| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Kh Bozhko, V I Tsaritsinskiĭ, L S Kostiukovskaia, V M Kulabukho. [The effect of an increased intensity of light on changes in the serotonin and melatonin content in patients with depression]. Likars'ka sprava. issue 7-8. 1995-04-24. PMID:7900366. |
[the effect of an increased intensity of light on changes in the serotonin and melatonin content in patients with depression]. |
1995-04-24 |
2023-08-12 |
Not clear |
| D B Montgomery, A Roberts, M Green, T Bullock, D Baldwin, S A Montgomer. Lack of efficacy of fluoxetine in recurrent brief depression and suicidal attempts. European archives of psychiatry and clinical neuroscience. vol 244. issue 4. 1995-04-20. PMID:7888419. |
the possibility that antidepressants with selective action on the reuptake of serotonin might be effective in preventing recurrences of brief depression has been investigated. |
1995-04-20 |
2023-08-12 |
Not clear |
| D C Manoli. The perils of Prozac. Minnesota medicine. vol 78. issue 1. 1995-03-31. PMID:7794331. |
prozac and the other selective serotonin re-uptake inhibitors have been determined to be safe and effective treatment for depression. |
1995-03-31 |
2023-08-12 |
Not clear |
| K M Lawrence, J Falkowski, R R Jacobson, R W Horto. Platelet 5-HT uptake sites in depression: three concurrent measures using [3H] imipramine and [3H] paroxetine. Psychopharmacology. vol 110. issue 1-2. 1995-03-29. PMID:7870891. |
platelet 5-ht uptake sites in depression: three concurrent measures using [3h] imipramine and [3h] paroxetine. |
1995-03-29 |
2023-08-12 |
human |
| K M Lawrence, J Falkowski, R R Jacobson, R W Horto. Platelet 5-HT uptake sites in depression: three concurrent measures using [3H] imipramine and [3H] paroxetine. Psychopharmacology. vol 110. issue 1-2. 1995-03-29. PMID:7870891. |
this study provides no support for the view that the number of platelet 5-ht uptake sites are reduced in depression. |
1995-03-29 |
2023-08-12 |
human |
| P D Hrdina, D Bakish, J Chudzik, A Ravindran, Y D Lapierr. Serotonergic markers in platelets of patients with major depression: upregulation of 5-HT2 receptors. Journal of psychiatry & neuroscience : JPN. vol 20. issue 1. 1995-03-27. PMID:7865496. |
the uptake of [3h]5-ht and the density (bmax) as well as affinity (kd) of 5-ht uptake sites labelled with [3h]paroxetine and of 5-ht2 receptors labelled by [3h]lsd were determined in platelets from 25 medication-free patients with major depression and 20 normal controls. |
1995-03-27 |
2023-08-12 |
human |
| R C Shelto. The role of sertraline in the management of depression. Clinical therapeutics. vol 16. issue 5. 1995-03-21. PMID:7859236. |
this serotonin reuptake inhibitor shows promise as an important therapeutic and prophylactic alternative in the pharmacologic management of depression. |
1995-03-21 |
2023-08-12 |
Not clear |
| M K Nixon, M Hascoet, M Bourin, M C Colombe. Additive effects of lithium and antidepressants in the forced swimming test: further evidence for involvement of the serotoninergic system. Psychopharmacology. vol 115. issue 1-2. 1995-03-20. PMID:7862913. |
these results, using an animal behavioral model of depression and combining our present knowledge of the acute action of various ads, support the hypothesis that the potentiation by lithium of ads is via direct 5ht mechanisms, indirectly via a na/5ht link, and/or by second messenger systems. |
1995-03-20 |
2023-08-12 |
mouse |
| K Tsuiki, A Takada, S Nagahiro, M Grdisa, M Diksic, H M Pappiu. Synthesis of serotonin in traumatized rat brain. Journal of neurochemistry. vol 64. issue 3. 1995-03-17. PMID:7861164. |
the results confirmed that 3 days after the lesion was made, at the time of greatest depression of glucose use, serotonin synthesis was significantly increased in cortical areas throughout the injured hemisphere. |
1995-03-17 |
2023-08-12 |
rat |
| M M Katz, J W Maas, A Frazer, S H Koslow, C L Bowden, N Berman, A C Swann, P E Stoke. Drug-induced actions on brain neurotransmitter systems and changes in the behaviors and emotions of depressed patients. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 11. issue 2. 1995-03-07. PMID:7530963. |
despite cumulative evidence that the tricyclic drugs result in significant changes in the functioning of brain serotonergic (5-ht) and nordrenergic (ne) systems, such changes have not been found to be associated with recovery from depression. |
1995-03-07 |
2023-08-12 |
Not clear |
| M M Katz, J W Maas, A Frazer, S H Koslow, C L Bowden, N Berman, A C Swann, P E Stoke. Drug-induced actions on brain neurotransmitter systems and changes in the behaviors and emotions of depressed patients. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 11. issue 2. 1995-03-07. PMID:7530963. |
adopting this approach of looking for relationships between changes in components of major depression and changes in neurotransmitter system function, decreases in 5-ht and ne metabolite concentrations in cerebrospinal fluid (csf) in patients treated with tricyclics, were found to be correlated with changes in specific behaviors. |
1995-03-07 |
2023-08-12 |
Not clear |
| P Schoeffter, C Waebe. 5-Hydroxytryptamine receptors with a 5-HT6 receptor-like profile stimulating adenylyl cyclase activity in pig caudate membranes. Naunyn-Schmiedeberg's archives of pharmacology. vol 350. issue 4. 1995-03-07. PMID:7845473. |
in antagonist studies, methiothepin (0.1 and 1 mumol/l) shifted the 5-ht curve to the right with no depression of the emax, yielding pkb values of 7.4-8.0. |
1995-03-07 |
2023-08-12 |
Not clear |
| A J Flin. Recent developments in geriatric psychopharmacotherapy. Canadian journal of psychiatry. Revue canadienne de psychiatrie. vol 39. issue 8 Suppl 1. 1995-02-23. PMID:7828123. |
the current roles of tricyclic antidepressants, selective serotonin reuptake inhibitors (ssris) and monoamine oxidase inhibitors (maois) in the treatment of depression in old age are discussed. |
1995-02-23 |
2023-08-12 |
Not clear |
| A Kamoun, B Delalleau, M Ozu. [Can a serotonin uptake agonist be an authentic antidepressant? Results of a multicenter, multinational therapeutic trial]. L'Encephale. vol 20. issue 5. 1995-02-23. PMID:7828515. |
the classical biochemical hypothesis of depression posits a functional deficit in central neurotransmitter systems particularly serotonin (5-ht) and noradrenaline. |
1995-02-23 |
2023-08-12 |
mouse |
| A Kamoun, B Delalleau, M Ozu. [Can a serotonin uptake agonist be an authentic antidepressant? Results of a multicenter, multinational therapeutic trial]. L'Encephale. vol 20. issue 5. 1995-02-23. PMID:7828515. |
numerous clinical trials have demonstrated the antidepressant efficacy of such types of serotoninergic agents, supporting 5-ht deficit as the main origin of depression. |
1995-02-23 |
2023-08-12 |
mouse |
| A Kamoun, B Delalleau, M Ozu. [Can a serotonin uptake agonist be an authentic antidepressant? Results of a multicenter, multinational therapeutic trial]. L'Encephale. vol 20. issue 5. 1995-02-23. PMID:7828515. |
therefore, everything seemed clear: depression was caused by 5-ht deficit. |
1995-02-23 |
2023-08-12 |
mouse |
| S B Deshpande, J E Warnic. Thyrotropin-releasing hormone reverses the supersensitively depressed monosynaptic transmission by serotonin in 5,7-dihydroxytryptamine-treated neonatal rats in vitro. Brain research. vol 655. issue 1-2. 1995-02-06. PMID:7812785. |
the depression was about 25% at 10 microm of serotonin, in either control or vehicle-treated groups. |
1995-02-06 |
2023-08-12 |
rat |
| S B Deshpande, J E Warnic. Thyrotropin-releasing hormone reverses the supersensitively depressed monosynaptic transmission by serotonin in 5,7-dihydroxytryptamine-treated neonatal rats in vitro. Brain research. vol 655. issue 1-2. 1995-02-06. PMID:7812785. |
while for the same concentration of serotonin, the depression was 97 +/- 2.1% of the control in cords from 5,7 dihydroxytryptamine (5,7-dht)-treated animals. |
1995-02-06 |
2023-08-12 |
rat |
| C B Montan. Recognition and treatment of depression in a primary care setting. The Journal of clinical psychiatry. vol 55 Suppl. 1995-02-06. PMID:7814355. |
the introduction of the serotonin selective reuptake inhibitors (ssris), antidepressants that are far less toxic and have a milder side effect profile than the tricyclic antidepressants (tcas), has made it possible for depression to be treated more successfully in the primary care setting. |
1995-02-06 |
2023-08-12 |
Not clear |
| T Partone. Involvement of melatonin and serotonin in winter depression. Medical hypotheses. vol 43. issue 3. 1995-02-06. PMID:7815972. |
involvement of melatonin and serotonin in winter depression. |
1995-02-06 |
2023-08-12 |
Not clear |