| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C D Wang, T K Gallaher, J C Shi. Site-directed mutagenesis of the serotonin 5-hydroxytrypamine2 receptor: identification of amino acids necessary for ligand binding and receptor activation. Molecular pharmacology. vol 43. issue 6. 1993-07-23. PMID:8316224. |
serotonin 5-hydroxytryptamine (5-ht)2 receptors are implicated in the etiology of mental disease and depression. |
1993-07-23 |
2023-08-12 |
Not clear |
| A Khan, H Mirolo, M H Mirolo, D J Dobi. Depression in the elderly: a treatable disorder. Geriatrics. vol 48 Suppl 1. 1993-07-13. PMID:8508961. |
bupropion and the new selective serotonin reuptake inhibitors are effective in treating depression and are better tolerated than the tricyclics. |
1993-07-13 |
2023-08-12 |
Not clear |
| D J Halee. Function specific supersensitivity of m-chlorophenyl piperazine-induced serotonergic neurotransmission in female compared to male rats. Life sciences. vol 52. issue 25. 1993-07-01. PMID:8388982. |
the findings along with our previous report show a functional supersensitivity of 5-ht neurotransmission involved in the regulation of hypothalamo-pituitary adrenocortical axis and appetite suppression in female sex, and suggest a possible basis for the greater occurrence of depression and anorexia in women than men. |
1993-07-01 |
2023-08-12 |
rat |
| S H Preskor. Recent pharmacologic advances in antidepressant therapy for the elderly. The American journal of medicine. vol 94. issue 5A. 1993-06-30. PMID:8503477. |
the practicing clinician now has five distinct classes of antidepressant medications that may be used for treating depression in the elderly: tricyclic antidepressants (tcas; e.g., desipramine, nortriptyline), monoamine oxidase inhibitors (maois; e.g., isocarboxazid, tranylcypromine), selective serotonin reuptake inhibitors (ssris; i.e., fluoxetine, sertraline, and paroxetine), aminoketones (i.e., bupropion), and triazolopyridines (i.e., trazodone). |
1993-06-30 |
2023-08-12 |
Not clear |
| R C Zimmermann, C J McDougle, M Schumacher, J Olcese, J W Mason, G R Heninger, L H Pric. Effects of acute tryptophan depletion on nocturnal melatonin secretion in humans. The Journal of clinical endocrinology and metabolism. vol 76. issue 5. 1993-06-23. PMID:8496306. |
however, a dysregulation in serotonin function has also been implicated in the pathophysiology of depression. |
1993-06-23 |
2023-08-12 |
human |
| A I Green, C P Austi. Psychopathology of pancreatic cancer. A psychobiologic probe. Psychosomatics. vol 34. issue 3. 1993-06-17. PMID:8493302. |
although confirmatory data are lacking, informed speculation centers on the potential role of adrenocorticotropic hormone, parathyroid hormone, thyrotropin-releasing hormone, glucagon, serotonin, insulin, and bicarbonate in the production of depression and/or anxiety in this disease. |
1993-06-17 |
2023-08-12 |
Not clear |
| F Song, N Freemantle, T A Sheldon, A House, P Watson, A Long, J Maso. Selective serotonin reuptake inhibitors: meta-analysis of efficacy and acceptability. BMJ (Clinical research ed.). vol 306. issue 6879. 1993-05-17. PMID:8471919. |
to examine the evidence for using selective serotonin reuptake inhibitors instead of tricyclic antidepressants in the first line treatment of depression. |
1993-05-17 |
2023-08-12 |
Not clear |
| D N Osse. A systematic approach to the classification and pharmacotherapy of nonpsychotic major depression and dysthymia. Journal of clinical psychopharmacology. vol 13. issue 2. 1993-05-06. PMID:8463446. |
after family and past history of response and cost of drug are considered, a tricyclic antidepressant is usually selected for autonomous depression patients, and mood-reactive depression patients are initially given a serotonin reuptake inhibitor. |
1993-05-06 |
2023-08-12 |
Not clear |
| D G Schlundt, K L Virts, T Sbrocco, J Pope-Cordle, J O Hil. A sequential behavioral analysis of craving sweets in obese women. Addictive behaviors. vol 18. issue 1. 1993-05-03. PMID:8465679. |
these data are not consistent with the hypothesis that sweet craver's consume high-carbohydrate, low-protein meals and snacks in order to self-medicate depression caused by serotonin depletion. |
1993-05-03 |
2023-08-12 |
human |
| Y God. [Ventilatory mechanical analysis of respiratory depression induced by serotonin]. [Hokkaido igaku zasshi] The Hokkaido journal of medical science. vol 68. issue 1. 1993-04-02. PMID:8444402. |
[ventilatory mechanical analysis of respiratory depression induced by serotonin]. |
1993-04-02 |
2023-08-12 |
rat |
| D J Kupfe. Management of recurrent depression. The Journal of clinical psychiatry. vol 54 Suppl. 1993-04-02. PMID:8444832. |
the results of 1-year studies of maintenance therapy with serotonin selective reuptake inhibiting agents suggest that these medications will play a major role in prophylaxis for recurrent depression. |
1993-04-02 |
2023-08-12 |
Not clear |
| J P Ottervanger, P M van den Bemt, G H de Koning, B H Stricke. [Risk of hemorrhage with the use of fluoxetine (Prozac) or fluvoxamine (Fevarin)]. Nederlands tijdschrift voor geneeskunde. vol 137. issue 5. 1993-03-12. PMID:8433763. |
fluoxetine (prozac) and fluvoxamine (fevarin) are nontricyclic serotonin (5-hydroxytryptamine) reuptake inhibitors prescribed for the treatment of depression. |
1993-03-12 |
2023-08-12 |
Not clear |
| H M van Praa. About the centrality of mood lowering in mood disorders. Plenary Lecture ECNP Congress, Monte Carlo, October 1991. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 2. issue 4. 1993-03-01. PMID:1362659. |
5-ht disturbances in depression (as exemplified by lowered csf 5-hiaa) are not syndrome specific but related to components of the depressive syndrome, specifically to increased anxiety and aggression. |
1993-03-01 |
2023-08-11 |
Not clear |
| H M van Praa. About the centrality of mood lowering in mood disorders. Plenary Lecture ECNP Congress, Monte Carlo, October 1991. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 2. issue 4. 1993-03-01. PMID:1362659. |
in "5-ht related depression", the key psychopathological disturbances are dysregulation of anxiety and aggression, while mood lowering is a "by-product". |
1993-03-01 |
2023-08-11 |
Not clear |
| H M van Praa. About the centrality of mood lowering in mood disorders. Plenary Lecture ECNP Congress, Monte Carlo, October 1991. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 2. issue 4. 1993-03-01. PMID:1362659. |
based on this hypothesis it was predicted that agents which ameliorate anxiety and/or aggression via harmonization of 5-ht ergic transmission will, in addition, exert overall antidepressant effect in "5-ht related depression". |
1993-03-01 |
2023-08-11 |
Not clear |
| S Dey, R H Singh, P K De. Exercise training: significance of regional alterations in serotonin metabolism of rat brain in relation to antidepressant effect of exercise. Physiology & behavior. vol 52. issue 6. 1993-02-17. PMID:1283013. |
these findings have been discussed in an attempt to explain the antidepressant effect of exercise based on the 5ht deficiency theory of endogenous depression. |
1993-02-17 |
2023-08-11 |
rat |
| S J Warringto. Clinical implications of the pharmacology of serotonin reuptake inhibitors. International clinical psychopharmacology. vol 7 Suppl 2. 1993-02-17. PMID:1484174. |
the similarities between the ssris are more obvious than their differences: all are highly potent and selective inhibitors of serotonin reuptake with efficacy in the treatment of depression. |
1993-02-17 |
2023-08-11 |
Not clear |
| J Mendel. The acute and long-term treatment of major depression. International clinical psychopharmacology. vol 7 Suppl 2. 1993-02-17. PMID:1484175. |
the availability of a new class of antidepressant medications--the selective serotonin reuptake inhibitors (ssris)--heralds a new phase in the treatment of depression. |
1993-02-17 |
2023-08-11 |
Not clear |
| C Thompso. Bridging the gap between psychiatric practice and primary care. International clinical psychopharmacology. vol 7 Suppl 2. 1993-02-17. PMID:1484176. |
however, prescriptions of the selective serotonin reuptake inhibitors (ssris) for depression are gradually increasing here and in other countries such as the usa, france and canada, where the ssris as a class account for upwards of 30% of new antidepressant prescriptions. |
1993-02-17 |
2023-08-11 |
Not clear |
| G Chouinar. Sertraline in the treatment of obsessive compulsive disorder: two double-blind, placebo-controlled studies. International clinical psychopharmacology. vol 7 Suppl 2. 1993-02-17. PMID:1484177. |
sertraline is a non-tricyclic, potent and selective serotonin reuptake inhibitor (ssri) which is currently approved for the treatment of depression in several countries, including the uk and the usa. |
1993-02-17 |
2023-08-11 |
Not clear |