| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Tsuiki, A Takada, S Nagahiro, M Grdisa, M Diksic, H M Pappiu. Synthesis of serotonin in traumatized rat brain. Journal of neurochemistry. vol 64. issue 3. 1995-03-17. PMID:7861164. |
the results confirmed that 3 days after the lesion was made, at the time of greatest depression of glucose use, serotonin synthesis was significantly increased in cortical areas throughout the injured hemisphere. |
1995-03-17 |
2023-08-12 |
rat |
| M M Katz, J W Maas, A Frazer, S H Koslow, C L Bowden, N Berman, A C Swann, P E Stoke. Drug-induced actions on brain neurotransmitter systems and changes in the behaviors and emotions of depressed patients. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 11. issue 2. 1995-03-07. PMID:7530963. |
despite cumulative evidence that the tricyclic drugs result in significant changes in the functioning of brain serotonergic (5-ht) and nordrenergic (ne) systems, such changes have not been found to be associated with recovery from depression. |
1995-03-07 |
2023-08-12 |
Not clear |
| M M Katz, J W Maas, A Frazer, S H Koslow, C L Bowden, N Berman, A C Swann, P E Stoke. Drug-induced actions on brain neurotransmitter systems and changes in the behaviors and emotions of depressed patients. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 11. issue 2. 1995-03-07. PMID:7530963. |
adopting this approach of looking for relationships between changes in components of major depression and changes in neurotransmitter system function, decreases in 5-ht and ne metabolite concentrations in cerebrospinal fluid (csf) in patients treated with tricyclics, were found to be correlated with changes in specific behaviors. |
1995-03-07 |
2023-08-12 |
Not clear |
| P Schoeffter, C Waebe. 5-Hydroxytryptamine receptors with a 5-HT6 receptor-like profile stimulating adenylyl cyclase activity in pig caudate membranes. Naunyn-Schmiedeberg's archives of pharmacology. vol 350. issue 4. 1995-03-07. PMID:7845473. |
in antagonist studies, methiothepin (0.1 and 1 mumol/l) shifted the 5-ht curve to the right with no depression of the emax, yielding pkb values of 7.4-8.0. |
1995-03-07 |
2023-08-12 |
Not clear |
| A J Flin. Recent developments in geriatric psychopharmacotherapy. Canadian journal of psychiatry. Revue canadienne de psychiatrie. vol 39. issue 8 Suppl 1. 1995-02-23. PMID:7828123. |
the current roles of tricyclic antidepressants, selective serotonin reuptake inhibitors (ssris) and monoamine oxidase inhibitors (maois) in the treatment of depression in old age are discussed. |
1995-02-23 |
2023-08-12 |
Not clear |
| A Kamoun, B Delalleau, M Ozu. [Can a serotonin uptake agonist be an authentic antidepressant? Results of a multicenter, multinational therapeutic trial]. L'Encephale. vol 20. issue 5. 1995-02-23. PMID:7828515. |
the classical biochemical hypothesis of depression posits a functional deficit in central neurotransmitter systems particularly serotonin (5-ht) and noradrenaline. |
1995-02-23 |
2023-08-12 |
mouse |
| A Kamoun, B Delalleau, M Ozu. [Can a serotonin uptake agonist be an authentic antidepressant? Results of a multicenter, multinational therapeutic trial]. L'Encephale. vol 20. issue 5. 1995-02-23. PMID:7828515. |
numerous clinical trials have demonstrated the antidepressant efficacy of such types of serotoninergic agents, supporting 5-ht deficit as the main origin of depression. |
1995-02-23 |
2023-08-12 |
mouse |
| A Kamoun, B Delalleau, M Ozu. [Can a serotonin uptake agonist be an authentic antidepressant? Results of a multicenter, multinational therapeutic trial]. L'Encephale. vol 20. issue 5. 1995-02-23. PMID:7828515. |
therefore, everything seemed clear: depression was caused by 5-ht deficit. |
1995-02-23 |
2023-08-12 |
mouse |
| S B Deshpande, J E Warnic. Thyrotropin-releasing hormone reverses the supersensitively depressed monosynaptic transmission by serotonin in 5,7-dihydroxytryptamine-treated neonatal rats in vitro. Brain research. vol 655. issue 1-2. 1995-02-06. PMID:7812785. |
the depression was about 25% at 10 microm of serotonin, in either control or vehicle-treated groups. |
1995-02-06 |
2023-08-12 |
rat |
| S B Deshpande, J E Warnic. Thyrotropin-releasing hormone reverses the supersensitively depressed monosynaptic transmission by serotonin in 5,7-dihydroxytryptamine-treated neonatal rats in vitro. Brain research. vol 655. issue 1-2. 1995-02-06. PMID:7812785. |
while for the same concentration of serotonin, the depression was 97 +/- 2.1% of the control in cords from 5,7 dihydroxytryptamine (5,7-dht)-treated animals. |
1995-02-06 |
2023-08-12 |
rat |
| C B Montan. Recognition and treatment of depression in a primary care setting. The Journal of clinical psychiatry. vol 55 Suppl. 1995-02-06. PMID:7814355. |
the introduction of the serotonin selective reuptake inhibitors (ssris), antidepressants that are far less toxic and have a milder side effect profile than the tricyclic antidepressants (tcas), has made it possible for depression to be treated more successfully in the primary care setting. |
1995-02-06 |
2023-08-12 |
Not clear |
| T Partone. Involvement of melatonin and serotonin in winter depression. Medical hypotheses. vol 43. issue 3. 1995-02-06. PMID:7815972. |
involvement of melatonin and serotonin in winter depression. |
1995-02-06 |
2023-08-12 |
Not clear |
| P J McGrath, J W Stewart, F M Quitkin, S Wager, S W Jenkins, D G Archibald, J C Stringfellow, D S Robinso. Gepirone treatment of atypical depression: preliminary evidence of serotonergic involvement. Journal of clinical psychopharmacology. vol 14. issue 5. 1995-02-01. PMID:7806692. |
this is a report of a controlled trial of gepirone, a 5-hydroxytryptamine (5-ht1a) partial agonist azapirone related to buspirone, in the treatment of atypical depression. |
1995-02-01 |
2023-08-12 |
Not clear |
| D E King, D H Finestone, J G Pede. Combination antidepressant therapy in primary care. Archives of family medicine. vol 3. issue 12. 1995-01-31. PMID:7804494. |
increasing clinical experience with the selective serotonin reuptake inhibitors and tricyclic antidepressants make combination antidepressant therapy at times a reasonable alternative to single-agent therapy in primary care patients with depression. |
1995-01-31 |
2023-08-12 |
Not clear |
| P Martin, F Lemonnie. [The role of type 2 serotonin receptors, 5-HT2A and 5-HT2C, in depressive disorders: effect of medifoxamine]. L'Encephale. vol 20. issue 4. 1995-01-12. PMID:7988407. |
the serotonin (5-ht) is implicated in many centrally-regulated functions and has shown to be involved in affective disorders, such as depression and anxiety disorders. |
1995-01-12 |
2023-08-12 |
human |
| E Perucca, G Gatti, E Spin. Clinical pharmacokinetics of fluvoxamine. Clinical pharmacokinetics. vol 27. issue 3. 1995-01-11. PMID:7988100. |
fluvoxamine is a selective inhibitor of serotonin reuptake that is widely used in the management of depression. |
1995-01-11 |
2023-08-12 |
human |
| J M Andrews, C B Nemerof. Contemporary management of depression. The American journal of medicine. vol 97. issue 6A. 1995-01-11. PMID:7992823. |
treatment of depression has improved in recent years because of the availability of effective and well-tolerated antidepressants, such as the selective serotonin reuptake inhibitors (ssris). |
1995-01-11 |
2023-08-12 |
Not clear |
| C D Kilt. Recent pharmacologic advances in antidepressant therapy. The American journal of medicine. vol 97. issue 6A. 1995-01-11. PMID:7992824. |
the serotonergic properties of newer generation antidepressants underscore the role of 5-hydroxytryptamine (5-ht, serotonin) in both the pathophysiology and the pharmacotherapy of major depression. |
1995-01-11 |
2023-08-12 |
Not clear |
| R M Hirschfeld, A F Schatzber. Long-term management of depression. The American journal of medicine. vol 97. issue 6A. 1995-01-11. PMID:7992825. |
the selective serotonin reuptake inhibitors (ssris) have been studied in recurrent depression and are rational choices for initial maintenance therapy because of demonstrated efficacy, safety, and tolerance during long-term therapy. |
1995-01-11 |
2023-08-12 |
Not clear |
| B Levine, A J Jenkins, J E Smiale. Distribution of sertraline in postmortem cases. Journal of analytical toxicology. vol 18. issue 5. 1995-01-06. PMID:7990446. |
sertraline is a potent inhibitor of serotonin reuptake in the central nervous system and is used clinically to treat depression and obsessive-compulsive behavior. |
1995-01-06 |
2023-08-12 |
Not clear |