schwarz, Cristina Colombo, Francesco Benedett. Kynurenine pathway and white matter microstructure in bipolar disorder. European archives of psychiatry and clinical neuroscience. vol 268. issue 2. 2018-09-11. PMID:27619930. |
decreased availability of serotonin in the central nervous system has been suggested to be a central factor in the pathogenesis of depression. |
2018-09-11 |
2023-08-13 |
Not clear |