| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anindit Chhibber, Sarah K Woody, M A Karim Rumi, Michael J Soares, Liqin Zha. Estrogen receptor β deficiency impairs BDNF-5-HT Psychoneuroendocrinology. vol 82. 2018-04-03. PMID:28544903. |
in this study, the role of estrogen receptor (er) subtypes, erα and erβ, in the regulation of brain-derived neurotrophic factor (bdnf) and serotonin (5-ht) signaling was investigated; two pathways that have been hypothesized to be interrelated in the etiology of depression. |
2018-04-03 |
2023-08-13 |
Not clear |
| Tanveer Singh, Neetu Bagga, Anureet Kaur, Navjot Kaur, Dinesh Yugraj Gawande, Rajesh Kumar Goe. Agmatine for combined treatment of epilepsy, depression and cognitive impairment in chronic epileptic animals. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 92. 2018-04-03. PMID:28586743. |
thus, study concluded that agmatine ameliorated seizure severity, depression and cognitive impairment in epileptic animals, possibly via restoring glutamate-gaba neurotransmission and serotonin synthesis with decreased nitrosative stress. |
2018-04-03 |
2023-08-13 |
mouse |
| Zsofia Nemoda, Moshe Szy. Epigenetic Alterations and Prenatal Maternal Depression. Birth defects research. vol 109. issue 12. 2018-03-30. PMID:28714605. |
recent human studies show that dna methylation changes of hypothesis-driven candidate gene regions, such as the promoter of the glucocorticoid receptor and the serotonin transporter, were associated with maternal depression in peripheral tissue samples of newborns' cord blood, infants' saliva, or adults' peripheral blood. |
2018-03-30 |
2023-08-13 |
human |
| Lucyna Antkiewicz-Michaluk, Irena Romańska, Agnieszka Wąsik, Jerzy Michalu. Antidepressant-Like Effect of the Endogenous Neuroprotective Amine, 1MeTIQ in Clonidine-Induced Depression: Behavioral and Neurochemical Studies in Rats. Neurotoxicity research. vol 32. issue 1. 2018-03-27. PMID:28367606. |
biogenic amines such as norepinephrine, dopamine, and serotonin play a well-described role in the treatment of mood disorders especially depression. |
2018-03-27 |
2023-08-13 |
rat |
| Vishal Bali, Satabdi Chatterjee, Michael L Johnson, Hua Chen, Ryan M Carnahan, Rajender R Aparas. Comparative risk of hip fractures in elderly nursing home patients with depression using paroxetine and other selective serotonin reuptake inhibitors. Journal of comparative effectiveness research. vol 5. issue 5. 2018-03-26. PMID:27426927. |
comparative risk of hip fractures in elderly nursing home patients with depression using paroxetine and other selective serotonin reuptake inhibitors. |
2018-03-26 |
2023-08-13 |
Not clear |
| Cathryn Gordon Green, Vanessa Babineau, Alexia Jolicoeur-Martineau, Andrée-Anne Bouvette-Turcot, Klaus Minde, Roberto Sassi, Martin St-André, Normand Carrey, Leslie Atkinson, James L Kennedy, Meir Steiner, John Lydon, Helene Gaudreau, Jacob A Burack, Robert Levitan, Michael J Meaney, Ashley Wazan. Prenatal maternal depression and child serotonin transporter linked polymorphic region (5-HTTLPR) and dopamine receptor D4 (DRD4) genotype predict negative emotionality from 3 to 36 months. Development and psychopathology. vol 29. issue 3. 2018-03-26. PMID:27427178. |
prenatal maternal depression and child serotonin transporter linked polymorphic region (5-httlpr) and dopamine receptor d4 (drd4) genotype predict negative emotionality from 3 to 36 months. |
2018-03-26 |
2023-08-13 |
Not clear |
| Daniel Kondziell. The Top 5 Neurotransmitters from a Clinical Neurologist's Perspective. Neurochemical research. vol 42. issue 6. 2018-03-19. PMID:27822666. |
from our point of view the most important neurotransmitters are, in alphabetical order, acetylcholine (associated with alzheimer's disease and myasthenia gravis), dopamine (parkinson's disease), glutamate and gaba (epilepsy and seizures), and serotonin (major depression; although this is arguably the domain of psychiatrists). |
2018-03-19 |
2023-08-13 |
Not clear |
| Åsa Edvinsson, Emma Bränn, Charlotte Hellgren, Eva Freyhult, Richard White, Masood Kamali-Moghaddam, Jocelien Olivier, Jonas Bergquist, Adrian E Boström, Helgi B Schiöth, Alkistis Skalkidou, Janet L Cunningham, Inger Sundström-Poroma. Lower inflammatory markers in women with antenatal depression brings the M1/M2 balance into focus from a new direction. Psychoneuroendocrinology. vol 80. 2018-03-14. PMID:28292683. |
antenatal depression and use of serotonin reuptake inhibitors (ssri) in pregnancy have both been associated with an increased risk of poor pregnancy outcomes, such as preterm birth and impaired fetal growth. |
2018-03-14 |
2023-08-13 |
Not clear |
| Sarah Delcourte, Erika Abrial, Adeline Etiévant, Renaud Rovera, Jørn Arnt, Michael Didriksen, Nasser Haddjer. Asenapine modulates mood-related behaviors and 5-HT CNS neuroscience & therapeutics. vol 23. issue 6. 2018-03-12. PMID:28417559. |
the objective of this study was to investigate its antidepressant-like and antimanic-like properties on relevant animal models of depression and mania and to assess the acute and chronic effect of asenapine on dorsal raphe nucleus (drn) 5-ht cell firing activity. |
2018-03-12 |
2023-08-13 |
Not clear |
| Katarzyna Głombik, Aneta Stachowicz, Ewa Trojan, Rafał Olszanecki, Joanna Ślusarczyk, Maciej Suski, Katarzyna Chamera, Bogusława Budziszewska, Władysław Lasoń, Agnieszka Basta-Kai. Evaluation of the effectiveness of chronic antidepressant drug treatments in the hippocampal mitochondria - A proteomic study in an animal model of depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 78. 2018-03-09. PMID:28526399. |
the purpose of our study was to compare the impact of chronic treatment with two antidepressant drugs with different mechanisms of action, a tricyclic antidepressant (tca), imipramine, and an antidepressant of the selective serotonin reuptake inhibitor (ssri) class, fluoxetine, on the mitochondria-enriched subproteome profile in the hippocampus of 3-month-old male rats following a prenatal stress procedure (an animal model of depression). |
2018-03-09 |
2023-08-13 |
rat |
| Yan-Jye Shyong, Mao-Hsien Wang, Li-Wei Kuo, Chang-Fu Su, Wei-Ting Kuo, Kuo-Chi Chang, Feng-Huei Li. Mesoporous hydroxyapatite as a carrier of olanzapine for long-acting antidepression treatment in rats with induced depression. Journal of controlled release : official journal of the Controlled Release Society. vol 255. 2018-03-08. PMID:28392460. |
serotonin (5-ht), one of the most important biomarker in depression can also be increased by mesohap-olz, leading to increased hippocampus activity as measured by functional magnetic resonance imaging (fmri). |
2018-03-08 |
2023-08-13 |
rat |
| Davide Zarcone, Simona Corbett. Shared mechanisms of epilepsy, migraine and affective disorders. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 38. issue Suppl 1. 2018-03-08. PMID:28527083. |
a chronic lowering of 5-ht (serotonin) levels has been demonstrated both in migraineurs and in depressed patients; amitriptyline and venlafaxine are the most indicated drugs in the treatment of migraine with comorbid depression currently. |
2018-03-08 |
2023-08-13 |
Not clear |
| Simone Wachholz, Alexandra Knorr, Leonie Mengert, Jennifer Plümper, Rainer Sommer, Georg Juckel, Astrid Frieb. Interleukin-4 is a participant in the regulation of depressive-like behavior. Behavioural brain research. vol 326. 2018-03-07. PMID:28315756. |
interleukin-4, the major th2 type cytokine, might be protective against depression due to its ability to counter-regulate inflammation and to inhibit serotonin transporter activity. |
2018-03-07 |
2023-08-13 |
mouse |
| José Alfonso Ontiveros-Sánchez de la Barquer. [Response to serotonergic and noradrenergic antidepressants: a crossover study of fluoxetine and desipramine in patients with first major depression episode]. Gaceta medica de Mexico. vol 153. issue 6. 2018-03-01. PMID:29206826. |
however, there are still few comparative studies with selective reuptake inhibition on serotonin or norepinephrine in the same sample of major depression patients. |
2018-03-01 |
2023-08-13 |
Not clear |
| Cynthia L Bethea, Arubala P Reddy, Fernanda Lima Christia. How Studies of the Serotonin System in Macaque Models of Menopause Relate to Alzheimer's Disease1. Journal of Alzheimer's disease : JAD. vol 57. issue 4. 2018-02-23. PMID:27662311. |
serotonin plays a key role in mood or affect, and dysfunction of the serotonin system has been linked to depression in humans and animal models. |
2018-02-23 |
2023-08-13 |
monkey |
| Alex G Nackenoff, Linda D Simmler, Nicole L Baganz, Alan L Pehrson, Connie Sánchez, Randy D Blakel. Serotonin Transporter-Independent Actions of the Antidepressant Vortioxetine As Revealed Using the SERT Met172 Mouse. ACS chemical neuroscience. vol 8. issue 5. 2018-02-07. PMID:28272863. |
selective serotonin (5-ht, sert) reuptake inhibitors (ssris) are the most commonly prescribed treatments for depression. |
2018-02-07 |
2023-08-13 |
mouse |
| Matthew J Robson, Meagan A Quinlan, Randy D Blakel. Immune System Activation and Depression: Roles of Serotonin in the Central Nervous System and Periphery. ACS chemical neuroscience. vol 8. issue 5. 2018-02-07. PMID:28345868. |
immune system activation and depression: roles of serotonin in the central nervous system and periphery. |
2018-02-07 |
2023-08-13 |
Not clear |
| Matthew J Robson, Meagan A Quinlan, Randy D Blakel. Immune System Activation and Depression: Roles of Serotonin in the Central Nervous System and Periphery. ACS chemical neuroscience. vol 8. issue 5. 2018-02-07. PMID:28345868. |
how 5-ht is utilized by the immune system to effect cns function and ultimately behaviors related to depression is still not well understood. |
2018-02-07 |
2023-08-13 |
Not clear |
| Matthew J Robson, Meagan A Quinlan, Randy D Blakel. Immune System Activation and Depression: Roles of Serotonin in the Central Nervous System and Periphery. ACS chemical neuroscience. vol 8. issue 5. 2018-02-07. PMID:28345868. |
this review summarizes the evidence that immune system alterations related to depression affect cns 5-ht signaling that can alter mdd-relevant behaviors and that 5-ht regulates immune system signaling within the cns and periphery. |
2018-02-07 |
2023-08-13 |
Not clear |
| Mirko Manchia, Bernardo Carpiniello, Flavia Valtorta, Stefano Coma. Serotonin Dysfunction, Aggressive Behavior, and Mental Illness: Exploring the Link Using a Dimensional Approach. ACS chemical neuroscience. vol 8. issue 5. 2018-02-07. PMID:28378993. |
in particular, reduced 5-ht activity has been associated with depression as well as with aggressive behavior, especially with impulsive aggression. |
2018-02-07 |
2023-08-13 |
Not clear |