| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A H Chester, R Panda, J A Borland, S Tadjkarimi, C J Schyns, G S O'Neil, M H Yacou. Effect of mode of application of papaverine on the contractile response of the internal mammary artery. The British journal of surgery. vol 81. issue 4. 1994-07-11. PMID:8205426. |
segments of ima exposed to only intraluminal papaverine (10(-4) mol/l) for 15 min recovered their contractile response to 90 mmol/l potassium chloride to pretreatment levels within 2 h. in contrast, combined intraluminal and extraluminal administration of papaverine resulted in a significant depression of the contractile response to 90 mmol/l potassium chloride (p < 0.001), which persisted for at least 5 h. responses to 5-hydroxytryptamine, noradrenaline, the thromboxane mimetic u46619, histamine and dopamine were not significantly different between control tissues and those that had received intraluminal papaverine. |
1994-07-11 |
2023-08-12 |
Not clear |
| P J Cowen, A C Power, C J Ware, I M Anderso. 5-HT1A receptor sensitivity in major depression. A neuroendocrine study with buspirone. The British journal of psychiatry : the journal of mental science. vol 164. issue 3. 1994-07-07. PMID:8199791. |
within the limitations that attend the use of buspirone as a 5-ht1a probe, our data suggest that the decrement in serotonin neurotransmission at post-synaptic 5-ht1a receptors in depression is due to decreased serotonin release rather than impaired responsivity of post-synaptic 5-ht1a receptors. |
1994-07-07 |
2023-08-12 |
Not clear |
| R M Salomon, H L Miller, P L Delgado, D Charne. The use of tryptophan depletion to evaluate central serotonin function in depression and other neuropsychiatric disorders. International clinical psychopharmacology. vol 8 Suppl 2. 1994-07-07. PMID:8201246. |
the use of tryptophan depletion to evaluate central serotonin function in depression and other neuropsychiatric disorders. |
1994-07-07 |
2023-08-12 |
human |
| G Andersen, K Vestergaard, L Lauritze. Effective treatment of poststroke depression with the selective serotonin reuptake inhibitor citalopram. Stroke. vol 25. issue 6. 1994-07-01. PMID:8202964. |
effective treatment of poststroke depression with the selective serotonin reuptake inhibitor citalopram. |
1994-07-01 |
2023-08-12 |
Not clear |
| A Eckert, H Gann, D Riemann, J Aldenhoff, W E Mülle. Platelet and lymphocyte free intracellular calcium in affective disorders. European archives of psychiatry and clinical neuroscience. vol 243. issue 5. 1994-06-09. PMID:8172937. |
1991b) about elevated [ca2+]i after serotonin stimulation in platelets of depressed patients was interpreted as further evidence for enhanced serotonergic sensitivity in depression. |
1994-06-09 |
2023-08-12 |
Not clear |
| J Svestk. [Antidepressives of the 3rd, 4th and 5th generation]. Ceskoslovenska psychiatrie. vol 90. issue 1. 1994-06-08. PMID:8174184. |
the antidepressant action of preparations of the third generation is mediated only by one of the three main neurotransmitter systems for depression (5-ht, noradrenaline, dopamine) and does not affect muscarine, histamine and adrenergic cerebral systems (e.g. |
1994-06-08 |
2023-08-12 |
Not clear |
| R W Fuller, S K Hemrick-Luecke, H D Snodd. Effects of duloxetine, an antidepressant drug candidate, on concentrations of monoamines and their metabolites in rats and mice. The Journal of pharmacology and experimental therapeutics. vol 269. issue 1. 1994-06-02. PMID:7513356. |
in vitro, duloxetine had little effect on either type a (serotonin as substrate) or type b (phenylethylamine as substrate) monoamine oxidase, ic50 concentrations being above 10(-5) m. these data extend evidence that duloxetine inhibits serotonin and norepinephrine transporters in vivo, actions that may lead to therapeutic efficacy in mental depression. |
1994-06-02 |
2023-08-12 |
mouse |
| A Apter, G Ratzoni, R A King, A Weizman, I Iancu, M Binder, M A Riddl. Fluvoxamine open-label treatment of adolescent inpatients with obsessive-compulsive disorder or depression. Journal of the American Academy of Child and Adolescent Psychiatry. vol 33. issue 3. 1994-06-02. PMID:8169178. |
fluvoxamine, a monocyclic, specific serotonin uptake inhibitor with demonstrated efficacy in obsessive-compulsive disorder (ocd) and depression in adults, is marketed in more than 30 countries worldwide, including israel. |
1994-06-02 |
2023-08-12 |
Not clear |
| H Agren, L Reibrin. PET studies of presynaptic monoamine metabolism in depressed patients and healthy volunteers. Pharmacopsychiatry. vol 27. issue 1. 1994-05-19. PMID:8159778. |
the availability of 11c-labelled 5-hydroxytryptophan (5-htp) and l-dopa, the direct precursors in the synthetic pathways to serotonin and dopamine, has allowed positron emission tomographic (pet) studies in 8 healthy volunteers and 6 patients suffering from unipolar depression. |
1994-05-19 |
2023-08-12 |
human |
| J Demlin. [Fear, violence and depression--does too little serotonin make the mind ill?]. Fortschritte der Medizin. vol 112. issue 4. 1994-05-12. PMID:8150402. |
[fear, violence and depression--does too little serotonin make the mind ill? |
1994-05-12 |
2023-08-12 |
Not clear |
| P Toren, A Weizma. Is serotonin the main culprit in depression? Israel journal of medical sciences. vol 30. issue 2. 1994-05-10. PMID:8150604. |
is serotonin the main culprit in depression? |
1994-05-10 |
2023-08-12 |
Not clear |
| F S Guimarães, E A Del Bel, C M Padovan, S M Netto, R T de Almeid. Hippocampal 5-HT receptors and consolidation of stressful memories. Behavioural brain research. vol 58. issue 1-2. 1994-04-25. PMID:8136041. |
it has been suggested that postsynaptic 5-ht1a receptors in the hippocampus, innervated by 5-ht neurons localized in the median raphe nucleus, mediate adaptive or coping responses to aversive events and that dysfunction of this system is related to symptoms of depression. |
1994-04-25 |
2023-08-12 |
rat |
| V Manna, F Bolino, L Di Cicc. Chronic tension-type headache, mood depression and serotonin: therapeutic effects of fluvoxamine and mianserine. Headache. vol 34. issue 1. 1994-04-15. PMID:8132440. |
chronic tension-type headache, mood depression and serotonin: therapeutic effects of fluvoxamine and mianserine. |
1994-04-15 |
2023-08-12 |
human |
| J Ortiz, C Mariscot, E Alvarez, F Artiga. Effects of the antidepressant drug tianeptine on plasma and platelet serotonin of depressive patients and healthy controls. Journal of affective disorders. vol 29. issue 4. 1994-04-08. PMID:7510316. |
however, long-term treatment tended (p < 0.06) to increase basal plasma 5-ht concentrations, in covariation with decreases of madrs (montgomery-asberg depression rating scale) and hars (hamilton anxiety rating scale). |
1994-04-08 |
2023-08-12 |
Not clear |
| P L Delgado, H L Miller, R M Salomon, J Licinio, G R Heninger, A J Gelenberg, D S Charne. Monoamines and the mechanism of antidepressant action: effects of catecholamine depletion on mood of patients treated with antidepressants. Psychopharmacology bulletin. vol 29. issue 3. 1994-04-07. PMID:8121966. |
the 3 desipramine- and 2 mazindol-responders had a rapid increase in depression score during ampt but not placebo (diphenhydramine) challenge whereas only 1 of 9 selective serotonin reuptake inhibitor (ssri)-treated patients did. |
1994-04-07 |
2023-08-12 |
Not clear |
| E H Jaffe, V De Frias, C Ibarr. Changes in basal and stimulated release of endogenous serotonin from different nuclei of rats subjected to two models of depression. Neuroscience letters. vol 162. issue 1-2. 1994-04-04. PMID:8121620. |
changes in basal and stimulated release of endogenous serotonin from different nuclei of rats subjected to two models of depression. |
1994-04-04 |
2023-08-12 |
rat |
| E H Jaffe, V De Frias, C Ibarr. Changes in basal and stimulated release of endogenous serotonin from different nuclei of rats subjected to two models of depression. Neuroscience letters. vol 162. issue 1-2. 1994-04-04. PMID:8121620. |
this constitutes the first direct demonstration of a decreased tonic release of serotonin from different nuclei during depression. |
1994-04-04 |
2023-08-12 |
rat |
| J Akiyoshi, K Tsuchiyama, Y Mizobe, M Nakamura, H Kuranaga, H Nagayam. Effects of chronic mianserin administration on serotonin metabolism and receptors in the 5-hydroxytryptophan depression model. Progress in neuro-psychopharmacology & biological psychiatry. vol 18. issue 1. 1994-03-31. PMID:7509496. |
effects of chronic mianserin administration on serotonin metabolism and receptors in the 5-hydroxytryptophan depression model. |
1994-03-31 |
2023-08-12 |
Not clear |
| M J Owens, C B Nemerof. Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clinical chemistry. vol 40. issue 2. 1994-03-24. PMID:7508830. |
role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. |
1994-03-24 |
2023-08-12 |
Not clear |
| M J Owens, C B Nemerof. Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clinical chemistry. vol 40. issue 2. 1994-03-24. PMID:7508830. |
in our studies, this reduction in platelet 5-ht transporter binding is not due to prior antidepressant treatment of hypercortisolemia and is not observed in mania, alzheimer disease, schizophrenia, panic disorder, fibromyalgia, or atypical depression. |
1994-03-24 |
2023-08-12 |
Not clear |