| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Akikazu Takada, Fumiko Shimizu, Tetsuya Taka. [Tryptophan Metabolites in Plasma of Patients with Depression]. Brain and nerve = Shinkei kenkyu no shinpo. vol 70. issue 9. 2019-05-09. PMID:30177580. |
plasma levels of serotonin were very low or undetectable in patients with monopolar depression. |
2019-05-09 |
2023-08-13 |
Not clear |
| Ewelina Dziurkowska, Marek Wesolowsk. Sertraline - isolation methods and quantitation in biological material. Psychiatria polska. vol 52. issue 6. 2019-05-08. PMID:30659562. |
sertraline (srt) is a modern and relatively safe selective serotonin reuptake inhibitor often used in the treatment of depression. |
2019-05-08 |
2023-08-13 |
Not clear |
| Elisabeth Kap, Marcel Konrad, Karel Koste. Persistence with selective serotonin (norepinephrine) reuptake inhibitors in Germany-A retrospective database analysis. Journal of affective disorders. vol 247. 2019-05-08. PMID:30665077. |
selective serotonin (norepinephrine) reuptake inhibitors (ss(n)ris) are used in the treatment of depression. |
2019-05-08 |
2023-08-13 |
Not clear |
| Lisa Giardinelli, Lorenzo Lelli, Valentina Ugolini, Lisa Lazzeretti, Iuliia Burian, Giuliana Lino, Clara Lunardi, Giovanni Castellini, Valdo Ricc. Comparison of two different treatments in depressed pregnant women: fetal growth characteristics and neonatal outcomes. Journal of perinatal medicine. vol 47. issue 1. 2019-05-06. PMID:30024856. |
background in this pilot study, the effects of selective serotonin reuptake inhibitors (ssris) and psychological intervention on fetal growth characteristics and neonatal outcomes were evaluated in two different groups of women affected by prenatal depression. |
2019-05-06 |
2023-08-13 |
Not clear |
| Vinod Yalamanchili, J Christopher Gallaghe. Dose ranging effects of vitamin D3 on the geriatric depression score: A clinical trial. The Journal of steroid biochemistry and molecular biology. vol 178. 2019-05-01. PMID:29104103. |
depression is a common problem affecting millions, usually treated with selective serotonin uptake inhibitors. |
2019-05-01 |
2023-08-13 |
human |
| Leslie Alejandra Ramírez, Elsy Arlene Pérez-Padilla, Francisco García-Oscos, Humberto Salgado, Marco Atzori, Juan Carlos Pined. A new theory of depression based on the serotonin/kynurenine relationship and the hypothalamicpituitary- adrenal axis Biomedica : revista del Instituto Nacional de Salud. vol 38. issue 3. 2019-04-16. PMID:30335249. |
a new theory of depression based on the serotonin/kynurenine relationship and the hypothalamicpituitary- adrenal axis the serotonergic and immunological hypothesis of depression proposes that certain types of excessive stress distort the relationship between the activities of the innate immune and central nervous systems, so that the stress caused by an infection, or excessive psychological stress, activate toll-like receptors such as the tlr-4, the transcription factor nf-kb, the inflammasome nlrp3, as well as the secretion of interleukin-1 beta (il-1β), interleukin-6 (il-6) and other factors of the innate immune response, causing first, the general symptoms of the disease which appear with any infection, but also those characteristic of depressive illness such as dysphoria and anhedonia.the evidence indicates that, if the stimulus persists or recurs within 24 hours, the indole-2, 3-dioxygenase enzyme (ido) of the kynurenine metabolic pathway, which increases the synthesis of quinolinic acid, is activated with an associated reduction of serotonin synthesis. |
2019-04-16 |
2023-08-13 |
Not clear |
| Yong-Ku Kim, Byung-Joo Ham, Kyu-Man Ha. Interactive effects of genetic polymorphisms and childhood adversity on brain morphologic changes in depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 91. 2019-04-15. PMID:29535036. |
childhood adversity showed an interaction with the brain-derived neurotrophic factor (bdnf) gene val66met polymorphism, serotonin transporter-linked promoter region (5-httlpr), and fk506 binding protein 51 (fkbp5) gene rs1360780 in brain morphologic changes in patients with depression and in a non-clinical population. |
2019-04-15 |
2023-08-13 |
Not clear |
| Nicholas A Keks, Judy Hope, Simone Keogh, David L Copolo. Milnacipran: serotonin-noradrenaline reuptake inhibitor approved for fibromyalgia may be a useful antidepressant. Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists. vol 26. issue 5. 2019-04-09. PMID:30198305. |
milnacipran is a serotonin noradrenaline reuptake inhibitor (snri) approved for treatment of fibromyalgia in australia, but is used for depression in europe and elsewhere. |
2019-04-09 |
2023-08-13 |
Not clear |
| M S Mendonça, P M Mangiavacchi, P F De Sousa, J A S Crippa, A V Mendes, S R Loureiro, R Martín-Santos, C R Quirino, M M Kanashiro, A F L Rio. Epigenetic variation at the SLC6A4 gene promoter in mother-child pairs with major depressive disorder. Journal of affective disorders. vol 245. 2019-04-08. PMID:30447571. |
genetic and epigenetic variations of the serotonin transporter gene (slc6a4) have been related to the etiology of depression. |
2019-04-08 |
2023-08-13 |
Not clear |
| Marina L Câmara, Talita B Almeida, Fabiane de Santi, Beatriz M Rodrigues, Paulo S Cerri, Flávia L Beltrame, Estela Sasso-Cerr. Fluoxetine-induced androgenic failure impairs the seminiferous tubules integrity and increases ubiquitin carboxyl-terminal hydrolase L1 (UCHL1): Possible androgenic control of UCHL1 in germ cell death? Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 109. 2019-03-28. PMID:30551363. |
the selective serotonin reuptake inhibitor fluoxetine has been used for the treatment of depression. |
2019-03-28 |
2023-08-13 |
rat |
| Zeng-Liang Jin, Xiao-Fei Chen, Yu-Hua Ran, Xiao-Rong Li, Jie Xiong, Yuan-Yuan Zheng, Na-Na Gao, Yun-Feng L. Mouse strain differences in SSRI sensitivity correlate with serotonin transporter binding and function. Scientific reports. vol 7. issue 1. 2019-03-25. PMID:28819255. |
selective serotonin reuptake inhibitors (ssris) bind 5-ht transporters, leading to the accumulation of 5-ht and amelioration of depression. |
2019-03-25 |
2023-08-13 |
mouse |
| David S Kessler, Stephanie J MacNeill, Deborah Tallon, Glyn Lewis, Tim J Peters, William Hollingworth, Jeff Round, Alison Burns, Carolyn A Chew-Graham, Ian M Anderson, Tom Shepherd, John Campbell, Chris M Dickens, Mary Carter, Caroline Jenkinson, Una Macleod, Helen Gibson, Simon Davies, Nicola J Wile. Mirtazapine added to SSRIs or SNRIs for treatment resistant depression in primary care: phase III randomised placebo controlled trial (MIR). BMJ (Clinical research ed.). vol 363. 2019-03-25. PMID:30381374. |
to investigate the effectiveness of combining mirtazapine with serotonin-noradrenaline reuptake inhibitor (snri) or selective serotonin reuptake inhibitor (ssri) antidepressants for treatment resistant depression in primary care. |
2019-03-25 |
2023-08-13 |
Not clear |
| S N Reisinger, E Kong, B Molz, T Humberg, S Sideromenos, A Cicvaric, T Steinkellner, J-W Yang, M Cabatic, F J Monje, H H Sitte, B J Nichols, D D Polla. Flotillin-1 interacts with the serotonin transporter and modulates chronic corticosterone response. Genes, brain, and behavior. vol 18. issue 2. 2019-03-21. PMID:29667320. |
gene by environment interactions contribute to the development of depression and involve modulation of the availability and functional activity of the serotonin transporter (sert). |
2019-03-21 |
2023-08-13 |
Not clear |
| Tim Regan, Andrew C Gill, Sara M Clohisey, Mark W Barnett, Carmine M Pariante, Neil A Harrison, David A Hume, Edward T Bullmore, Tom C Freema. Effects of anti-inflammatory drugs on the expression of tryptophan-metabolism genes by human macrophages. Journal of leukocyte biology. vol 103. issue 4. 2019-03-18. PMID:29377288. |
we suggest that inflammatory processes in the brain or periphery could impact on depression by altering the availability of tryptophan for serotonin synthesis and/or by increasing production of neurotoxic kynurenine. |
2019-03-18 |
2023-08-13 |
human |
| Xuke Han, Huangan Wu, Ping Yin, Zeqin Chen, Xiaohua Cao, Yanhong Duan, Jian Xu, Lixing Lao, Shifen X. Electroacupuncture restores hippocampal synaptic plasticity via modulation of 5-HT receptors in a rat model of depression. Brain research bulletin. vol 139. 2019-03-12. PMID:29524471. |
electroacupuncture restores hippocampal synaptic plasticity via modulation of 5-ht receptors in a rat model of depression. |
2019-03-12 |
2023-08-13 |
rat |
| Terrill Bravende. Mental Disorders and Learning Disabilities in Children and Adolescents: Depression in Adolescents. FP essentials. vol 475. 2019-03-07. PMID:30556689. |
moderate to severe depression likely will improve with a combination of cognitive behavioral therapy and a selective serotonin reuptake inhibitor. |
2019-03-07 |
2023-08-13 |
Not clear |
| Brent M Kious, Douglas G Kondo, Perry F Rensha. Living High and Feeling Low: Altitude, Suicide, and Depression. Harvard review of psychiatry. vol 26. issue 2. 2019-03-05. PMID:29517615. |
we argue that hypobaric hypoxia could promote suicide and depression by altering serotonin metabolism and brain bioenergetics; both of these pathways are implicated in depression, and both are affected by hypoxia. |
2019-03-05 |
2023-08-13 |
Not clear |
| Brent M Kious, Douglas G Kondo, Perry F Rensha. Living High and Feeling Low: Altitude, Suicide, and Depression. Harvard review of psychiatry. vol 26. issue 2. 2019-03-05. PMID:29517615. |
finally, we briefly examine treatment strategies to address hypoxia-related depression and suicidal ideation that are suggested by these findings, including creatine monohydrate and the serotonin precursors tryptophan and 5-hydroxytryptophan. |
2019-03-05 |
2023-08-13 |
Not clear |
| Elmira Ismaylova, Melissa L Lévesque, Florence B Pomares, Moshe Szyf, Zsofia Nemoda, Cherine Fahim, Frank Vitaro, Mara Brendgen, Ginette Dionne, Michel Boivin, Richard E Tremblay, Linda Booi. Serotonin transporter promoter methylation in peripheral cells and neural responses to negative stimuli: A study of adolescent monozygotic twins. Translational psychiatry. vol 8. issue 1. 2019-03-04. PMID:30089832. |
several studies have examined associations between peripheral dna methylation patterns of the serotonin transporter gene (slc6a4) promoter and symptoms of depression and anxiety. |
2019-03-04 |
2023-08-13 |
Not clear |
| Fredrik Hieronymus, Alexander Lisinski, Jakob Näslund, Elias Eriksso. Multiple possible inaccuracies cast doubt on a recent report suggesting selective serotonin reuptake inhibitors to be toxic and ineffective. Acta neuropsychiatrica. vol 30. issue 5. 2019-02-25. PMID:28718394. |
according to a systematic review on the use of selective serotonin reuptake inhibitors (ssris) in adult depression that was recently published in bmc psychiatry, the results of which have been widely disseminated in lay media, these drugs increase the risk for serious adverse events (saes) while exerting poor antidepressant efficacy. |
2019-02-25 |
2023-08-13 |
Not clear |