| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Mendels, F Reimherr, R N Marcus, D L Roberts, R J Francis, S F Anto. A double-blind, placebo-controlled trial of two dose ranges of nefazodone in the treatment of depressed outpatients. The Journal of clinical psychiatry. vol 56 Suppl 6. 1995-09-28. PMID:7649971. |
nefazodone hydrochloride, a 5-ht2 receptor antagonist that selectively inhibits serotonin reuptake, was evaluated in a double-blind, dose-finding study of novel design, involving 240 patients with major depression. |
1995-09-28 |
2023-08-12 |
Not clear |
| K Rickels, D S Robinson, E Schweizer, R N Marcus, D L Robert. Nefazodone: aspects of efficacy. The Journal of clinical psychiatry. vol 56 Suppl 6. 1995-09-28. PMID:7649973. |
nefazodone hydrochloride, a 5-ht2 receptor antagonist and serotonin (5-ht) uptake inhibitor, was evaluated in four phase 3 double-blind, imipramine- and placebo-controlled studies involving outpatients with major depression. |
1995-09-28 |
2023-08-12 |
Not clear |
| H H Berendse. Interactions between 5-hydroxytryptamine receptor subtypes: is a disturbed receptor balance contributing to the symptomatology of depression in humans? Pharmacology & therapeutics. vol 66. issue 1. 1995-09-07. PMID:7630928. |
interactions between 5-hydroxytryptamine receptor subtypes: is a disturbed receptor balance contributing to the symptomatology of depression in humans? |
1995-09-07 |
2023-08-12 |
Not clear |
| I Hindmarc. The behavioural toxicity of the selective serotonin reuptake inhibitors. International clinical psychopharmacology. vol 9 Suppl 4. 1995-08-31. PMID:7622818. |
the serotonin reuptake inhibitors (ssris) are generally better tolerated than the traditional tricyclic antidepressants (tcas) in the treatment of major depression. |
1995-08-31 |
2023-08-12 |
Not clear |
| D Baldwin, S Rudg. The role of serotonin in depression and anxiety. International clinical psychopharmacology. vol 9 Suppl 4. 1995-08-31. PMID:7622823. |
the role of serotonin in depression and anxiety. |
1995-08-31 |
2023-08-12 |
Not clear |
| D Baldwin, S Rudg. The role of serotonin in depression and anxiety. International clinical psychopharmacology. vol 9 Suppl 4. 1995-08-31. PMID:7622823. |
recent research has identified that various abnormalities in serotonergic function are involved in the pathogenesis of depression and anxiety, and has facilitated the development of new pharmacological agents with great therapeutic potential, for example the selective serotonin reuptake inhibitors (ssris). |
1995-08-31 |
2023-08-12 |
Not clear |
| P Robert, S A Montgomer. Citalopram in doses of 20-60 mg is effective in depression relapse prevention: a placebo-controlled 6 month study. International clinical psychopharmacology. vol 10 Suppl 1. 1995-08-30. PMID:7622809. |
the aim of the present study was to determine whether, in patients with depression who had responded favourably to the selective serotonin reuptake inhibitor citalopram, there was a therapeutic benefit in continuation treatment. |
1995-08-30 |
2023-08-12 |
Not clear |
| D T Wong, F P Bymaster, E A Englema. Prozac (fluoxetine, Lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: twenty years since its first publication. Life sciences. vol 57. issue 5. 1995-08-28. PMID:7623609. |
the historical background of the proposed involvement of 5-ht in psychiatric disorders and the activity of tricyclic antidepressants in depression is reviewed. |
1995-08-28 |
2023-08-12 |
Not clear |
| M Bijak, M Pap. The effect of chronic treatment with imipramine on the responsiveness of hippocampal CA1 neurons to phenylephrine and serotonin in a chronic mild stress model of depression. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 5. issue 1. 1995-08-24. PMID:7613100. |
the effect of chronic treatment with imipramine on the responsiveness of hippocampal ca1 neurons to phenylephrine and serotonin in a chronic mild stress model of depression. |
1995-08-24 |
2023-08-12 |
rat |
| C Maudhuit, M Hamon, J Adrie. Electrophysiological activity of raphe dorsalis serotoninergic neurones in a possible model of endogenous depression. Neuroreport. vol 6. issue 4. 1995-08-17. PMID:7605927. |
this suggests that neonatal clomipramine treatment results in a long lasting desensitization of somatodendritic 5-ht1a autoreceptors, leading possibly to a dysregulation of 5-ht neurone activity in this proposed model of depression. |
1995-08-17 |
2023-08-12 |
human |
| F Orallo, A Fernández Alzueta, M Campos-Toimil, J M Callej. Study of the in vivo and in vitro cardiovascular effects of (+)-glaucine and N-carbethoxysecoglaucine in rats. British journal of pharmacology. vol 114. issue 7. 1995-08-17. PMID:7606346. |
in isolated intact aorta of rat, (+)-glaucine (0.15-5 microm) competitively inhibited the contractions induced by na (with a pa2 value of 7.14) and non-competitively those induced by 5-ht (in normal krebs solution) and ca2+ (in depolarizing ca(2+)-free high-k+ 50 mm solution), with depression of the maximal response and with pd2 values of 5.56 and 5.26, respectively. |
1995-08-17 |
2023-08-12 |
rat |
| S C Pandey, J M Davis, G N Pande. Phosphoinositide system-linked serotonin receptor subtypes and their pharmacological properties and clinical correlates. Journal of psychiatry & neuroscience : JPN. vol 20. issue 3. 1995-07-27. PMID:7786883. |
the 5-ht2a receptor subtype is the most widely studied of the 5-ht receptors in psychiatric disorders (for example, suicide, depression and schizophrenia) as well as in relation to the mechanism of action of antidepressant drugs. |
1995-07-27 |
2023-08-12 |
Not clear |
| Y I Sheline, M E Bardgett, J L Jackson, J W Newcomer, J G Csernansk. Platelet serotonin markers and depressive symptomatology. Biological psychiatry. vol 37. issue 7. 1995-07-27. PMID:7786957. |
to examine the specificity of relationships between cognitive and vegetative symptom groupings and platelet serotonin measures, we assessed 35 depressed outpatients using the hamilton rating scale for depression and collected platelets after a minimum 3-week drug-free period. |
1995-07-27 |
2023-08-12 |
Not clear |
| Y I Sheline, M E Bardgett, J L Jackson, J W Newcomer, J G Csernansk. Platelet serotonin markers and depressive symptomatology. Biological psychiatry. vol 37. issue 7. 1995-07-27. PMID:7786957. |
the results showed that depressed patients had lower platelet serotonin (5-ht) uptake site density values than controls and that 5-ht uptake site density values were inversely correlated with the severity of cognitive symptoms of depression. |
1995-07-27 |
2023-08-12 |
Not clear |
| H Pertz, S El. In-vitro pharmacology of sarpogrelate and the enantiomers of its major metabolite: 5-HT2A receptor specificity, stereoselectivity and modulation of ritanserin-induced depression of 5-HT contractions in rat tail artery. The Journal of pharmacy and pharmacology. vol 47. issue 4. 1995-07-27. PMID:7791029. |
in-vitro pharmacology of sarpogrelate and the enantiomers of its major metabolite: 5-ht2a receptor specificity, stereoselectivity and modulation of ritanserin-induced depression of 5-ht contractions in rat tail artery. |
1995-07-27 |
2023-08-12 |
rat |
| E Le Poul, L Lima, A M Laporte, C Even, E Doucet, C M Fattaccini, N Laaris, M Hamon, L Lanfume. [Central serotonin receptors and chronic treatment with selective serotonin reuptake inhibitors in the rat: comparative effects of fluoxetine and paroxetine]. L'Encephale. vol 21. issue 2. 1995-07-20. PMID:7781583. |
the hypothesis that a dysfunction of serotonergic neurotransmission is implicated in depression is supported by the clinical efficiency of selective serotonin (5-hydroxytryptamine, 5-ht) reuptake inhibitors (ssris) in the treatment of depressive disorders. |
1995-07-20 |
2023-08-12 |
rat |
| G Andersen, K Vestergaard, L U Lauritze. [Effective treatment of depression following apoplexy with citalopram]. Ugeskrift for laeger. vol 157. issue 14. 1995-06-05. PMID:7740639. |
the aim of the study was to investigate the efficacy and safety of the selective serotonin reuptake inhibitor citalopram in treating post-stroke depression. |
1995-06-05 |
2023-08-12 |
Not clear |
| G Andersen, K Vestergaard, L U Lauritze. [Effective treatment of depression following apoplexy with citalopram]. Ugeskrift for laeger. vol 157. issue 14. 1995-06-05. PMID:7740639. |
the trial demonstrates that the selective serotonin reuptake inhibitor citalopram offers an advantageous new treatment of post-stroke depression that is both safe and effective. |
1995-06-05 |
2023-08-12 |
Not clear |
| E G Hantouche, S Lancrenon, J M Chigno. [Effect of antidepressant treatment on sense of dyscontrol: preliminary studies]. L'Encephale. vol 21. issue 1. 1995-05-25. PMID:7720623. |
cumulative data in the field of phenomenology, neurobiology and psychopharmacology indicate "discontrol" as a dimension probably linked to serotonin central activity and frequently observed in major depression and other related disorders. |
1995-05-25 |
2023-08-12 |
Not clear |
| K P Lesch, J Gross, E Franzek, B L Wolozin, P Riederer, D L Murph. Primary structure of the serotonin transporter in unipolar depression and bipolar disorder. Biological psychiatry. vol 37. issue 4. 1995-05-18. PMID:7711157. |
primary structure of the serotonin transporter in unipolar depression and bipolar disorder. |
1995-05-18 |
2023-08-12 |
Not clear |