| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Keng-Fan Liu, Yingxiao Li, Kai Chun Cheng, Chao Chin Hsu, Juei-Tang Cheng, Wen-Huang Pen. Changes in PPARδ expression in a rat model of stress-induced depression. Clinical and experimental pharmacology & physiology. vol 44. issue 6. 2018-01-01. PMID:28267873. |
taken together, we found that pparδ plays an important role in the regulation of serotonin transporter expression and that chronic stress may lower pparδ expression in the brain via apoptosis and may attenuate serotonin transporter expression, thus inducing depression in rats. |
2018-01-01 |
2023-08-13 |
rat |
| Barry Wright, David Alexander, Assad Aghahosein. Does preoperative depression and/or serotonin transporter gene polymorphism predict outcome after laparoscopic cholecystectomy? BMJ open. vol 6. issue 9. 2017-12-25. PMID:27601483. |
does preoperative depression and/or serotonin transporter gene polymorphism predict outcome after laparoscopic cholecystectomy? |
2017-12-25 |
2023-08-13 |
Not clear |
| Barry Wright, David Alexander, Assad Aghahosein. Does preoperative depression and/or serotonin transporter gene polymorphism predict outcome after laparoscopic cholecystectomy? BMJ open. vol 6. issue 9. 2017-12-25. PMID:27601483. |
to determine whether preoperative psychological depression and/or serotonin transporter gene polymorphism are associated with poor outcomes after the common procedure of laparoscopic cholecystectomy. |
2017-12-25 |
2023-08-13 |
Not clear |
| Marc Fakhour. Revisiting the Serotonin Hypothesis: Implications for Major Depressive Disorders. Molecular neurobiology. vol 53. issue 5. 2017-12-22. PMID:25823514. |
this paper also describes some of the main molecules involved in the internalization of 5-ht receptors and illustrates the changes in 5-ht neurotransmission in knockout mice and animal model of depression. |
2017-12-22 |
2023-08-13 |
mouse |
| Isabella Caroline da Silva Dias, Bruno Carabelli, Daniela Kaori Ishii, Helen de Morais, Milene Cristina de Carvalho, Luiz E Rizzo de Souza, Silvio M Zanata, Marcus Lira Brandão, Thiago Mattar Cunha, Anete Curte Ferraz, Joice Maria Cunha, Janaina Menezes Zanovel. Indoleamine-2,3-Dioxygenase/Kynurenine Pathway as a Potential Pharmacological Target to Treat Depression Associated with Diabetes. Molecular neurobiology. vol 53. issue 10. 2017-12-22. PMID:26671617. |
however, the activation of the indoleamine-2,3-dioxygenase (ido), an enzyme that participate of the tryptophan metabolism leading to a decrease of serotonin (5-ht) levels and whose expression is associated with an immune system activation, has been proposed as a common mechanism that links depression and diabetes. |
2017-12-22 |
2023-08-13 |
rat |
| Isabella Caroline da Silva Dias, Bruno Carabelli, Daniela Kaori Ishii, Helen de Morais, Milene Cristina de Carvalho, Luiz E Rizzo de Souza, Silvio M Zanata, Marcus Lira Brandão, Thiago Mattar Cunha, Anete Curte Ferraz, Joice Maria Cunha, Janaina Menezes Zanovel. Indoleamine-2,3-Dioxygenase/Kynurenine Pathway as a Potential Pharmacological Target to Treat Depression Associated with Diabetes. Molecular neurobiology. vol 53. issue 10. 2017-12-22. PMID:26671617. |
taken together, our data support our hypothesis that neuroinflammation in the hip followed by ido activation with a consequent decrease in the 5-ht levels can be a possible pathophysiological mechanism that links depression to diabetes. |
2017-12-22 |
2023-08-13 |
rat |
| Min Ma, Qian Ren, Chun Yang, Ji-Chun Zhang, Wei Yao, Chao Dong, Yuta Ohgi, Takashi Futamura, Kenji Hashimot. Antidepressant effects of combination of brexpiprazole and fluoxetine on depression-like behavior and dendritic changes in mice after inflammation. Psychopharmacology. vol 234. issue 4. 2017-12-21. PMID:27844095. |
addition of low doses of atypical antipsychotic drugs with selective serotonin reuptake inhibitors (ssris) could promote a rapid antidepressant effect in treatment-resistant patients with major depression. |
2017-12-21 |
2023-08-13 |
mouse |
| Kasper D Tidemand, Günther H Peters, Pernille Harris, Eva Stensgaard, Hans E M Christense. Isoform-Specific Substrate Inhibition Mechanism of Human Tryptophan Hydroxylase. Biochemistry. vol 56. issue 46. 2017-12-19. PMID:29035515. |
tryptophan hydroxylase (tph) catalyzes the initial and rate-limiting step in the biosynthesis of serotonin, which is associated with a variety of disorders such as depression and irritable bowel syndrome. |
2017-12-19 |
2023-08-13 |
human |
| Jun-Ichi Iga, Shin-Ya Watanabe, Shusuke Numata, Hidehiro Umehara, Akira Nishi, Makoto Kinoshita, Masatoshi Inoshita, Shinji Shimodera, Hirokazu Fujita, Tetsuro Ohmor. Association study of polymorphism in the serotonin transporter gene promoter, methylation profiles, and expression in patients with major depressive disorder. Human psychopharmacology. vol 31. issue 3. 2017-12-15. PMID:27005686. |
the aims of this study were (1) to investigate the association between 5htt methylation or expression in leukocytes and depression and (2) to investigate a possible effect of 5htt methylation, expression, and genotype on clinical symptoms in mdd. |
2017-12-15 |
2023-08-13 |
Not clear |
| Mark J Millan, Jean-Michel Rivet, Alain Gober. The frontal cortex as a network hub controlling mood and cognition: Probing its neurochemical substrates for improved therapy of psychiatric and neurological disorders. Journal of psychopharmacology (Oxford, England). vol 30. issue 11. 2017-12-15. PMID:27756833. |
this approach has revealed a complex mesh of autoreceptor and heteroceptor interactions amongst monoaminergic pathways, and led from selective 5-ht reuptake inhibitors to novel classes of multi-target drugs for treating depression like the mixed α |
2017-12-15 |
2023-08-13 |
Not clear |
| Marina Sagud, Matea Nikolac Perkovic, Bjanka Vuksan-Cusa, Anja Maravic, Dubravka Svob Strac, Alma Mihaljevic Peles, Maja Zivkovic, Zorana Kusevic, Nela Piva. A prospective, longitudinal study of platelet serotonin and plasma brain-derived neurotrophic factor concentrations in major depression: effects of vortioxetine treatment. Psychopharmacology. vol 233. issue 17. 2017-12-12. PMID:27356518. |
a prospective, longitudinal study of platelet serotonin and plasma brain-derived neurotrophic factor concentrations in major depression: effects of vortioxetine treatment. |
2017-12-12 |
2023-08-13 |
Not clear |
| Marina Sagud, Matea Nikolac Perkovic, Bjanka Vuksan-Cusa, Anja Maravic, Dubravka Svob Strac, Alma Mihaljevic Peles, Maja Zivkovic, Zorana Kusevic, Nela Piva. A prospective, longitudinal study of platelet serotonin and plasma brain-derived neurotrophic factor concentrations in major depression: effects of vortioxetine treatment. Psychopharmacology. vol 233. issue 17. 2017-12-12. PMID:27356518. |
to further elucidate its mechanism of action, we have investigated the effects of vortioxetine on platelet 5-ht and plasma bdnf concentrations in patients with major depression. |
2017-12-12 |
2023-08-13 |
Not clear |
| Jake Rogers, Shanshan Li, Laurence Lanfumey, Anthony J Hannan, Thibault Renoi. Environmental enrichment reduces innate anxiety with no effect on depression-like behaviour in mice lacking the serotonin transporter. Behavioural brain research. vol 332. 2017-12-12. PMID:28629963. |
along with being the main target of many antidepressant medications, the serotonin transporter (5-htt) is known to be involved in the pathophysiology of depression and anxiety disorders. |
2017-12-12 |
2023-08-13 |
mouse |
| Zhiying Hu, Yuting Jiang, Xue Huo, Yang Yang, Henry Davies, Benson O A Botchway, Marong Fan. Prospective Role of MicroRNAs in Depression. Current medicinal chemistry. vol 24. issue 32. 2017-12-12. PMID:28714388. |
alterations in brain regions, synaptic plasticity, hypothalamic-pituitary-adrenal (hpa) axis, changes in the levels of serotonin and glucocorticoids, together with stress response have been proven to be involved in depression. |
2017-12-12 |
2023-08-13 |
Not clear |
| Glenda MacQueen, Pasqualina Santaguida, Homa Keshavarz, Natalia Jaworska, Mitchell Levine, Joseph Beyene, Parminder Rain. Systematic Review of Clinical Practice Guidelines for Failed Antidepressant Treatment Response in Major Depressive Disorder, Dysthymia, and Subthreshold Depression in Adults. Canadian journal of psychiatry. Revue canadienne de psychiatrie. vol 62. issue 1. 2017-12-08. PMID:27554483. |
this systematic review critically evaluated clinical practice guidelines (cpgs) for treating adults with major depressive disorder, dysthymia, or subthreshold or minor depression for recommendations following inadequate response to first-line treatment with selective serotonin reuptake inhibitors (ssris). |
2017-12-08 |
2023-08-13 |
Not clear |
| Marie-Laure Ancelin, Jacqueline Scali, Joanna Norton, Karen Ritchie, Anne-Marie Dupuy, Isabelle Chaudieu, Joanne Rya. Heterogeneity in HPA axis dysregulation and serotonergic vulnerability to depression. Psychoneuroendocrinology. vol 77. 2017-12-07. PMID:28024274. |
variability in the serotonin transporter (5-httlpr) gene can influence the risk of depression associated with adversity, as well as cortisol stress reactivity, although not consistently. |
2017-12-07 |
2023-08-13 |
human |
| B R Godlewska, M Browning, R Norbury, P J Cowen, C J Harme. Early changes in emotional processing as a marker of clinical response to SSRI treatment in depression. Translational psychiatry. vol 6. issue 11. 2017-12-04. PMID:27874847. |
thirty-five unmedicated patients with major depression took the selective serotonin re-uptake inhibitor (ssri), escitalopram (10 mg), over 6 weeks, and were classified as responders (22 patients) versus non-responders (13 patients), based on at least a 50% reduction in symptoms by the end of treatment. |
2017-12-04 |
2023-08-13 |
Not clear |
| Yeshwant Kurhe, R Mahesh, Thangaraj Devados. Novel 5-HT Psychopharmacology. vol 234. issue 7. 2017-12-01. PMID:28238069. |
novel 5-ht depression associated with obesity remains an interesting area to study the biological mechanisms and novel therapeutic intervention. |
2017-12-01 |
2023-08-13 |
Not clear |
| Lisa L Giles, D Richard Martin. Challenges and Promises of Pediatric Psychopharmacology. Academic pediatrics. vol 16. issue 6. 2017-11-30. PMID:27064142. |
selective serotonin reuptake inhibitors (ssris) have documented efficacy for pediatric depression and multiple different anxiety disorders with childhood onset. |
2017-11-30 |
2023-08-13 |
Not clear |
| Sang Won Jeon, Yong-Ku Ki. Inflammation-induced depression: Its pathophysiology and therapeutic implications. Journal of neuroimmunology. vol 313. 2017-11-29. PMID:29153615. |
this paper reviews the body of evidence, not only for the action of tryptophan (try) and consequent serotonin depletion, but also for the detrimental effects of try catabolites and the key enzymes in the kyn pathway that play important roles in the pathophysiology of inflammation-induced depression. |
2017-11-29 |
2023-08-13 |
Not clear |